Somatosensory evoked potentials of hand muscles in stroke and their modification by botulinumtoxin: A preliminary study

Objective: To determine the effect of botulinum toxin A on spasticity and somatosensory evoked potentials of hand muscles in patients who have undergone cerebrovascular accident. Design: Preliminary, prospective, before-after study design. Patients: Six subjects prospectively followed after application of botulinum toxin A in the rehabilitation department of a university hospital. Methods: All patients underwent botulinum toxin A injection to the upper extremity muscles in varying combinations and carried out a home-based exercise programme. Primary outcome measure was median somatosensory evoked potential of hand muscles (N20). Secondary outcome measures were: spasticity assessed clinically by Modified Ashworth Scales (MAS); functional ability analysis assessed by Physician's Rating Scale (PRS); and functional difficulties reported by patients or their care-givers by patient disability and caregiver burden rating scale (PD & CBRS). Results: MAS, PRS and PD & CBRS improved with botulinum toxin A treatment. In the affected limb, N20 potentials were impaired compared with those in the unaffected side. With botulinum toxin A treatment, although improvement in overall N20-P25 amplitudes was significant, as a result of limited sample size, post hoc pair-wise comparisons with Bonferroni correction failed to yield any significant pairs. Conclusion: The improvement in the median somatosensory evoked potentials following botulinum toxin A treatment suggests that central somatosensory patterns in hemiplegia can be modified by peripheral inputs. © 2012 Foundation of Rehabilitation Information.

Yazar Basaran A.
Emre U.
Karadavut K.I.
Bulmus N.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7575
Tek Biçim Adres 10.2340/16501977-0978
Konu Başlıkları Botulinum toxin
Somatosensory evoked potentials
Spasticity
Stroke
Upper extremity
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Rehabilitation Medicine
Dergi Cilt Bilgisi 44
Dergi Sayısı 7
Sayfalar 541 - 546
Yayın Yılı 2012
Eser Adı
[dc.title]
Somatosensory evoked potentials of hand muscles in stroke and their modification by botulinumtoxin: A preliminary study
Yazar
[dc.contributor.author]
Basaran A.
Yazar
[dc.contributor.author]
Emre U.
Yazar
[dc.contributor.author]
Karadavut K.I.
Yazar
[dc.contributor.author]
Bulmus N.
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: To determine the effect of botulinum toxin A on spasticity and somatosensory evoked potentials of hand muscles in patients who have undergone cerebrovascular accident. Design: Preliminary, prospective, before-after study design. Patients: Six subjects prospectively followed after application of botulinum toxin A in the rehabilitation department of a university hospital. Methods: All patients underwent botulinum toxin A injection to the upper extremity muscles in varying combinations and carried out a home-based exercise programme. Primary outcome measure was median somatosensory evoked potential of hand muscles (N20). Secondary outcome measures were: spasticity assessed clinically by Modified Ashworth Scales (MAS); functional ability analysis assessed by Physician's Rating Scale (PRS); and functional difficulties reported by patients or their care-givers by patient disability and caregiver burden rating scale (PD & CBRS). Results: MAS, PRS and PD & CBRS improved with botulinum toxin A treatment. In the affected limb, N20 potentials were impaired compared with those in the unaffected side. With botulinum toxin A treatment, although improvement in overall N20-P25 amplitudes was significant, as a result of limited sample size, post hoc pair-wise comparisons with Bonferroni correction failed to yield any significant pairs. Conclusion: The improvement in the median somatosensory evoked potentials following botulinum toxin A treatment suggests that central somatosensory patterns in hemiplegia can be modified by peripheral inputs. © 2012 Foundation of Rehabilitation Information.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Botulinum toxin
Konu Başlıkları
[dc.subject]
Somatosensory evoked potentials
Konu Başlıkları
[dc.subject]
Spasticity
Konu Başlıkları
[dc.subject]
Stroke
Konu Başlıkları
[dc.subject]
Upper extremity
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1650-1977
İlk Sayfa Sayısı
[dc.identifier.startpage]
541
Son Sayfa Sayısı
[dc.identifier.endpage]
546
Dergi Adı
[dc.relation.journal]
Journal of Rehabilitation Medicine
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
44
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.2340/16501977-0978
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7575
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
4
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 18:02
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Tıklayınız
botulinum somatosensory treatment muscles patients evoked potentials functional median outcome significant spasticity improvement assessed although unaffected overall compared Objective impaired affected N20-P25 Results improved amplitudes modified central patterns hemiplegia peripheral following inputs Foundation Rehabilitation Information
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