Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications
Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (ß-TCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity of the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 ß-TCP) w/w in ß-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
| Yazar |
İlhan, Elif Karahaliloğlu, Zeynep Kılıçay, Ebru Hazer, Baki Denkbaş, Emir Baki |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.12628/7088 |
| Konu Başlıkları |
Bone cement
polystyrene pre-osteoblastic MCT3T3-E1 cells silver nanoparticle soybean oil |
| Koleksiyonlar |
Fakülteler Fen Edebiyat Fakültesi Kimya Bölümü Makale Koleksiyonu (Kimya Bölümü) Meslek Yüksekokulları Zonguldak MYO Makale Koleksiyonu (Zonguldak MYO) Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD Scopus İndeksli Yayınlar Koleksiyonu Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD WoS İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Materials Technology |
| Sayfalar | - |
| Yayın Yılı | 2019 |
| Eser Adı [dc.title] | Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications |
| Yazar [dc.contributor.author] | İlhan, Elif |
| Yazar [dc.contributor.author] | Karahaliloğlu, Zeynep |
| Yazar [dc.contributor.author] | Kılıçay, Ebru |
| Yazar [dc.contributor.author] | Hazer, Baki |
| Yazar [dc.contributor.author] | Denkbaş, Emir Baki |
| Yayın Yılı [dc.date.issued] | 2019 |
| Yayıncı [dc.publisher] | Taylor and Francis Ltd. |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (ß-TCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity of the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 ß-TCP) w/w in ß-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2019-12-23 |
| Açık Erişim Tarihi [dc.date.available] | 2019-12-23 |
| Yayın Dili [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Bone cement |
| Konu Başlıkları [dc.subject] | polystyrene |
| Konu Başlıkları [dc.subject] | pre-osteoblastic MCT3T3-E1 cells |
| Konu Başlıkları [dc.subject] | silver nanoparticle |
| Konu Başlıkları [dc.subject] | soybean oil |
| Künye [dc.identifier.citation] | Ilhan, E., Karahaliloglu, Z., Kilicay, E., Hazer, B. ve Denkbas, E. B. (2020). Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications. Materials Technology, 35(3), 179-194. doi:10.1080/10667857.2019.1661157 |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| ISSN [dc.identifier.issn] | 1066-7857 |
| Dergi Adı [dc.relation.journal] | Materials Technology |
| Tek Biçim Adres [dc.identifier.uri] | https://dx.doi.org/10.1080/10667857.2019.1661157 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.12628/7088 |
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