Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy

The aim of this study was to evaluate therapeutic potential of curcumin-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) PHBHHx nanoparticles (CUR-NPs) and concanavaline A conjugated curcumin-loaded NPs (ConA-CUR-NPs) for breast cancer treatment. The size and zeta potential of prepared NPs were about 228 ± 5 nm and -23.3 mV, respectively. The entrapment efficiencies of polymer/drug weight ratios, 1.25CUR-NPs, 2.5CUR-NPs, 5CUR-NPs, ConA-1.25CUR-NPs, ConA-2.5CUR-NPs and ConA-5CUR-NPs were found to be ?68, 55, 45, 70, 60 and 51%, respectively. Optimized NPs formulations in the freeze-dried form were assessed with their short-term stability for 30 days of storage at 4 °C and 25 °C. Anticancer activity of ConA-CUR-NPs was proved by MTT assay and reconfirmed by double staining and flow cytometry results. The anticancer activity of ConA-CUR-NPs was measured in human breast cancer cells (MDA-MB 231) in vitro, and the results revealed that the ConA-CUR-NPs had better tumor cells decline activity. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Eser Adı
[dc.title]
Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy
Yazar
[dc.contributor.author]
Kılıçay, Ebru
Yazar
[dc.contributor.author]
Karahaliloğlu, Zeynep
Yazar
[dc.contributor.author]
Hazer, Baki
Yazar
[dc.contributor.author]
Tekin, İshak Özel
Yazar
[dc.contributor.author]
Denkbaş, Emir Baki
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Taylor and Francis Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of this study was to evaluate therapeutic potential of curcumin-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) PHBHHx nanoparticles (CUR-NPs) and concanavaline A conjugated curcumin-loaded NPs (ConA-CUR-NPs) for breast cancer treatment. The size and zeta potential of prepared NPs were about 228 ± 5 nm and -23.3 mV, respectively. The entrapment efficiencies of polymer/drug weight ratios, 1.25CUR-NPs, 2.5CUR-NPs, 5CUR-NPs, ConA-1.25CUR-NPs, ConA-2.5CUR-NPs and ConA-5CUR-NPs were found to be ?68, 55, 45, 70, 60 and 51%, respectively. Optimized NPs formulations in the freeze-dried form were assessed with their short-term stability for 30 days of storage at 4 °C and 25 °C. Anticancer activity of ConA-CUR-NPs was proved by MTT assay and reconfirmed by double staining and flow cytometry results. The anticancer activity of ConA-CUR-NPs was measured in human breast cancer cells (MDA-MB 231) in vitro, and the results revealed that the ConA-CUR-NPs had better tumor cells decline activity. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
concanavaline A
Konu Başlıkları
[dc.subject]
curcumin
Konu Başlıkları
[dc.subject]
drug delivery
Konu Başlıkları
[dc.subject]
human breast cancer cells
Konu Başlıkları
[dc.subject]
PHBHHx
Konu Başlıkları
[dc.subject]
PHBHHx nanoparticles
Künye
[dc.identifier.citation]
Kilicay, E., Karahaliloglu, Z., Hazer, B., Tekin, I. Ö. ve Denkbas, E. B. (2016). Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy. Journal of Microencapsulation, 33(3), 274-285. doi:10.3109/02652048.2016.1169325
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0265-2048
İlk Sayfa Sayısı
[dc.identifier.startpage]
274
Son Sayfa Sayısı
[dc.identifier.endpage]
285
Dergi Adı
[dc.relation.journal]
Journal of Microencapsulation
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
33
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3109/02652048.2016.1169325
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4874
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5CUR-NPs ConA-CUR-NPs activity potential 25CUR-NPs curcumin-loaded cancer breast results respectively proved Anticancer storage reconfirmed double staining stability cytometry Francis Taylor trading Limited Informa decline anticancer better revealed (MDA-MB measured short-term (ConA-CUR-NPs) prepared treatment conjugated concanavaline
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