Astrositlerin noron dmamiklenne etkileri fifects of astrocytes on neuronal dynamics

Astrocytes are star-shaped glia cells and the most common cell type in the human brain with neurons. Astrocytes fulfill many functions in human brain. Providing support to the cells of the blood-brain barrier, balancing the extracellular ion concentration, supplying nutrients to the nerve tissue, and controlling the development of nerve cells are some of these tasks. In this study, the effects of calcium (Ca') ion concentration oscillations occuring in astrocytes on the neuron firing dynamics are investigated. When the obtained results are examined, it is observed that the production rate of insole 1,4,5-triphosphate (IP3), which is an agent that triggers calcium release from the resoruces in astrocytes, and the degradation time of that within the cell are important effects on the spike production dynamics of the neuron in contact with astrocyte. It is determined that neurons without any stimulation continue to produce spikes through calcium oscillations in the astrocytes, at high IP3 production rates and longer IP3 degradation times.

Eser Adı
[dc.title]
Astrositlerin noron dmamiklenne etkileri fifects of astrocytes on neuronal dynamics
Yazar
[dc.contributor.author]
Erkan, Yasemin
Yazar
[dc.contributor.author]
Özer, Mahmut
Yazar
[dc.contributor.author]
Yılmaz, Ergin
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
IEEE
Yayın Türü
[dc.type]
proceedings
Açıklama
[dc.description]
Medical Technologies National Congress (TIPTEKNO) -- OCT 12-14, 2017 -- TRABZON, TURKEY
Açıklama
[dc.description]
WOS: 000427649500043
Özet
[dc.description.abstract]
Astrocytes are star-shaped glia cells and the most common cell type in the human brain with neurons. Astrocytes fulfill many functions in human brain. Providing support to the cells of the blood-brain barrier, balancing the extracellular ion concentration, supplying nutrients to the nerve tissue, and controlling the development of nerve cells are some of these tasks. In this study, the effects of calcium (Ca') ion concentration oscillations occuring in astrocytes on the neuron firing dynamics are investigated. When the obtained results are examined, it is observed that the production rate of insole 1,4,5-triphosphate (IP3), which is an agent that triggers calcium release from the resoruces in astrocytes, and the degradation time of that within the cell are important effects on the spike production dynamics of the neuron in contact with astrocyte. It is determined that neurons without any stimulation continue to produce spikes through calcium oscillations in the astrocytes, at high IP3 production rates and longer IP3 degradation times.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
astrocyte
Konu Başlıkları
[dc.subject]
neuron
Konu Başlıkları
[dc.subject]
Ca2+ oscillations
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
Sponsor YAYINCI
[dc.description.sponsorship]
IEEE Turkey Sect
Dergi Adı
[dc.relation.journal]
2017 MEDICAL TECHNOLOGIES NATIONAL CONGRESS (TIPTEKNO)
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2134
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calcium astrocytes production dynamics neuron oscillations degradation effects concentration Astrocytes neurons blood-brain resoruces release important triggers 5-triphosphate within spikes longer star-shaped through produce contact continue stimulation without determined astrocyte common insole tissue development controlling functions
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