Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications

Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (ß-TCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity of the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 ß-TCP) w/w in ß-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Eser Adı
[dc.title]
Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications
Yazar
[dc.contributor.author]
İlhan, Elif
Yazar
[dc.contributor.author]
Karahaliloğlu, Zeynep
Yazar
[dc.contributor.author]
Kılıçay, Ebru
Yazar
[dc.contributor.author]
Hazer, Baki
Yazar
[dc.contributor.author]
Denkbaş, Emir Baki
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Taylor and Francis Ltd.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel non-antibiotic alternative approaches to this problem are urgently needed. Based on these expectations, in this work, in order to enhance the cytocompatibility and antibacterial performances of poly (methyl methacrylate (PMMA) and beta-tricalcium phosphate (ß-TCP) bone cements were impregnated with polystyrene (PS)-g-soybean oil graft copolymer containing AgNPs (PS-Agsbox), and we assessed the antimicrobial activity of the fabricated bone cements against Staphylococcus aureus and Escherichia coli. Nanoparticles at concentration of 1.25% (5 ß-TCP) w/w in ß-TCP bone cements were able to inhibit pathogens growth, while a concentration of 3.75% (15PMMA) was needed for PMMA bone cement. Therefore, the impregnated bone cements with PS-AgsboxNPs may be further explored as an alternative antimicrobial therapy for the treatment of infected bone defects. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bone cement
Konu Başlıkları
[dc.subject]
polystyrene
Konu Başlıkları
[dc.subject]
pre-osteoblastic MCT3T3-E1 cells
Konu Başlıkları
[dc.subject]
silver nanoparticle
Konu Başlıkları
[dc.subject]
soybean oil
Künye
[dc.identifier.citation]
Ilhan, E., Karahaliloglu, Z., Kilicay, E., Hazer, B. ve Denkbas, E. B. (2020). Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications. Materials Technology, 35(3), 179-194. doi:10.1080/10667857.2019.1661157
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1066-7857
Dergi Adı
[dc.relation.journal]
Materials Technology
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/10667857.2019.1661157
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7088
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cements concentration treatment impregnated alternative antimicrobial needed ß-TCP inhibit ß-TCP) Postoperative growth Nanoparticles Escherichia aureus Staphylococcus against fabricated pathogens therapy Francis Taylor trading Limited Informa defects infected explored further PS-AgsboxNPs Therefore cement (15PMMA) activity assessed
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