Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types
Amphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. For this purpose, PHB-b-PEG-NH2 block copolymers were synthesized via transesterification reactions. The copolymers obtained were characterized by Proton Nuclear Magnetic Resonance (1H-NMR), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) techniques. The cytotoxic, apoptotic and necrotic effects of these nanoparticles in the MDA 231 human breast cancer cell, the A549 human lung cancer cell and the L929 fibroblast cell lines were also investigated. © 2015 Taylor & Francis.
| Yazar |
Kılıçay, Ebru Erdal, Ebru Hazer, Baki Türk, Mustafa Denkbaş, Emir Baki |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.12628/4317 |
| Konu Başlıkları |
Antisense oligonucleotide
fibroblast cells human breast cancer cells human lung cancer cells PHB-PEG block copolymer PHB-PEG nanoparticle |
| Koleksiyonlar |
Fakülteler Fen Edebiyat Fakültesi Kimya Bölümü Makale Koleksiyonu (Kimya Bölümü) Meslek Yüksekokulları Zonguldak MYO Makale Koleksiyonu (Zonguldak MYO) Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD Scopus İndeksli Yayınlar Koleksiyonu Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD WoS İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Artificial Cells, Nanomedicine and Biotechnology |
| Dergi Cilt Bilgisi | 44 |
| Dergi Sayısı | 8 |
| Sayfalar | 1938 - 1948 |
| Yayın Yılı | 2016 |
| Eser Adı [dc.title] | Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types |
| Yazar [dc.contributor.author] | Kılıçay, Ebru |
| Yazar [dc.contributor.author] | Erdal, Ebru |
| Yazar [dc.contributor.author] | Hazer, Baki |
| Yazar [dc.contributor.author] | Türk, Mustafa |
| Yazar [dc.contributor.author] | Denkbaş, Emir Baki |
| Yayın Yılı [dc.date.issued] | 2016 |
| Yayıncı [dc.publisher] | Taylor and Francis Ltd. |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Amphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. For this purpose, PHB-b-PEG-NH2 block copolymers were synthesized via transesterification reactions. The copolymers obtained were characterized by Proton Nuclear Magnetic Resonance (1H-NMR), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) techniques. The cytotoxic, apoptotic and necrotic effects of these nanoparticles in the MDA 231 human breast cancer cell, the A549 human lung cancer cell and the L929 fibroblast cell lines were also investigated. © 2015 Taylor & Francis. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2019-12-23 |
| Açık Erişim Tarihi [dc.date.available] | 2019-12-23 |
| Yayın Dili [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Antisense oligonucleotide |
| Konu Başlıkları [dc.subject] | fibroblast cells |
| Konu Başlıkları [dc.subject] | human breast cancer cells |
| Konu Başlıkları [dc.subject] | human lung cancer cells |
| Konu Başlıkları [dc.subject] | PHB-PEG block copolymer |
| Konu Başlıkları [dc.subject] | PHB-PEG nanoparticle |
| Künye [dc.identifier.citation] | Kilicay, E., Erdal, E., Hazer, B., Türk, M. ve Denkbas, E. B. (2016). Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types. Artificial Cells, Nanomedicine and Biotechnology, 44(8), 1938–1948. doi:10.3109/21691401.2015.1115409 |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| ISSN [dc.identifier.issn] | 2169-1401 |
| İlk Sayfa Sayısı [dc.identifier.startpage] | 1938 |
| Son Sayfa Sayısı [dc.identifier.endpage] | 1948 |
| Dergi Adı [dc.relation.journal] | Artificial Cells, Nanomedicine and Biotechnology |
| Dergi Sayısı [dc.identifier.issue] | 8 |
| Dergi Cilt Bilgisi [dc.identifier.volume] | 44 |
| Tek Biçim Adres [dc.identifier.uri] | https://dx.doi.org/10.3109/21691401.2015.1115409 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.12628/4317 |
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copolymers
cancer
delivery
effects
necrotic
(FTIR)
Thermogravimetric
Analysis
cytotoxic
apoptotic
Differential
techniques
Calorimetry
Scanning
Amphiphilic
breast
nanoparticles
Francis
Taylor
investigated
fibroblast
Infrared
Spectrometer
Magnetic
Transform
(PHB-b-PEG-NH2)
adsorbed
nucleic
prepare
platform
applications
interesting
nanoparticle
Fourier
obtained
