Tumor Necrosis Factor-Alpha (TNF-alpha-308G > A) Polymorphism in High-grade Gliomas

Background/Aim: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligo-dendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-alpha -308 G>A polymorphism in a Turkish population. Patients and Methods: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. Results: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). Conclusion: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities.

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Eser Adı
(dc.title)
Tumor Necrosis Factor-Alpha (TNF-alpha-308G > A) Polymorphism in High-grade Gliomas
Yazar
(dc.contributor.author)
Ozdogan, Selcuk
Yazar
(dc.contributor.author)
Yaltirik, Cumhur Kaan
Yazar
(dc.contributor.author)
Yilmaz, Seda Gulec
Yazar
(dc.contributor.author)
Kaya, Mustafa
Yazar
(dc.contributor.author)
Duzkalir, Ali Haluk
Yazar
(dc.contributor.author)
Demirel, Nail
Yazar
(dc.contributor.author)
Kafadar, Ali
Yayın Yılı
(dc.date.issued)
2018
Yayıncı
(dc.publisher)
INT INST ANTICANCER RESEARCH
Yayın Türü
(dc.type)
article
Özet
(dc.description.abstract)
Background/Aim: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligo-dendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-alpha -308 G>A polymorphism in a Turkish population. Patients and Methods: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. Results: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). Conclusion: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities.
Açıklama
(dc.description)
WOS: 000426048600010
Açıklama
(dc.description)
PubMed: 29475911
Kayıt Giriş Tarihi
(dc.date.accessioned)
2019-12-23

(dc.date.available)
2019-12-23
Yayın Dili
(dc.language.iso)
eng
Konu Başlıkları
(dc.subject)
Tumor necrosis factor
Konu Başlıkları
(dc.subject)
polymorphism
Konu Başlıkları
(dc.subject)
high-grade gliomas
Haklar
(dc.rights)
info:eu-repo/semantics/openAccess
ISSN
(dc.identifier.issn)
0258-851X
ISSN
(dc.identifier.issn)
1791-7549
İlk Sayfa Sayısı
(dc.identifier.startpage)
287
Son Sayfa Sayısı
(dc.identifier.endpage)
289
Dergi Adı
(dc.relation.journal)
IN VIVO
Dergi Sayısı
(dc.identifier.issue)
2
Dergi Cilt Bilgisi
(dc.identifier.volume)
32
Tek Biçim Adres
(dc.identifier.uri)
https://dx.doi.org/10.21873/invivo.11236
Tek Biçim Adres
(dc.identifier.uri)
https://hdl.handle.net/20.500.12628/3730
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