Ankaferd blood stopper enhances healing after osseous grafting in patients with intrabony periodontal defects

Background and Objective: The aim of this clinical study were to compare the clinical efficacy of ankaferd blood stopper (ABS) when used in combination with autogenous cortical bone graft (ACB) in the treatment of intrabony periodontal defects. Material and Methods: The study was planned as a split-mouth design. Fifteen patients with chronic periodontitis at 30 sites (six men, nine women; 42 ± 7 years) were included. Treatment sites had probing pocket depths (PPD) of ? 6 mm and osseous defect depths of ? 4 mm as radiographically assessed. Following the initial periodontal therapy, patients were randomly assigned to two treatments in contralateral areas of the dentition: ACB + ABS or ACB alone. At baseline and 6 mo after surgery, clinical parameters of plaque index, gingival index, PPD, clinical attachment level and gingival recession (GR) were recorded. The primary outcome variable was the change in clinical attachment level between baseline and 24 wk after surgery. Gingival crevicular fluid samples were collected immediately before surgery and at 2, 4, 6, 12 and 24 wk after the surgery. Gingival crevicular fluid volume was calculated and vascular endothelial growth factor levels in gingival crevicular fluid were measured. Results: PPD decreased, clinical attachment level improved and gingival index decreased significantly in response to both modes of treatment (p < 0.05). Both treatment modalities resulted in a significant gain in radiographic bone levels compared to baseline (p < 0.05). Intergroup comparisons showed that there was a significantly higher gain in clinical attachment level in the ABS/ACB group compared to ACB group (p < 0.05) with significantly less GR (p < 0.05). Similarly, vascular endothelial growth factor concentration in gingival crevicular fluid was significantly higher in the ABS/ACB group at postoperative weeks 2 and 4 compared to the ACB group (p < 0.01). Conclusions: The findings suggest that ABS enhances the soft tissue healing during the periodontal defect fill by the ACB by stimulating angiogenesis and vascular endothelial cell function, prevents GR and thereby increases the clinical attachment gain. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Yazar Pamuk F.
Cetinkaya B.O.
Keles G.C.
Balli U.
Koyuncuoglu C.Z.
Cintan S.
Kantarci A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4292
Tek Biçim Adres 10.1111/jre.12334
Konu Başlıkları blood stopper
intrabony defects
periodontal regeneration
VEGF
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Periodontal Research
Dergi Cilt Bilgisi 51
Dergi Sayısı 4
Sayfalar 540 - 547
Yayın Yılı 2016
Eser Adı
[dc.title]
Ankaferd blood stopper enhances healing after osseous grafting in patients with intrabony periodontal defects
Yazar
[dc.contributor.author]
Pamuk F.
Yazar
[dc.contributor.author]
Cetinkaya B.O.
Yazar
[dc.contributor.author]
Keles G.C.
Yazar
[dc.contributor.author]
Balli U.
Yazar
[dc.contributor.author]
Koyuncuoglu C.Z.
Yazar
[dc.contributor.author]
Cintan S.
Yazar
[dc.contributor.author]
Kantarci A.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Blackwell Munksgaard
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and Objective: The aim of this clinical study were to compare the clinical efficacy of ankaferd blood stopper (ABS) when used in combination with autogenous cortical bone graft (ACB) in the treatment of intrabony periodontal defects. Material and Methods: The study was planned as a split-mouth design. Fifteen patients with chronic periodontitis at 30 sites (six men, nine women; 42 ± 7 years) were included. Treatment sites had probing pocket depths (PPD) of ? 6 mm and osseous defect depths of ? 4 mm as radiographically assessed. Following the initial periodontal therapy, patients were randomly assigned to two treatments in contralateral areas of the dentition: ACB + ABS or ACB alone. At baseline and 6 mo after surgery, clinical parameters of plaque index, gingival index, PPD, clinical attachment level and gingival recession (GR) were recorded. The primary outcome variable was the change in clinical attachment level between baseline and 24 wk after surgery. Gingival crevicular fluid samples were collected immediately before surgery and at 2, 4, 6, 12 and 24 wk after the surgery. Gingival crevicular fluid volume was calculated and vascular endothelial growth factor levels in gingival crevicular fluid were measured. Results: PPD decreased, clinical attachment level improved and gingival index decreased significantly in response to both modes of treatment (p < 0.05). Both treatment modalities resulted in a significant gain in radiographic bone levels compared to baseline (p < 0.05). Intergroup comparisons showed that there was a significantly higher gain in clinical attachment level in the ABS/ACB group compared to ACB group (p < 0.05) with significantly less GR (p < 0.05). Similarly, vascular endothelial growth factor concentration in gingival crevicular fluid was significantly higher in the ABS/ACB group at postoperative weeks 2 and 4 compared to the ACB group (p < 0.01). Conclusions: The findings suggest that ABS enhances the soft tissue healing during the periodontal defect fill by the ACB by stimulating angiogenesis and vascular endothelial cell function, prevents GR and thereby increases the clinical attachment gain. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
blood stopper
Konu Başlıkları
[dc.subject]
intrabony defects
Konu Başlıkları
[dc.subject]
periodontal regeneration
Konu Başlıkları
[dc.subject]
VEGF
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0022-3484
İlk Sayfa Sayısı
[dc.identifier.startpage]
540
Son Sayfa Sayısı
[dc.identifier.endpage]
547
Dergi Adı
[dc.relation.journal]
Journal of Periodontal Research
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
51
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/jre.12334
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4292
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
235
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Haziran 2024 08:55
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Tıklayınız
clinical attachment gingival surgery significantly crevicular compared periodontal treatment endothelial vascular baseline decreased depths ABS/ACB defect higher Gingival growth factor patients levels measured response Results volume calculated improved Background function healing during stimulating angiogenesis prevents
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