Role of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in rats

Objectives: This study was evaluated to investigate the efficacy of caffeic acid phenethyl ester (CAPE), which is a natural honeybee product exhibits a spectrum of biological activities including anti-microbial, anti-inflammatory, antioxidant and anti-tumoral actions, on the prevention of stricture development after esophageal caustic injuries in the rat. Methods: Thirty healthy male Wistar albino rats were utilized in this study. The rats were randomly allotted into one of three experimental groups: group A (sham) animals were uninjured. Caustic esophageal burn was created by applying 1 ml 37.5% NaOH to the distal esophagus. Group B rats were injured but untreated. Group C rats were injured and received CAPE (10 µmol/kg/day i.p. for 28 days). Efficacy of the treatment was assessed by measuring the esophageal transit time, stenosis index, histopathologic damage score and biochemically by determining tissue hydroxyproline content, lipid peroxidation and antioxidant enzyme activities. Results: The esophageal transit time, the stenosis index, histopathologic damage score and the hydroxyproline level were significantly increased in the untreated group compared with the sham and CAPE-treated groups. Treatment with CAPE decreased tissue hydroxyproline levels, histological damage, and the stenosis index, but except the esophageal transit time. Caustic esophageal burn also increased the lipid peroxidation and decreased the antioxidant enzyme activities in the untreated group. CAPE treatments decreased the elevated lipid peroxidation and also increased the reduced antioxidant enzyme activities. In corrosive esophageal burn group with no treatment, the most consistent findings were degenerative changes and increased in submucosal collagen content, and the luminal narrowing. CAPE treatment protected esophagus. Nevertheless, there was the slight increase in submucosal collagen. Conclusions: It is concluded that CAPE has a preventive effect on the stricture development after esophageal caustic injuries in the rat. © 2006 Elsevier Ireland Ltd. All rights reserved.

Dergi Adı International Journal of Pediatric Otorhinolaryngology
Dergi Cilt Bilgisi 70
Dergi Sayısı 10
Sayfalar 1731 - 1739
Yayın Yılı 2006
Eser Adı
[dc.title]
Role of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in rats
Yazar
[dc.contributor.author]
Ocakci A.
Yazar
[dc.contributor.author]
Kanter M.
Yazar
[dc.contributor.author]
Cabuk M.
Yazar
[dc.contributor.author]
Buyukbas S.
Yayın Yılı
[dc.date.issued]
2006
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: This study was evaluated to investigate the efficacy of caffeic acid phenethyl ester (CAPE), which is a natural honeybee product exhibits a spectrum of biological activities including anti-microbial, anti-inflammatory, antioxidant and anti-tumoral actions, on the prevention of stricture development after esophageal caustic injuries in the rat. Methods: Thirty healthy male Wistar albino rats were utilized in this study. The rats were randomly allotted into one of three experimental groups: group A (sham) animals were uninjured. Caustic esophageal burn was created by applying 1 ml 37.5% NaOH to the distal esophagus. Group B rats were injured but untreated. Group C rats were injured and received CAPE (10 µmol/kg/day i.p. for 28 days). Efficacy of the treatment was assessed by measuring the esophageal transit time, stenosis index, histopathologic damage score and biochemically by determining tissue hydroxyproline content, lipid peroxidation and antioxidant enzyme activities. Results: The esophageal transit time, the stenosis index, histopathologic damage score and the hydroxyproline level were significantly increased in the untreated group compared with the sham and CAPE-treated groups. Treatment with CAPE decreased tissue hydroxyproline levels, histological damage, and the stenosis index, but except the esophageal transit time. Caustic esophageal burn also increased the lipid peroxidation and decreased the antioxidant enzyme activities in the untreated group. CAPE treatments decreased the elevated lipid peroxidation and also increased the reduced antioxidant enzyme activities. In corrosive esophageal burn group with no treatment, the most consistent findings were degenerative changes and increased in submucosal collagen content, and the luminal narrowing. CAPE treatment protected esophagus. Nevertheless, there was the slight increase in submucosal collagen. Conclusions: It is concluded that CAPE has a preventive effect on the stricture development after esophageal caustic injuries in the rat. © 2006 Elsevier Ireland Ltd. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antioxidant enzyme activities
Konu Başlıkları
[dc.subject]
Caffeic acid phenethyl ester
Konu Başlıkları
[dc.subject]
Caustic burn
Konu Başlıkları
[dc.subject]
Fibrosis
Konu Başlıkları
[dc.subject]
Lipid peroxidation
Konu Başlıkları
[dc.subject]
Stricture
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0165-5876
İlk Sayfa Sayısı
[dc.identifier.startpage]
1731
Son Sayfa Sayısı
[dc.identifier.endpage]
1739
Dergi Adı
[dc.relation.journal]
International Journal of Pediatric Otorhinolaryngology
Dergi Sayısı
[dc.identifier.issue]
10
Dergi Cilt Bilgisi
[dc.identifier.volume]
70
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.ijporl.2006.05.018
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7445
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
160
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
27 Mayıs 2024 04:15
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Tıklayınız
esophageal antioxidant activities increased enzyme peroxidation hydroxyproline decreased damage treatment stenosis transit untreated submucosal Caustic esophagus groups injured content tissue collagen histopathologic development stricture caustic injuries reserved preventive compared Results significantly effect Elsevier Ireland rights
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