Electroconvulsive therapy combined with antipsychotic therapy in the treatment of acute schizophrenia inpatients: symptom profile of the clinical response

OBJECTIVE: The aim of the study was to examine the efficacy of electroconvulsive therapy (ECT) combined with antipsychotic (AP) medication on symptom profile in patients with a diagnosis of schizophrenia who had received acute psychiatric inpatient treatment. METHODS: In this prospective study, patients were evaluated for inclusion in the study who were diagnosed with schizophrenia according to DSM-IV diagnostic criteria and were to receive ECT. The patients were evaluated using the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), and Clinical Global Impression - Improvement (CGI-I) sub-scale before the first session ECT, once following every two subsequent sessions and after the final session. RESULTS: The patients showed significant improvements in BPRS scores at each evaluation compared with their scores at baseline, and a significant clinical improvement was found on the CGI-I sub-scale at the end of treatment. Across all SAPS sub-scores, significant decreases were found, and the symptoms related to hallucinations and positive formal thought disorder showed the most rapid response to treatment. Across all SANS sub-scores, significant decreases were found, and affective flattening or blunting symptoms responded most rapidly to treatment. CONCLUSION: One of the most important findings in the present study of hospitalized patients with acute schizophrenia was the good response to treatment, which provided significant improvements in both positive and negative symptoms. The most rapid response to treatment was found for hallucinations, positive formal thought disorder, and affective flattening or blunting symptoms. The most important limitation of our study may be the small number of cases. In future, well-standardized studies using a double-blinded, comparative, prospective design and including a sufficient number of patients are needed.

Yazar Ipekcioglu, Derya
Yazar, Menekse Sila
Canbek, Ozge
Yuksel, Ozge
Meterelliyoz, Kumru Senyasar
Ilnem, Mehmet Cem
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2529
Tek Biçim Adres 10.1080/24750573.2018.1446729
Konu Başlıkları Schizophrenia symptoms
antipsychotic medication
electroconvulsive therapy
treatment response
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
Dergi Cilt Bilgisi 28
Dergi Sayısı 4
Sayfalar 363 - 370
Yayın Yılı 2018
Eser Adı
[dc.title]
Electroconvulsive therapy combined with antipsychotic therapy in the treatment of acute schizophrenia inpatients: symptom profile of the clinical response
Yazar
[dc.contributor.author]
Ipekcioglu, Derya
Yazar
[dc.contributor.author]
Yazar, Menekse Sila
Yazar
[dc.contributor.author]
Canbek, Ozge
Yazar
[dc.contributor.author]
Yuksel, Ozge
Yazar
[dc.contributor.author]
Meterelliyoz, Kumru Senyasar
Yazar
[dc.contributor.author]
Ilnem, Mehmet Cem
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
OBJECTIVE: The aim of the study was to examine the efficacy of electroconvulsive therapy (ECT) combined with antipsychotic (AP) medication on symptom profile in patients with a diagnosis of schizophrenia who had received acute psychiatric inpatient treatment. METHODS: In this prospective study, patients were evaluated for inclusion in the study who were diagnosed with schizophrenia according to DSM-IV diagnostic criteria and were to receive ECT. The patients were evaluated using the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), and Clinical Global Impression - Improvement (CGI-I) sub-scale before the first session ECT, once following every two subsequent sessions and after the final session. RESULTS: The patients showed significant improvements in BPRS scores at each evaluation compared with their scores at baseline, and a significant clinical improvement was found on the CGI-I sub-scale at the end of treatment. Across all SAPS sub-scores, significant decreases were found, and the symptoms related to hallucinations and positive formal thought disorder showed the most rapid response to treatment. Across all SANS sub-scores, significant decreases were found, and affective flattening or blunting symptoms responded most rapidly to treatment. CONCLUSION: One of the most important findings in the present study of hospitalized patients with acute schizophrenia was the good response to treatment, which provided significant improvements in both positive and negative symptoms. The most rapid response to treatment was found for hallucinations, positive formal thought disorder, and affective flattening or blunting symptoms. The most important limitation of our study may be the small number of cases. In future, well-standardized studies using a double-blinded, comparative, prospective design and including a sufficient number of patients are needed.
Açıklama
[dc.description]
WOS: 000452309400002
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Schizophrenia symptoms
Konu Başlıkları
[dc.subject]
antipsychotic medication
Konu Başlıkları
[dc.subject]
electroconvulsive therapy
Konu Başlıkları
[dc.subject]
treatment response
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2475-0573
ISSN
[dc.identifier.issn]
2475-0581
İlk Sayfa Sayısı
[dc.identifier.startpage]
363
Son Sayfa Sayısı
[dc.identifier.endpage]
370
Dergi Adı
[dc.relation.journal]
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
28
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/24750573.2018.1446729
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2529
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Nisan 2024 05:33
Google Kontrol
Tıklayınız
treatment patients significant symptoms positive response schizophrenia formal sub-scale thought disorder important affective Assessment blunting Symptoms evaluated prospective improvements hallucinations flattening decreases sub-scores number session Across scores showed related OBJECTIVE present responded needed sufficient including
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms