Numanoğlu, Kemal Varın | Tatlı, Duygu

Article | 2008 | Journal of Pediatric Surgery43 ( 7 )

We report the first case of urinary bladder hemangioma that caused hemorrhagic shock consequent to massive hematuria. A 2-year-old girl was presented with hemorrhagic shock and macroscopic hematuria. After rapid resuscitation was performed, radiologic investigations demonstrated a solid enhancing mass originating from the dome of bladder. Partial cystectomy was made. Histopathologic examination of resected specimen revealed cavernous hemangioma. Although bladder hemangiomas are rare benign tumors, it should be kept in mind that they can lead to life-threatening complications when the diagnosis is delayed. © 2008 Elsevier Inc. All ri . . .ghts reserved Daha fazlası Daha az

Cakmak, G. Karadeniz | Emre, A. U. | Uslu, R. | Engin, H. | Bahadir, B. | Bakkal, Bekir Hakan

Conference Object | 2019 | BREAST44

Goals: In the era of neoadjuvant chemotherapy (NAC), the prediction of pathologic response is a major challenge with the potential to modify surgical approach. The aim of the present study was to evaluate the precision of ultrasonography (US) and 18F-FDG-PET/CT for predicting pathologic complete response (ypCR = ypT0, ypN0) after NAC. Methods: A single-institution, retrospective review of a prospectively maintained database was analyzed to identify breast cancer patients treated with NAC. The study included 253 invasive breast cancer patients treated with NAC followed by standard breast and axillary nodal surgery. US and 18F-FDG PET . . ./CT evaluation was done before and after NAC with documentation of clinical complete response. All US studies were interpreted, as “normal” according to the absence of specific characteristics shown to be commonly associated with metastatic involvement both at diagnosis and at the date of operation. 18F-FDG PET/CT scans was termed as negative or positive due to the standardized uptake value. Results: 102 patients (40,3%) achieved pCR and all of whom had a corresponding clinical complete response. Among 134 patients with clinical negative axilla and initial nodal US demonstrating N0 disease, 41.8% had a breast pCR and all of these cases showed no evidence of axillary lymph node metastases after NAC. For 119 patients with initially nod positive disease, 88.2% patients with a breast pCR and 32.3% patients without breast pCR had axillary N0 disease after NAC. Overall sensitivity, specificity, PPV and NPV for prediction of pCR after NAC was found to be 90%, 92%, 90%, 76% for US and 89%, 84%, 81%, 75% for 18F-FDG-PET/CT, respectively. The PPV for predicting axillary status using US alone was 66.1% and for 18 FDG-PET-CT was 55%. Overall accuracy for pCR was found to be 82.6% for US and 78.6% for 18-FDG-PET/CT. The presence of in situ carcinomawas found to be the only significant factor associated with false negative US for pCR. Micrometastatic disease, the size and number of metastatic nodes were significantly associated with false negative PET/CT results for axillary disease. Conclusions: Breast pCR is highly correlated with nodal status after NAC. US is a beneficial tool with the potential of accurate prediction of pCR in up to 80% of patients following NAC. Nevertheless, in cases of rest in situ carcinoma the accuracy of US should be interrogated cautiously. Moreover, in terms of axillary status neither US, nor 18-FDG-PET-CT is highly capable of predicting N0 disease after NAC. Conflict of Interest: No significant relationships Daha fazlası Daha az

Kaya, Ceren | Erkaymaz, Okan | Ayar, Orhan | Özer, Mahmut

Proceedings | 2017 | 2016 Medical Technologies National Conference, TIPTEKNO 2016

The insulin hormone secreted from the pancreas gland in the body is not present in sufficient amount, or because they do not fit, which is defined as the elevation of blood glucose 'Diabetes Mellitus (Diabetes)'. 'Diabetic Retinopathy' is the most common in diabetes-related eye diseases. It had done damages in the retina that detect light on behind the eye as a result of changes in the arteries that is one of the reasons that makes blindness (loss of vision) in people. In this study, horizontal and vertical Video-Oculography (VOG) signals captured by using internal tracking camera in Metrovision MonPackOne Electrooculography device. . . . In order to filter the noise from the signals, the wavelet transform method was used. Obtained signals have shown that the signals of diabetic retinopathy patients have higher amplitude and irregular characteristic than the signals obtained from healthy groups. In both groups, significant Daubechies-6 wavelet coefficients (A6-D6) gave better results than Daubechies-4 wavelet coefficients (A4-D4). Obtained data as a result of using wavelet transform sheds light on feature extraction and classification in proposed future works. © 2016 IEEE Daha fazlası Daha az

Gülle, Kanat | Akpolat, Meryem | Öz, Zehra Safi | Bakkal, Bekir Hakan | Araslı, Mehmet | Köktürk, Fürüzan

Article | 2017 | Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi8 ( 1 ) , pp.33 - 37

Amaç: Radyasyon hücrelerin çekirdek ve sitoplazmasında bir takım değişikliklere sebebiyet verebilir, memeli germ hücreleri de iyonize radyasyona (İR) karşı oldukça duyarlıdır. İyonize radyasyon ovaryum folliküllerindeki dejenerasyonu arttırır. Bu çalışmanın amacı tüm vücudu iyonize radyasyona maruz kalan sıçanların ovaryum folliküllerinde L-karnitinin (LK) antiapoptotik ve radyoprotektif etkilerini araştırmaktır. Materyal-Method: Çalışmamızda 30 adet Wistar albino dişi sıçan 5 ayrı gruba ayrıldı. Radyasyon hasarı için kontrol hariç tüm sıçanlara 8,3 Gy X ışını uygulandı. LK gruplarına ışınlamadan önce günlük 200mg/kg LK uygulandı. I . . .şınlama sonrası 6.saatte (Rad-1) ve 4. günde (Rad-2) ovaryum dokuları toplandı. Ovaryum dokusundan her 5. kesit alınarak hematoksilen-eozin boyaması yapılarak oosit çekirdeğinin görüldüğü her oosit sayıldı. Folliküller primordiyal, primer, preantral ve antral olacak şekilde sınıflandırıldı. Serumdaki IL-1? (interlökin-1 alfa), IL-4 (interlökin-4) ve GM-CSF (granülosit monosit koloni sitümülan faktör) değerleri flow sitometri ile analiz edildi. Bulgular: İyonize radyasyon uygulamasının sonrasında 6.saat ve 4. gün ovaryum dokuları alınan gruplarda atretik folliküllerin oranında artış gözlendi. Granüloza hücreleri yuvarlak şekilli ve apoptotik hücre görünümünde izlendi. İyonize radyasyona maruz kalan sıçanların ovaryum dokuları incelendiğinde 4.gün İR grubunda atretik folliküllerin sayısı 6. saat İR grubuna göre belirgin bir şekilde artmıştı. LK uygulanan gruplarda İR'nun yarattığı hasarda belirgin bir düzelme gözlendi. İR gruplarında serumdaki IL-1?, IL-4 ve GM-CSF düzeyleri kontrol grubu ve tedavi grubuna göre artmış olarak izlendi.Sonuç: İyonize radyasyonun akut olarak primordiyal ve primer folliküllerdeki dejenerasyonu arttırdığı sonucuna varılmıştır. Ayrıca, L-karnitinin iyonize radyasyona bağlı gelişen folliküler atrezide koruyucu bir rolü olduğunu düşünmekteyiz. Objective: This study deals with the morphological degenerations of normal and atretic follicles based on artificially induced radiation apoptosis. Ovarian follicular degeneration is accelerated by ionising radiation. The aim of the present study was to assess the radioprotective effects of L-carnitine on ovarian follicles. Material-Method: Thirty Wistar albino female rats were divided into five groups. Rats with or without pretreatment with 200 mg/kg L-carnitine, were irradiated with 8.3 Gy of X ray. The ovaries were collected at 6 h and 4 d after irradiation. Every fifth section throughout the entire ovary was stained with Hematoxylin and Eosin and follicles with a nucleus present in the oocyte were counted. The follicles were classified as primordial, primary, preantral and antral. The levels of IL-1?, IL-4 and GM-CSF in serum were determined by flow cytometric analysis. Results: The ratio (%) of normal to atretic follicles decreased with time after the irradiation in primordial follicles and in primary follicles as well. At 6 h after irradiation, the number of degenerated primordial follicles increased. Granulosa cells became round in shape and apoptotic cells started to appear. When the ovarian tissues of the rats exposed to ionizing radiation were examined, the number of atretic follicles in the 4th day ID group was significantly prominent at 6th hour according to the IR group. A significant improvement in IR damage was observed in LK treated groups. Serum levels of IL-1?, IL-4 and GM-CSF were increased in the IR groups compared to the control group and the treatment group. Conclusions: It is concluded that the ionizing radiation acutely induces the degeneration of primordial and primary follicles These results can provide morphological clues for the identification of the degenerating primordial and primary follicles in normal and irradiated rat ovaries Daha fazlası Daha az

Özdoğan, Mehmet Emin | Erer, Dilek | İriz, Erkan | Büyükateş, Mustafa | Oktar, Levent | Ünal, Yusuf | Abacı, Adnan

Other | 2007 | Anadolu Kardiyoloji Dergisi7 ( 4 ) , pp.456 - 457

…

Tatlı, Duygu | Numanoğlu, Kemal Varın

Article | 2008 | Cases Journal1 ( 1 ) , pp.456 - 457

Transverse testicular ectopia is rarely associated with incarcerated inguinal hernia. A 14-month-old male complaint of irreducible inguinal hernia due to transverse testicular ectopia is reported. The clinical and operative findings and treatment options are discussed. It is thought that surgeons who frequently repair inguinal hernias should be aware of the appropriate surgical management options available to them when this condition is unexpectedly identified during inguinal exploration. © 2008 Tatli and Numanoglu; licensee BioMed Central Ltd.

Özer, Tülay | Uzun, Lokman | Numanoğlu, Kemal Varın | Savranlar, Ahmet | Hoşnuter, Mübin | Gündoğdu, Sadi

Article | 2004 | Tanisal ve girişimsel radyoloji : Tibbi Görüntüleme ve Girişimsel Radyoloji Dernegi yayin organi10 ( 4 ) , pp.272 - 279

PURPOSE: To investigate the accompanied craniofacial and cervical spine anomalies in congenital muscular torticollis (CMT) with three-dimensional computerized tomography (3D-CT). MATERIALS AND METHODS: We examined six cases of CMT. Cranial and cervical 3D CT was performed in all cases. Facial midline deviation angle (FDA), upper hemifacial width, lower hemifacial width (LHFW), length of hemimandible and zygomatic arcus, posterior hemicranial width (PHCW), anterior hemicranial width and cranial base midline deviation angle (CBDA) were measured on cranial 3D-CT images. Value of orbital index was calculated. Data achieved both ipsilate . . .rally and contralaterally were compared with paired t-test. Atlanto-axial rotation angle (AARA) and atlantodental interval (ADI) values were measured on cervical 3D-CT images. RESULTS: Ages ranged between 2-26 years with a M/F ratio of 1/5. Facial asymmetry was diagnosed in all cases and LHFW was significantly undersized when compared to contralateral side (p < 0.05). FDA was measured 5.4+/-2.0 degrees on the average. Zygomatic arcus and hemimandible were significantly undersized on the side of torticollis (p < 0.05). Occipital plagiocephaly existed in all cases and PHCW was significantly extensive on torticollis side (p < 0.05). CBDA was measured 4.5+/-1.7 degrees on the average. Rotational movement of atlas over axis was observed in all cases where the AARA was 15.0+/-7.4 degrees. ADI was lesser than 3 mm in all cases. CONCLUSION: Even occipital plagiocephaly, maxillary and orbital deformity were commonly found in cases of CMT, most dominant asymmetry was observed in lower hemifacial region, zygomatic arcus and mandible by 3D-CT imaging. Rotational movement of first cervical vertebra over the second one was determined in all cases Daha fazlası Daha az

Numanoğlu-Yurdakan, Gamze | Kertiş, Gürkan | Bahadır, Burak | Numanoğlu, Kemal Varın | Özdamar, Şükü Oğuz

Article | 2008 | Ondokuz Mayis Universitesi Tip Dergisi25 ( 1 ) , pp.25 - 29

Renal dysplasia is a disorganized development of the kidney because anomalous differentiation of the metanephrosis. Abnormalities of the collecting system are common. They include obstruction of the ureteropelvic junction, ureteral atresia and urethral obstruction. The case was a six months old female child with ultrasonografically detected right hydronephrosis and oligohydroamniosis at the 20 th week of gestation. She underwent an operation for bilateral hydroureteronephrosis at 1 month of age. There was no serious and related illness in family history and self-history. She underwent right nephrectomy at 6 months of age. The specim . . .en included an atrophic nephrectomy material with lobulations and a dilated ureter. When sectioned, it was observed that the pericaliceal areas were dilated and the cortex-medulla border was obscured. On microscopic examination, the cortex was thin, contained rare small glomerules, primitive ducts and mononuclear cell infiltration were seen. A focus of cartilage was observed at the cortex-medulla junction. The case was diagnosed as renal hypoplastic dysplasia. During 4 months of follow-up, no complication was reported. This case is presented considering the uncommon occurence of renal dysplasia and its differential diagnosis from other congenital cystic renal malformations Daha fazlası Daha az

Numanoğlu, Kemal Varın | Ermiş, Bahri | Dursun, Ahmet | Battal, Fatih | Örnek, Zuhal | Doğan, Sait Mesut | Uğur, Birol

Article | 2007 | Clinical Dysmorphology16 ( 4 ) , pp.269 - 270

Supernumerary nostril is an extremely rare congenital anomaly. It can be unilateral or bilateral and it sometimes occurs in association with other congenital abnormalities. We describe a newborn infant with bilateral supernumerary nostrils together with oesophageal atresia and patent ductus arteriosus, an association that has not been reported previously in the literature. © 2007 Lippincott Williams & Wilkins, Inc.

Aydemir, Selim | Tekin, Solak Nilgün | Aktunç, Erol | Numanoğlu, Gamze | Üstündağ, Yücel

Article | 2004 | Turkish Journal of Gastroenterology15 ( 3 ) , pp.192 - 195

Amaç: Celiac hastalığı ince barsakların glutene intoleransı sonucu oluşan bir hastalıktır. Epidemiolojik çalışmalarda prevalansı hakkında çok farklı veriler vardı. Hastalarda genellikle çok geniş spektrumda semptom ve bulgulara neden olabildiğinden celiac hastalığı tanısının konulması zor olabilmektedir. Hastalığın erken evrede yakalanması önemlidir. Çünkü bu hastalarda barsak lenfoması gelişme riski artmıştır. Celiac hastalığı olan hastalarda rekürren aftoz stomatit prevalansındaki yükseklik nedeniyle rekürren aftoz stomatitli hastaların celiac hastalığı yönünden araştırılması asemptomatik celiac hastalığı olan hastaların tanı alma . . .sını sağlayabilir. Bu çalışma rekürren aftoz stomatit nedeniyle başvuran olgularda celiac hastalığı prevalansını saptamak için planlanmıştır. Yöntem: Çalışma gurubu olarak rekürren aftoz stomatit öyküsü olan, kontrol grubu olarak ise rekürren aftoz stomatit öyküsü olmayan olgular alındı. Tüm olgularda anti gliadin IgG, antigliadin IgA ve anti endomisium antikorları bakıldı. Ayrıca endoskopi yapılarak duodenum distal kesiminden biyopsiler alındı. Bulgular: Rekürren aftoz stomatit öyküsü olan 41 olgunun ikisinde patolojik inceleme ile doğrulanan celiac hastalığı bulundu (%4.8). Celiac hastalığı saptanan bu iki olgunun her ikisinde de anti gliadin IgA ve endomisium antikorları pozitif bulundu. Anti gliadin IgG antikoru ise olguların birinde pozitifti. Kontrol grubundaki 49 olgunun hiçbirinde celiac hastalığı saptanmadı. Sonuç: Rekürren aftoz stomatit olgularında celiac hastalığı açısında ileri incelenmeler yapılmalıdır. Endoskopinin invaziv ve daha pahalı olması nedeniyle rekürren aftoz stomatitli olgularda celiac hastalığı ı araştırmak için öncelikli olarak serolojik tetkikler yapılmalı, seroljik markır pozitif olan olgularda endoskopik olarak duodenum ikinci kesiminden biyopsiler alınmalıdır. Background/aims: Celiac disease is a condition related to the small intestine&#8217;s intolerance to gluten. In epidemiologic studies the prevalence is highly variable. The diagnosis can be difficult due to the wide spectrum of signs and symptoms. As the risk for intestinal lymphoma is higher in these patients, early diagnosis has its privileges. The higher prevalence of recurrent aphthous stomatitis in celiac disease led us to investigate the celiac disease prevalence in patients with recurrent aphthous stomatitis, which might assist in diagnosis of asymptomatic celiac disease patients. The aim of this study was to determine the prevalence of celiac disease in patients presenting with recurrent aphthous stomatitis. Methods: The study group consisted of patients having a history of recurrent aphthous stomatitis. The control group included patients not having aphthous stomatitis. Antibodies to gliadin IgG and IgA and antibodies to endomysium were determined from the serum samples of all patients. Biopsies were obtained from the distal part of the duodenum. Results: Biopsies of two patients (4.8%) out of 41 belonging to the study group were diagnosed as celiac disease. In serum samples of both, antibodies to gliadin IgA and antibodies to endomysium were found to be positive. Antibodies to gliadin IgG antibody were positive in only one of these two patients. None of the 49 patients in the control group was diagnosed as celiac disease. Conclusion: Further evaluation of recurrent aphthous stomatitis patients for celiac disease must be performed. As the endoscopic procedures are invasive and costly, evaluation of recurrent aphthous stomatitis patients for celiac disease must include serologic markers at the beginning. If any positivity is determined in markers, then endoscopic procedures including biopsies of the duodenum must be considered as the second-step intervention Daha fazlası Daha az

Özaçmak, Veysel Haktan | Barut, Figen | Özaçmak-Sayan, Hale

Article | 2009 | Journal of Pineal Research47 ( 2 ) , pp.156 - 163

Oxidative stress is believed to contribute to functional and histopathologic disturbances associated with chronic cerebral hypoperfusion (CCH) in rats. Melatonin has protective effects against cerebral ischemia/reperfusion injury. This effect has mainly been attributed to its antioxidant properties. In the present study, we evaluate the effects of melatonin on chronic cerebral hypoperfused rats and examined its possible influence on oxidative stress, superoxide dismutase (SOD) activity, reduced glutathione (GSH) levels, and heat shock protein (HSP) 70 induction. CCH was induced by permanent bilateral common carotid artery occlusion . . .in ovariectomized female rats. Extensive neuronal loss in the hippocampus at day 14 following CCH was observed. The ischemic changes were preceded by increases in malondialdehyde (MDA) concentration and HSP70 induction as well as reductions in GSH and SOD. Melatonin treatment restored the levels of MDA, SOD, GSH, and HSP70 induction as compared to the ischemic group. Histopathologic analysis confirmed the protective effect of melatonin against CCH-induced morphologic alterations. Taken together, our results document that melatonin provides neuroprotective effects in CCH by attenuating oxidative stress and stress protein expression in neurons. This suggests melatonin may be helpful for the treatment of vascular dementia and cerebrovascular insufficiency. © 2009 John Wiley and Sons A/S Daha fazlası Daha az

Dogan S.M. | Bilici H.M. | Bakkal, Bekir Hakan | Aydin M. | Karabag T. | Sayin M.R. | Aktop Z.

Article | 2012 | Coronary Artery Disease23 ( 3 ) , pp.146 - 154

BACKGROUND: Radiation-induced heart disease is a complication that may be encountered after radiotherapy (RT) of tumors in the vicinity of the heart. In this study, we aimed to evaluate the effect of RT on the heart, by comparing conventional and tissue Doppler echocardiography parameters obtained before and after RT. METHODS: Forty patients who had undergone RT for either lung or left breast cancer were included in the study. ECG, conventional, and tissue Doppler echocardiography were performed before and 4-6 weeks after RT. RESULTS: The mean value of the radiation dose applied to all regions of the heart was calculated as 13.1±2.2 . . . Gy (maximum 41.7 Gy). The value for the left ventricle was 10.2±2.0 Gy (maximum 43.6 Gy). A decrease in early transmitral diastolic velocity (E), E/A ratio, EF, Em, and Em/Am, and an increase in E-wave deceleration time, isovolumic relaxation time, isovolumic contraction time, ejection time, and QTc were found after RT. CONCLUSION: We found detrimental effects of RT on systolic and diastolic cardiac functions and the electrical conduction system of the heart. Maximal prevention should be provided for the patients during RT. © 2012 Lippincott Williams & Wilkins, Inc Daha fazlası Daha az