Buyukates M. | Barut F. | Aktunc E.

Article | 2015 | Journal of Cardiovascular Surgery56 ( 6 ) , pp.913 - 918

Aim. We have conducted this study to seek and observe visual clues through immunohistochemical staining for differences in Et-1/2/3 expression and the free-low capacity measuring the blood flow through grafts, in the left internal mammary artery grafts prepared either with clipped or nonclipped techniques. Methods. A total of 40 consecutive patients with a diagnosis of coronary artery disease who would benefit from elective coronary artery bypass graft surgery were randomised into two groups consisting 20 patients each. Left internal mammary artery was harvested by a traditional clipped (control group) and a modified nonclipped (stu . . .dy group) technique in each of the groups. All harvested arterial segments were evaluated for luminal endothelial integrity through hematoxylin&eosin and immunohistochemical staining. Results. The free-low capacity of left internal mammary artery grafts were significantly higher in nonclipped arteries when compared with that of clipped ones (P=0.001). The arterial lumen of the nonclipped segments were visibly more dilated than the clipped ones. Nonclipped segments presented a lighter immunostaining for Et-1/2/3 when compared with the clipped ones ( Daha fazlası Daha az

Turan, İnci | Özaçmak-Sayan, Hale | Özaçmak, Veysel Haktan | Barut, Figen

Proceedings | 2018 | ACTA PHYSIOLOGICA225 , pp.50 - 50

WOS: 000453220100106

Çağavi, Ferda | Kalaycı, Murat | Tekin, İshak Özel | Numanoğlu, Gamze | Çağavi, Zeynep | Gül, Şener | Açıkgöz, Bektaş

Article | 2006 | Clinical Neurology and Neurosurgery108 ( 2 ) , pp.168 - 173

About 90% of Hodgkin's disease cases originate from lymph nodes whereas 10% from extranodal regions. Patients rarely present with spinal cord compression due to epidural Hodgkin's disease. Primary spinal extradural Hodgkin's disease which does not have any other organ involvement in the body is even rarer. A 39-year-old male patient who complained of lumbar pain had normal findings upon neurological examination. Radiological examination revealed a mass on the epidural space at level L3 and the involvement of the vertebral corpus accompanied by the involvement of C6 vertebral body. Primary focus could not be identified despite furthe . . .r investigation. The patient underwent L3 laminectomy and posterior decompression and biopsy was obtained from the lesion extending to epidural space. The pathological result was reported as lymphocyte dominant type Hodgkin's disease. Flow cytometry was performed to the lesion, also. The patient was evaluated as Stage 4A according to Ann Arbor classification. Postoperative radiotherapy was applied to lumbar and cervical region. In the literature we have not come across any case of primary spinal extranodal Hodgkin's disease with involvement at two levels. In conclusion, although it might be extremely rare, primary spinal extranodal Hodgkin's disease with involvement at two levels might be observed. © 2004 Elsevier B.V. All rights reserved Daha fazlası Daha az

Barut A. | Barut F. | Kandemir N.O. | Aktunc E. | Arikan I. | Harma M. | Harma M.I.

Article | 2012 | Gynecologic and Obstetric Investigation73 ( 2 ) , pp.141 - 151

Background/Aims: Chorangiosis is considered to be strongly associated with fetal, maternal, and placental disorders, and has been found to be correlated with increased fetal morbidity and mortality. In this study, it is aimed to investigate the association of angiogenesis and oxidative stress with the pathogenesis of chorangiosis. Methods: Expressions of heat shock protein 70 (HSP70), vascular endothelial growth factor-A (VEGF-A) and basic fibroblast growth factor (b-FGF), which are investigated with avidin-biotin-peroxidase method in formalin-fixed, paraffin-embedded sections from placental tissues diagnosed as no chorangiosis (n = . . . 18) and chorangiosis (n = 18), have been evaluated in a semiquantitative manner. Results: There were significant differences between chorangiosis and no chorangiosis cases with respect to birth weight, birth length, and Apgar scores (p < 0.001). Statistically significant (p < 0.001), diffuse and strong expressions with HSP70, VEGF-A and b-FGF were observed in the villous tissue of placental chorangiosis cases when compared with no chorangiosis cases. Conclusion: The majority of the chorangiosis cases had an accompanying poor perinatal outcome, and also those with accompanying angiogenesis and increased oxidative stress demonstrated diffuse and strong expressions of HSP70, VEGF-A and b-FGF. The interaction of maternal, placental, and fetal factors with increased oxidative stress and angiogenesis may possibly contribute to this arising pathologic change. Copyright © 2012 S. Karger AG, Basel Daha fazlası Daha az

Çakmak, Güldeniz Karadeniz | Çağlar, Emrah | Buzkan, Aktuğ | Emre, Ali | Engin, Huseyin | Bahadır, Burak | Elmas, Özlem

Proceedings | 2019 | ANNALS OF SURGICAL ONCOLOGY26 , pp.129 - 130

20th Annual Meeting of the American-Society-of-Breast-Surgeons -- APR 30-MAY 05, 2019 -- Dallas, TX WOS: 000467382700095

Numanoğlu, Kemal Varın | Cihan, Alper | Salman, Bülent | Uçan, Bülent Hamdi | Çakmak-Karadeniz, Güldeniz | Cesur, Ali | Balbaloğlu, Hakan | İlhan, Mustafa N.

Article | 2007 | Asian Journal of Surgery30 ( 2 ) , pp.96 - 101

OBJECTIVE: Intraabdominal adhesion formation and prevention is one of the major conflicts of modern surgery. We aimed to determine the effects of powdered gloves versus powder-free gloves and hyaluronate/carboxymethylcellulose membrane (H/CMCm) in a rat caecal serosal abrasion model. METHODS: Sixty wistar albino rats were subjected to a standardized lesion by caecal abrasion model. In group 1, the procedure was performed with sterile powdered gloves. In group 2, the procedure was performed with powder-free sterile gloves. The H/CMCm was applied directly to the abraded caecum in group 3. Formation of adhesions were determined on one . . .half of the animals from each group on the 7th postoperative day, and on the other half on the 15th postoperative day. RESULTS: There was a statistically significant difference between the adhesion scores on day 7 and 15 in groups 1 and 2 (p = 0.005, p = 0.007). There was no significant difference in adhesion scores on day 7 and 15 in group 3 (p = 0.145). The mean adhesion score was significantly higher in group 1 (powdered glove group) than group 2 (powder-free glove group) and group 3 (powder-free glove plus H/CMCm) on post-operative day 7 (p = 0.001). However, no significant difference was found between groups regarding adhesion scores on postoperative day 15 (p = 0.607). The comparisons of group 2 versus group 3, both on postoperative day 7 (p = 0.051) was not statistically significant, whereas a significant difference was detected between group 1 versus group 2 and group 3 on postoperative day 7 (p = 0.013, p = 0.001). CONCLUSION: Our experiment shows that the use of powder-free gloves may be as beneficial as Seprafilm in preventing postoperative adhesion formation. © 2007 Elsevier. All rights reserved Daha fazlası Daha az

Özdamar, Şükrü Oğuz | Bahadır, Burak | Ekem, Tulu Emre | Kertiş, Gürkan | Gün-Doğan, Banu | Numanoğlu, Gamze | Yünten, Zafer | Kuzey-Mocan, Gamze

Article | 2006 | Turkish Journal of Cancer36 ( 4 ) , pp.157 - 161

Intraoperative consultation is a high-risk procedure of pathology departments with important consequences. Therefore, it is critical to determine institutional efficiency of frozen section performance periodically. Frozen section diagnoses of 552 specimens from 401 cases between June 2001 and January 2005 were rewieved and correlated with subsequent histopathological examination, to assess concordant, discordant and deferred diagnoses as well as false negative and false positive rates and to determine reasons for discordance. Each individual specimen from the same case was considered and evaluated as one case. Excluding deferred dia . . .gnosis constituting 4.53% of the cases, accuracy, false negative and false positive rates were consecutively found 97.47%, 2.08%, and 0.57%. Interestingly, a great proportion of false negative cases were found to be associated with papillary carcinoma of thyroid. Gross sampling error and misinterpretation appeared as the leading reasons for frozen section discordance. Considering discordant frozen section diagnoses have a great impact on patient's care, intra and interinstitutional monitoring of frozen section performance may serve as a quality control programme Daha fazlası Daha az

Kandemir, N. Onak | Barut, Figen | Yurdakan, G. | Bayar, U.

Conference Object | 2008 | HISTOPATHOLOGY53 , pp.198 - 198

27th International Congress of the International-Academy-of-Pathology -- OCT 12-17, 2008 -- Athens, GREECE WOS: 000259524800452

Gonca E. | Barut F. | Erdem S.

Article | 2017 | Turkish Journal of Thoracic and Cardiovascular Surgery25 ( 2 ) , pp.273 - 281

Background: This study aims to evaluate the effects of zileuton on myocardial ischemia/reperfusion injury and ischemia-induced ventricular arrhythmias and to investigate the role of 5-lipoxygenase pathway in the pathogenesis of myocardial ischemia/reperfusion injury. Methods: In anesthetized rats, myocardial ischemia was induced by the ligation of the left main coronary artery for 30 min before 120-min reperfusion period. Zileuton was given both at the doses of 3 and 10 mg/kg 15 min before the ligation. During the experiment, electrocardiography, blood pressure, and heart rate were recorded. The duration of arrhythmia types were det . . .ermined during the ischemic period. To evaluate the ischemia/reperfusion injury in the myocardial tissue, histopathological examination was performed and the infarct size was determined by 2,3,5-triphenyltetrazolium chloride staining. Results: Zileuton at a dose of 3 mg/kg significantly decreased the infarct size and the tissue injury score obtained using histopathological examinations (infarct size [% of the area at risk]: zileuton 3 mg/kg 36±7% versus control 66±6%, p < 0.05). Zileuton 10 mg/kg was found to be ineffective. Both 3 and 10 mg/kg doses of zileuton did not shorten the duration of arrhythmias during the ischemic period. Conclusion: Our study results showed that 3 mg/kg dose of zileuton protected the heart against myocardial ischemia/ reperfusion injury. However, it was ineffective to reduce the ischemia-induced ventricular arrhythmias. Based on these results, zileuton may be a promising drug for the treatment of myocardial ischemia/reperfusion injury. © 2017. Turkish Society of Cardiovascular Surgery Daha fazlası Daha az

Barut F. | Özdamar S.O. | Dogan Gün B. | Bahadir B. | Bektaş S.

Article | 2011 | Turk Onkoloji Dergisi26 ( 2 ) , pp.76 - 81

Merkel cell carcinoma is an uncommon tumor arising usually on the sun-exposed skin of elderly individuals. A 64-year-old male patient, who undergone total laryngectomy operation seven years ago because of squamous cell carcinoma of larynx and got postoperative radiotherapy applied to the hospital with a subcostal mass. Histopathologic examination of the mass revealed tumoral infltration with cytokeratin-20 expression that forming sheets and solid nests in subcutaneous tissue. The diagnosis was Merkel cell carcinoma. A vegetative tumor located in left main bronchi was observed during synchronously performed bronchoscopy and multiple . . .biopsies were taken. Histopathologic diagnosis was pulmonary small cell carcinoma displaying positive reaction with thyroid transcription fac-tor-1 without cytokeratin-20 expression. It's extremely rare to encounter Merkel cell carcinoma coexisting with pulmonary small cell carcinoma. The current case has special importance due to being an extremely rare encountered tumor besides con-frming these markers' reliability in distinguishing Merkel cell carcinoma from pulmonary small cell carcinoma. © 2011 Association of Oncology Daha fazlası Daha az

Karakaya K. | Barut F. | Emre A.U. | Ucan H.B. | Cakmak G.K. | Irkorucu O. | Tascilar O.

Article | 2008 | World Journal of Gastroenterology14 ( 14 ) , pp.2280 - 2283

The mucocele of the appendix is an uncommon disorder which is often asymptomatic but sometimes causes acute appendicitis-like symptoms. Sometimes, patients with mucocele can present with confusing symptoms. Preoperative suspicion and diagnosis of appendiceal mucocele are important. Ultrasonography and camputed tomography are useful tools for the diagnosis of appendiceal mucocele. It may be also recognised by colonoscopy as a smooth submucosal lesion of the cecum. Optimal management of the mucocele could be achieved through accurate preoperative diagnosis. Preoperative diagnosis is a major component for minimizing intra-operative and . . . post-operative complications. We herein report five cases and discuss the diagnostic methods and surgical treatment. © 2008 WJG. All rights reserved Daha fazlası Daha az

Barut F. | Kandemir N.O. | Gun B.D. | Ozdamar S.O.

Article | 2016 | Journal of the Pakistan Medical Association66 ( 7 ) , pp.905 - 907

T-cell/histiocyte-rich large B-cell lymphoma is an unusually encountered lymphoid neoplasm of stomach with aggressive course, and is an uncommon morphologic variant of diffuse large B-cell lymphoma. An ulceratedmass, 7x5x1 cm in size was observed within the gastrectomy specimen of a 76-year-old female patient. In cross sections, besides mature lymphoid cells displaying T-cell phenotype, a neoplastic formation composed of large, pleomorphic atypical lymphoid cells with, prominent nucleoli, vesicular nuclei and abundant eosinophilic cytoplasm displaying B-cell phenotype were observed. Meanwhile, histiocyte-like mononuclear cells and R . . .eed-Sternberg-like multinuclear cells expressing CD68 and Mac387 were also observed. The diagnosis of the case was T cell/histiocyte-rich large B-cell lymphoma. This rarely encountered neoplasm should be kept in mind in the differential diagnosis of primary gastric lymphomas. © 2016, Pakistan Medical Association. All rights reserved Daha fazlası Daha az