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Lipoma within inverted Meckel's diverticulum as a cause of recurrent partial intestinal obstruction and hemorrhage: A case report and review of literature

Cakmak, Guleniz Karadeniz | Emre, Ali Ugur | Tascilar, Oge | Bektas, Sibel | Ucan, Bulent Hamdi | Irkorucu, Oktay | Karakaya, Kemal

Article | 2007 | WORLD JOURNAL OF GASTROENTEROLOGY13 ( 7 ) , pp.1141 - 1143

Lipoma within an inverted Meckel's diverticulum presenting with hemorrhage and partial intestinal obstruction is an exceptional clinical entity. We report a case of 47-year-old male with a history of recurrent episodes of partial intestinal obstruction and melena due to a subserosal lipoma located in the base of an inverted Meckel's diverticulum. According to our knowledge, this is the first case of a lipoma within a Meckel's diverticulum giving rise to this clinical scenario without the existence of heterotrophic gastric or pancreatic tissues. (c) 2007 The WJG Press. All rights reserved.

Obstructive jaundice leads to accumulation of oxidized low density lipoprotein in human liver tissue

Comert, Mustafa | Ustundag, Yucel | Tekin, Ishak Ozel | Gun, Banu Dogan | Barut, Figen

Letter | 2006 | WORLD JOURNAL OF GASTROENTEROLOGY12 ( 31 ) , pp.5094 - 5095

Oxidized low density lipoprotein (ox-LDL) molecule is one of the most important modified lipoproteins produced during the oxidative stress. Modified lipoproteins have been defined as being part of the immune inflammatory mechanisms in association with oxidant stress. We have reported the accumulation of ox-LDL in Balb/c mice liver after bile duct ligation previously. Here, we investigated this finding in human beings with obstructive jaundice. Our study demonstrates that obstructive jaundice results in tremendous accumulation of ox-LDL in the liver tissue of patients. (C) 2006 The WJG Press. All rights reserved.

Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats

Kanter, Mehmet | Demir, Halit | Karakaya, Cengiz | Ozbek, Hanefi

Article | 2005 | WORLD JOURNAL OF GASTROENTEROLOGY11 ( 42 ) , pp.6662 - 6666

AIM: To evaluate the role of reactive oxygen species in the pathogenesis of acute ethanol-induced gastric mucosal lesions and the effect of Nigella sativa L oil (NS) and its constituent thymoquinone (TQ) in an experimental model. METHODS: Male Wistar albino rats were assigned into 4 groups. Control group was given physiologic saline orally (10 mL/kg body weight) as the vehicle (gavage); ethanol group was administrated 1 mL (per rat) absolute alcohol by gavage; the third and fourth groups were given NS (10 mL/kg body weight) and TQ (10 mg/kg body weight p.o) respectively 1 h prior to alcohol intake. One hour after ethanol administrat . . .ion, stomach tissues were excised for macroscopic examination and biochemical analysis. RESULTS: NS and TQ could protect gastric mucosa against the injurious effect of absolute alcohol and promote ulcer healing as evidenced from the ulcer index (UI) values. NS prevented alcohol-induced increase in thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation. NS also increased gastric glutathione content (GSH), enzymatic activities of gastric superoxide dismutase (SOD) and glutathione-S-transferase (GST). Likewise, TQ protected against the ulcerating effect of alcohol and mitigated most of the biochemical adverse effects induced by alcohol in gastric mucosa, but to a lesser extent than NS. Neither NS nor TQ affected catalase activity in gastric tissue. CONCLUSION: Both NS and TQ, particularly NS can partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects might be induced, at least partly by their radical scavenging activity. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved Daha fazlası Daha az

Helicobacter pyloriinfection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin

Aydemir, Selim | Boyacioglu, Sedat | Gur, Gurden | Demirbilek, Muge | Can, Fusun Kamber | Korkmaz, Murat | Yilmaz, Ugur

Article | 2005 | WORLD JOURNAL OF GASTROENTEROLOGY11 ( 6 ) , pp.842 - 845

AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls. METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age-and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique. RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the . . . ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant ( Daha fazlası Daha az

Precut sphincterotomy: A reliable salvage for difficult biliary cannulation

Saritas, Ulku | Ustundag, Yucel | Harmandar, Ferda

Editorial | 2013 | WORLD JOURNAL OF GASTROENTEROLOGY19 ( 1 ) , pp.1 - 7

Even experienced endoscopists have 90% success in achieving deep biliary cannulation with standard methods. Biliary cannulation may become difficult in 10%-15% of patients with biliary obstruction and precut (access) sphincterotomy is frequently chosen as a rescue treatment in these cases. Generally, precut sphincterotomy ensures a rate of 90%-100% successful deep biliary cannulation. The precut technique has been performed as either a fistulotomy with a needle knife sphincterotome or as a transpapillary septotomy with a standard sphincterotome. Both methods have similar efficacy and complication rates when administered to the prope . . .r patient. Although precut sphincterotomy ensures over 90% success of biliary cannulation, it has been characterized as an independent risk factor for pancreatitis. The complications of the precut technique are not limited to pancreatitis. Two more important ones, bleeding and perforation, are also reported in some publications as being observed more commonly than during standard sphincterotomy. It is also reported that precut sphincterotomy increases morbidity when performed in patients without dilatation of their biliary tract. Nevertheless, precut sphincterotomy is a good alternative as a rescue method in the setting of a failed standard cannulation method. This paper discusses the technical details, timing, efficacy and potential complications of precut sphincterotomy. (C) 2013 Baishideng. All rights reserved Daha fazlası Daha az

Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: Feasible or not?

Tascilar, Oge | Cakmak, Gueleniz Karadeniz | Tekin, Ishak Ozel | Emre, Ali Ugur | Ucan, Bulent Hamdi | Irkorucu, Oktay | Karakaya, Kemal

Article | 2007 | WORLD JOURNAL OF GASTROENTEROLOGY13 ( 41 ) , pp.5476 - 5480

AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one . . .case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 months follow-up. CONCLUSION: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence. (C) 2007 WJG. All rights reserved Daha fazlası Daha az

Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis

Taşçılar, Öğe | Çakmak, Güldeniz Karadeniz | Tekin, İshak Özel | Emre, Ali Uğur | Uçan, Bülent Hamdi | Bahadır, Burak | Açıkgöz, Serefden | İrkörücü, Oktay | Karakaya, Kemal | Balbaloğlu, Hakan | Kertiş, Gürkan | Ankaralı, Handan | Cömert, Mustafa

Article | 2007 | WORLD JOURNAL OF GASTROENTEROLOGY13 ( 46 ) , pp.6172 - 6182

AIM: To investigate the effect of exogenous erythropoietin (EPO) administration on acute lung injury (ALI) in an experimental model of sodium taurodeoxycholate-induced acute necrotizing pancreatitis (ANP). METHODS: Forty-seven male Wistar albino rats were randomly divided into 7 groups: sham group (n = 5), 3 ANP groups (n = 7 each) and 3 EPO groups (n = 7 each). ANP was induced by retrograde infusion of 5% sodium taurodeoxycholate into the common bile duct. Rats in EPO groups received 1000 U/kg intramuscular EPO immediately after induction of ANP Rats in ANP groups were given 1 mL normal saline instead. All animals were sacrificed a . . .t postoperative 24 h, 48 h and 72 h. Serum amilase, IL-2, IL-6 and lung tissue malondialdehyde (MDA) were measured. Pleural effusion volume and lung/body weight (LW/BW) ratios were calculated. Tissue levels of TNF-alpha, IL-2 and IL-6 were screened immunohistochemically. Additionally, ox-LDL accumulation was assessed with immune-fluorescent staining. Histopathological alterations in the lungs were also scored. RESULTS: The mean pleural effusion volume, calculated LW/BW ratio, serum IL-6 and lung tissue MDA levels were significantly lower in EPO groups than in ANP groups. No statistically significant difference was observed in either serum or tissue values of IL-2 among the groups. The level of tumor necrosis factor-alpha (TNF-alpha) and IL-6 and accumulation of ox-LDL were evident in the lung tissues of ANP groups when compared to EPO groups, particularly at 72 h. Histopathological evaluation confirmed the improvement in lung injury parameters after exogenous EPO administration, particularly, at 48 h and 72 h. CONCLUSION: EPO administration leads to a significant decrease in ALI parameters by inhibiting polymorphonuclear leukocyte (PMNL) accumulation, decreasing the levels of proinflammatory cytokines in circulation, preserving microvascular endothelial cell integrity and reducing oxidative stress-associated lipid peroxidation and therefore, can be regarded as a cytoprotective agent in ANP-induced ALI. (c) 2007 WJG. All rights reserved Daha fazlası Daha az

Clinical evaluation of submucosal colonic lipomas: Decision making

Tascilar, Oge | Cakmak, Gueldeniz Karadeniz | Guen, Banu Dogan | Ucan, Buelent Hamdi | Balbaloglu, Hakan | Cesur, Ali | Emre, Ali Ugur

Article | 2006 | WORLD JOURNAL OF GASTROENTEROLOGY12 ( 31 ) , pp.5075 - 5077

Even lipomas are the most common mesenchymal benign tumors of the gastrointestinal tract, symptomatic colonic presentation is rare. Herein, we evaluated four patients suffering from various size of colonic lipomas and approached by different therapeutic modalities. (C) 2006 The WJG Press. All rights reserved.

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