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Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats [Siçanlarda künt akciğer travmasina bağli akut akciğer hasarinda nitrik oksit sentaz inhibitörlerinin etkisi]

Akgül A.G. | Şahin D. | Temel U. | Eliçora A. | Dillioğlugil M. | Kir H.M. | Özsoy Ö.D.

Article | 2019 | Turkish Journal of Thoracic and Cardiovascular Surgery27 ( 1 ) , pp.63 - 72

Background: This study aims to investigate the effects of blunt lung trauma performed in experimental rat model on lung tissue and blood as well as proinflammatory cytokines, oxidant-antioxidant enzymes and histopathological parameters after Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine administration. Methods: The study included 50 adult male Wistar albino rats (weighing 350 to 400 g). Rats were randomly allocated into four groups. Except in the control, moderate-level pulmonary contusion was created in all other groups. Intraperitoneal saline solution was performed in groups 1 and 2, 25 mg.kg-1 Ngamma-nitro-L-a . . .rginine methyl ester in group 3, and 20 mg.kg-1 N-iminoethyl-L-ornithine in group 4. Blood and lung tissues were studied biochemically and histopathologically. Results: Best outcomes were recorded statistically significantly in groups with administration of Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine when malondialdehyde response, mucous and histopathological values were examined. Significant improvement was detected in superoxide dismutase values in the group with administration of competitive nitric oxide synthase inhibitor Ngamma-nitro-L-arginine methyl ester. Nitric oxide values were substantially decreased in N-iminoethyl-L-ornithine group, while no significance was detected. Conclusion: Free oxygen radicals and lipid peroxidation played a role in pulmonary contusion after blunt lung trauma. According to biochemical and histopathological outcomes, effects of inflammation were decreased and protective effects were formed with administration of both Ngammanitro- L-arginine methyl ester and N-iminoethyl-L-ornithine. © 2019 Turkish Society of Cardiovascular Surgery.Amaç: Bu çalişmada deneysel siçan modeli üzerinde uygulanan künt akciğer travmasinin akciğer dokusu ve kandaki etkileri ile Ngammanitro- L-arginin metil ester ve N-iminoetil-L-ornitin uygulamasini takiben proenflamatuvar sitokinler, oksidan-antioksidan enzimler ve histopatolojik parametreler araştirildi. çalişma plani: çalişmaya 50 erişkin erkek Wistar albino siçan (ağirlik 350-400 g) dahil edildi. Siçanlar rastgele dört gruba ayrildi. Kontrol dişindaki diğer tüm gruplarda orta şiddette pulmoner kontüzyon oluşturuldu. Grup 1 ve 2'ye intraperitoneal salin solüsyonu, grup 3'e 25 mg.kg-1 Ngamma-nitro-L-arginin metil ester, grup 4'e 20 mg.kg-1 N-iminoetil-L-ornitin uygulandi. Kan ve akciğer dokulari biyokimyasal ve histopatolojik açidan incelendi. Bulgular: Malondialdehit yaniti, müköz ve histopatolojik değerler incelendiğinde, en iyi sonuçlar istatistiksel olarak anlamli şekilde Ngamma-nitro-L-arginin metil ester ve N-iminoetil-L-ornitin uygulanan gruplarda kaydedildi. Yarişmali nitrik oksit sentaz inhibitorü Ngamma-nitro-L-arginin metil ester uygulanan grupta süperoksit dismutaz değerlerinde anlamli iyileşme saptandi. Nitrik oksit değerleri N-iminoetil-L-ornitin grubunda oldukça düşük idi ancak anlamlilik saptanmadi. Sonuç: Künt akciğer travmasi sonrasi pulmoner kontüzyonda serbest oksijen radikalleri ve lipid peroksidasyon rol oynadi. Biyokimyasal ve histopatolojik sonuçlara göre, enflamasyon etkileri hem Ngamma-nitro- L-arginin metil ester hem N-iminoetil-L-ornitin uygulamasi ile azaldi ve koruyucu etkiler oluştu. © 2019 Turkish Society of Cardiovascular Surgery Daha fazlası Daha az

Our open heart surgery experience in factor XII deficiency: A case report [Faktör XII eksikliginde açik kalp cerrahisi deneyimimiz: Olgu sunumu]

Coşkun E. | Büyükateş M.

Article | 2016 | Turkish Journal of Thoracic and Cardiovascular Surgery24 ( 3 ) , pp.561 - 564

Factor XII deficiency is an important hematological problem which is characterized by isolated prolongation of the activated partial thromboplastin time and presents with thrombosis and thromboembolism tendency rather than expected bleeding diathesis in clinical practice. A 55-year-old male patient who was scheduled for aortic coronary bypass graft surgery had elevated activated partial thromboplastin time (109.4 sec) as a laboratory finding. The patient was diagnosed with factor XII deficiency and operated in our clinic. No thromboembolic event was seen during follow-up. The patient was discharged in the seventh postoperative day u . . .neventfully. Herein, we highlight the importance of this disease due to its rare occurrence and present our treatment strategy applied Daha fazlası Daha az

Giant liposarcoma in hemithorax

Gökçe M. | Saydam Ö. | Altin R. | Yurdakan G.

Article | 2012 | Turkish Journal of Thoracic and Cardiovascular Surgery20 ( 4 ) , pp.938 - 940

A 57-year-old female with obesity was admitted to the emergency service with the complaint of severe dyspnea and chest pain. Chest X-ray showed opacity occupying left hemithorax completely and the right mediastinal shift. Thoracic computed tomography indicated a heterogeneous density of a giant mass in the left hemithorax and right mediastinal shift. Complete surgical resection of the liposarcoma was performed. The pathological examination following surgery suggested pleural liposarcoma. In this article, treatment of pleural liposarcoma was discussed in the light of literature review.

Nadir bir koroner trombektomi olgusu

Coşkun E. | Büyükateş M.

Article | 2016 | Turkish Journal of Thoracic and Cardiovascular Surgery24 ( 1 ) , pp.122 - 125

A 59-year-old male patient was admitted to our clinic with the complaint of chest pain. Coronary angiography revealed acute myocardial infarction due to a thrombosis at the right coronary artery. Herein, we report a case undergoing quadruple coronary bypass grafting and revascularization and coronary thrombectomy on right coronary artery due to atherosclerotic heart disease and inferior myocardial infarction.

The role of cerebral oximetry monitoring in off-pump coronary artery bypass surgery of Moyamoya disease

Küçükosman G. | Aydin B.G. | Bereket M.M. | Ayoğlu H.

Article | 2018 | Turkish Journal of Thoracic and Cardiovascular Surgery26 ( 3 ) , pp.464 - 466

Moyamoya disease is a chronic cerebrovascular disease characterized by the development of compensatory collateral vessels due to progressive narrowing or obstruction of the intracranial arteries. Neurological complications after coronary bypass in patients with Moyamoya disease may be prevented by recent technical developments, surgical modifications, and cerebral monitorization. The objective of perioperative anesthetic management is to provide balance between oxygen supply and consumption of the brain. In this case report, we aim to share our anesthetic experience in a patient with Moyamoya disease who underwent off-pump coronary . . .artery bypass surgery and cerebral oximetry monitoring. ©2018 All right reserved by the Turkish Society of Cardiovascular Surgery Daha fazlası Daha az

Cardioprotective effect of zileuton: A 5-lipoxygenase inhibitor against myocardial ischemia/reperfusion injury

Gonca E. | Barut F. | Erdem S.

Article | 2017 | Turkish Journal of Thoracic and Cardiovascular Surgery25 ( 2 ) , pp.273 - 281

Background: This study aims to evaluate the effects of zileuton on myocardial ischemia/reperfusion injury and ischemia-induced ventricular arrhythmias and to investigate the role of 5-lipoxygenase pathway in the pathogenesis of myocardial ischemia/reperfusion injury. Methods: In anesthetized rats, myocardial ischemia was induced by the ligation of the left main coronary artery for 30 min before 120-min reperfusion period. Zileuton was given both at the doses of 3 and 10 mg/kg 15 min before the ligation. During the experiment, electrocardiography, blood pressure, and heart rate were recorded. The duration of arrhythmia types were det . . .ermined during the ischemic period. To evaluate the ischemia/reperfusion injury in the myocardial tissue, histopathological examination was performed and the infarct size was determined by 2,3,5-triphenyltetrazolium chloride staining. Results: Zileuton at a dose of 3 mg/kg significantly decreased the infarct size and the tissue injury score obtained using histopathological examinations (infarct size [% of the area at risk]: zileuton 3 mg/kg 36±7% versus control 66±6%, p < 0.05). Zileuton 10 mg/kg was found to be ineffective. Both 3 and 10 mg/kg doses of zileuton did not shorten the duration of arrhythmias during the ischemic period. Conclusion: Our study results showed that 3 mg/kg dose of zileuton protected the heart against myocardial ischemia/ reperfusion injury. However, it was ineffective to reduce the ischemia-induced ventricular arrhythmias. Based on these results, zileuton may be a promising drug for the treatment of myocardial ischemia/reperfusion injury. © 2017. Turkish Society of Cardiovascular Surgery Daha fazlası Daha az

Veins of the heart: An evaluation of the terminology [Kalbin venleri: Terminolojik inceleme]

Kaçar D. | Barut Ç.

Article | 2011 | Turkish Journal of Thoracic and Cardiovascular Surgery19 ( 4 ) , pp.529 - 532

https://dx.doi.org/10.5606/tgkdc.dergisi.2011.082 https://hdl.handle.net/20.500.12628/8492

Evaluation of quality of life after minimally invasive varicose vein treatment

çoban P.T. | Dirimeşe E.

Article | 2019 | Turkish Journal of Thoracic and Cardiovascular Surgery27 ( 1 ) , pp.49 - 56

Background: This cross-sectional study aims to evaluate the changes in quality of life after minimally invasive procedures in patients with varicose veins. Methods: The study included 150 patients (58 males, 92 females; mean age 47.1±12.0; range, 19 to 80 years) with varicose veins who were treated using minimally invasive techniques. Data were collected using patient information forms and the Venous Insufficiency Epidemiological and Economic Study-Quality of life/Symptoms questionnaire. Before the minimally invasive procedures, patients were informed about varicose veins and medical approaches for relief. They were also provided in . . .formation about the use of compression stockings. Varicose vein symptoms and quality of life were evaluated before the minimally invasive procedures and four weeks following the last operation. Results: Females, individuals aged between 51-60 years, those with Body Mass Index > 30, or having had a pregnancy had higher prevalence of variceal disease and lower quality of life. Clinical severity of the disease decreased and the quality of life improved in patients treated with minimally invasive procedures. After treatment, 45.33% of patients put on compression stockings regularly for one month. Conclusion: After minimally invasive treatment, severe disease symptoms decreased and quality of life increased in patients with varicose veins. Lifestyle modifications, use of compression stockings, and roles of nurses and healthcare workers are significant in maintaining healthy veins. © 2019 by the Turkish Society of Cardiovascular Surgery.Amaç: Bu kesitsel çalişmada varisli hastalarda minimal invaziv işlemler sonrasinda yaşam kalitesindeki değişimler değerlendirildi. çalişma plani: çalişmaya minimal invaziv tekniklerle tedavi edilen varisli 150 hasta (58 erkek, 92 kadin; ort. yaş 47.1±12.0 yil; dağilim 19-80 yil) dahil edildi. Veriler hasta bilgi formlari ve Venöz Yetmezlikte Epidemiyolojik ve Ekonomik çalişma-Yaşam Kalitesi/Semptomlar Anketi kullanilarak toplandi. Minimal invaziv işlemlerden önce, hastalar varisler ve rahatlama amaçli tibbi yaklaşimlar hakkinda bilgilendirildi. Ayrica, kompresyon çoraplarinin kullanimi hakkinda da kendilerine bilgi sağlandi. Varis semptomlari ve yaşam kalitesi minimal invaziv işlemlerden önce ve son işlemden dört hafta sonra değerlendirildi. Bulgular: Kadinlar, 51-60 yaş araliğindaki bireyler, Vücut Kütle Indeksi > 30 olanlar veya gebelik geçirmiş olanlarda varis hastaliği prevalansi daha yüksek ve yaşam kalitesi daha düşük idi. Minimal invaziv işlemler ile tedavi edilen hastalarda hastaliğin klinik şiddeti azaldi ve yaşam kalitesi düzeldi. Tedavi sonrasi, hastalarin %45.33'ü bir ay boyunca düzenli olarak kompresyon çorabi giydi. Sonuç: Minimal invaziv tedavi sonrasi varisli hastalarda şiddetli hastalik semptomlari azaldi ve yaşam kalitesi artti. Yaşam tarzi değişiklikleri, kompresyon çorabi kullanimi ve hemşire ve sağlik çalişanlarinin rolleri damar sağliğinin korunmasinda önemlidir. © 2019 by the Turkish Society of Cardiovascular Surgery Daha fazlası Daha az

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