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Primary thyroid lymphoma arising in the setting of Hashimoto's thyroiditis

Dogan Gün B. | Gün M.O. | Karamanoglu Z.

Article | 2004 | Turkish Journal of Medical Sciences34 ( 6 ) , pp.395 - 398

[No abstract available]

Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma

Aydın, Muammer Merve | Bayın, Nermin Sumru | Acun, Tolga | Yakıcıer, Mustafa Cengiz | Akçalı, Kamil Can

Article | 2016 | Turkish Journal of Medical Sciences46 ( 2 ) , pp.572 - 571

Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models. Materials and methods: We used Snu398 cells that express FLT3. We investigated these cells’ in vitro proliferation and invasion abilities by treatment with the FLT3 inhibitor K-252a or by knocking-down with FLT3 shRNA,. Furthermore, the ef . . .fect of blocking FLT3 activity and expression during in vivo tumorigenesis was assessed with xenograft models. Results: After K-252a treatment or stable knock-down, these cells’ proliferation and migration abilities were highly diminished in vitro. In addition, significant diminution in tumorigenicity of Snu398 cells was also obtained in vivo. When FLT3 knocked-down Snu398 cells were injected into nude mice, we did not detect αSMA expression in these tumors, suggesting a role for FLT3 in in vivo invasiveness. Conclusion: Our data provided evidence that FLT3 has a crucial role both in hepatocarcinogenesis and its invasiveness. Therefore, targeting FLT3 and/or its activity may be a promising tool for combating hepatocellular carcinomas. Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models. Materials and methods: We used Snu398 cells that express FLT3. We investigated these cells’ in vitro proliferation and invasion abilities by treatment with the FLT3 inhibitor K-252a or by knocking-down with FLT3 shRNA,. Furthermore, the effect of blocking FLT3 activity and expression during in vivo tumorigenesis was assessed with xenograft models. Results: After K-252a treatment or stable knock-down, these cells’ proliferation and migration abilities were highly diminished in vitro. In addition, significant diminution in tumorigenicity of Snu398 cells was also obtained in vivo. When FLT3 knocked-down Snu398 cells were injected into nude mice, we did not detect αSMA expression in these tumors, suggesting a role for FLT3 in in vivo invasiveness. Conclusion: Our data provided evidence that FLT3 has a crucial role both in hepatocarcinogenesis and its invasiveness. Therefore, targeting FLT3 and/or its activity may be a promising tool for combating hepatocellular carcinomas Daha fazlası Daha az

Total white blood cell count, liver enzymes, and metabolic syndrome in schizophrenia

Karakaş Uğurlu G. | Ulusoy Kaymak S. | Uğurlu M. | Örsel S. | Çayköylü A.

Article | 2016 | Turkish Journal of Medical Sciences46 ( 2 ) , pp.259 - 264

Background/aim: Metabolic syndrome (MetS) is an important clinical issue in patients with schizophrenia, but its associated factors are still ambiguous. The aim of the present study was to test whether there are any associations between MetS and white blood cell (WBC) levels, liver enzymes, or sociodemographic variables. Materials and methods: The study included 91 patients with a diagnosis of schizophrenia. We used the National Cholesterol Education Program’s Third Adult Treatment Protocol criteria to evaluate MetS in patients. Schizophrenia patients with MetS were compared with those without MetS on the basis of demographic and cl . . .inical characteristics and total WBC counts. We conducted Spearman’s correlation and binary logistic regression analyses to achieve the best prediction of MetS in schizophrenia. Results: Compared with schizophrenia patients without MetS, those with MetS were older, less educated, and more likely to be smokers. They were also more likely to have a longer duration of the illness, a longer untreated period, and higher alanine aminotransferase (ALT) and WBC levels. MetS was correlated with age, duration of illness, income, ALT, gamma-glutamyl transpeptidase, WBC, and hemoglobin values. Age and WBC levels were found to be the best predictors of MetS. Conclusion: Hemograms and liver tests should be conducted to test for MetS in schizophrenia. © TÜBİTAK Daha fazlası Daha az

Evaluation of plantar pressure distributions in patients with anterior cruciate ligament deficiency: preoperative and postoperative changes

Çetin, Engin | Deveci, Mehmet Ali | Songür, Murat | Özer, Hamza | Turanlı, Sacit

Article | 2017 | Turkish Journal of Medical Sciences47 ( 2 ) , pp.587 - 591

Background/aim: Anterior cruciate ligament (ACL) deficiency results in several kinematic changes in the lower extremities. The aim of this study is to define the plantar pressure parameters in ACL-deficient patients and to show the effect of ACL reconstruction on dynamic plantar pressure. Materials and methods: Forty patients with unilateral ACL rupture and 40 healthy controls were included in this study. Dynamic plantar pressures of both groups were recorded by the EMED SF-2 system during level walking. Thirteen of the patients who had ACL reconstructions with hamstring autografts (HS group) were reevaluated at an average of 14.5 m . . .onths following the ACL reconstructions. Results: ACL-deficient patients had significantly lower hindfoot (P = 0.007) but higher midfoot pressure values (P = 0.03) on their ipsilateral foot compared to control group subjects. Ipsilateral hindfoot pressures were also found to be significantly lower than those of the contralateral foot (P = 0.001). Hindfoot pressure values of the HS group were increased in postoperative measurements (P = 0.01). Conclusion: ACL-deficient patients have altered plantar pressure distributions and ACL reconstructions restore these changes to normal. Pedobarography might be used as a practical method for dynamic functional assessment of ACL-deficient patients. Background/aim: Anterior cruciate ligament (ACL) deficiency results in several kinematic changes in the lower extremities. The aim of this study is to define the plantar pressure parameters in ACL-deficient patients and to show the effect of ACL reconstruction on dynamic plantar pressure. Materials and methods: Forty patients with unilateral ACL rupture and 40 healthy controls were included in this study. Dynamic plantar pressures of both groups were recorded by the EMED SF-2 system during level walking. Thirteen of the patients who had ACL reconstructions with hamstring autografts (HS group) were reevaluated at an average of 14.5 months following the ACL reconstructions. Results: ACL-deficient patients had significantly lower hindfoot (P = 0.007) but higher midfoot pressure values (P = 0.03) on their ipsilateral foot compared to control group subjects. Ipsilateral hindfoot pressures were also found to be significantly lower than those of the contralateral foot (P = 0.001). Hindfoot pressure values of the HS group were increased in postoperative measurements (P = 0.01). Conclusion: ACL-deficient patients have altered plantar pressure distributions and ACL reconstructions restore these changes to normal. Pedobarography might be used as a practical method for dynamic functional assessment of ACL-deficient patients Daha fazlası Daha az

The status of oxidants and antioxidants in the neutrophils of patients with recurrent aphthous stomatitis

Altınyazar, Hilmi Cevdet | Gürel, Ahmet | Koca, Rafet | Armutçu, Ferah | Ünalacak, Murat

Article | 2006 | Turkish Journal of Medical Sciences36 ( 2 ) , pp.87 - 91

Recurrent aphthous stomatitis (RAS) is an inflammatory condition of unknown etiology. The exact role of the leukocytes in the pathogenesis of RAS is not known. The aim of this study was to evaluate the status of the oxidative system in neutophils of RAS patients. A total of 26 patients and 22 sex and age matched healthy control subjects were analyzed by measuring intracellular oxidant/antioxidant enzymes and related parameters; myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD), adenosine deaminase (AD), malondialdehyde (MDA) and nitric oxide (NO). Statistically significant increases in the acti . . .vities of SOD, CAT and levels of MDA, NO were detected in the neutrophils of patients. There was no significant difference in MPO, AD and XO activities of neutrophils. Although the functions of neutrophils were normal, there may be an oxidative stress affecting neutrophils in RAS. Recurrent aphthous stomatitis (RAS) is an inflammatory condition of unknown etiology. The exact role of the leukocytes in the pathogenesis of RAS is not known. The aim of this study was to evaluate the status of the oxidative system in neutophils of RAS patients. A total of 26 patients and 22 sex and age matched healthy control subjects were analyzed by measuring intracellular oxidant/antioxidant enzymes and related parameters; myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT), superoxide dismutase (SOD), adenosine deaminase (AD), malondialdehyde (MDA) and nitric oxide (NO). Statistically significant increases in the activities of SOD, CAT and levels of MDA, NO were detected in the neutrophils of patients. There was no significant difference in MPO, AD and XO activities of neutrophils. Although the functions of neutrophils were normal, there may be an oxidative stress affecting neutrophils in RAS Daha fazlası Daha az

An indispensable toxin known for 2500 years: Victims of mad honey

Demir Akca A.S. | Kahveci F.O.

Article | 2012 | Turkish Journal of Medical Sciences42 ( SUPPL.2 ) , pp.1499 - 1504

Aim: Mad honey (bitter honey) is a local name for a particular type of honey used in alternative medicine to treat gastric pain, bowel disorders, and hypertension, and as a sexual stimulant in the Black Sea coastal region of Turkey. Grayonotoxin behaves like cholinergic agents and has dosage dependent adverse effects on the cardiovascular system including bradycardia, atrioventricular block (AVB), and arterial hypotension. In this manuscript, we report 37 cases of mad honey intoxication from the western Black Sea region. Materials and methods: This was a retrospective case series of 37 patients who were admitted to the emergency dep . . .artment of a tertiary center with a history of mad honey intake between June 2003 and June 2010. Results: Patients consisted of 31 males (83.7%) and 6 females (16.3%). Mean age was 56.17 ± 12.56 and 69.66 ± 11.75 in males and females, respectively. Initial physical examination findings included hypotension in 18 patients, sinus bradycardia in 17, and complete AVB in 5 patients. Conclusion: Mad honey poisoning is an important, life-threatening issue in the Black Sea region of Turkey. Mad honey intoxication should be considered in the differential diagnosis in emergency cases of bradycardia and hypotension. © TÜBİTAK Daha fazlası Daha az

Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma

Aydin M.M. | Bayin N.S. | Acun T. | Yakicier M.C. | Akçali K.C.

Article | 2016 | Turkish Journal of Medical Sciences46 ( 2 ) , pp.572 - 581

Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models. Materials and methods: We used Snu398 cells that express FLT3. We investigated these cells’ in vitro proliferation and invasion abilities by treatment with the FLT3 inhibitor K-252a or by knocking-down with FLT3 shRNA,. Furthermore, the ef . . .fect of blocking FLT3 activity and expression during in vivo tumorigenesis was assessed with xenograft models. Results: After K-252a treatment or stable knock-down, these cells’ proliferation and migration abilities were highly diminished in vitro. In addition, significant diminution in tumorigenicity of Snu398 cells was also obtained in vivo. When FLT3 knocked-down Snu398 cells were injected into nude mice, we did not detect ?SMA expression in these tumors, suggesting a role for FLT3 in in vivo invasiveness. Conclusion: Our data provided evidence that FLT3 has a crucial role both in hepatocarcinogenesis and its invasiveness. Therefore, targeting FLT3 and/or its activity may be a promising tool for combating hepatocellular carcinomas. © TÜBİTAK Daha fazlası Daha az

The effect of caffeine on oxidative stress in liver and heart tissues of rats [Kafeinin rat karaciger ve kalp dokusunda oksidan stres üerine etkisi]

Paşaoglu H. | Ofluoglu demir F.E. | Yilmaz Demirtaş C. | Hussein A. | Paşaoglu O.T.

Article | 2011 | Turkish Journal of Medical Sciences41 ( 4 ) , pp.665 - 671

To investigate the effect of caffeine on the levels of malondialdehyde (MDA), nitric oxide (NO), and advanced oxidation protein products (AOPP) in the liver and heart tissues of rats. The current study included 30 rats, which were divided into 3 groups: a control group and 2 caffeine-treated groups. Group 1 was given caffeine at 30 mg/kg and Group 2 was given caffeine at 100 mg/kg (a high nontoxic dose) for 14 days. MDA and AOPP levels in the liver tissue of the caffeine-treated groups decreased signicantly as a result of the dose. MDA and AOPP levels in the heart tissue also decreased, but this effect was not signicantly affected b . . .y the dose. NO levels in the liver tissue of the caffeine-treated groups were higher than those in the control group; in the heart tissues, however, NO levels were not signicantly affected by caffeine. These results show at e short-term consumption of 2 different doses of caffeine may potentially protect against oxidative stress in the liver. This effect is related to the dose of caffeine in the liver tissue. Further studies will be needed to discover e mechanisms responsible for these findings. © TÜBİTAK Daha fazlası Daha az

Premenstrual syndrome and life quality in Turkish health science students

Işık, Hatice | Ergöl, Şule | Aynıoğlu, Öner | Şahbaz, Ahmet | Kuzu, Ayşe | Uzun, Müge

Article | 2016 | Turkish Journal of Medical Sciences46 ( 3 ) , pp.695 - 701

Background/aim: The purpose of the present study was to investigate the incidence of PMS, risk factors affecting PMS symptoms, and life quality in health science students. Materials and methods: A total of 608 volunteer female students studying at the health campus of a state university in Turkey were included in the study. The participants were asked to fill out questionnaires on sociodemographic data, PMS symptoms, and SF-36 life quality tests. Results: The overall frequency of PMS among participants was 84.5%. The average PMS and general health SF scores were 118.34 ± 37.3 and 20.03 ± 3.72, respectively. Students who had irregula . . .r breakfast, drank &#8805;2 cups of coffee/day, and consumed alcohol or fast food had higher PMS scores. Irregular menstruation and family history increased PMS scores and decreased life quality (P < 0.05). The life quality of the students significantly decreased as the severity of PMS increased (P < 0.001). Conclusion: Low body mass index, family history, irregular menstruation, bad eating habits such as fast food consumption and irregular breakfasts, and coffee and alcohol consumption increased PMS risk significantly. In order to improve their life quality, students should be informed about the symptoms, risk factors, and management options of PMS. Background/aim: The purpose of the present study was to investigate the incidence of PMS, risk factors affecting PMS symptoms, and life quality in health science students. Materials and methods: A total of 608 volunteer female students studying at the health campus of a state university in Turkey were included in the study. The participants were asked to fill out questionnaires on sociodemographic data, PMS symptoms, and SF-36 life quality tests. Results: The overall frequency of PMS among participants was 84.5%. The average PMS and general health SF scores were 118.34 ± 37.3 and 20.03 ± 3.72, respectively. Students who had irregular breakfast, drank &#8805;2 cups of coffee/day, and consumed alcohol or fast food had higher PMS scores. Irregular menstruation and family history increased PMS scores and decreased life quality (P < 0.05). The life quality of the students significantly decreased as the severity of PMS increased (P < 0.001). Conclusion: Low body mass index, family history, irregular menstruation, bad eating habits such as fast food consumption and irregular breakfasts, and coffee and alcohol consumption increased PMS risk significantly. In order to improve their life quality, students should be informed about the symptoms, risk factors, and management options of PMS Daha fazlası Daha az

Effect of montelukast treatment on serum paraoxonase activity in asthmatic children

Can M. | Mungan A.G. | Açikgöz Ş. | Yüksel B. | Demirtaş S. | Tomaç N.

Article | 2007 | Turkish Journal of Medical Sciences37 ( 6 ) , pp.373 - 376

Montelukast, widely used in the treatment of asthma, is a selective and potent oral cysteinyl leukotriene-1 receptor antagonist. In this study, we investigated the effects of montelukast on oxidative stress and antioxidant defense in childhood asthma by measuring malondialdehyde and the paraoxonase activity. Twenty-five children with mild to moderate atopic asthma and 25 nonatopic children as controls were enrolled in the study. Asthmatic children were treated with montelukast, 5 mg tablets, for one month. Serum paraoxonase, malondialdehyde and high-density lipoprotein (HDL) cholesterol levels were measured before and after treatmen . . .t. Serum paraoxonase and paraoxonase/HDL ratios were significantly increased after montelukast treatment. These parameters were significantly higher when compared with the normal subjects. Although montelukast treatment caused an enhancement in serum malondialdehyde, this increase did not reach statistical significance between the groups. The present study clearly demonstrates that montelukast increases paraoxonase activity in children with bronchial asthma. However, for better understanding of this enhancement, additional in vivo and in vitro studies are required. © TÜBİTAK Daha fazlası Daha az

Hormone replacement therapy-related changes in the early postmenopausal period (critical window): An in vivo brain proton magnetic resonance spectroscopy study

Mahmutyazicioglu K. | Beşir F.H. | Bardakçi M. | Tanriverdi H.A. | Ankarali H.

Article | 2014 | Turkish Journal of Medical Sciences44 ( 5 ) , pp.853 - 861

Aim: Findings from clinical studies in postmenopausal women with late initiation of hormone replacement therapy (HRT) that test whether HRT protects cognitive functions in women are inconsistent. The aim of this study was to investigate the effects of HRT on brain metabolite ratios when initiated in the early postmenopausal period (critical window). Materials and methods: Proton magnetic resonance spectrometry (1H MRS) was performed in 4 brain regions of 47 healthy postmenopausal women (21 received HRT, 26 did not). The subjects were aged between 45 and 65 years. The duration of HRT ranged from 1 to 12 years (mean: 6.3 years). The d . . .uration of menopause was 2-12 years (mean: 6.1 years) for HRT users and 1-20 years (mean: 7.8 years) for non-HRT users. Metabolite ratios [N-acetyl aspartate/choline (NAA/Cho), NAA/creatine (Cr), and Cho/Cr] were evaluated. Results: Cho/Cr ratios were significantly increased and NAA/Cho ratios significantly decreased in all 4 regions in the HRT user group compared to the other group after elimination of the effects of age and menopause duration. Regression analysis revealed an association only between NAA/Cho and duration of menopause. Conclusion: HRT-related changes in metabolite ratios are found in all brain regions. Decreased NAA/Cho and increased Cho/Cr levels do not support the neuroprotective role of HRT in the critical window. © TÜBİTAK Daha fazlası Daha az

Assessment of nasal mucociliary clearance in anesthetists

Horasanli E. | Acar A. | Muslu B. | Çayönü M. | Çimencan M. | Kayabaşi S.

Article | 2015 | Turkish Journal of Medical Sciences45 ( 1 ) , pp.197 - 201

Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT).Background/aim: To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally.Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex . . ., height, or weight. The median SNTT for the anesthetists (10 min) was longer than that for the control group (8.3 min). The difference was significant (P = 0.025). In addition, there was a significant correlation between the SNTT and the working time (P = 0.02). Furthermore, anesthetists who had worked for 4 years or more had prolonged SNTT compared to those who had worked less than 4 years (P < 0.001).Conclusion: The present study demonstrated the impairment of mucociliary clearance in anesthetists. Increasing impairment with increasing working time was also detected. © TÜBİtak Daha fazlası Daha az

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