In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft

Hazer, Derya Burcu | Bal, Ercan | Nurlu, Gülay | Benli, Kemal | Balcı, Serdar | Öztürk, Feral | Hazer, Baki

Objective: This study aims to investigate the degree of biocompatibility and neuroregeneration of a polymer tube, poly-3-hydroxyoctanoate (PHO) in nerve gap repair. Methods: Forty Wistar Albino male rats were randomized into two groups: autologous nerve gap repair group and PHO tube repair group. In each group, a 10-mm right sciatic nerve defect was created and reconstructed accordingly. Neuroregeneration was studied by sciatic function index (SFI), electromyography, and immunohistochemical studies on Days 7, 21, 45 and 60 of implantation. Biocompatibility was analyzed by the capsule formation ...Daha fazlası

Makale 2013 Journal of Zhejiang University: Science B14 ( 11 ) , pp. 9 - 1003 572 Görüntülenme

Anticonvulsant and hypnotic effects of amiodarone

Ozbakis-Dengiz G. | Bakirci A.

Amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart. Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. Convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine mode ...Daha fazlası

Makale 2009 Journal of Zhejiang University: Science B10 ( 4 ) , pp. 3 - 322 227 Görüntülenme