Eicosanoids mediate Galleria mellonella cellular immune response to viral infection

Büyükgüzel, Ender | Tunaz , Hasan | Stanley, David | Büyükgüzel, Kemal

Nodulation is the predominant insect cellular immune response to bacterial and fungal infections and it can also be induced by some viral infections. Treating seventh instar larvae of greater wax moth Galleria mellonella with Bovine herpes simplex virus-1 (BHSV-1) induced nodulation reactions in a dose-dependent manner. Because eicosanoids mediate nodulation reactions to bacterial and fungal infection, we hypothesized that eicosanoids also mediate nodulation reactions to viral challenge. To test this idea, we injected G. mellonella larvae with indomethacin, a nonsteroidal anti-inflammatory dru ...Daha fazlası

Eicosanoids mediate melanotic nodulation reactions to viral infection in larvae of the parasitic wasp, Pimpla turionellae

Durmuş, Yonca | Büyükgüzel, Ender | Terzi, Burçin | Tunaz, Hasan | Stanley, David | Büyükgüzel, Kemal

Nodulation is the quantitatively predominant insect cellular immune function activated in response to bacterial, fungal and some viral infections. We posed the hypothesis that parasitoid insects express melanotic nodulation reactions to viral challenge and that eicosanoids mediate these reactions. Treating fifth-instar larvae of the ichneumonid endoparasitoid Pimpla turionellae with Bovine Herpes Simplex Virus-1 (BHSV-1) induced nodulation reactions in a challenge dose-dependent manner. Experimental larvae treated with the cyclooxygenase inhibitor, indomethacin, the lipoxygenase inhibitor, esc ...Daha fazlası

The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor

Büyükgüzel, Ender | Tunaz, Hasan | Stanley, David | Büyükgüzel, Kemal

Eicosanoids are oxygenated metabolites of three C20 polyunsaturated fatty acids, mainly arachidonic acid (AA; 20:4n-6), but also 20:3n-6 and 20:5n-3. Aside from their importance in biomedicine, eicosanoids act in invertebrate biology. Prostaglandins (PGs) influence salt and water transport physiology in insect rectal epithelia and in Malpighian tubules. PGs also influence a few insect behaviors, including releasing oviposition behavior and behavioral fever. Eicosanoids act in ovarian development and in insect immunity. Because eicosanoids act in several areas of insect biology, we posed the hy ...Daha fazlası

The influence of chronic eicosanoid biosynthesis inhibition on life history of the Greater waxmoth Galleria mellonella and its ectoparasitoid Bracon hebetor

Büyükgüzel E, H Tunaz, D W Stanley, K, Büyükgüzel

Eicosanoids mediate melantoic nodulation reactions to viral infection in larvae of the parasitic wasp Pimpla turioinellae

Durmuş Y,BÜYÜKGÜZEL ENDER,Terzi B,Tunaz H,Stanley D,BÜYÜKGÜZEL KEMAL