Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries

Kececi M. | Akpolat M. | Gulle K. | Gencer E. | Sahbaz A.

Article | 2016 | Archives of Gynecology and Obstetrics293 ( 6 ) , pp.1255 - 1262

Purpose: Cancer is the second leading cause of death in children in developed countries and most of childhood malignancies can be treated with chemo-radiotherapy. Although radiation therapy is a successful treatment modality in cancer patients, it has various adverse effects. Especially the gonads are very sensitive and prone to radiation-related damage. Radiation impairs the ovaries by triggering apoptosis of follicular cells and chromosomal damage and oxidative stress. Shilajit, a traditional medicinal agent in India, Russia, and other parts of the world, contains various antioxidant agents and has ovogenic effects. To evaluate th . . .e ability of shilajit to prevent radiation-induced ovarian damage. Methods: Forty Wistar albino female rats were divided into four groups as: Control group, shilajit group, radiation only group, and radiation + shilajit group. Four days after radiation exposure, the rats were sacrificed and the ovaries were removed and evaluated immuno-histopathologically. Results: There was a statistically significant difference in follicle counts (primordial, primary, preantral, antral, and atretic follicles) between the groups (p Daha fazlası Daha az

Pycnogenol prevents peritoneal adhesions

Sahbaz A. | Aynioglu O. | Isik H. | Gun B.D. | Cengil O. | Erol O.

Article | 2015 | Archives of Gynecology and Obstetrics292 ( 6 ) , pp.1279 - 1284

Purpose: This study tested the ability of pycnogenol, an extract from the bark of the French maritime pine (Pinus pinaster), to prevent intra-abdominal adhesions. Methods: Thirty female Wistar albino rats were separated randomly into three equal groups: Group (1) the control group, which underwent surgery, but was given no drug; Group (2) given 10 mg/kg of pycnogenol dissolved in normal saline intraperitoneally for 10 days after surgery; and Group (3) given 0.1 mL of normal saline for 10 days intraperitoneally after surgery. On post-operative day 10, all of the animals were killed and any adhesions were evaluated macroscopically and . . . histopathologically. Results: The macroscopic adhesion scores (mean ± SD) for Groups 1, 2, and 3 were 2.5 ± 0.53, 0.60 ± 0.70, and 2.0 ± 0.82, respectively. The macroscopic adhesion score was significantly lower in Group 2 than in Groups 1 and 3 (p Daha fazlası Daha az

Comparative study of oxidative stress in maternal blood with that of cord blood and maternal milk

Erdem M. | Harma M. | Harma I.M. | Arikan I. | Barut A.

Article | 2012 | Archives of Gynecology and Obstetrics285 ( 2 ) , pp.371 - 375

Objective Oxidative stress has been implicated in pregnancy-induced hypertension and preeclampsia. There is still some debate over whether this is confined to the placenta or occurs in the maternal circulation. This study was designed to investigate this question by comparing parameters of oxidative stress in samples of maternal blood and cord blood taken from normotensive and hypertensive pregnant women. A further aim was to compare these parameters in maternal milk from the two populations. Study design Forty-six hypertensive (31 preeclamptic and 15 chronic hypertensive) and 60 normotensive pregnant women were recruited. Antecubit . . .al blood was collected from each woman before and after delivery, cord blood just after delivery, and maternal milk for the first 3 days post-partum. Total antioxidant capacity, total peroxides and sulphydryl concentration were measured and total antiox-idant capacity calculated for each specimen. Results For all specimens (maternal blood plasma, cord blood plasma, maternal milk) total antioxidant capacity and sulphydryl concentration were significantly lower in the hypertensive women than in the normotensive, while total peroxide and oxidative stress index were significantly higher. Conclusion These results support the association between hypertension in pregnancy and oxidative stress and the view that this occurs throughout the maternal circulation. They show further that oxidative stress may be transmitted from mother to newborn in maternal milk. Supplementation with antioxidants could, in view of our findings, possibly provide protection to the mother and fetus and also, through transmission in maternal milk, to the newborn. © 2011 Springer-Verlag Daha fazlası Daha az

Effects of increasing ratio of progesterone in estrogen/progesterone combination on total oxidant/antioxidant status in rat uterus and plasma

Hekimoglu A. | Bilgin H.M. | Kurcer Z. | Ocak A.R.

Article | 2010 | Archives of Gynecology and Obstetrics281 ( 1 ) , pp.23 - 28

Purpose: The relationship between increasing ratio of progesterone in estrogen/progesterone combination and oxidative stress (OS) was investigated. Methods: Thirty non-pregnant Wistar Albino female rats were divided into five groups and bilaterally ovariectomized (Ovx) except sham group. Groups: Sham + 0.3 cc seaseme oil, Ovx + 0.3 cc seaseme oil, Ovx + estradiol propionate (E2) (1 µg/kg), Ovx + E2 + medroxyprogesterone acetate (MPA) 1 mg/kg, Ovx + E2 + MPA 20 mg/kg. Hormones were applied for three consecutive days after 28 days of ovariectomy. Their uteri and blood samples were collected and nitric oxide (NO), malondialdehyde (MDA) . . ., total oxidative status (TOS) and total antioxidant capacity (TAC) levels were determined. Results: E2 + MPA1 treatment decreased NO, MDA and TOS levels and increased TAC levels in uterus. Plasma NO levels elevated in all groups and MDA production increased due to E2 treatment when compared to ovariectomy. E2 + MPA20 treatment increased TOS levels, while TAC levels decreased when compared to ovariectomy in plasma. Conclusions: Using E2 plus low dose progesterone may prevent pathologies resourced of OS. © 2009 Springer-Verlag Daha fazlası Daha az

Turkish obstetricians' personal preference for mode of delivery and attitude toward cesarean delivery on maternal request

Arikan D.C. | Özer A. | Arikan I. | Coskun A. | Kiran H.

Article | 2011 | Archives of Gynecology and Obstetrics284 ( 3 ) , pp.543 - 549

Objective(s): (1) To investigate the cesarean rate among actively practicing obstetricians in Turkey and reasons why they choose this mode of delivery for themselves/partners. (2) To investigate the attitudes, practices, and beliefs with respect to cesarean delivery on maternal request (CDMR) among actively practicing obstetricians in Turkey. Study design: This is a descriptive study performed at 7th Congress Of Turkish Society Of Gynecology and Obstetrics. A self-administered questionnaire was used for data collection. During the congress, from the obstetricians attending the congress, 500 were randomly selected; due to the room nu . . .mbers, the questionnaires (total, 500) and the consent forms were distributed every fourth room. The sampled obstetricians were instructed to return the completed questionnaires and signed consent forms to the congress information desk located throughout the congress. In total, 387 (77.4%) obstetricians responded. Results: Of the respondents (if female) or their partners (if male), 239 (61.8%) respondents had undergone at least one previous cesarean section (CS), and, of these, 212 (88.7%) were primary elective cesarean deliveries. The most common reason influencing the decision of obstetricians in choosing CS for themselves/partners was reduced anorectal trauma (63.6%). In addition, 158 (40.8%) of the respondents believe that every woman has the right to request a cesarean as a mode of delivery. About half of the respondents (53.2%) said that they would perform a patientrequested CS. The most common reason why obstetricians perform CS due to maternal request was 'anxiety of patient and her partner and due to their insistence'. Conclusions: Two-thirds of Turkish obstetricians prefer CS as mode of delivery for themselves/partners. Also half of the obstetricians in our study believe that a woman has the right to request and obtain CDMR, and half of them would agree to perform one. © Springer-Verlag 2010 Daha fazlası Daha az

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