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Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats

Bakkal, Bekir Hakan | Gultekin F.A. | Guven B. | Turkcu U.O. | Bektas S. | Can M.

Ionizing radiation causes its biological effects mainly through oxidative damage induced by reactive oxygen species. Previous studies showed that ozone oxidative preconditioning attenuated pathophysiological events mediated by reactive oxygen species. As inhalation of ozone induces lung injury, the aim of this study was to examine whether ozone oxidative preconditioning potentiates or attenuates the effects of irradiation on the lung. Rats were subjected to total body irradiation, with or without treatment with ozone oxidative preconditioning (0.72 mg/kg). Serum proinflammatory cytokine levels ...Daha fazlası

Erişime Açık

Effects of ozone oxidative preconditioning on radiation-induced organ damage in rats

Gultekin F.A. | Bakkal, Bekir Hakan | Guven B. | Tasdoven I. | Bektas S. | Can M. | Comert M.

Because radiation-induced cellular damage is attributed primarily to harmful effects of free radicals, molecules with direct free radical scavenging properties are particularly promising as radioprotectors. It has been demonstrated that controlled ozone administration may promote an adaptation to oxidative stress, preventing the damage induced by reactive oxygen species. Thus, we hypothesized that ozone would ameliorate oxidative damage caused by total body irradiation (TBI) with a single dose of 6 Gy in rat liver and ileum tissues. Rats were randomly divided into groups as follows: control gr ...Daha fazlası

Effects of ozone oxidative preconditioning on liver regeneration after partial hepatectomy in rats

Gultekin F.A. | Cakmak G.K. | Turkcu U.O. | Yurdakan G. | Demir F.E.O. | Comert M.

Aim: Similar protective effect of ischemic and ozone oxidative preconditioning (OzoneOP) in hepatic ischemia-reperfusion (I/R) injury was demonstrated, providing evidences that both preconditioning settings shared similar biochemical mechanisms of protection. We investigated the effects of OzoneOP on liver regeneration after 70% partial hepatectomy (PHx) in rats. Methods: Rats were divided into three groups: PHx, I/R + PHx, and OzoneOP + I/R + PHx groups. Ozone (intraperitoneal, 1.2 mg/kg) was given to rats subjected to I/R and 70% hepatectomy daily five times before operation. At 24 hr and 48 ...Daha fazlası

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