Yıldız, Ufuk | Hazer, Baki | Tauer, Klaus

Review | 2012 | Polymer Chemistry3 ( 5 ) , pp.1107 - 1118

Hazer, Derya Burcu | Kılıçay, Ebru | Hazer, Baki

Review | 2012 | Materials Science and Engineering C32 ( 4 ) , pp.637 - 647

Biomaterials have played an important role in the treatment of disease and the improvement of health care. Synthetic and naturally occurring biodegradable and biocompatible polymers have been used as biomaterials. Polyhydroxyalkanoates (PHAs) are promising materials for biomedical applications because they are biodegradable, non-toxic and biocompatible. We will shortly summarize the modification reactions, which include functionalization and grafting reactions, to improve the mechanical, thermal and hydrophilic properties of PHAs. The use of the modified PHAs in numerous biomedical applications, such as sutures, cardiovascular patch . . .es, wound dressings, scaffolds in tissue engineering, tissue repair/regeneration devices, drug carriers will be discussed in this review. © 2012 Elsevier B.V. All rights reserved Daha fazlası Daha az

Hazer, Baki

Review | 2010 | International Journal of Polymer Science2010 , pp.637 - 647

Poly(3-hydroxy alkanoate)s, PHAs, have been very attractive as biomaterials due to their biodegradability and biocompatibility. These hydrophobic natural polyesters, PHAs, need to have hydrophilic character particularly for drug delivery systems. In this manner, poly(ethylene glycol) (PEG) and hydrophilic functional groups such as amine, hydroxyl, carboxyl, and sulfonic acid have been introduced into the PHAs in order to obtain amphiphilic polymers. This review involves in the synthesis and characterization of the amphiphilic PHAs. Copyright © 2010 Baki Hazer.