Filtreler
Filtreler
Bulunan: 4.178 Adet 0.006 sn
Koleksiyon [20]
Tam Metin [2]
Yazar [20]
Yayın Yılı [20]
Konu Başlıkları [20]
Yayıncı [20]
Yayın Dili [10]
Dergi Adı [20]
Araştırmacılar
Celiac disease in patients having recurrent aphthous stomatitis

Aydemir, Selim | Tekin, Solak Nilgün | Aktunç, Erol | Numanoğlu, Gamze | Üstündağ, Yücel

Article | 2004 | Turkish Journal of Gastroenterology15 ( 3 ) , pp.192 - 195

Amaç: Celiac hastalığı ince barsakların glutene intoleransı sonucu oluşan bir hastalıktır. Epidemiolojik çalışmalarda prevalansı hakkında çok farklı veriler vardı. Hastalarda genellikle çok geniş spektrumda semptom ve bulgulara neden olabildiğinden celiac hastalığı tanısının konulması zor olabilmektedir. Hastalığın erken evrede yakalanması önemlidir. Çünkü bu hastalarda barsak lenfoması gelişme riski artmıştır. Celiac hastalığı olan hastalarda rekürren aftoz stomatit prevalansındaki yükseklik nedeniyle rekürren aftoz stomatitli hastaların celiac hastalığı yönünden araştırılması asemptomatik celiac hastalığı olan hastaların tanı alma . . .sını sağlayabilir. Bu çalışma rekürren aftoz stomatit nedeniyle başvuran olgularda celiac hastalığı prevalansını saptamak için planlanmıştır. Yöntem: Çalışma gurubu olarak rekürren aftoz stomatit öyküsü olan, kontrol grubu olarak ise rekürren aftoz stomatit öyküsü olmayan olgular alındı. Tüm olgularda anti gliadin IgG, antigliadin IgA ve anti endomisium antikorları bakıldı. Ayrıca endoskopi yapılarak duodenum distal kesiminden biyopsiler alındı. Bulgular: Rekürren aftoz stomatit öyküsü olan 41 olgunun ikisinde patolojik inceleme ile doğrulanan celiac hastalığı bulundu (%4.8). Celiac hastalığı saptanan bu iki olgunun her ikisinde de anti gliadin IgA ve endomisium antikorları pozitif bulundu. Anti gliadin IgG antikoru ise olguların birinde pozitifti. Kontrol grubundaki 49 olgunun hiçbirinde celiac hastalığı saptanmadı. Sonuç: Rekürren aftoz stomatit olgularında celiac hastalığı açısında ileri incelenmeler yapılmalıdır. Endoskopinin invaziv ve daha pahalı olması nedeniyle rekürren aftoz stomatitli olgularda celiac hastalığı ı araştırmak için öncelikli olarak serolojik tetkikler yapılmalı, seroljik markır pozitif olan olgularda endoskopik olarak duodenum ikinci kesiminden biyopsiler alınmalıdır. Background/aims: Celiac disease is a condition related to the small intestine’s intolerance to gluten. In epidemiologic studies the prevalence is highly variable. The diagnosis can be difficult due to the wide spectrum of signs and symptoms. As the risk for intestinal lymphoma is higher in these patients, early diagnosis has its privileges. The higher prevalence of recurrent aphthous stomatitis in celiac disease led us to investigate the celiac disease prevalence in patients with recurrent aphthous stomatitis, which might assist in diagnosis of asymptomatic celiac disease patients. The aim of this study was to determine the prevalence of celiac disease in patients presenting with recurrent aphthous stomatitis. Methods: The study group consisted of patients having a history of recurrent aphthous stomatitis. The control group included patients not having aphthous stomatitis. Antibodies to gliadin IgG and IgA and antibodies to endomysium were determined from the serum samples of all patients. Biopsies were obtained from the distal part of the duodenum. Results: Biopsies of two patients (4.8%) out of 41 belonging to the study group were diagnosed as celiac disease. In serum samples of both, antibodies to gliadin IgA and antibodies to endomysium were found to be positive. Antibodies to gliadin IgG antibody were positive in only one of these two patients. None of the 49 patients in the control group was diagnosed as celiac disease. Conclusion: Further evaluation of recurrent aphthous stomatitis patients for celiac disease must be performed. As the endoscopic procedures are invasive and costly, evaluation of recurrent aphthous stomatitis patients for celiac disease must include serologic markers at the beginning. If any positivity is determined in markers, then endoscopic procedures including biopsies of the duodenum must be considered as the second-step intervention Daha fazlası Daha az

Reactions of anionic living polymers with bromomethyl-functionalized benzoyl peroxides

Hazer, Baki | Hirao, Akira | Volga, Cüneyt

Article | 1999 | Macromolecular Chemistry and Physics200 ( 1 ) , pp.71 - 76

In order to synthesize benzoyl peroxide functionalized polystyrene (PSt), polyisoprene (PI) and poly(methyl methacrylate) (PMMA), anionic living PSt, PI, and PMMA were allowed to react with an excess amount of 4-(bromomethyl)benzoyl tert-butyl peroxide (BMtB) or bis[3,5-bis(bromomethyl)benzoyl] peroxide (BDBP) in tetrahydrofuran (THF) at -78°C. The results indicate that coupling reactions leading to dimers are significant during the reaction. Dimer formation was avoided when the living polystyrene was modified to the alcoholate anion by reaction with ethylene oxide (EO). © Wiley-VCH Verlag GmbH, 1999.

Molybdenum tetracarbonyl complexes with linear chain polyether-containing Schiff base ligands and their reactivity in the polymerization of methyl methacrylate

Menteş, Ayger | Sarbay, Mithat | Hazer, Baki | Arslan, Hülya

Article | 2005 | Applied Organometallic Chemistry19 ( 1 ) , pp.76 - 80

Mo(CO)6 was reacted with the Schiff base ligand obtained by condensation reaction of 2-acetyl- or benzoylpyridine with poly(propylene glycol)bis(2-aminopropyl ether) to obtain polymeric, dinuclear metal tetracarbonyl compounds. The long-chain Schiff base complexes are highly soluble even in non-polar solvents such as petroleum ether, diethyl ether and n-hexane. These complexes, as free-radical initiators, afforded methyl methacrylate polymerization in chlorinated solvents. Copyright © 2004 John Wiley & Sons, Ltd.

Synthesis and characterization of ozonated oil nanoemulsions

Tığlı-Aydın, Rahime Seda | Kazancı, Füsun

Article | 2018 | JAOCS, Journal of the American Oil Chemists' Society95 ( 11 ) , pp.1385 - 1398

In recent years, the use of ozonated oil (ozone enriched oil form) is being increasingly preferred for biomedical applications because of its antibacterial activity. Among most important reasons of this choice is the high molecular affinity of the ozone molecule and intracellular effects of the products of ozone and the unsaturated fatty-acid chemical reactions in cellular signaling systems. The aim of the present study was to synthesize and optimize the ozonated oil nanoemulsion system that would be transferred into the living systems easily, suggesting a promising carrier system for various biomedical applications. By varying form . . .ulation parameters (surfactant-to-oil ratio, surfactant concentration, mixing rate, and surfactant type), nanoemulsions were investigated in terms of mean particle diameters, distributions, and stabilities. Nanoemulsions with high stability and small droplet diameters (212.7 nm) could be produced under optimized conditions with Tween 40 as the surfactant at a 750 rpm mixing rate using the emulsion inversion point (EIP) low-energy method. Spherical and uniformly distributed nanoemulsions were observed by SEM, which also supports mean particle diameter measurements. Fourier-transform infrared spectroscopy (FTIR) and 13C NMR (nuclear magnetic resonance) studies indicated an ozonide structure within the nanoemulsion system, which remained even after 30 days of storage. The antibacterial activity of ozonated oil emulsions against Staphylococcus aureus and Escherichia coli suggests promising applications in the biomedical field. © 2018 AOC Daha fazlası Daha az

Newly designed bioanode for glucose/O2 biofuel cells to generate renewable energy

Korkut, Şeyda | Kılıç, Muhammet Samet | Hazer, Baki

Article | 2019 | Asia-Pacific Journal of Chemical Engineering14 ( 6 ) , pp.1385 - 1398

A copolymer poly(methyl methacrylate-co-vinylferrocene) was synthesized and used for the first time in a biofuel cell design. Bioanaode enzyme glucose oxidase and biocathode enzyme bilirubin oxidase were physically immobilized onto the copolymer-modified electrodes. Characterization studies were conducted by scanning electron microscopy, carbon-13, fourier transform infrared and hydrogen-1 nuclear magnetic resonance, and cyclic voltammograms. The designed biofuel cell was operated with linear sweep voltammetry. The maximum current was at 45°C with 120 µg of polymer amount. An improved power density of 323 µW cm-2 that is higher than . . . other ferrocene-based fuel cells was obtained with 10-mM glucose at 0.4 V with the designed bioanode. © 2019 John Wiley & Sons Ltd Daha fazlası Daha az

Synthesis of PMMA-PTHF-PMMA and PMMA-PTHF-PST linear and star block copolymers

Macit, Hülya | Hazer, Baki

Article | 2004 | Journal of Applied Polymer Science93 ( 1 ) , pp.219 - 226

Combination of cationic, redox free radical, and thermal free radical polymerizations was performed to obtain linear and star polytetramethylene oxide (poly-THF)-polymethyl methacrylate (PMMA)/polystyrene (PSt) multiblock copolymers. Cationic polymerization of THF was initiated by the mixture of AgSbF6 and bis(4,4' bromo-methyl benzoyl) peroxide (BBP) or bis (3,5,3',5' dibromom-ethyl benzoyl) peroxide (BDBP) at 20°C to obtain linear and star poly-THF initiators with MW varying from 7,500 to 59,000 Da. Poly-THF samples with hydroxyl ends were used in the methyl methacrylate (MMA) polymerization in the presence of Ce(IV) salt at 40°C . . .to obtain poly(THF-b-MMA) block copolymers containing the peroxide group in the middle. Poly(MMA-b-THF) linear and star block copolymers having the peroxide group in the chain were used in the polymerization of methyl methacrylate (MMA) and styrene (St) at 80°C to obtain PMMA-b-PTHF-b-PMMA and PMMA-b-PTHF-PSt linear and star multiblock copolymers. Polymers obtained were characterizated by GPC, FT-IR, DSC, TGA, 1H-NMR, and 13C-NMR techniques and the fractional precipitation method. © 2004 Wiley Periodicals, Inc Daha fazlası Daha az

The synthesis of PHA-g-(PTHF-b-PMMA) multiblock/graft copolymers by combination of cationic and radical polymerization

Macit, Hülya | Hazer, Baki | Arslan, Hülya | Noda, Isao

Article | 2009 | Journal of Applied Polymer Science111 ( 5 ) , pp.2308 - 2317

A new and promising method for the diversification of microbial polyesters based on chemical modifications is introduced. Poly(3-hydroxy alkanoate)-g-(poly(tetrahydrofuran)-b-poly(methyl methacrylate)) (PHAg-(PTHF-b-PMMA)) multigraft copolymers were synthesized by the combination of cationic and free radical polymerization. PHA-g-PTHF graft copolymer was obtained by the cationic polymerization of THF initiated by the carbonium cations generated from the chlorinated PHAs, poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV), and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHx) in the presence of AgSbF 6. Therefore, PHA-g-PTHF gr . . .aft copolymers with hydroxyl ends were produced. In the presence of Ce +4 salt, these hydroxyl ends of the graft copolymer can initiate the redox polymerization of MMA to obtain PHA-g-(PTHF-b-PMMA) multigraft copolymer. Polymers obtained were purified by fractional precipitation. In this manner, their ?-values (volume ratio of nonsolvent to the solvent) were also determined. Their molecular weights were determined by GPC technique. The structures were elucidated using 1H-NMR and FTIR spectroscopy. Thermal analyses of the products were carried out using differential scanning calorimeter (DSC) and thermogravimetric analysis (TGA). © 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 2308-2317, 2009 Daha fazlası Daha az

One-step synthesis of triarm block copolymers via simultaneous reversible-addition fragmentation chain transfer and ring-opening polymerization

Öztürk, Temel | Göktaş, Melahat | Hazer, Baki

Article | 2010 | Journal of Applied Polymer Science117 ( 3 ) , pp.1638 - 1645

One-step synthesis of star copolymers by reversible addition-fragmentation chain transfer (RAFT) and ring-opening polymerization (ROP) by using a novel dual initiator is reported. Triarm block copolymers comprising one polystyrene (or polyacrylamide) arm and two poly(b-butyrolactone) arms were synthesized in one-step by simultaneous RAFT polymerization of styrene (St) (or acrylamide, designated as AAm) and ROP of b-butyrolactone (BL) in the presence of a novel trifunctional initiator, 1,2-propanediol ethyl xanthogenate (RAFT-ROP agent). This dual initiator was obtained through the reaction of 3-chloro-1,2- propanediol with the potas . . .sium salt of ethyl xanthogenate. The principal parameters such as monomer concentration, initiator concentration, and polymerization time that affect the one-step polymerization reaction were evaluated. The characterization of the products was achieved using Fourier-transform infrared spectroscopy (FTIR), 1H-nuclear magnetic resonance (1HNMR),13C-nuclear magnetic resonance ( 13C-NMR), Gas chromatography-mass spectrometry (GC-MS), gel-permeation chromatography (GPC), thermogravimetric analysis (TGA), and fractional precipitation (c) techniques. VC 2010 Wiley Periodicals, Inc Daha fazlası Daha az

Hyperbranched homo and thermoresponsive graft copolymers by using ATRP-macromonomer initiators

Allı, Sema | Allı, Abdulkadir | Hazer, Baki

Article | 2012 | Journal of Applied Polymer Science124 ( 1 ) , pp.536 - 548

Macromonomer initiators behave as macro cross-linkers, macro initiators, and macromonomers to obtain branched and cross-linked block/graft copolymers. A series of new macromonomer initiators for atom transfer radical polymerization (MIM-ATRP) based on polyethylene glycol (M n = 495D, 2203D, and 4203D) (PEG) were synthesized by the reaction of the hydroxyl end of mono-methacryloyl polyethylene glycol with 2-bromo propanoyl chloride, leading to methacryloyl polyethylene glycol 2-bromo propanoyl ester. Poly (ethylene glycol) functionalized with methacrylate at one end was reacted with 2-bromopropionyl chloride to form a macromonomeric . . .initiator for ATRP. ATRP was found to be a more controllable polymerization method than conventional free radical polymerization in view of fewer cross-linked polymers and highly branched polymers produced from macromonomer initiators as well. In another scenario, ATRP of N-isopropylacrylamide (NIPAM) was initiated by MIM-ATRP to obtain PEG-b-PNIPAM branched block/graft copolymers. Thermal analysis, FTIR, 1H NMR, TEM, and SEM techniques were used in the characterization of the products. They had a thermo-responsive character and exhibited volume phase transition at â 36°C. A plasticizer effect of PEG in graft copolymers was also observed, indicating a lower glass transition temperature than that of pure PNIPAM. Homo and copolymerization kinetics were also evaluated. © 2011 Wiley Periodicals, Inc Daha fazlası Daha az

The effects of boric acid-induced oxidative stress on antioxidant enzymes and survivorship in Galleria mellonella

Hyršl, Pavel | Büyükgüzel, Ender | Büyükgüzel, Kemal

Article | 2007 | Archives of Insect Biochemistry and Physiology66 ( 1 ) , pp.23 - 31

Larvae of the wax moth, Galleria mellonella (L.), were reared from first instar on a diet supplemented with 156, 620, 1,250, or 2,500 ppm boric acid (BA). The content of malondialdehyde (MDA, an oxidative stress indicator), and activities of the antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx)] were determined in the fat body and hemolymph in the 7th instar larvae and newly emerged pupae. Relative to control larvae, MDA was significantly increased in larval hemolymph, larval and pupal fat body, but decreased in the pupal hemolymph. Insects reared on di . . .ets with 156-and 620-ppm BA doses yielded increased SOD activity but 1,250- and 2,500-ppm doses resulted in decreased SOD activity in larval hemolymph. SOD activity was significantly increased but CAT was decreased in the larval fat body. High dietary BA treatments led to significantly decreased GST activity. However, they increased GPx activity in larval hemolymph. Dietary BA also affected larval survival. The 1,250- and 2,500-ppm concentrations led to significantly increased larval and pupal mortality and prolonged development. In contrast, the lowest BA concentration increased longevity and shortened development. We infer that BA toxicity is related, at least in part, to oxidative stress management. © 2007 Wiley-Liss, Inc Daha fazlası Daha az

The influence of dietary alpha-solanine on the waxmoth galleria mellonellal

Büyükgüzel, Ender | Büyükgüzel, Kemal | Erdem, Meltem | Adamski, Zbigniew | Adamski, Zbigniew | Marciniak, Pawel | Ziemnicki, Kazimierz

Article | 2013 | Archives of Insect Biochemistry and Physiology83 ( 1 ) , pp.15 - 24

Plant allelochemicals are nonnutritional chemicals that interfere with the biology of herbivores. We posed the hypothesis that ingestion of a glycoalkaloid allelochemical, ?-solanine, impairs biological parameters of greater wax moths Galleria mellonella. To test this idea, we reared wax moths on artificial diets with 0.015, 0.15, or 1.5 mg/100 g diet of ?-solanine. Addition of ?-solanine to the diet affected survival of seventh-instar larvae, pupae, and adults; and female fecundity and fertility. The diet containing the highest ?-solanine concentration led to decreased survivorship, fecundity, and fertility. The diets supplemented . . .with ?-solanine led to increased malondialdehyde and protein carbonyl contents in midgut and fat body and the effect was dose-dependent. Dietary ?-solanine led to increased midgut glutathione S-transferase activity and to decreased fat body glutathione S-transferase activitiy. We infer from these findings that ?-solanine influences life history parameters and antioxidative enzyme activities in the midgut and fat body of G. mellonella. © 2013 Wiley Periodicals, Inc Daha fazlası Daha az

Nitroxide-mediated copolymerization of styrene and pentafluorostyrene initiated by polymeric linoleic acid

Allı, Abdulkadir | Allı, Sema | Becer, C. Remzi | Hazer, Baki

Article | 2016 | European Journal of Lipid Science and Technology118 ( 2 ) , pp.279 - 287

Polymeric linoleic asit graft copolymers were synthesized via a nitroxide-mediated radical polymerization (NMRP) method in the presence of 2,2-6,6-tetramethylpiperidinyl-1-oxy (TEMPO). For this purpose, PLina-ox was exposed to polymerization with styrene (Sty) or Sty and pentafluorostyrene (F5Sty) in the presence of TEMPO by NMRP method in order to obtain PLina-g-PSty and PLina-g-PF5Sty-g-PSty graft copolymers with controlled structure and low polydispersity. Chain extension study was evaluated. Principal parameters, such as monomer concentration, initiator concentration, and polymerization time, which effect the polymerization reac . . .tions, were evaluated. The products thus obtained were well characterized by 1H NMR, GPC, and 19F NMR measurements. Practical application: We report for the first time the synthesis of PLina-g-PSty and PLina-g-PSty-g-PF5Sty graft copolymers in the presence of TEMPO. NMRP reactions were performed in the presence of TEMPO in order to obtain graft copolymers with controlled molecular weight and polydispersity. Chain-extension reactions were also successfully carried out because of the activation of TEMPO terminated chain ends of graft copolymers. Pure linoleic acid was auto-oxidized under daylight and air oxygen, yielding peroxidized PLina (PLina-ox). PLina-ox has been used in the polymerization of styrene (Sty) or copolymerization of Sty and pentafluorostyrene (F5Sty). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Daha fazlası Daha az


6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.


Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.