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Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia

Küçükçongar A. | Yenicesu I. | Tümer L. | Kasapkara C.S. | Ezgü F.S. | Paşaoglu O. | Demirtaş C.

Article | 2013 | Transfusion and Apheresis Science48 ( 3 ) , pp.391 - 396

Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or severe heterozygous FH utilized in cases. The recruitment of leucocytes into the arterial intima is dependent on a cascade of events mediated through a diverse family of adhesion molecules. Several pro-inflammatory adhesion molecules are cleared by various lipid apheresis methods. This study showed that, LDL-apheresis led to several changes in circulating inflammatory factors which induc . . .ed antiinflammatory and antiatherogenic changes in the plasma profile in homozygous familial hypercholesterolemic patients. © 2013 Elsevier Ltd Daha fazlası Daha az

Experiences Shared Through the Interviews from Fifteen Mothers of Children with Cerebral Palsy

Kurtuncu M. | Akhan L.U. | Yildiz H. | Demirbag B.C.

Article | 2015 | Sexuality and Disability33 ( 3 ) , pp.349 - 363

The study utilized an interview format to examine the difficulties experienced by mothers of children with cerebral palsy. Interviews were conducted in the province of Zonguldak between December 2013 and February 2014, Turkey, at a special rehabilitation center with 15 children with cerebral palsy and their mothers registered at the center. A voice recorder was used during the interviews, but since the mothers expressed their unwillingness to have their voices recorded during the interviews when they talked about their sexual lives, face to face interviews were held in a suitable physical environment without the use of a recorder. A . . . semi-structured questionnaire was used during the interviews. The couples are troubled with many difficulties that include personal relations, social and economic problems, as well as issues involving the sick child’s care and education. Many difficulties that include personal relations, social and economic problems, as well as issues involving the sick child’s care and education, trouble couples with children diagnosed with cerebral palsy. In connection with these difficulties, it was also seen that the situation took a toll on the sexual lives of parents. In the light of these findings, our recommendation is that rehabilitation centers catering to the education of children with cerebral palsy should have qualified nurses on hand to provide a professional approach to reviewing the difficulties mothers face and emphasizing the importance of sexuality. © 2014, Springer Science+Business Media New York Daha fazlası Daha az

Intracranial haemorrhage due to late-onset vitamin K deficiency

Karaci M. | Toroslu E. | Karsli T. | Kanber Y. | Uysal S. | Albayrak D.

Article | 2015 | Hong Kong Journal of Paediatrics20 ( 2 ) , pp.80 - 85

Objective: Deficiency of vitamin K predisposes to bleeding and it can be divided into early, classical, or late vitamin K deficiency bleeding (VKDB) according to their onset. Late VKDB occurs after 7th day of life at neonatal period and is associated with intracranial bleeding, serious neurological sequels and death. This retrospective study reviewed the clinical presentations, demographic features and radiological findings of infants with intracranial haemorrhage due to late-onset VKDB. Materials and methods: We identified 26 cases of late VKDB admitted to our hospital from February 1992 to November 2006. Cranial computerised tomog . . .raphy was performed in all patients at diagnosis and at subsequent evaluation. Results: Sixteen of twenty-six patients with late VKDB (61.5%) had intracranial haemorrhage (ICH). The mean age of these 16 patients with ICH was 1.6±0.7 months. All of them were on breastfeeding. Eighteen of them received one mg of vitamin K intramuscularly (IM) shortly after birth. None of them received any other medication. The most common sign and symptom of patients with ICH was bulging fontanel (69%). The most common bleeding site was parenchymal (n=7, 43.7%). The mortality rate was 44% among patients with ICH. Conclusion: For neonates on strict breast-feeding, despite some with vitamin K prophylaxis, some patients still may suffer from intracranial and extracranial bleeding due to vitamin K deficiency. Therefore, additional IM dose of vitamin K may be needed. However, further evidence from larger prospective study is needed to verify this observation. © 2015, Medcom Limited. All Rights Reserved Daha fazlası Daha az

The association between serum vitamin B12 deficiency and tension-type headache in Turkish children

Calik M. | Aktas M.S. | Cecen E. | Piskin I.E. | Ayaydın H. | Ornek Z. | Karaca M.

Article | 2018 | Neurological Sciences39 ( 6 ) , pp.1009 - 1014

This study aimed to determine the relationship between serum vitamin B12 level and tension-type headache. The study groups consisted of 75 patients (40 females, 35 males) with headache and a control group of 49 healthy children (25 females, 24 males). Serum vitamin B12 level < 200 pg/ml was defined as deficient, and < 160 pg/ml as severely deficient. The serum vitamin B12 level was measured by the electrochemiluminescence (ECLIA) method. The serum vitamin B12 levels in the headache and control groups were 273.01 ± 76.77 and 316.22 ± 74.53 pg/ml, with the difference determined as statistically significant (p = 0.003). In the ca . . .se group, 18/75 patients (24%) had a serum vitamin B12 level below the normal of 200 pg/ml, and in the control group 4/49 (8%) patients were also below the normal range (p = 0.021). The serum vitamin B12 level in the children with tension-type headache was significantly lower than that in the control group. From the results of the study, it was concluded that there may be an association between vitamin B12 level and tension-type headache. However, further clinical studies are needed. © 2018, Springer-Verlag Italia S.r.l., part of Springer Nature Daha fazlası Daha az

Otoacoustic emissions and effects of contralateral white noise stimulation on transient evoked otoacoustic emissions in diabetic children

Ugur A.K. | Kemaloglu Y.K. | Ugur M.B. | Gunduz B. | Saridogan C. | Yesilkaya E. | Bideci A.

Article | 2009 | International Journal of Pediatric Otorhinolaryngology73 ( 4 ) , pp.555 - 559

Objective: In this study, our aim was to determine presence of dysfunction in the efferent auditory system of children with type-I diabetes mellitus (DM) presenting no evidence of symptomatic neuropathy. Methods: Thirty children with type-I DM (DM group) and 31 age matched healthy children (control group) with normal hearing and middle ear function were entered to the study. Distortion product otoacoustic emissions (DPOAE), transiently evoked otoacoustic emissions (TEOAE), and spontaneous otoacoustic emissions (SOAE) measurements were performed. Then, the TEOAE recording was repeated while a continuous broadband white noise (bandwid . . .th: 50-8000 Hz) presented at 40 dB SL was delivered to the contralateral ear for efferent auditory system suppression. Results: We found that contralateral stimulation (CS) with white noise resulted in significantly more pronounced suppression of the TEOAE response amplitude in healthy controls compared to DM group at 2000 and 4000 Hz frequencies. Further, a relatively higher percentage of the controls had suppression in at least three frequencies compared to DM group. SOAE prevalence was found to be higher in the DM group. Conclusions: Our findings suggest presence of a dysfunction in medial olivocochlear efferent system in diabetic children. This may be regarded as an early central manifestation of diabetic neuropathy. © 2008 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Cross-sectional internal diameters of radial, thoracodorsal, and dorsalis pedis arteries in children: Relationship to subject sex, age, and body size

Babuccu O. | Ozdemir H. | Hosnuter M. | Kargi E. | Sögüt A. | Ayoglu F.N.

Article | 2006 | Journal of Reconstructive Microsurgery22 ( 1 ) , pp.49 - 52

The purpose of this study was to determine the average diameter of the radial, thoracodorsal, and dorsalis pedis arteries in a pediatric population and to evaluate the relationship of these measurements to the subject's age, sex, height, weight, and body mass index (BMI). The internal diameters of the radial, thoracodorsal, and dorsalis pedis arteries were non-invasively studied in 45 normotensive, presumed normal children of various ages (4 to 14 years) with the use of a Doppler system. The average diameters of the radial, thoracodorsal, and dorsalis pedis arteries in females and males were as follows: radial artery 1.39 (SD ± 0.18 . . .) mm and 1.57 (SD ± 0.18) mm; thoracodorsal artery 1.27 (SD ± 0.11) mm and 1.36 (SD ± 0.2) mm; and dorsalis pedis artery 1.22 (SD ± 0.08) mm and 1.34 (SD ± 0.12) mm. These were correlated with the age, height, weight, and BMI. Gender had a strong influence on the diameter of these arteries. In a linear regression model, weight was found to be statistically the best independent variable for predicting radial and dorsalis pedis diameters, whereas age was the best predictor for the diameter of the thoracodorsal artery. The diameters of these three arteries in an age group of 4 to 14 years ranged between 1 to 2 mm. The age and weight of the children predicted the diameters of the peripheral arteries. Copyright © 2006 by Thieme Medical Publishers, Inc Daha fazlası Daha az

Knowledge of Turkish mothers with children in the 0-13 age group about cancer symptoms

Demirbag B.C. | Kürtüncü M. | Güven H.

Article | 2013 | Asian Pacific Journal of Cancer Prevention14 ( 2 ) , pp.1031 - 1035

Background: There have been few studies in Turkey on the incidence of childhood cancers. A mother's knowledge about signs and symptoms of cancer is important for early diagnosis, effective treatment, and improvement of life expectancy. This study was conducted with a group of mothers of children, aged 0-13, at a Family Health Center (FHC) in Turkey's Eastern Black Sea Region, to analyze their knowledge about cancer symptoms in childhood. Materials and Methods: The study group of this descriptive/cross-sectional research comprised 2,061 mothers, ages 19-49, at an FHC in the Eastern Black Sea Region in February 1, 2011 - June 1, 2011. . . . Before the study, permission was obtained from the local ethics board and the institutions concerned. A value of Daha fazlası Daha az

Effects of intramuscular and peritonsillar injection of tramadol before tonsillectomy: A double blind, randomized, placebo-controlled clinical trial

Ugur M.B. | Yilmaz M. | Altunkaya H. | Cinar F. | Ozer Y. | Beder L.

Article | 2008 | International Journal of Pediatric Otorhinolaryngology72 ( 2 ) , pp.241 - 248

Background/aims: Our objective was to investigate the efficacy of intramuscular injection and peritonsillar infiltration of tramadol to prevent pain in children undergoing tonsillectomy. Methods: In a double-blinded trial, 45 children were randomized into three groups: infiltration anesthesia with tramadol (2 mg kg-1) to the peritonsillar area (INF group, n = 15), intramuscular analgesia with tramadol (2 mg kg-1) (IM group, n = 15), and the placebo controls (PL group, n = 15). Visual analog scale (VAS) scores for pain assessment, heart rate (HR) and mean arterial pressure (MAP) during and after anesthesia were recorded. Results: Mea . . .n HR values were higher in INF than PL group at 10th, 20th, and 30th minutes of operation (P < 0.05). Nine children required analgesics within the first hour after surgery in PL compared to 1 child in INF group (P = 0.036). VAS scores on awakening were significantly better in INF than PL group (P = 0.015). The difference between IM and PL groups was not significant for any of the parameters. Conclusion: Peritonsillar infiltration with tramadol provided good intraoperative analgesia, less postoperative pain on awakening and lower analgesic requirement within the first hour after surgery. © 2007 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Early cardiac abnormalities and serum N-terminal pro B-type natriuretic peptide levels in obese children

Battal F. | Ermis B. | Aktop Z. | Can M. | Demirel F.

Article | 2011 | Journal of Pediatric Endocrinology and Metabolism24 ( 09.Oct ) , pp.723 - 726

Objective: The aim of this study was to evaluate early cardiac abnormalities in obese children by the conventional echocardiography and to verify whether N-terminal pro B-type natriuretic peptide (NT-proBNP) differ between obese and healthy children. Methods: We started this study with 68 obese children and 35 healthy controls matched for age and sex. Body mass index (BMI) was calculated. Children with a BMI ?95th percentile were considered obese. Thirty children in the obese group were also diagnosed with metabolic syndrome, according to the International Diabetes Federation criteria. Standard echocardiographic study was performed . . .on each patient and control subject. Diastolic filling parameters were evaluated using pulsed-wave tissue Doppler method. Blood samples were taken at 8 a.m. to study blood biochemistry tests, including insulin, lipids, glucose, and NT-proBNP. Serum NT-proBNP levels were measured by a solid-phase, enzymelabeled chemiluminescent immunometric assay. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Children with HOMA-IR >3.16 were considered insulin-resistant. Results: There were diastolic filling abnormalities in obese children, as shown by a decreased mitral valve early filling (E) wave/late filling (A) ratio and a prolongation in E-wave deceleration time. The levels of NT-proBNP were not statistically different among the groups. The levels of NT-proBNP were not different between obese children with and without metabolic syndrome, those with and without hypertension, and those with and without insulin resistance, respectively. Conclusion: Although there were diastolic filling abnormalities in obese children, their NT-proBNP levels were not different from healthy controls. It seems that there is no diagnostic value in NT-proBNP levels between obese children and healthy controls © 2011 by Walter de Gruyter • Berlin • Boston Daha fazlası Daha az

Assessment of cardiac autonomic regulation in children with monosymptomatic nocturnal enuresis by analysis of heart rate variability

Unalacak M. | Aydin M. | Ermis B. | Ozeren A. | Sogut A. | Demirel F. | Unluoglu I.

Article | 2004 | Tohoku Journal of Experimental Medicine204 ( 1 ) , pp.63 - 69

The pathogenesis of monosymptomatic nocturnal enuresis is controversial. Various urodynamic studies showed bladder hyperactivity in enuretic children. But the exact cause is not precisely known. The aim of this study was to understand whether the autonomic nervous system dysfunction is involved in this bladder hyperactivity or not. Heart rate variability measurement is widely used for evaluation of cardiac autonomic activity. We evaluated cardiac autonomic nervous system functions in monosymptomatic nocturnal enuretic children by using 24-hour Holter electrocardiogram. The study group consisted of 32 enuretic children (20 boys and 1 . . .2 girls) and the control group consisted of 20 healthy children (12 boys and 8 girls). In these two growps, we assessed cardiac autonomic regulation by analysis of heart rate variability, and found a significantly higher parasympathetic activity in enuretic children than controls. We suggest that the parasympathetic nervous system hyperactivity plays a role in nocturnal enuresis by causing vesical hyperactivity in monosymptomatic enuretic children. © 2004 Tohoku University Medical Press Daha fazlası Daha az

Factors affecting the prevalence of obesity among primary school students in Turkey

Ayyildiz T.K. | Kurtuncu M. | Kulakci H. | Celik S.

Article | 2014 | Iranian Red Crescent Medical Journal16 ( 12 ) , pp.63 - 69

Background: Obesity is an energy metabolism disorder which results in the excessive storage of fat and may also lead to physical and psychological problems. Since the 1980s, obesity has drastically increased across all age and socio-economic groups around the world.Objectives: The purpose of the study was to investigate the risk factors affecting obesity in students in the age group of 6-15 years.Patients and Methods: This was a population-based cross-sectional study on 868 students in Bahçelievler elementary school in Zonguldak, Turkey from March to April in 2010. Data was collected using demographic questionary forms and weight-le . . .ngth measurements.Results: The median age was 10.3 ± 2.1; 47.6% of the children were female and 52.4% of them were male. About 70.2% of the students consumed fast food. It was identified that 67.1% of the students in the 6-10-year age group and 32.9% in 11-15-year age group were obese (P = 0.000). The obesity prevalence of children with one or two siblings was higher than the ones with more than two siblings (P = 0.001).Conclusions: The study concluded that there were certain criteria related to development of obesity during a specific period of childhood and taking certain precautions could be effective in preventing it. © 2014, Iranian Red Crescent Medical Journal Daha fazlası Daha az

Effects of parent's presence on pain tolerance in children during venipuncture: A randomised controlled trial

Ozcetin M. | Suren M. | Karaaslan E. | Colak E. | Kaya Z. | Guner O.

Article | 2011 | Hong Kong Journal of Paediatrics16 ( 4 ) , pp.247 - 252

Introduction: The aim of this study is to determine whether presence of parents can change tolerance of pain and distress in children. Materials and Methods: A hundred thirty five children (62 girls, and 73 boys) between 3-6 years who were admitted to the paediatric outpatient clinic were included in the study. The cases were randomised into two groups: those who were accompanied by a parent (group 1), and those who were accompanied by a hospital staff member (group 2). We used the Wong-Baker FACES Pain Rating Scale to evaluate pain. Analyses were performed using commercially software (PASW ver. 18, ID:33478001 SPSS inc. Chicago, IL . . .). A p-value Daha fazlası Daha az

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