Aydemir, Selim | Tekin, Solak Nilgün | Aktunç, Erol | Numanoğlu, Gamze | Üstündağ, Yücel

Article | 2004 | Turkish Journal of Gastroenterology15 ( 3 ) , pp.192 - 195

Amaç: Celiac hastalığı ince barsakların glutene intoleransı sonucu oluşan bir hastalıktır. Epidemiolojik çalışmalarda prevalansı hakkında çok farklı veriler vardı. Hastalarda genellikle çok geniş spektrumda semptom ve bulgulara neden olabildiğinden celiac hastalığı tanısının konulması zor olabilmektedir. Hastalığın erken evrede yakalanması önemlidir. Çünkü bu hastalarda barsak lenfoması gelişme riski artmıştır. Celiac hastalığı olan hastalarda rekürren aftoz stomatit prevalansındaki yükseklik nedeniyle rekürren aftoz stomatitli hastaların celiac hastalığı yönünden araştırılması asemptomatik celiac hastalığı olan hastaların tanı alma . . .sını sağlayabilir. Bu çalışma rekürren aftoz stomatit nedeniyle başvuran olgularda celiac hastalığı prevalansını saptamak için planlanmıştır. Yöntem: Çalışma gurubu olarak rekürren aftoz stomatit öyküsü olan, kontrol grubu olarak ise rekürren aftoz stomatit öyküsü olmayan olgular alındı. Tüm olgularda anti gliadin IgG, antigliadin IgA ve anti endomisium antikorları bakıldı. Ayrıca endoskopi yapılarak duodenum distal kesiminden biyopsiler alındı. Bulgular: Rekürren aftoz stomatit öyküsü olan 41 olgunun ikisinde patolojik inceleme ile doğrulanan celiac hastalığı bulundu (%4.8). Celiac hastalığı saptanan bu iki olgunun her ikisinde de anti gliadin IgA ve endomisium antikorları pozitif bulundu. Anti gliadin IgG antikoru ise olguların birinde pozitifti. Kontrol grubundaki 49 olgunun hiçbirinde celiac hastalığı saptanmadı. Sonuç: Rekürren aftoz stomatit olgularında celiac hastalığı açısında ileri incelenmeler yapılmalıdır. Endoskopinin invaziv ve daha pahalı olması nedeniyle rekürren aftoz stomatitli olgularda celiac hastalığı ı araştırmak için öncelikli olarak serolojik tetkikler yapılmalı, seroljik markır pozitif olan olgularda endoskopik olarak duodenum ikinci kesiminden biyopsiler alınmalıdır. Background/aims: Celiac disease is a condition related to the small intestine’s intolerance to gluten. In epidemiologic studies the prevalence is highly variable. The diagnosis can be difficult due to the wide spectrum of signs and symptoms. As the risk for intestinal lymphoma is higher in these patients, early diagnosis has its privileges. The higher prevalence of recurrent aphthous stomatitis in celiac disease led us to investigate the celiac disease prevalence in patients with recurrent aphthous stomatitis, which might assist in diagnosis of asymptomatic celiac disease patients. The aim of this study was to determine the prevalence of celiac disease in patients presenting with recurrent aphthous stomatitis. Methods: The study group consisted of patients having a history of recurrent aphthous stomatitis. The control group included patients not having aphthous stomatitis. Antibodies to gliadin IgG and IgA and antibodies to endomysium were determined from the serum samples of all patients. Biopsies were obtained from the distal part of the duodenum. Results: Biopsies of two patients (4.8%) out of 41 belonging to the study group were diagnosed as celiac disease. In serum samples of both, antibodies to gliadin IgA and antibodies to endomysium were found to be positive. Antibodies to gliadin IgG antibody were positive in only one of these two patients. None of the 49 patients in the control group was diagnosed as celiac disease. Conclusion: Further evaluation of recurrent aphthous stomatitis patients for celiac disease must be performed. As the endoscopic procedures are invasive and costly, evaluation of recurrent aphthous stomatitis patients for celiac disease must include serologic markers at the beginning. If any positivity is determined in markers, then endoscopic procedures including biopsies of the duodenum must be considered as the second-step intervention Daha fazlası Daha az

Macit, Hülya | Hazer, Baki

Article | 2004 | Journal of Applied Polymer Science93 ( 1 ) , pp.219 - 226

Combination of cationic, redox free radical, and thermal free radical polymerizations was performed to obtain linear and star polytetramethylene oxide (poly-THF)-polymethyl methacrylate (PMMA)/polystyrene (PSt) multiblock copolymers. Cationic polymerization of THF was initiated by the mixture of AgSbF6 and bis(4,4' bromo-methyl benzoyl) peroxide (BBP) or bis (3,5,3',5' dibromom-ethyl benzoyl) peroxide (BDBP) at 20°C to obtain linear and star poly-THF initiators with MW varying from 7,500 to 59,000 Da. Poly-THF samples with hydroxyl ends were used in the methyl methacrylate (MMA) polymerization in the presence of Ce(IV) salt at 40°C . . .to obtain poly(THF-b-MMA) block copolymers containing the peroxide group in the middle. Poly(MMA-b-THF) linear and star block copolymers having the peroxide group in the chain were used in the polymerization of methyl methacrylate (MMA) and styrene (St) at 80°C to obtain PMMA-b-PTHF-b-PMMA and PMMA-b-PTHF-PSt linear and star multiblock copolymers. Polymers obtained were characterizated by GPC, FT-IR, DSC, TGA, 1H-NMR, and 13C-NMR techniques and the fractional precipitation method. © 2004 Wiley Periodicals, Inc Daha fazlası Daha az

Hoşnuter, Mübin | Babucçu, Orhan | Kargı, Eksal | Numanoğlu, Gamze | Koca, Rafet | Babucçu, Berfu

Article | 2004 | European Journal of Plastic Surgery27 ( 5 ) , pp.246 - 248

Cylindroma is a rare tumor which originates from skin appendages and occurs predominantly on the scalp and face. It is considered to be benign, but malignant transformation has been reported. It has two distinct clinical presentations, solitary and multiple. A review of the literature revealed that the majority of malignant cylindromas occur among multiple type cylindromas. Only 36 malignant cylindromas have been reported, and only 9 were of the solitary type. A case with a solitary type of cylindroma exhibiting malignant transformation of the scalp is presented. © Springer-Verlag 2004.

Koca, Rafet | Altinyazar, H. Cevet | Numanoğlu, Gamze | Ünalacak, Murat

Article | 2004 | Journal of Tropical Pediatrics50 ( 3 ) , pp.178 - 179

A 7-year-old boy presented to our clinic with a 1-week history of guttate psoriasis-like lesions after BCG vaccination. Although the patient did not have any history of psoriasis, his father and uncle had a history of psoriasis vulgaris. He was treated successfully with topical corticosteroid. Complete healing was seen after 3 weeks and the patient was still in remission 4 months after the cessation of the therapy. We proposed that patients who have psoriasis or predisposition to psoriasis must be carefully followed after BCG vaccination. © Oxford University Press 2004; all rights reserved.

Özer, Mahmut

Article | 2004 | NeuroReport15 ( 9 ) , pp.1451 - 1455

We previously formulated dynamics of ion channel gates by the path probability method. In this study, we apply that theoretical approach to derive the activation rate kinetics of T-type calcium channel in thalamic relay neurons. We derive explicit expressions of the forward and backward rate constants and show that the proposed rate constants accurately capture form of the empirical time constant, and that they also provide its saturation to a constant value at depolarized membrane potentials. We also compare our derivations with linear and nonlinear thermodynamic models of rate kinetics obtained from the same calcium channel, and s . . .how that it is possible to capture saturation of the time constant for the depolarized membrane potentials by the only proposed rate constants. © 2004 Lippincott Williams & Wilkins Daha fazlası Daha az

Arslan, Hülya | Menteş, Ayfer | Hazer, Baki

Article | 2004 | Journal of Applied Polymer Science94 ( 4 ) , pp.1789 - 1796

A poly[(R,S)-3-hydroxybutyrate] macroinitiator (PHB-MI) was obtained through the condensation reaction of poly[(R,S)-3-hydroxybutyrate] (PHB) oligomers containing dihydroxyl end functionalities with 4,4'-azobis(4-cyanopentanoyl chloride). The PHB-MI obtained in this way had hydroxyl groups at two end of the polymer chain and an internal azo group. The synthesis of ABA-type PHB-b-PMMA block copolymers [where A is poly(methyl methacrylate) (PMMA) and B is PHB] via PHB-MI was accomplished in two steps. First, multiblock active copolymers with azo groups (PMMA-PHB-MI) were prepared through the redox free-radical polymerization of methyl . . . methacrylate (MMA) with a PHB-MI/Ce(IV) redox system in aqueous nitric acid at 40°C. Second, PMMA-PHB-MI was used in the thermal polymerization of MMA at 60°C to obtain PHB-b-PMMA. When styrene (S) was used instead of MMA in the second step, ABCBA-type PMMA-b-PHB-b-PS multiblock copolymers [where C is polystyrene (PS)] were obtained. In addition, the direct thermal polymerization of the monomers (MMA or S) via PHB-MI provided AB-type diblocks copolymers with MMA and BCB-type triblock copolymers with S. The macroinitiators and block copolymers were characterized with ultraviolet-visible spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography, cryoscopic measurements, and thermogravimetric analysis. The increases in the intrinsic viscosity and fractional precipitation confirmed that a block copolymer had been obtained. © 2004 Wiley Periodicals, Inc Daha fazlası Daha az

Hosnuter, M | Kargi, E | Babuccu, O

Letter | 2004 | PLASTIC AND RECONSTRUCTIVE SURGERY114 ( 6 ) , pp.1678 - 1678

WOS: 000224809700075 PubMed: 15509995

Genç, Ayten | Tosun, İsmail

Article | 2004 | Chemical Engineering Communications191 ( 1 ) , pp.125 - 136

A mathematical model based on multiphase filtration theory is developed to describe the electrofiltration process. The model takes both electrophoretic and electroosmotic effects into account. The electrophoretic migration velocity of solid particles is predicted from the model using the filtrate volume time data obtained from electrofiltration experiments.

Özer, Mahmut | İşler, Yalçın | Özer, Halil

Article | 2004 | Computer Methods and Programs in Biomedicine75 ( 1 ) , pp.51 - 57

In this paper, a new computer software package, Yalzer, is introduced for simulating single-compartmental model of neurons. Passive or excitable membranes with voltage-gated ion channels can be modeled, and current clamp and voltage clamp experiments can be simulated. In the Yalzer, first-order differential equations used to define the dynamics of the gate variables and the membrane potential are solved by two separate integration methods with variable time steps: forward Euler and exponential Euler methods. Outputs of the simulation are shown on a spreadsheet template for allowing flexible data manipulation and can be graphically d . . .isplayed. The user can define the model in detail, and examine the excitability of the model and the dynamics of voltage-gated ion channels. The software package addresses to ones who want to run simple simulations of neurons without need to any programming language skills or expensive software. It can also be used for educational purposes. © 2003 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Özer, Mahmut | Erdem, Rıza

Article | 2004 | Physica A: Statistical Mechanics and its Applications331 ( 01.Feb ) , pp.51 - 60

Dynamics of voltage-gated ion channels in the excitable cell membranes is formulated by the path probability method of nonequilibrium statistical physics and approaches of the system toward the steady or equilibrium states are presented. For a single-particle noninteractive two-state model, a first-order rate equation or dynamic equation is derived by introducing the path probability rate coefficients which satisfy the detailed balancing relation. Using known parameters for the batrachotoxin (BTX)-modified sodium channels in giand squid axon as an example, the rate equation is solved and voltage dependence of the time constant (?) a . . .nd its temperature effect are investigated. An increase in voltage caused a shift in ? towards shorter durations while increasing temperature caused a shift in time distribution towards longer durations. Results are compared with the kinetic model for the squid axon BTX-modified sodium channels by the cut-open axon technique and a very good agreement is found. © 2003 Elsevier B.V. All rights reserved Daha fazlası Daha az

Özer, Tülay | Uzun, Lokman | Numanoğlu, Kemal Varın | Savranlar, Ahmet | Hoşnuter, Mübin | Gündoğdu, Sadi

Article | 2004 | Tanisal ve girişimsel radyoloji : Tibbi Görüntüleme ve Girişimsel Radyoloji Dernegi yayin organi10 ( 4 ) , pp.272 - 279

PURPOSE: To investigate the accompanied craniofacial and cervical spine anomalies in congenital muscular torticollis (CMT) with three-dimensional computerized tomography (3D-CT). MATERIALS AND METHODS: We examined six cases of CMT. Cranial and cervical 3D CT was performed in all cases. Facial midline deviation angle (FDA), upper hemifacial width, lower hemifacial width (LHFW), length of hemimandible and zygomatic arcus, posterior hemicranial width (PHCW), anterior hemicranial width and cranial base midline deviation angle (CBDA) were measured on cranial 3D-CT images. Value of orbital index was calculated. Data achieved both ipsilate . . .rally and contralaterally were compared with paired t-test. Atlanto-axial rotation angle (AARA) and atlantodental interval (ADI) values were measured on cervical 3D-CT images. RESULTS: Ages ranged between 2-26 years with a M/F ratio of 1/5. Facial asymmetry was diagnosed in all cases and LHFW was significantly undersized when compared to contralateral side (p < 0.05). FDA was measured 5.4+/-2.0 degrees on the average. Zygomatic arcus and hemimandible were significantly undersized on the side of torticollis (p < 0.05). Occipital plagiocephaly existed in all cases and PHCW was significantly extensive on torticollis side (p < 0.05). CBDA was measured 4.5+/-1.7 degrees on the average. Rotational movement of atlas over axis was observed in all cases where the AARA was 15.0+/-7.4 degrees. ADI was lesser than 3 mm in all cases. CONCLUSION: Even occipital plagiocephaly, maxillary and orbital deformity were commonly found in cases of CMT, most dominant asymmetry was observed in lower hemifacial region, zygomatic arcus and mandible by 3D-CT imaging. Rotational movement of first cervical vertebra over the second one was determined in all cases Daha fazlası Daha az

Sayan, Hale | Özaçmak, Veysel Haktan | Özen, Oğuz Aslan | Coşkun, Ömer | Arslan, S. Oktay | Sezen, S. Cem | Aktaş, R. Gülhan

Article | 2004 | Journal of Pineal Research37 ( 3 ) , pp.143 - 148

Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and to damage of the nervous tissue. Melatonin, a main secretory product of the pineal gland, has free radical scavenging and antioxidant properties and has been shown to diminish I/R injury in many tissues. There are a limited number of studies related to the effects of melatonin on I/R injury in the peripheral nervous system. Therefore, in the present study, the protective effect of melatonin was investigated in rats subjected to 2 hr of sciatic nerve ischemia followed by 3 hr of reperfusion. Following reperfusion, nerve tissue . . .samples were collected for quantitative assesment of malondialdehyde (MDA). an oxidative stress marker, and superoxide dismutase (SOD), a principal antioxidant enzyme. Samples were further evaluated at electron microscopic level to examine the neuropathological changes. I/R elevated the concentration of MDA significantly while there was a reduction at SOD levels. Melatonin treatment reversed the I/R-induced increase and decrease in MDA and SOD levels, respectively. Furthermore, melatonin salvaged the nerve fibers from ischemic degeneration. Histopathologic findings in the samples of melatonin-treated animals indicated less edema and less damage to the myelin sheaths and axons than those observed in the control samples. Our results suggest that administration of melatonin protects the sciatic nerve from I/R injury, which may be attributed to its antioxidant property Daha fazlası Daha az