Synchronization-induced spike termination in networks of bistable neurons

Uzuntarla, Muhammet | Torres, Joaquin J. | Çalım, Ali | Barreto, Ernest

Article | 2019 | Neural Networks110 , pp.131 - 140

We observe and study a self-organized phenomenon whereby the activity in a network of spiking neurons spontaneously terminates. We consider different types of populations, consisting of bistable model neurons connected electrically by gap junctions, or by either excitatory or inhibitory synapses, in a scale-free connection topology. We find that strongly synchronized population spiking events lead to complete cessation of activity in excitatory networks, but not in gap junction or inhibitory networks. We identify the underlying mechanism responsible for this phenomenon by examining the particular shape of the excitatory postsynaptic . . . currents that arise in the neurons. We also examine the effects of the synaptic time constant, coupling strength, and channel noise on the occurrence of the phenomenon. © 2018 Elsevier Lt Daha fazlası Daha az

Double inverse stochastic resonance with dynamic synapses

Uzuntarla, Muhammet | Torres, Joaquin J. | So, Paul | Özer, Mahmut | Barreto, Ernest

Article | 2017 | Physical Review E95 ( 1 ) , pp.131 - 140

We investigate the behavior of a model neuron that receives a biophysically realistic noisy postsynaptic current based on uncorrelated spiking activity from a large number of afferents. We show that, with static synapses, such noise can give rise to inverse stochastic resonance (ISR) as a function of the presynaptic firing rate. We compare this to the case with dynamic synapses that feature short-term synaptic plasticity and show that the interval of presynaptic firing rate over which ISR exists can be extended or diminished. We consider both short-term depression and facilitation. Interestingly, we find that a double inverse stocha . . .stic resonance (DISR), with two distinct wells centered at different presynaptic firing rates, can appear. © 2017 American Physical Society Daha fazlası Daha az

Effects of dynamic synapses on noise-delayed response latency of a single neuron

Uzuntarla, Muhammet | Özer, Mahmut | İleri, Uğur | Çalım, Ali | Torres, Joaquin J.

Article | 2015 | Physical Review E - Statistical, Nonlinear, and Soft Matter Physics92 ( 6 ) , pp.131 - 140

The noise-delayed decay (NDD) phenomenon emerges when the first-spike latency of a periodically forced stochastic neuron exhibits a maximum for a particular range of noise intensity. Here, we investigate the latency response dynamics of a single Hodgkin-Huxley neuron that is subject to both a suprathreshold periodic stimulus and a background activity arriving through dynamic synapses. We study the first-spike latency response as a function of the presynaptic firing rate f. This constitutes a more realistic scenario than previous works, since f provides a suitable biophysically realistic parameter to control the level of activity in . . .actual neural systems. We first report on the emergence of classical NDD behavior as a function of f for the limit of static synapses. Second, we show that when short-term depression and facilitation mechanisms are included at the synapses, different NDD features can be found due to their modulatory effect on synaptic current fluctuations. For example, an intriguing double NDD (DNDD) behavior occurs for different sets of relevant synaptic parameters. Moreover, depending on the balance between synaptic depression and synaptic facilitation, single NDD or DNDD can prevail, in such a way that synaptic facilitation favors the emergence of DNDD whereas synaptic depression favors the existence of single NDD. Here we report the existence of the DNDD effect in the response latency dynamics of a neuron. © 2015 American Physical Society Daha fazlası Daha az

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