Tatlı, Duygu | Numanoğlu, Kemal Varın

Makale | 2008 | Cases Journal1 ( 1 )

Transverse testicular ectopia is rarely associated with incarcerated inguinal hernia. A 14-month-old male complaint of irreducible inguinal hernia due to transverse testicular ectopia is reported. The clinical and operative findings and treatment options are discussed. It is thought that surgeons who frequently repair inguinal hernias should be aware of the appropriate surgical management options available to them when this condition is unexpectedly identified during inguinal exploration. © 2008 Tatli and Numanoglu; licensee BioMed Central Ltd.

Onak Kandemir N. | Barut F. | Yurdakan G. | Bayar Ü. | Özdamar Ş.O.

Makale | 2010 | Turk Patoloji Dergisi/Turkish Journal of Pathology26 ( 1 ) , pp.85 - 88

Heterotopic pregnancy is a very uncommon entity with a difficult preoperative diagnosis. In the present study, we presented an ovarian heterotopic pregnancy case, clinically mimicking endometrioma developed in a 33-year-old female following an in vitro fertilization procedure. The importance of clinical, histopathological, and immunohistochemical examinations in the diagnosis of heterotopic pregnancy are emphasized.

Sancak, Banu | Coşkun, Uğur | Günel, Nazan | Onuk, Erhan | Cihan, Alper | Karamercan, Ahmet | Yıldırım, Yeşim | Özkan, Serhan

Makale | 2004 | Internal Medicine Journal34 ( 6 ) , pp.310 - 315

Background: Angiogenesis is essential for tumour growth and metastasis. Vascular endothelial growth factor (VEGF) has been suggested as the major angiogenic factor in breast carcinoma. Both insulin-like growth factor-I (IGF-I) and prolactin are involved in the progression of breast cancer at least partly by stimulating angiogenesis. Aim: The aim of the present study was to investigate the association between serum IGF-I, VEGF and prolactin levels and clinicopathological characteristics of breast carcinoma. Methods: Serum IGF-I, VEGF and prolactin levels were measured in breast cancer patients and controls and these levels were compa . . .red with well-known clinicopathological characteristics of breast carcinoma, including tumour size, axillary lymph node and oestrogen/progesterone receptor status, tumour grade and disease stage. Results: Serum prolactin, VEGF and IGF-I levels were found to be similar in breast cancer patients and control subjects (P > 0.05). When the patients were divided into groups according to their tumour size, axillary lymph node status, tumour grade, oestrogen/progesterone receptor status and disease stage, no significant differences in serum prolactin, VEGF and IGF-I levels were found among the groups (P > 0.05). Conclusions: The present study failed to demonstrate an association between serum levels of VEGF, IGF-I and prolactin and well-known clinicopathological characteristics of breast carcinoma Daha fazlası Daha az

Barut, Figen | Kandemir, Onak Nilüfer | Özdamar, Şükrü Oğuz | Gül, Sanser | Bektaş, Sibel | Gün, Doğan Banu | Bahadır, Burak

Makale | 2009 | Turkish Neurosurgery19 ( 4 ) , pp.417 - 422

Gliosarkom, bifazik histolojik patern ile karakterize santral sinir sisteminin nadir tümörüdür. Amacımız, kondroblastik osteosarkomatöz farklılaşmayla birlikte olan iki gliosarkom olgusunun klinik, morfolojik ve immünhistokimyasal özelliklerini tanımlamak ve onların patogenetik mekanizmalarını tartışmaktır. Olgu 1: Anaplastik ependimom nedeniyle parietal kraniotomiye gitmiş 52 yaşında erkek hastadır. Olguya postoperatif radyoterapi ve kemoterapi verildi. İlk operasyondan sonra, dördüncü, yedinci ve onuncu aylarda rekürrensden dolayı tümör için ilave rezeksiyonlar yapıldı. Sonuncu tümör rezeksiyonundan sonra hasta exitus oldu. Postmo . . .rtem biyopsinin histopatolojik incelemesinde, hem gliomatöz hem de sarkomatöz komponentler içeren bifazik morfolojik patern sergileyen neoplazi gözlendi. Olgu 2: Histolojik olarak, sarkomatöz ve glial komponent sergileyen gliosarkom tanısı alan sağ frontal lob kitlesi olan 69 yaşında erkek hastadır. İmmünhistokimyasal özellikleri genelde ilk olgununkine benzemekte, fakat p53 protein ile diffüz nükleer reaksiyon her iki komponentte saptandı. “Kondroblastik osteosarkom özellikleri ile beraber olan gliosarkom” olarak oldukça nadir histopatolojik tanılı iki olgu rapor ettik. Gliosarcoma is a rare tumor of the central nervous system characterized by a biphasic histological pattern. Our objective is to describe clinical, morphological and immunohistochemical features of two cases of gliosarcoma with chondroblastic osteosarcomatous differentiation and to discuss its pathogenetic mechanisms. Case 1: A52- year-old male patient underwent parietal craniotomy due to anaplastic ependymoma. The case had radiotherapy and chemotherapy postoperatively. After the first operation, additional resections were performed for tumor because of recurrences at the fourth, seventh and tenth months. The patient died after the last tumor resection. Histopathologic examination of the postmortem biopsy revealed neoplasm displaying a biphasic morphologic pattern including both gliomatous and sarcomatous components. Case 2: The case was a 69-year-old male patient with a right frontal lobe mass histologically diagnosed as gliosarcoma displaying sarcomatous and glial components. Immunohistochemical features were similar to those of the first case in general, but diffuse nuclear reaction with p53 protein was detected in both components. We report two cases with an extremely rare histopathologic aldiagnosis of “gliosarcoma with features of chondroblastic osteosarcoma” Daha fazlası Daha az

Akman, Tulay | Tanrıverdı, Ozgur | Ozturk, Mehmet A. | Petekkaya, Ibrahim | Bakkal, Bekir Hakan | Sonmez, Ozlem U. | Avcı, Nilufer

Makale | 2014 | Uluslararası Hematoloji-Onkoloji Dergisi24 ( 3 ) , pp.195 - 201

Günümüzde onkoloji alanında her geçen gün deneysel ve klinik araştırmaların sonucu olarak yeni bir gelişme olmaktadır. Kişi başına düşen yayın sayısına bakıldığında, Türkiye diğer gelişmiş Avrupa ülkelerinden epeyce geride yer almaktadır. Örneğin tüm dünyada kanser alanında yapılmış olan yayınların sayısı 2,134,964 iken, Türkiye’dekilerin sayısının toplamı 15.576’dır ve toplam yayın sayısı nüfus oranları ile karşılaştırıldığında diğer gelişmiş Avrupa ülkelerine göre epeyce geride kalmaktadır. Türkiye’de klinik çalışmaların önündeki en önemli engellerin finansal sorunlar, çalışma şartlarının zorlukları, iş yoğunluğu nedeniyle zaman k . . .ısıtlılığı, deneyimli-eğitimli insan gücü eksikliği, bilimsel çalışmanın tüm aşamalarında yardımcı olacak bir ekibin eksikliği, proje hazırlama ve etik kurul izin sürecinde yaşanan sıkıntılar, motivasyon eksikliği olduğu düşünülebilir. Biz genç onkologlar olarak bu yazımızda; dünya genelinde ülkemizin bilimsel ve klinik araştırmalardaki yerini, bilimsel araştırmaların yapılamamasının nedenlerini, ülkemizde yapılmakta olan yayınların çeşit ve kalitesini, bizim ülkemize ait varolan ger- çekleri ve bunlara yönelik getirilebilecek çözüm önerilerini tartışmayı amaçladık. There is a new improvement in oncology nearly in every day as a result of preclinical or clinical. As the number of publication per capita, Turkey is far behind the other developed European countries. For example, the number of publications in oncology field is 2.134.964 in the world, it is 15.576 in our country. The most important obstacles for clinical trials in Turkey may be listed as financial problems, difficulties of working conditions, time limitation due to work intensity, inadequate experienced/trained man-power, absence of assistance team at all steps of a scientific trial, difficulties faced during project planning and ethics committee submissions, and lack of motivation. In this article, we, as young oncologists, aimed to discuss the place of Turkey in areas of scientific and clinical trials in the world; underlying causes for inadequate number, type and quality of national studies and possible solution proposals in our countr Daha fazlası Daha az

Solak Tekin N. | Tekin I.O. | Barut F. | Yilmaz Sipahi E.

Makale | 2007 | Mediators of Inflammation2007 , pp.195 - 201

Background. Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in epidermis with lesion. However, the exact etiology of psoriasis is unknown. Abnormalities in essential fatty acid metabolism, free radical generation, lipid peroxidation, and release of lymphokines have been proposed. Objective. Our purpose was to evaluate the plasma lipids and oxidized low-density lipoprotein accumulation in psoriatic skin lesion in order to ascertain the possible participation of oxidative stress and oxidative modification of lipids in pathogenesis of psorias . . .is. Methods. The study group included 84 patients with psoriasis, and 40 sex- and age-matched healthy volunteers. Blood lipid profile was determined. Psoriatic and nonlesional skin samples of psoriatic patients were evaluated for the presence of oxidized low-density lipoprotein by using an immune-fluorescent staining method. Results. The mean levels of lipids (total cholesterol, triglyceride, and LDL cholesterol) in patients with psoriasis were found to be significantly higher than those of healthy subjects. Psoriatic skins were shown positive oxidized low-density lipoprotein staining. There was no staining in nonlesional skin samples of the same individuals. Conclusion. Lipid peroxidation mediated by free radicals is believed to be one of the important causes of cell membrane destruction and cell damage. This study shows for the first time the accumulation of oxidized low-density lipoprotein in psoriatic skin lesion. We believe that accumulation of ox-LDL in psoriatic skin may have an important role in the immune-inflammatory events that result in progressive skin damage. Copyright © 2007 Nilgun Solak Tekin et al Daha fazlası Daha az

Misir A.F. | Birol Ugur M. | Kandemir N.O.

Makale | 2014 | Cumhuriyet Dental Journal1 , pp.53 - 57

The radicular cyst variously known as periapical, apical periodontal, dentoalveolar or rootend cyst is an inflammatory jaw cyst at the apices of teeth with infected and necrotic pulps. A radicular cyst arises from the epithelial residues in the periodontal ligament as a result of inflammation, usually following death of the pulp. Radicular cysts are the most common odontogenic cystic lesions of inflammatory origin and are managed either by surgical enucleation or by marsupialization. We illustrate the possibility of complete healing of a cystic periapical lesion of huge proportion in permanent dentition of a 58 year-old male patient . . . under general anesthesia with conservation of vital structures and without using any bone substitute Daha fazlası Daha az

Kandemir N.O. | Bektaş S. | Yurdakan G. | Taş E.

Makale | 2009 | Turk Onkoloji Dergisi24 ( 2 ) , pp.80 - 84

Benign osteoclast-like multinuclear giant cells are rarely found in tumors other than bone and soft tissue neoplasms, and they are even rarer in squamous cell carcinomas. We examined a nasopharyngeal tumor from a 52-year-old female who had undergone surgery one year earlier for hypopharyngeal squamous cell carcinoma. Histopathologically, in addition to tumor infiltration by atypical epithelial cells with squamoid differentiation, giant cells with 10-20 nuclei and a large amount of eosinophilic cytoplasm were seen infiltrating the tumor. The giant cells did not show atypia or mitosis. Immunohistochemically, the tumor cells stained fo . . .r pan-keratin and epithelial membrane antigen, and the giant cells were positive for leukocyte common antigen, CD68, and Mac 387. This case was diagnosed as moderately differentiated squamous cell carcinoma with multinuclear giant cells. In this case, the giant cells infiltrating the tumor were benign and of monocytic/histiocytic origin. Studies including large case series are needed to obtain reliable information on the clinical and prognostic importance of this histological feature Daha fazlası Daha az

Numanoğlu-Yurdakan, Gamze | Kertiş, Gürkan | Bahadır, Burak | Numanoğlu, Kemal Varın | Özdamar, Şükü Oğuz

Makale | 2008 | Ondokuz Mayis Universitesi Tip Dergisi25 ( 1 ) , pp.25 - 29

Renal dysplasia is a disorganized development of the kidney because anomalous differentiation of the metanephrosis. Abnormalities of the collecting system are common. They include obstruction of the ureteropelvic junction, ureteral atresia and urethral obstruction. The case was a six months old female child with ultrasonografically detected right hydronephrosis and oligohydroamniosis at the 20 th week of gestation. She underwent an operation for bilateral hydroureteronephrosis at 1 month of age. There was no serious and related illness in family history and self-history. She underwent right nephrectomy at 6 months of age. The specim . . .en included an atrophic nephrectomy material with lobulations and a dilated ureter. When sectioned, it was observed that the pericaliceal areas were dilated and the cortex-medulla border was obscured. On microscopic examination, the cortex was thin, contained rare small glomerules, primitive ducts and mononuclear cell infiltration were seen. A focus of cartilage was observed at the cortex-medulla junction. The case was diagnosed as renal hypoplastic dysplasia. During 4 months of follow-up, no complication was reported. This case is presented considering the uncommon occurence of renal dysplasia and its differential diagnosis from other congenital cystic renal malformations Daha fazlası Daha az

Bayraktaroğlu, Taner | Kargı, Eksal | Yeşilli, Çetin | Numanoğlu, Gamze | Borazan, Ali | Üstündağ, Yücel

Makale | 2004 | Bağımlılık Dergisi5 ( 1 ) , pp.35 - 39

Bu çalışmada kısa süreli marihuana (esrar) kullanımı sonrası oligoastenospermi ve jinekomasti belirlenen bir olgunun sunulması amaçlanmıştır. Olgu: Otuzbir yaşında erkek, yaklaşık 20 günlük sol göğüs meme başı altında kitle yakınması ile başvurdu. Kitlenin ortaya çıkmaya başlamasından önceki yaklaşık 15 gün boyunca günlük esrar kullanımı tanımlamaktaydı. Fiziki muayenede sol meme areola altında hassas olmayan, çevre dokuya fikse olmamış 50 mm'lik kitle palpe edildi. Hastanın serum östradiol düzeyi yüksek bulundu. Ayrıca; sperm sayısının azalmış ve motilitesinin kaybolmuş olduğu saptandı. Meme ultrasonografisinde; sol memede 45 x 35 . . .x 25 mm'lik kitle vardı. Belirlenen kitlenin total eksizyonu ile yapılan patolojik inceleme ile hipertrofik meme dokusuna ait fibroadipoz doku içinde duktal yapılarında kistik genişlemeler dikkati çekti. A tipi veya displazi bulgusu mevcut değildi. Hastaya bu bulgularla jinekomasti tanısı konuldu ve ek tedavi planı yapılmadı. Hasta rutin poliklinik kontrollerine çağrıldı. Bu bir yıllık dönemde esrar hiç kullanmayan hastada jinekomasti bulgusu tekrarlamadı. Medikal tedavisiz bir yıllık takipte olgunun jinekomasti açısından herhangi bir yakınması yoktu ve serum estradiol seviyesi normal bulundu. Ayrıca; kontrol sperm analizinde düzelmeye başladığı saptandı. Bu olgu, bize kısa dönem esrar kullanımı ile bile jinekomasti ve oligoastenospermi gelişebileceğini düşündürmektedir. We aimed to present a case with oligoasthenospermia and gynecomastia after short term use of marihuana (cannabis). Case: Thirty one years old male admitted with complaint of sensation of mass in his left breast for the last 20 days. He was using cannabis for 15 days before noticing the mass. At physical examination; he had a subareolar nontender mass in his left breast which was approximately 50 millimeters in diameter and without signs of fixation into surrounding tissue. The patient had elevated serum estradiole levels. Sperm analysis revealed decreased sperm count and loss of sperm motility. Breast sonography revealed a hypoechoic mass 45x35x25 millimeters in diameters in his left breast. Abdomi-nal and scrotal sonographic examinations were normal. To-tal excision of the defined mass revealed hypertrophic mam-mary glands with cystic dilatations of several ductal structure in a fibroadipose tissue. There was no sign of atypia and or dysplasia. Gynecomastia was diagnosed and no further treatment was planned. He was called for routine follow up. During the next one year, he did not use cannabis and gynecomastia did not reappear. His control serum estradiol levels were decreased to normal ranges. Moreover; control sperm analyses were also evaluated as nearly normal. This case suggests that even short term use of cannabis can lead to gynecomastia and oligoasthenospermia Daha fazlası Daha az

Barut F. | Onak Kandemir N. | Karakaya K. | Kökten N. | Özdamar Ş.O.

Makale | 2011 | Turkish Journal of Gastroenterology22 ( 3 ) , pp.324 - 328

Multifocal and skip involvement is quite a rare developmental pattern for primary gastrointestinal lymphomas. A 25-year-old male patient with diffuse large B-cell lymphoma of the small intestine, with macroscopic features and clinical aspects imitating Crohn's disease and attracting attention with cobblestone-like appearance, is presented herein together with the clinical and pathological features. Multiple ulcerated lesions were also observed infiltrating the serosa with polypoid appearance, 2.5 cm in largest diameter, within the resected jejunoileal specimen, which displayed patchy, healthy-appearing mucosal areas. In microscopic . . .examination, a tumoral infiltration was observed comprised of pleomorphic, atypical lymphoid cells with abundant eosinophilic cytoplasm, marked nucleoli and vesicular nuclei. A B-cell phenotype immunoreaction was observed by vimentin, LCA, CD20, and CD79a in those atypical cells. The diagnosis of the case was diffuse large B-cell lymphoma.The possibility of the presence of this disorder, although rare, is emphasized here for patients applying to the hospital with the signs and symptoms of Crohn's disease Daha fazlası Daha az

Keser, Selçuk | Bayar, Ahmet | Numanoğlu, Gamze

Makale | 2005 | Knee Surgery, Sports Traumatology, Arthroscopy13 ( 7 ) , pp.585 - 588

Lipoma is the most frequently encountered benign soft tissue tumor. However, intra-articular lipomas are rarely seen. Anterior knee pain is a frequent complaint of adults and is of diverse etiology. This 42-year-old female patient had severe anterior knee pain, unresponsive to medical treatment. Magnetic resonance imaging revealed an intra-articular tumor of the knee joint. Arthroscopic intervention and subsequent histological examination resulted in the diagnosis of strangulated lipoma originating from infrapatellar fat pad. We present clinical, radiological and operative features of this rare case of intra-articular lipoma. © Spri . . .nger-Verlag 2005 Daha fazlası Daha az