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Araştırmacılar

Autapse-induced multiple coherence resonance in single neurons and neuronal networks
Enhancement of pacemaker induced stochastic resonance by an autapse in a scale-free neuronal network
Enhancement of temporal coherence via time-periodic coupling strength in a scale-free network of stochastic Hodgkin-Huxley neurons
Vibrational resonance in a heterogeneous scale free network of neurons
Delayed feedback and detection of weak periodic signals in a stochastic Hodgkin-Huxley neuron
Collective firing regularity of a scale-free Hodgkin-Huxley neuronal network in response to a subthreshold signal
Effects of subthreshold excitation characteristics on vibrational resonance in weighted scale-free network
Simulation of Parkinsonian Basal nuclei with network motifs
Effect of channel noise and dynamic synapse structure on latency dynamics in neural system
Classification of refractive disorders from electrooculogram (EOG) signals by using data mining techniques
Effects of inhibitory autapse on the weak signal detection of Hodgkin-Huxley Neuron
Simulation of Parkinsonian Globus Pallidus Nuclei with various network motifs

Koleksiyon: Elektrik - Elektroni ... ✕Koleksiyon: Mühendislik Fakültes ... ✕Koleksiyon: Biyomedikal Mühendis ... ✕

- Mühendislik Fakültesi 49
- Elektrik - Elektronik Mühendisliği Bölümü 49
- Fakülteler 49
- Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD 49
- Scopus İndeksli Yayınlar Koleksiyonu 46
- WoS İndeksli Yayınlar Koleksiyonu 42
- Bildiri Koleksiyonu (Biyomedikal Mühendisliği Bölümü) 27
- Bildiri Koleksiyonu (Elektrik - Elektronik Mühendisliği Bölümü) 27
- Makale Koleksiyonu (Biyomedikal Mühendisliği Bölümü) 22
- Makale Koleksiyonu (Elektrik - Elektronik Mühendisliği Bölümü) 22
- Bilgisayar Mühendisliği Bölümü 6
- Bildiri Koleksiyonu (Bilgisayar Mühendisliği Bölümü) 5
- Tıp Fakültesi 4
- Cerrahi Bilimler Bölümü 4
- Bildiri Koleksiyonu (Cerrahi Bilimler Bölümü) 3
- Diğer Yayınlar Koleksiyonu (Biyomedikal Mühendisliği Bölümü) 1
- Makale Koleksiyonu (Bilgisayar Mühendisliği Bölümü) 1
- Makale Koleksiyonu (Cerrahi Bilimler Bölümü) 1 Daha fazlası Daha az

- Özer, Mahmut 43
- Uzuntarla, Muhammet 23
- Yılmaz, Ergin 22
- Çalım, Ali 16
- Baysal, Veli 13
- Kaya, Ceren 6
- Perc, Matjaž 5
- Ayar, Orhan 4
- Ağaoğlu, Şükrüye Nihal 4
- Erkaymaz, Okan 4
- Erkan, Yasemin 3
- Erkaymaz, Hande 3
- Torres, Joaquin J. 3
- İleri, Uğur 3
- Barreto, Ernest 2
- Hövel, Philipp 2
- Saraç, Zehra 2
- Uzun, Rukiye 2
- Barreto, Erenest 1
- Cressman John R. 1 Daha fazlası Daha az

- Hodgkin-Huxley neuron 4
- Vibrational resonance 4
- vibrational resonance 4
- Autapse 3
- Channel noise 3
- Scale-free network 3
- Ca2+ oscillations 2
- Direction Detect 2
- EOG 2
- FitzHugh-Nagumo 2
- H-H neuron 2
- Neuron 2
- Parkinson 2
- Stochastic resonance 2
- Synchronization 2
- Video-Oculography (VOG) 2
- autapse 2
- basal ganglia 2
- channel noise 2
- network motifs 2 Daha fazlası Daha az

- Institute of Electrical and Electronics Engineers Inc. 20
- IEEE 4
- American Physical Society 3
- Elsevier 3
- Elsevier B.V. 3
- IEEE Computer Society 3
- Elsevier Ltd 2
- Istanbul University 1
- Nature Publishing Group 1
- SPRINGER 1
- Springer Netherlands 1
- Springer Verlag 1
- TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY 1 Daha fazlası Daha az

- 2017 Medical Technologies National Conference, TIPTEKNO 2017 6
- 26th IEEE Signal Processing and Communications Applications Conference, SIU 2018 4
- Physica A: Statistical Mechanics and its Applications 4
- 2014 22nd Signal Processing and Communications Applications Conference, SIU 2014 - Proceedings 3
- 2015 23rd Signal Processing and Communications Applications Conference, SIU 2015 - Proceedings 3
- 2017 25th Signal Processing and Communications Applications Conference, SIU 2017 3
- 2016 Medical Technologies National Conference, TIPTEKNO 2016 2
- Chaos, Solitons and Fractals 2
- Physical Review E 2
- Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2
- Physics Letters, Section A: General, Atomic and Solid State Physics 2
- 2015 19TH NATIONAL BIOMEDICAL ENGINEERING MEETING (BIYOMUT) 1
- 2015 23RD SIGNAL PROCESSING AND COMMUNICATIONS APPLICATIONS CONFERENCE (SIU) 1
- 2016 24th Signal Processing and Communication Application Conference, SIU 2016 - Proceedings 1
- 2016 MEDICAL TECHNOLOGIES NATIONAL CONFERENCE (TIPTEKNO) 1
- 2017 MEDICAL TECHNOLOGIES NATIONAL CONGRESS (TIPTEKNO) 1
- Communications in Nonlinear Science and Numerical Simulation 1
- European Physical Journal B 1
- Istanbul University - Journal of Electrical and Electronics Engineering 1
- NONLINEAR DYNAMICS 1 Daha fazlası Daha az

Yılmaz, Ergin | Özer, Mahmut | Baysal, Veli | Perc, Matjaž

Article | 2016 | Scientific Reports6

We study the effects of electrical and chemical autapse on the temporal coherence or firing regularity of single stochastic Hodgkin-Huxley neurons and scale-free neuronal networks. Also, we study the effects of chemical autapse on the occurrence of spatial synchronization in scale-free neuronal networks. Irrespective of the type of autapse, we observe autaptic time delay induced multiple coherence resonance for appropriately tuned autaptic conductance levels in single neurons. More precisely, we show that in the presence of an electrical autapse, there is an optimal intensity of channel noise inducing the multiple coherence resonanc . . .e, whereas in the presence of chemical autapse the occurrence of multiple coherence resonance is less sensitive to the channel noise intensity. At the network level, we find autaptic time delay induced multiple coherence resonance and synchronization transitions, occurring at approximately the same delay lengths. We show that these two phenomena can arise only at a specific range of the coupling strength, and that they can be observed independently of the average degree of the network. © The Author(s) 2016 Daha fazlası Daha az

Yılmaz, Ergin | Baysal, Veli | Perc, Matjaž | Özer, Mahmut

Article | 2016 | Science China Technological Sciences59 ( 3 ) , pp.364 - 370

An autapse is an unusual synapse that occurs between the axon and the soma of the same neuron. Mathematically, it can be described as a self-delayed feedback loop that is defined by a specific time-delay and the so-called autaptic coupling strength. Recently, the role and function of autapses within the nervous system has been studied extensively. Here, we extend the scope of theoretical research by investigating the effects of an autapse on the transmission of a weak localized pacemaker activity in a scale-free neuronal network. Our results reveal that by mediating the spiking activity of the pacemaker neuron, an autapse increases . . .the propagation of its rhythm across the whole network, if only the autaptic time delay and the autaptic coupling strength are properly adjusted. We show that the autapse-induced enhancement of the transmission of pacemaker activity occurs only when the autaptic time delay is close to an integer multiple of the intrinsic oscillation time of the neurons that form the network. In particular, we demonstrate the emergence of multiple resonances involving the weak signal, the intrinsic oscillations, and the time scale that is dictated by the autapse. Interestingly, we also show that the enhancement of the pacemaker rhythm across the network is the strongest if the degree of the pacemaker neuron is lowest. This is because the dissipation of the localized rhythm is contained to the few directly linked neurons, and only afterwards, through the secondary neurons, it propagates further. If the pacemaker neuron has a high degree, then its rhythm is simply too weak to excite all the neighboring neurons, and propagation therefore fails. © 2016, Science China Press and Springer-Verlag Berlin Heidelberg Daha fazlası Daha az

Yılmaz, Ergin | Baysal, Veli | Özer, Mahmut

Article | 2015 | Physics Letters, Section A: General, Atomic and Solid State Physics379 ( 26-27 ) , pp.1594 - 1599

We investigate the effects of time-periodic coupling strength on the temporal coherence or firing regularity of a scale-free network consisting of stochastic Hodgkin-Huxley (H-H) neurons. The temporal coherence exhibits a resonance-like behavior depending on the cell size or the channel noise intensity. The best temporal coherence requires an optimal channel noise intensity, and this coherence can be significantly increased by time-periodic coupling strength when its frequency matches the integer multiples of the intrinsic subthreshold oscillation frequency of H-H neuron. Particularly, we find the multiple-coherence resonance depend . . .ing on frequency of time-periodic coupling strength at the optimal noise intensity. We also obtain a resonance-like dependence of temporal coherence on the amplitude of time-periodic coupling strength. Additionally, we investigate the effects of average degree on the temporal coherence and find that the temporal coherence exhibits a resonance-like behavior with respect to the network average degree, indicating that the best regularity requires an optimal average degree. © 2015 Elsevier B.V. All rights reserved Daha fazlası Daha az

Uzuntarla, Muhammet | Yılmaz, Ergin | Wagemakers, Alexandre | Özer, Mahmut

Article | 2015 | Communications in Nonlinear Science and Numerical Simulation22 ( 01.Mar ) , pp.367 - 374

Vibrational resonance (VR) is a phenomenon whereby the response of some dynamical systems to a weak low-frequency signal can be maximized with the assistance of an optimal intensity of another high-frequency signal. In this paper, we study the VR in a heterogeneous neural system having a complex network topology. We consider a scale-free network of neurons where the heterogeneity is in the intrinsic excitability of the individual neurons. It is shown that emergence of VR in heterogeneous neuron population requires less energy than a homogeneous population. We also find that electrical coupling strength among neurons plays a key role . . . in determining the weak signal processing capacity of the heterogeneous population. Lastly, we investigate the influence of interneuronal link density on the VR and demonstrate that the energy needed to obtain the resonance grows with the increase in average degree. © 2014 Elsevier B.V Daha fazlası Daha az

Yılmaz, Ergin | Özer, Mahmut

Article | 2015 | Physica A: Statistical Mechanics and its Applications421 , pp.455 - 462

We study the effect of the delayed feedback loop on the weak periodic signal detection performance of a stochastic Hodgkin-Huxley neuron. We consider an electrical autapse characterized by its coupling strength and delay time. The stochastic Hodgkin-Huxley neuron exhibits subthreshold oscillations, and thus has an intrinsic time scale with the subthreshold oscillations. Therefore, we investigate the interplay of the subthreshold oscillations, coupling strength and delay time on the weak periodic signal detection. Results indicate that the delayed feedback either enhances or suppresses the weak signal detection depending on its param . . .eters, when compared to that without the feedback. The delayed feedback augments the weak periodic signal detection for the optimal values of the intrinsic noise and the coupling strength when the delay time is close to the integer multiples of the period of the intrinsic oscillations, due to the multiple resonance among the weak signal, the intrinsic oscillations, and the delayed feedback. We analyze the interspike interval histograms and show that the delayed feedback enhances or suppresses the weak periodic signal detection by increasing or decreasing the phase locking (synchronization) between the spiking and the weak periodic signal. We also show that an optimal phase locking is obtained when the delay time is close to the period of the intrinsic oscillations, leading a single dominant time scale in the spike trains. © 2014 Elsevier B.V. All rights reserved Daha fazlası Daha az

Yılmaz, Ergin | Özer, Mahmut

Article | 2013 | Physics Letters, Section A: General, Atomic and Solid State Physics377 ( 18 ) , pp.1301 - 1307

We consider a scale-free network of stochastic HH neurons driven by a subthreshold periodic stimulus and investigate how the collective spiking regularity or the collective temporal coherence changes with the stimulus frequency, the intrinsic noise (or the cell size), the network average degree and the coupling strength. We show that the best temporal coherence is obtained for a certain level of the intrinsic noise when the frequencies of the external stimulus and the subthreshold oscillations of the network elements match. We also find that the collective regularity exhibits a resonance-like behavior depending on both the coupling . . .strength and the network average degree at the optimal values of the stimulus frequency and the cell size, indicating that the best temporal coherence also requires an optimal coupling strength and an optimal average degree of the connectivity. © 2013 Elsevier B.V Daha fazlası Daha az

Ağaoğlu, Şükrüye Nihal | Özer, Mahmut | Çalım, Ali | Uzuntarla, Muhammet

Proceedings | 2017 | 2017 25th Signal Processing and Communications Applications Conference, SIU 2017 , pp.1301 - 1307

In this paper, the phenomena of Vibrational Resonance is investigated in an excitable system which consists of FitzHugh-Nagumo neurons with electrical coupling. Weak signal detection performance of excitable system is examined in scale-free network (unweighted or weighted) topology. The simulation results show that; weighting the scale-free network, average connectivity degree, amplitude and frequency of weak signal play an active role to determine the data carrying performance of neurons based on Vibrational Resonance. It is determined that, the amount of required energy for creating resonance peaks of excitable system is decreased . . . significantly by choosing the correct value of weight control parameter in a weighted network especially. © 2017 IEEE Daha fazlası Daha az

Çalım, Ali | Özer, Mahmut | Uzuntarla, Muhammet

Proceedings | 2017 | 2017 25th Signal Processing and Communications Applications Conference, SIU 2017 , pp.1301 - 1307

Nowadays, neurodegenerative diseases which affect human life quite negatively with motor, cognitive and psychiatric disorders are becoming widespread. One of the most common neurodegenerative disorder is Parkinson's disease. Recent electrophysiological experiments have shown that Basal Ganglia, a special region in the midbrain, is related to Parkinsonism. Beta frequency oscillations, which are important symptoms of Parkinson's disease, emerge intensively in Globus Pallidus and Subtalamus nuclei. In this study, anatomical connections of Globus Pallidus and Subtalamus are constructed computationally, and the cellular properties that g . . .ive rise to emergence of beta oscillations are investigated. © 2017 IEEE Daha fazlası Daha az

Çalım, Ali | Özer, Mahmut | Uzuntarla, Muhammet

Proceedings | 2018 | 26th IEEE Signal Processing and Communications Applications Conference, SIU 2018 , pp.1 - 4

Experimental and theoretical studies in recent years suggest that the first spike latency is an effective information carrier and contains more neural information than other spikes. Noise Delayed Decay (NDD) phenomenon emerges when the first spike latency of the neuron exposed to the periodic driving is maximum at a certain noise intensity interval. In this study, the latency dynamics of a single Hodgkin-Huxley neuron is investigated under periodic driving, background activity through dynamic synapses, and channel noise. The system response with first spike latency is investigated as a function of the presynaptic firing rate, the pa . . .rameter with an appropriate biophysical reality to control the level of activity in the nervous system. First, NDD behavior is investigated under suprathreshold stimulation in the presence of synapses at different levels of depression and channel noise. It is then desired to observe the NDD phenomenon under subthreshold stimulation with the same strategy. Our results have shown that the background activity occurring in the presence of dynamic synapses and the channel noise are significant system dynamics in observing the NDD behavior. © 2018 IEEE Daha fazlası Daha az

Kaya, Ceren | Erkaymaz, Okan | Ayar, Orhan | Özer, Mahmut

Proceedings | 2018 | 26th IEEE Signal Processing and Communications Applications Conference, SIU 2018 , pp.1 - 4

Refractive disorders are common health problems in the community and they are the most important cause of visual impairment. In this study, it was aimed to classify the individuals who have hypermetropia and myopia refractive disorders or not. For this, horizontal and vertical Electrooculogram (EOG) signal data from the right and left eyes of the individuals were used. The performance of the data was investigated by using Logistic Regression (LR), Naive Bayes (NB), Random Forest (RF) and REP Tree (RT) data mining methods. According to the obtained results, REP Tree method has shown the most successful classification performance to d . . .etect hypermetropia and myopia refractive disorders from Electrooculogram (EOG) signals. © 2018 IEEE Daha fazlası Daha az

Baysal, Veli | Özer, Mahmut | Yılmaz, Ergin

Proceedings | 2017 | 2017 Medical Technologies National Conference, TIPTEKNO 20172017-January , pp.1 - 4

In this paper, the effects of autapse (a kind of synapse formed between the axon or soma of a neuron and its own dendrites) on the weak signal detection capacity of a Hodgkin-Huxley (H-H) neuron are investigated. In the study, we consider that the H-H neuron has an inhibitory autapse modeled as a chemical synapse. The subthreshold sine wave is injected to the H-H neuron as a weak signal. Obtained results indicate that inhibitory autapse prominently increases the weak signal detection capacity of a H-H neuron when the proper autaptic time delay and autaptic conductance values are choosen. © 2017 IEEE.

Çalım, Ali | Özer, Mahmut | Uzuntarla, Muhammet

Proceedings | 2017 | 2017 Medical Technologies National Conference, TIPTEKNO 20172017-January , pp.1 - 4

Parkinson's disease is a neurodegenerative disorder that affect human life quite negatively with motor, cognitive and psychiatric way. Recent electrophysiological experiments have shown that Basal Ganglia, spaced in the midbrain, can lead to Parkinsonism. Beta frequency oscillations and irregular burstings are most important symptoms of Parkinson's disease. They appear in Globus Pallidus and Subtalamus nuclei during the disease. In this study, anatomical connection features that may give rise to emergence of burstings are investigated, simulating Globus Pallidus and Subtalamus nuclei numerically. © 2017 IEEE.

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