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Araştırmacılar

Autapse-induced multiple coherence resonance in single neurons and neuronal networks
Enhancement of pacemaker induced stochastic resonance by an autapse in a scale-free neuronal network
Performance of small-world feedforward neural networks for the diagnosis of diabetes
Early prediction of paroxysmal atrial fibrillation based on short-term heart rate variability
Stochastic resonance on Newman-Watts networks of Hodgkin-Huxley neurons with local periodic driving
Weak signal propagation through noisy feedforward neuronal networks
Controlling the spontaneous spiking regularity via channel blocking on Newman-Watts networks of Hodgkin-Huxley neurons
Can scale-freeness offset delayed signal detection in neuronal networks?
Stochastic resonance in hybrid scale-free neuronal networks
Autaptic pacemaker mediated propagation of weak rhythmic activity across small-world neuronal networks
Noise-delayed decay in the response of a scale-free neuronal network
Multi-stage classification of congestive heart failure based on short-term heart rate variability

- Mühendislik Fakültesi 13
- Elektrik - Elektronik Mühendisliği Bölümü 13
- Fakülteler 13
- Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD 13
- Makale Koleksiyonu (Elektrik - Elektronik Mühendisliği Bölümü) 13
- Scopus İndeksli Yayınlar Koleksiyonu 13
- WoS İndeksli Yayınlar Koleksiyonu 13
- Biyomedikal Mühendisliği Bölümü 5
- Makale Koleksiyonu (Biyomedikal Mühendisliği Bölümü) 5
- Bilgisayar Mühendisliği Bölümü 1
- Bildiri Koleksiyonu (Elektrik - Elektronik Mühendisliği Bölümü) 1
- Makale Koleksiyonu (Bilgisayar Mühendisliği Bölümü) 1 Daha fazlası Daha az

- Genetic algorithm 2
- Heart rate variability 2
- Ion channel noise 2
- Neuronal dynamics 2
- Pacemaker 2
- Small-world network 2
- Stochastic resonance 2
- Autapse 1
- Congestive heart failure 1
- Diabetes 1
- Early prediction 1
- Feedforward network 1
- Feedforward neural network 1
- First spike 1
- Frequency-domain measure 1
- Hodgkin-Huxley neurons 1
- Hybrid synapses 1
- Multi-stage classifier 1
- Newman–Watts model 1
- Nonlinear variability 1 Daha fazlası Daha az

- Physica A: Statistical Mechanics and its Applications 3
- Chaos, Solitons and Fractals 2
- EPL 2
- Applied Mathematics and Computation 1
- Journal of Theoretical Biology 1
- NeuroReport 1
- Physics Letters, Section A: General, Atomic and Solid State Physics 1
- Science China Technological Sciences 1
- Scientific Reports 1 Daha fazlası Daha az

Yılmaz, Ergin | Özer, Mahmut | Baysal, Veli | Perc, Matjaž

Article | 2016 | Scientific Reports6

We study the effects of electrical and chemical autapse on the temporal coherence or firing regularity of single stochastic Hodgkin-Huxley neurons and scale-free neuronal networks. Also, we study the effects of chemical autapse on the occurrence of spatial synchronization in scale-free neuronal networks. Irrespective of the type of autapse, we observe autaptic time delay induced multiple coherence resonance for appropriately tuned autaptic conductance levels in single neurons. More precisely, we show that in the presence of an electrical autapse, there is an optimal intensity of channel noise inducing the multiple coherence resonanc . . .e, whereas in the presence of chemical autapse the occurrence of multiple coherence resonance is less sensitive to the channel noise intensity. At the network level, we find autaptic time delay induced multiple coherence resonance and synchronization transitions, occurring at approximately the same delay lengths. We show that these two phenomena can arise only at a specific range of the coupling strength, and that they can be observed independently of the average degree of the network. © The Author(s) 2016 Daha fazlası Daha az

Yılmaz, Ergin | Baysal, Veli | Perc, Matjaž | Özer, Mahmut

Article | 2016 | Science China Technological Sciences59 ( 3 ) , pp.364 - 370

An autapse is an unusual synapse that occurs between the axon and the soma of the same neuron. Mathematically, it can be described as a self-delayed feedback loop that is defined by a specific time-delay and the so-called autaptic coupling strength. Recently, the role and function of autapses within the nervous system has been studied extensively. Here, we extend the scope of theoretical research by investigating the effects of an autapse on the transmission of a weak localized pacemaker activity in a scale-free neuronal network. Our results reveal that by mediating the spiking activity of the pacemaker neuron, an autapse increases . . .the propagation of its rhythm across the whole network, if only the autaptic time delay and the autaptic coupling strength are properly adjusted. We show that the autapse-induced enhancement of the transmission of pacemaker activity occurs only when the autaptic time delay is close to an integer multiple of the intrinsic oscillation time of the neurons that form the network. In particular, we demonstrate the emergence of multiple resonances involving the weak signal, the intrinsic oscillations, and the time scale that is dictated by the autapse. Interestingly, we also show that the enhancement of the pacemaker rhythm across the network is the strongest if the degree of the pacemaker neuron is lowest. This is because the dissipation of the localized rhythm is contained to the few directly linked neurons, and only afterwards, through the secondary neurons, it propagates further. If the pacemaker neuron has a high degree, then its rhythm is simply too weak to excite all the neighboring neurons, and propagation therefore fails. © 2016, Science China Press and Springer-Verlag Berlin Heidelberg Daha fazlası Daha az

Erkaymaz, Okan | Özer, Mahmut | Perc, Matjaž

Article | 2017 | Applied Mathematics and Computation311 , pp.22 - 28

We investigate the performance of two different small-world feedforward neural networks for the diagnosis of diabetes. We use the Pima Indians Diabetic Dataset as input. We have previously shown than the Watts–Strogatz small-world feedforward neural network delivers a better classification performance than conventional feedforward neural networks. Here, we compare this performance further with the one delivered by the Newman–Watts small-world feedforward neural network, and we show that the latter is better still. Moreover, we show that Newman–Watts small-world feedforward neural networks yield the highest output correlation as well . . . as the best output error parameters. © 2017 Elsevier Inc Daha fazlası Daha az

Narin, Ali | İşler, Yalçın | Özer, Mahmut | Perc, Matjaž

Article | 2018 | Physica A: Statistical Mechanics and its Applications509 , pp.56 - 65

Atrial fibrillation (AF) is the most common arrhythmia type and its early stage is paroxysmal atrial fibrillation (PAF). PAF affects negatively the quality of life by causing dyspnea, chest pain, feeling of excessive fatigue, and dizziness. In this study, our aim is to predict the onset of paroxysmal atrial fibrillation (PAF) events so that patients can take precautions to prevent PAF events. We use an open data from Physionet, Atrial Fibrillation Prediction Database. We construct our approach based on the heart rate variability (HRV) analysis. Short-term HRV analysis requires 5-minute data so that each dataset was divided into 5-mi . . .nute data segments. HRV features for each segment are calculated from time-domain measures and frequency-domain measures using power spectral density estimations of fast Fourier transform, Lomb–Scargle, and wavelet transform methods. Different combinations of these HRV features are selected by Genetic Algorithm and then applied to k-nearest neighbors classification algorithm. We compute the classifier performances by the 10-fold cross-validation method. The proposed approach results in 92% sensitivity, 88% specificity and 90% accuracy in the 2.5–7.5 min time interval priors to PAF event. The proposed method results in better classification performance than the similar studies in literature. Comparing the existing studies, we propose that our approach provide better tool to predict PAF events. © 2018 Elsevier B.V Daha fazlası Daha az

Özer, Mahmut | Perc, Matjaž | Uzuntarla, Muhammet

Article | 2009 | Physics Letters, Section A: General, Atomic and Solid State Physics373 ( 10 ) , pp.964 - 968

We study the phenomenon of stochastic resonance on Newman-Watts small-world networks consisting of biophysically realistic Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise via voltage-gated ion channels embedded in neuronal membranes. Importantly thereby, the subthreshold periodic driving is introduced to a single neuron of the network, thus acting as a pacemaker trying to impose its rhythm on the whole ensemble. We show that there exists an optimal intensity of intrinsic ion channel noise by which the outreach of the pacemaker extends optimally across the whole network. This stochastic resonance phenomenon can be . . .further amplified via fine-tuning of the small-world network structure, and depends significantly also on the coupling strength among neurons and the driving frequency of the pacemaker. In particular, we demonstrate that the noise-induced transmission of weak localized rhythmic activity peaks when the pacemaker frequency matches the intrinsic frequency of subthreshold oscillations. The implications of our findings for weak signal detection and information propagation across neural networks are discussed. © 2009 Elsevier B.V. All rights reserved Daha fazlası Daha az

Özer, Mahmut | Perc, Matjaž | Uzuntarla, Muhammet | Koklukaya, Etem

Article | 2010 | NeuroReport21 ( 5 ) , pp.338 - 343

We determine under which conditions the propagation of weak periodic signals through a feedforward Hodgkin-Huxley neuronal network is optimal. We find that successive neuronal layers are able to amplify weak signals introduced to the neurons forming the first layer only above a certain intensity of intrinsic noise. Furthermore, we show that as low as 4% of all possible interlayer links are sufficient for an optimal propagation of weak signals to great depths of the feedforward neuronal network, provided the signal frequency and the intensity of intrinsic noise are appropriately adjusted. © 2010 Wolters Kluwer Health | Lippincott Wil . . .liams & Wilkins Daha fazlası Daha az

Özer, Mahmut | Perc, Matjaž | Uzuntarla, Muhammet

Article | 2009 | EPL86 ( 4 ) , pp.338 - 343

We investigate the regularity of spontaneous spiking activity on Newman-Watts small-world networks consisting of biophysically realistic Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise and fraction of blocked voltage-gated sodium and potassium ion channels embedded in neuronal membranes. We show that there exists an optimal fraction of shortcut links between physically distant neurons, as well as an optimal intensity of intrinsic noise, which warrant an optimally ordered spontaneous spiking activity. This doubly coherence resonance-like phenomenon depends significantly on, and can be controlled via, the fraction o . . .f closed sodium and potassium ion channels, whereby the impacts can be understood via the analysis of the firing rate function as well as the deterministic system dynamics. Potential biological implications of our findings for information propagation across neural networks are also discussed. © EPLA, 2009 Daha fazlası Daha az

Uzun, Rukiye | Özer, Mahmut | Perc, Matjaž

Article | 2014 | EPL105 ( 6 ) , pp.338 - 343

First-spike latency following stimulus onset is of significant physiological relevance. Neurons transmit information about their inputs by transforming them into spike trains, and the timing of these spike trains is in turn crucial for effectively encoding that information. Random processes and uncertainty that underly neuronal dynamics have been shown to prolong the time towards the first response in a phenomenon dubbed noise-delayed decay. Here we study whether Hodgkin-Huxley neurons with a tunable intensity of intrinsic noise might have shorter response times to external stimuli just above threshold if placed on a scale-free netw . . .ork. We show that the heterogeneity of the interaction network may indeed eradicate slow responsiveness, but only if the coupling between individual neurons is sufficiently strong. Increasing the average degree also favors a fast response, but it is less effective than increasing the coupling strength. We also show that noise-delayed decay can be offset further by adjusting the frequency of the external signal, as well as by blocking a fraction of voltage-gated sodium or potassium ion channels. For certain conditions, we observe a double peak in the response time depending on the intensity of intrinsic noise, indicating competition between local and global effects on the neuronal dynamics. © Copyright EPLA, 2014 Daha fazlası Daha az

Yılmaz, Ergin | Uzuntarla, Muhammet | Özer, Mahmut | Perc, Matjaž

Article | 2013 | Physica A: Statistical Mechanics and its Applications392 ( 22 ) , pp.5735 - 5741

We study the phenomenon of stochastic resonance in a system of coupled neurons that are globally excited by a weak periodic input signal. We make the realistic assumption that the chemical and electrical synapses interact in the same neuronal network, hence constituting a hybrid network. By considering a hybrid coupling scheme embedded in the scale-free topology, we show that the electrical synapses are more efficient than chemical synapses in promoting the best correlation between the weak input signal and the response of the system. We also demonstrate that the average degree of neurons within the hybrid scale-free network signifi . . .cantly influences the optimal amount of noise for the occurrence of stochastic resonance, indicating that there also exists an optimal topology for the amplification of the response to the weak input signal. Lastly, we verify that the presented results are robust to variations of the system size. © 2013 Elsevier B.V. All rights reserved Daha fazlası Daha az

Yılmaz, Ergin | Baysal, Veli | Özer, Mahmut | Perc, Matjaž

Article | 2016 | Physica A: Statistical Mechanics and its Applications444 , pp.538 - 546

We study the effects of an autapse, which is mathematically described as a self-feedback loop, on the propagation of weak, localized pacemaker activity across a Newman-Watts small-world network consisting of stochastic Hodgkin-Huxley neurons. We consider that only the pacemaker neuron, which is stimulated by a subthreshold periodic signal, has an electrical autapse that is characterized by a coupling strength and a delay time. We focus on the impact of the coupling strength, the network structure, the properties of the weak periodic stimulus, and the properties of the autapse on the transmission of localized pacemaker activity. Obta . . .ined results indicate the existence of optimal channel noise intensity for the propagation of the localized rhythm. Under optimal conditions, the autapse can significantly improve the propagation of pacemaker activity, but only for a specific range of the autaptic coupling strength. Moreover, the autaptic delay time has to be equal to the intrinsic oscillation period of the Hodgkin-Huxley neuron or its integer multiples. We analyze the inter-spike interval histogram and show that the autapse enhances or suppresses the propagation of the localized rhythm by increasing or decreasing the phase locking between the spiking of the pacemaker neuron and the weak periodic signal. In particular, when the autaptic delay time is equal to the intrinsic period of oscillations an optimal phase locking takes place, resulting in a dominant time scale of the spiking activity. We also investigate the effects of the network structure and the coupling strength on the propagation of pacemaker activity. We find that there exist an optimal coupling strength and an optimal network structure that together warrant an optimal propagation of the localized rhythm. © 2015 Elsevier B.V. All rights reserved Daha fazlası Daha az

Uzuntarla, Muhammet | Uzun, Rukiye | Yılmaz, Ergin | Özer, Mahmut | Perc, Matjaž

Article | 2013 | Chaos, Solitons and Fractals56 , pp.202 - 208

Noise-delayed decay occurs when the first-spike latency of a periodically forced neuron exhibits a maximum at particular noise intensity. Here we investigate this phenomenon at the network level, in particular by considering scale-free neuronal networks, and under the realistic assumption of noise being due to the stochastic nature of voltage-gated ion channels that are embedded in the neuronal membranes. We show that noise-delayed decay can be observed at the network level, but only if the synaptic coupling strength between the neurons is weak. In case of strong coupling or in a highly interconnected population the phenomenon vanis . . .hes, thus indicating that delays in signal detection can no longer be resonantly prolonged by noise. We also find that potassium channel noise plays a more dominant role in the occurrence of noise-delayed decay than sodium channel noise, and that poisoning the neuronal membranes may weakens or intensify the phenomenon depending on targeting. © 2013 Elsevier Ltd. All rights reserved Daha fazlası Daha az

İşler, Yalçın | Narin, Ali | Özer, Mahmut | Perc, Matjaž

Article | 2019 | Chaos, Solitons and Fractals118 , pp.145 - 151

In this study, we propose an automatic system to diagnose congestive heart failure using short-term heart rate variability analysis. The system involves a multi-stage classifier. The features of heart rate variability are computed from time-domain and frequency-domain measures through power spectral density estimations of different transform methods. Nonlinear heart rate variability measures are also calculated by using Poincare plot, symbolic dynamics, detrended fluctuation analysis, and sample entropy. Different combinations of heart rate variability features are selected according to their statistical significance levels and then . . . applied to the classifier. The first two stages of the classifier consist of simple perceptron classifiers that are trained by a genetic algorithm. Five different classifiers, namely k-nearest neighbors, linear discriminant analyses, multilayer perceptron, support vector machines, and radial basis function artificial neuronal network, are tested for the third stage. The proposed system results in a classification performance of an accuracy of 98.8%, specificity of 98.1%, and sensitivity of 100%. We show that our approach provides an effective and computationally efficient tool to automatically diagnose congestive heart failure patients. © 2018 Elsevier Lt Daha fazlası Daha az

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