Kandemir N.O. | Bektaş S. | Yurdakan G. | Taş E.

Article | 2009 | Turk Onkoloji Dergisi24 ( 2 ) , pp.80 - 84

Benign osteoclast-like multinuclear giant cells are rarely found in tumors other than bone and soft tissue neoplasms, and they are even rarer in squamous cell carcinomas. We examined a nasopharyngeal tumor from a 52-year-old female who had undergone surgery one year earlier for hypopharyngeal squamous cell carcinoma. Histopathologically, in addition to tumor infiltration by atypical epithelial cells with squamoid differentiation, giant cells with 10-20 nuclei and a large amount of eosinophilic cytoplasm were seen infiltrating the tumor. The giant cells did not show atypia or mitosis. Immunohistochemically, the tumor cells stained fo . . .r pan-keratin and epithelial membrane antigen, and the giant cells were positive for leukocyte common antigen, CD68, and Mac 387. This case was diagnosed as moderately differentiated squamous cell carcinoma with multinuclear giant cells. In this case, the giant cells infiltrating the tumor were benign and of monocytic/histiocytic origin. Studies including large case series are needed to obtain reliable information on the clinical and prognostic importance of this histological feature Daha fazlası Daha az

Onak Kandemir N. | Barut F. | Keser S. | Karadayi N. | Bektaş S. | Dogan Gün B. | Bahadir B.

Article | 2009 | Turk Onkoloji Dergisi24 ( 4 ) , pp.172 - 176

OBJECTIVES This study examined the frequency of chronic lymphocytic thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and the relationship between the presence of tumor-infiltrating lymphocytes (TIL) and CLT. METHODS The study included 61 TPC cases. In each case, the presence of the lymphocyte infiltration in the tumor tissue and non-neoplastic parenchyma was graded semi-quantitatively using a scale of 0 to 3. The cases were classified in two groups, TPC including CLT (Group I) and TPC not including CLT (Group II). RESULTS CLT was detected in 26.3% (Group I) of the TPCs and TIL was observed in 77% of the Group I cases; no lymp . . .hoid infiltration compatible with TIL was detected in Group II. A significant difference was observed in the TIL density between Groups I and II. CONCLUSION CLT is a frequent finding in TPC, and the presence of TIL is related to CLT. © 2009 Association of Oncology Daha fazlası Daha az

Onak Kandemir N. | Bektaş S. | Barut F. | Bahadir B. | Yurdakan G. | Dogan Gun B. | Mungan A.

Article | 2010 | Turk Onkoloji Dergisi25 ( 2 ) , pp.49 - 56

OBJECTIVES: The contribution of cytological methods to the diagnosis and follow-up of urinary system malignancies was investigated in this study, along with histological diagnosis and clinical follow-up results of the cases. METHODS: One hundred forty-four cases who underwent cystoscopy in ZKÜTF Urology Department between 2003 and 2007 were included in this study, and urinary cytology and biopsy samples were assessed in the Pathology Department. RESULTS: When cytological and histological diagnoses were compared, results in 17 positive cases and in 109 negative cases were consistent. Three cases were false-positive and 15 cases were . . .false-negative. In our series, sensitivity of urinary cytological diagnostic methods was 53% and specificity was 97%. CONCLUSION: Our study shows that urinary cytology has a high diagnostic value in the evaluation of urinary system diseases. However, decrease in the sensitivity of this method in low-grade urothelial tumors should be taken into account. © 2010 Association of Oncology Daha fazlası Daha az

Barut F. | Özdamar Ş.O. | Bektaş S. | Taşcilar Ö. | Dogan Gün B.

Article | 2010 | Turk Onkoloji Dergisi25 ( 4 ) , pp.161 - 164

The oncocytic variant of papillary thyroid carcinoma is an uncommon form of neoplasm, the clinicopathological features and biological behavior of which have not been precisely defined. The pattern of multifocal growth is an uncommon feature. The case was a 64-year-old female patient with multinodular goiter who had undergone total thyroidectomy. Microscopic examination of cross-sections of the multiple nodules revealed a tumoral lesion characterized by a predominant follicular growth pattern, and sparse, small, abortive papillary structures. Most of the tumor cells also displayed the classical nuclear features of papillary carcinoma . . ., like optically clear nuclei, overlapping of the nuclei, irregular nuclear membranes, and sparse nucleoli. Prominent nuclear grooves and intranuclear pseudoinclusions were seen in many of the neoplastic cells. Due to the presence of the characteristic nuclear features, the diagnosis was papillary carcinoma. The oncocytic variant of papillary carcinoma, although rare, appears to represent a morphologically distinctive variant of papillary cancer. © 2010 Onkoloji Dernegi - © 2010 Association of Oncology Daha fazlası Daha az

Barut F. | Özdamar S.O. | Dogan Gün B. | Bahadir B. | Bektaş S.

Article | 2011 | Turk Onkoloji Dergisi26 ( 2 ) , pp.76 - 81

Merkel cell carcinoma is an uncommon tumor arising usually on the sun-exposed skin of elderly individuals. A 64-year-old male patient, who undergone total laryngectomy operation seven years ago because of squamous cell carcinoma of larynx and got postoperative radiotherapy applied to the hospital with a subcostal mass. Histopathologic examination of the mass revealed tumoral infltration with cytokeratin-20 expression that forming sheets and solid nests in subcutaneous tissue. The diagnosis was Merkel cell carcinoma. A vegetative tumor located in left main bronchi was observed during synchronously performed bronchoscopy and multiple . . .biopsies were taken. Histopathologic diagnosis was pulmonary small cell carcinoma displaying positive reaction with thyroid transcription fac-tor-1 without cytokeratin-20 expression. It's extremely rare to encounter Merkel cell carcinoma coexisting with pulmonary small cell carcinoma. The current case has special importance due to being an extremely rare encountered tumor besides con-frming these markers' reliability in distinguishing Merkel cell carcinoma from pulmonary small cell carcinoma. © 2011 Association of Oncology Daha fazlası Daha az

Onak Kandemir N. | Barut F. | Yurdakan G. | Doğan Gün B. | Birol İ.E. | Özdamar Ş.O.

Article | 2017 | Turk Onkoloji Dergisi32 ( 4 ) , pp.165 - 168

Kaposi’s sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstit . . .ial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literature. © 2017, Turkish Society for Radiation Oncology Daha fazlası Daha az