Özdamar, Şükrü Oğuz | Gün, Banu Doğan | Barut, Figen | Bahadır, Burak

Article | 2007 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI27 ( 1 ) , pp.16 - 20

Objective: Traumatic neuroma is an exuberant, probably nonneoplastic proliferation of a nerve occurring in response to injury or surgery. We studied six cases of traumatic neuroma with light microscopic, histochemical and immunohistochemical methods to assess the cellular compositions of these lesions. Material and Methods: Sections from the formalin-fixed parafin-embedded tissues were stained with hematoxylin-eosin, Gomori's trichrome, Verhoeff elastica-von Gieson, reticuline, and S-100 protein, Epithelial Membrane Antigen, CD34 and CD68. Results: All cases revealed large numbers of small and haphazardly arranged regenerating nerve . . . fascicles within a densely collagenous and fibroblastic stroma. A focal chronic mononuclear cell inflammatory reaction was observed in three cases. In all cases, Gomori's trichrome revealed collagen. Axonal morphology was detected in nerve fibers histochemically by reticulin. In all cases, fascicles were stained diffusely with S-100 protein, and Epithelial Membrane Antigen showed a positive reaction in a thin band of cells surrounding the fascicles in three of the cases. CD34 positive cells were present in five cases. CD68 expressing cells were present in only in two specimens. Conclusion: In traumatic neuromas, specific staining of fascicles with S-100 protein, perineural cells reactive for Epithelial Membrane Antigen and the presence of CD34 positive cells may contribute to our understanding of their pathogenesis and differentiation of these lesions from mimickers Daha fazlası Daha az

Barut, Figen | Bektaş, Sibel | Gün, Banu Doğan | Bahadır, Burak | Özdamar, Şükrü Oğuz

Article | 2011 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI31 ( 2 ) , pp.321 - 327

WOS: 000291330700006

Barut, Figen | Özdamar, Şükrü Oğuz | Bahadır, Burak | Gün, Banu Doğan | Bektaş, Sibel | Çolak, Sacide | Kuzey, Gamze Mocan

Article | 2007 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI27 ( 2 ) , pp.179 - 183

Objective: Bronchoalveolar lavage performed during bronchoscopic examination is a type of cytologic sampling with great diagnostic significance. Its diagnostic value is enhanced when biopsy is unavailable and bronchoalveolar lavage is the unique sample. Determining the diagnostic accuracy of bronchoalveolar lavage by comparing it with the diagnostic yield of synchronous biopsies is an indicator of its effectiveness. Material and Methods: In this study, 435 bronchoalveolar lavage and 273 bronchoscopic biopsy specimens obtained from January 2003 to December 2005 in the Department of Pulmonary Diseases were retrospectively evaluated in . . . the Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University. Results: Overall, 373 cases (85.8%) were diagnosed as benign and 12 cases (2.8%) were reported as malignant, while IS cases (4.1%) were suspected to be malignant; the remaining 32 cases (7.3%) were reported as inadequate. The numbers and percentages of benign, malignant, suspected malignant and inadequate diagnoses of the 273 bronchoalveolar lavage cases with synchronous transbronchial biopsies were 229 (83.9%), 12 (4.5%), 16 (5.8%), and 16 (5.8%), respectively. After suspected malignant and inadequate samples were excluded, coomparison of cytologic and histologic diagnoses revealed that the diagnostic accuracy of bronchoalveolar lavage cytology was 79.4% and 91.6% for benign and malignant diagnoses, respectively; the rate of false negativity was 20.5% and false positivity was 8.3%. Conclusion: While sampling errors seemed to be the primary reason for false negative and false positive diagnoses, the rate of false cytologic evaluation was lower. Considering the false negative diagnoses for cases without biopsy specimens, comparison of bronchoalveolar lavage diagnoses with synchronous biopsies may serve as a quality control programme, since this condition may significantly influence the clinical course Daha fazlası Daha az

Gül, Şanser | Bahadır, Burak | Kalaycı, Murat | Ankaralı, Handan | Erdem, Oktay | Karakaya, Kemal | Açıkgöz, Bektaş

Article | 2011 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI31 ( 2 ) , pp.390 - 396

Objective: The influence of Ankaferd Blood Stopper (R) (ABS) was experimentally investigated on calvarial defects in rats. Material and Methods: Fourteen Wistar-albino rats equally divided into two groups, control group (G1) and drug group (G2), were included in the study. In G1, only right frontal craniectomy was performed. In G2, 0.5ml ABS was topically applied with a syringe after craniectomy. Surface areas of the defects were measured after four weeks, and comparative reconstruction images with were obtained, computed tomography (CT) as well. Blood samples were also collected to evaluate prothrombin time (PT), international norm . . .alized ratio (INR) and activated partial thromboplastin time (aPTT), and tissue samples were harvested for histologic examination. Results: Mean defect area in G1 (7.20 +/- 2.62 mm(2)) was significantly larger than that in G2 (1.83 +/- 1.65 mm(2)) (p0.05). Three dimensional (3D) CT analysis and histological examination revealed prominent osteogenesis in G2. Conclusion: We observed that surface area of the calvarial defects decreased significantly after ABS administration, and this observation was confirmed by 3D CT analysis and histology. Thus, ABS seems to have a potential of bone promoting effect; however, precise mechanisms underlying this osteogenetic activity still remain unexplained Daha fazlası Daha az