Aydemir, Selim | Bayraktaroğlu, Taner | Üstündağ, Yücel | Borazan, Ali | Sekirmez, Nedret | Aktunç, Erol | Numanoğlu, Gamze

Article | 2004 | Akademik Gastroenteroloji Dergisi3 ( 3 ) , pp.129 - 133

Giriş ve amaç: Standart üçlü tedavi ile Helicobacter pylori (H. pylori) eradikasyonu sağlanmayan olgularda ikinci tedavi ile eradikasyon daha zordur. H. pylori eradikasyon başarısızlıklarında uygulanacak tedavi kombinasyonları kesin belirlenmemiştir. Bu çalışmada lansoprazol, amoksisilin ve klaritromisin (LAK) ile yapılan standart üçlü tedavi ile H. pylori eradikasyonu sağlanamayan olgularda lansoprazol, ranitidin bizmut sitrat, tetrasiklin ve metronidazolden (LBTM) oluşan dörtlü tedavinin etkinliğini araştırdık. Gereç ve yöntem: Peptik ülser hastalığı veya nonülser dispepsi nedeniyle standart üçlü LAK tedavisi verilen ve H. pylori . . .eradikasyonu sağlanamayan toplam 36 olgu çalışmaya alındı. Bu olgulara lansoprazol (2x30 mg), ranitidin bizmut sitrat (2x400 mg), tetrasiklin (4x500 mg) ve metronidazolden (3x500 mg) oluşan dörtlü tedavi 14 gün verildi. Tedavinin bitiminden iki ay sonra endoskopik biyopsi ile H. pylori eradikasyonu değerlendirildi. Bulgular: Olgulardan beşi tedavi bitiminde kontrole gelmediğinden çalışma dışı bırakıldı. Dörtlü tedavi ile H. pylori eradikasyon oranı çalışmaya alınan tüm olgular değerlendirildiğinde %58.3, çalışma sonunda kontrole gelen olgular değerlendirildiğinde ise %67.7 saptandı. Sonuç: Bölgemizde standart LAK tedavisi ile H. pylori eradikasyonu sağlanamayan olgularda LBMT dörtlü tedavi kombinasyonunun başarı oranını oldukça düşük bulduk. Bu durumun ülkemizdeki metronidazol direncinin yüksek seviyelerde olması ile açıklanabileceğini düşünmekteyiz. Ülkemizde farklı bölgelerde H. pylorinin antibiyotik direnç durumunu ve tedavi başarısızlığı sebeplerini değerlendiren araştırmalara ihtiyaç vardır. Background/aim: Successful eradication of Helicobacter pylori (H. pylori) infection after failure of standard triple therapy is difficult. There are no guidelines on second-line therapies for H. pylori eradication failures. In the present study we investigated the efficacy of a 14-day quadruple regimen combining lansoprazole, ranitidine bismuth citrate (RBC), tetracycline and metronidazole as rescue treatment for Helicobacter pylori infection after failure of standard triple therapy combining lansoprazole, amoxicillin, clarithromycin (LAC). Materials and methods: A prospective study was designed consisting 36 patients infected with H. pylori and diagnosed with peptic ulcer or non-ulcer dyspepsia in whom triple therapy with LAC had failed. The patients were treated with quadruple therapy including lansoprazole, 30 mg twice daily, RBC, 400 mg twice daily, tetracycline, 500 mg four times daily, and metronidazole, 500 mg three times daily, for 14 days. Two months after completion of therapy, endoscopic biopsy evaluation was performed to confirm eradication. Results: Five cases who did not attend to the appointment were excluded from the study. With quadruple therapy, the H. pylori eradication rates were 58.3% by intention-to-treat analysis and 67.7% by per protocol analysis. Conclusion: The success rate of quadruple therapy with LBTM was found to be low in patients in whom standard triple therapy had failed in western Blacksea region. This finding may be explained by higher rates of metronidasole resistance in our country. We conclude that further studies about the drug resistance rates and explanation of reasons for treatment failure must be carried out Daha fazlası Daha az

Bakkal, Bekir Hakan | Elmas, Özlem | Gültekin, Fatma Ayça | Engin, Hüseyin | Bilir, Cemil | Bakkal, Yasemin Temi

Article | 2014 | Okmeydanı Tıp Dergisi30 ( 3 ) , pp.139 - 145

Amaç: Mide kanseri tanısıyla postoperatif kemoradyoterapi uyguladığımız olgularımızın tedavi sonuçları değerlendirildi. Gereç ve Yöntem: 2007-2011 yılları arasında postoperatif kemoradyoterapi uygulanan toplam 77 mide kanseri tanı- lı olgu geriye dönük olarak incelendi. Kemoradyoterapi, Intergroup-0116 çalışma protokolüne göre uygulandı. Üç boyutlu konformal planlama sonrası mide loju ve bölgesel lenfatiklere 45 Gy, cerrahi sınır pozitif olanlara 50.4 Gy radyoterapi verildi. Bulgular: Olguların 46’si erkek (% 59.7), 31’i kadın (% 40.3) olup, ortanca yaş 59 (dağılım 31-78) idi. Ortanca genel sağkalım ve hastalıksız sağkalım süreleri . . .sırasıyla 28.3 ve 21 aydı. Üç yıllık genel ve hastalıksız sağkalım oranları sı- rasıyla % 43.8 ve % 41.7 bulundu. Takipleri sırasında 10 olguda (% 13) lokal-bölgesel yineleme, 22 olguda (% 28.6) uzak organ metastazı, 3 olguda (% 3.9) ise hem lokal- bölgesel yineleme hem de uzak organ metastazı saptandı. Kemoradyoterapi süresi boyunca grad 1-2 hematolojik yan etki 23 (% 30) olguda, 3-4 hematolojik yan etki 46 (% 59.7) olguda, grad 1-2 gastrointestinal yan etki 30 (% 39) olgu- da, grad 3-4 gastrointestinal yan etki 11 (% 14.3) olguda görüldü. Tek değişkenli analizde lenf nodu evresi ve lenf nodu tutulum oranı hem genel hem de hastalıksız sağkalım üzerine etkili prognostik faktörler olarak bulunurken, çok değişkenli analizde lenf nodu diseksiyon tipi ve lenf nodu tutulum oranı genel ve hastalıksız sağkalım ile ilişkili prog- nostik faktörler olarak bulundu. Sonuç: Kemoradyoterapinin lokal kontrol üzerinde etkili olduğu, uzak metastaz gelişimini engellemede ise yetersiz kaldığı saptanmıştır. Erken dönem özellikle hematolojik yan etkiler sık gözlenmiştir. Objective: The treatment results of postopeative chemoradi- otherapy in patients with gastric carcinoma were evaluated. Material and Methods: A total of 77 patients with gast- ric carcinoma, treated with postoperative chemoradiothe- rapy between 2007-2011, were evaluated retrospectively. Chemoradiotherapy was applied in accordance with the Integroup-0116 study protocol. Total 45 Gy radiotherapy was delivered to the gastric bed and regional lymphatic no- des and 50.4 Gy was given to patients with positive surgical margins after 3-dimensional conformal planning. Results: Forty-six of the patients were male (59.7 %), and 31 of the patients were female (40.3 %) with a median age of 59 (31-78). Median overall survival and disease-fee sur- vival were 28.3, and 21 months, respectively. The 3-year overall and disease-free survival rates were 43.8 % and 41.7 %, respectively. Locoregional recurrence was detected in 10 (13 %), distant metastasis was detected in 22 (28.6 %) and both locoregional and distant metastasis were detected in 3 (3.9 %) of patients. During chemoradiotherapy grade 1-2 hematological toxicity was seen in 23 (30 %) patients, grade 3-4 hematological toxicity in 46 (59.7 %) patients, grade 1-2 gastrointestinal toxicity in 30 (39 %) patients, and grade 3-4 gastrointestinal toxicity in 11 (14.3 %) pa- tients. While in the univariate analysis lymph node stage and percentage of positive lymph nodes were found to be prognostic factors for overall and disease-free survival, in the multivariate analysis type of lymph node dissection and percentage of positive lymph nodes were found to be prog- nostic factors that are correlated with overall and disease- free survival. Conclusion: Chemoradiotherapy improved loco-regional control rather than reduction of distant metastases. Acute es- pecially hematologic side effects were commonly observed Daha fazlası Daha az

Özdoğan, Mehmet Emin | Erer, Dilek | İriz, Erkan | Büyükateş, Mustafa | Oktar, Levent | Ünal, Yusuf | Abacı, Adnan

Other | 2007 | Anadolu Kardiyoloji Dergisi7 ( 4 ) , pp.456 - 457

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Numanoğlu-Yurdakan, Gamze | Gün, Banu Doğan | Kertiş, Gürkan | Çolak, Sacide | Özdamar, Şükrü Oğuz

Article | 2007 | İnönü Üniversitesi Tıp Fakültesi Dergisi14 ( 3 ) , pp.189 - 193

Anjiyomiyolipoma böbrekte, retroperitoneal hemoraji yapabilen, mikroskopik olarak damar yapıları, düz kas ve yağ dokuları içeren benign tümöral lezyondur. Lenfanjiyomiyomatozis ise; akciğerleri difüz tutabilen, respiratuar yetmezlik, spontane pnömotoraks veya şilöz plevral efüzyon izlenebilen lezyondur. Mikroskopik olarak lenf damarları ve düz kas elementlerinin karışımının proliferasyonları ile karakterizedir. Her iki lezyon da az rastlanan bir sendrom olan tuberoskleroz kompleksinin komponenti olarak izlenebilir. Olgumuz göğüs ağrısı, nefes darlığı şikayeti olan 41 yaşında bayan hastadır. Toraks tomografisinde akciğer parankiminde . . ., ince duvarlı hava kistleri, abdominal tomografide böbreklerde büyüme ve yağ dansitesinde alanlar içeren lezyonlar belirlenmiştir. İntraabdominal kanama nedeniyle sağ nefrektomi uygulanmıştır. Mikroskobide, böbrek parankimindeki infiltratif tümörün matür lipomatöz, miyomatöz komponentler ve konjesyone vasküler yapılardan oluştuğu izlenmiş, immünohistokimyasal incelemede tümör hücrelerinde HMB-45 ile reaksiyon gözlenen olguya anjiyomiyolipoma tanısı konulmuştur. Akciğer lezyonlarının mikroskobik incelemesinde, kistik dilatasyonlu, düz kas hücreleri içeren lenf damarları izlenmiştir. Trikrom ile lenf damarları duvarında düz kas yönünde boyanma gözlenmiş ve lenfanjiyomiyomatozis olarak değerlendirilmiştir. Olgumuz postoperatif 16. günde gelişen kardiyopulmoner arest nedeni ile eksitus kabul edilmiştir. Angiomyolipoma is a benign tumoral lesion of the kidney which microscopically contains fat, smooth muscle and blood vessels, and may result in retroperitoneal hemorrhage. Lymphangiomyomatosis is a lesion that may lead to diffuse involvement of lungs and cause respiratory failure, spontaneous pneumothorax or pleural effusion. It is characterized by proliferation of a mixture of lymphatic and smooth muscle. Both lesions may be components of tuberous sclerosis, an uncommon syndrome. Our case is 41-year-old female presented with chest pain and dyspnea. Thin walled air cysts were determined in lung parenchyma by thorax tomography and images of enlarged kidneys and mass lesions including areas of adipose density were supplied by abdominal tomography. Right nephrectomy was performed because of intraabdominal hemorrhage. Infiltrative tumor microscopically composed of mature lipomatose, myomatose components and congested blood vessels, and reactive for HMB-45 [Melanoma (gp100) Ab-3 (clone HMB45+HMB50), Neomarkers] was diagnosed as angiomyolipoma. Microscopic evaluation of the lung lesions revealed cystic lymphatic containing smooth muscle cells. The tumor with presence of smooth muscle in the walls of lymphatic shown with trichrome and was diagnosed as lymphangiomyomatosis. The patient died because of irreversible cardiopulmonary arrest on the postoperative 16th day Daha fazlası Daha az

Özdamar, Şükrü Oğuz | Gün, Banu Doğan | Barut, Figen | Bahadır, Burak

Article | 2007 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI27 ( 1 ) , pp.16 - 20

Objective: Traumatic neuroma is an exuberant, probably nonneoplastic proliferation of a nerve occurring in response to injury or surgery. We studied six cases of traumatic neuroma with light microscopic, histochemical and immunohistochemical methods to assess the cellular compositions of these lesions. Material and Methods: Sections from the formalin-fixed parafin-embedded tissues were stained with hematoxylin-eosin, Gomori's trichrome, Verhoeff elastica-von Gieson, reticuline, and S-100 protein, Epithelial Membrane Antigen, CD34 and CD68. Results: All cases revealed large numbers of small and haphazardly arranged regenerating nerve . . . fascicles within a densely collagenous and fibroblastic stroma. A focal chronic mononuclear cell inflammatory reaction was observed in three cases. In all cases, Gomori's trichrome revealed collagen. Axonal morphology was detected in nerve fibers histochemically by reticulin. In all cases, fascicles were stained diffusely with S-100 protein, and Epithelial Membrane Antigen showed a positive reaction in a thin band of cells surrounding the fascicles in three of the cases. CD34 positive cells were present in five cases. CD68 expressing cells were present in only in two specimens. Conclusion: In traumatic neuromas, specific staining of fascicles with S-100 protein, perineural cells reactive for Epithelial Membrane Antigen and the presence of CD34 positive cells may contribute to our understanding of their pathogenesis and differentiation of these lesions from mimickers Daha fazlası Daha az

Barut, Figen | Özdamar, Şükrü Oğuz | Bahadır, Burak | Gün, Banu Doğan | Bektaş, Sibel | Çolak, Sacide | Kuzey, Gamze Mocan

Article | 2007 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI27 ( 2 ) , pp.179 - 183

Objective: Bronchoalveolar lavage performed during bronchoscopic examination is a type of cytologic sampling with great diagnostic significance. Its diagnostic value is enhanced when biopsy is unavailable and bronchoalveolar lavage is the unique sample. Determining the diagnostic accuracy of bronchoalveolar lavage by comparing it with the diagnostic yield of synchronous biopsies is an indicator of its effectiveness. Material and Methods: In this study, 435 bronchoalveolar lavage and 273 bronchoscopic biopsy specimens obtained from January 2003 to December 2005 in the Department of Pulmonary Diseases were retrospectively evaluated in . . . the Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University. Results: Overall, 373 cases (85.8%) were diagnosed as benign and 12 cases (2.8%) were reported as malignant, while IS cases (4.1%) were suspected to be malignant; the remaining 32 cases (7.3%) were reported as inadequate. The numbers and percentages of benign, malignant, suspected malignant and inadequate diagnoses of the 273 bronchoalveolar lavage cases with synchronous transbronchial biopsies were 229 (83.9%), 12 (4.5%), 16 (5.8%), and 16 (5.8%), respectively. After suspected malignant and inadequate samples were excluded, coomparison of cytologic and histologic diagnoses revealed that the diagnostic accuracy of bronchoalveolar lavage cytology was 79.4% and 91.6% for benign and malignant diagnoses, respectively; the rate of false negativity was 20.5% and false positivity was 8.3%. Conclusion: While sampling errors seemed to be the primary reason for false negative and false positive diagnoses, the rate of false cytologic evaluation was lower. Considering the false negative diagnoses for cases without biopsy specimens, comparison of bronchoalveolar lavage diagnoses with synchronous biopsies may serve as a quality control programme, since this condition may significantly influence the clinical course Daha fazlası Daha az

Kandemir, Nilüfer Onak | Gün, Banu Doğan | Barut, Figen | Yurdakan, Gamze | Bahadır, Burak | Bektaş, Sibel | Gün, Mustafa | Keser, Sevinç Hallaç | Özdemir, Nagehan | Özdamar, Şükrü Oğuz

Article | 2010 | TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY44 ( 2 ) , pp.73 - 78

Background and Design: Kaposi sarcomas (KS) are vascular tumors with a low malignant potential which include overlapping infectious, immunologic, and neoplastic processes. Recently, many histological subtypes have been defined. Material and Method: In the present study, 151 cutaneous classic KS lesions in 56 patients were retrospectively evaluated with regard to histological subtypes. Determination of the subtypes was based on the predominant histopathological component in the lesion. We examined changes in epidermis and dermis along with intratumoral inflammatory response characteristics in the lesions. By defining histopathologica . . .l variants of the cases, differences regarding subtypes were investigated. Results: Cases that bear the ordinary characteristics of KS and those that can not be classified otherwise, comprised 82..8% of the study group. Twenty-six cases showed consistency with the subtypes outlined in the literature in terms of their histopathological properties. The most common histological subtype was the lymphangiectatic variant in 7.3% of the cases. Bullous (2.6%), lymphangioma like (2.6%), intravascular (2%), and pyogenic granuloma like (2%) variants were less common. The most uncommon histological subtype was micronodular (0.6%) type. Lymphangiectatic, bullous, intravascular, and pyogenic granuloma like variants were frequently observed in the nodular stage of KSs. Lympangioma like changes were seen to be present in the early KS lesions. Lymphangiectatic type was oftenly associated with bullous component, whereas pyogenic granuloma like type demonstrated superficial ulceration and intense inflammatory response. Lymphangioma like and intravascular types exhibited a characteristic appearance, while other variants were accompanied by components belonging to different subtypes. Conclusion: In KS, histopathological subtypes can develop as a result of different pathological processes. The next stage of the current study, which is one of the largest case series in the literature, will be investigation of the clinical and prognostic characteristics of the variants. (Turkderm 2010; 44: 73-8 Daha fazlası Daha az

Kaya, Ceren | Erkaymaz, Okan | Ayar, Orhan | Özer, Mahmut

Proceedings | 2018 | 26th IEEE Signal Processing and Communications Applications Conference, SIU 2018 , pp.1 - 4

Refractive disorders are common health problems in the community and they are the most important cause of visual impairment. In this study, it was aimed to classify the individuals who have hypermetropia and myopia refractive disorders or not. For this, horizontal and vertical Electrooculogram (EOG) signal data from the right and left eyes of the individuals were used. The performance of the data was investigated by using Logistic Regression (LR), Naive Bayes (NB), Random Forest (RF) and REP Tree (RT) data mining methods. According to the obtained results, REP Tree method has shown the most successful classification performance to d . . .etect hypermetropia and myopia refractive disorders from Electrooculogram (EOG) signals. © 2018 IEEE Daha fazlası Daha az

Özer, Tülay | Uzun, Lokman | Numanoğlu, Kemal Varın | Savranlar, Ahmet | Hoşnuter, Mübin | Gündoğdu, Sadi

Article | 2004 | Tanisal ve girişimsel radyoloji : Tibbi Görüntüleme ve Girişimsel Radyoloji Dernegi yayin organi10 ( 4 ) , pp.272 - 279

PURPOSE: To investigate the accompanied craniofacial and cervical spine anomalies in congenital muscular torticollis (CMT) with three-dimensional computerized tomography (3D-CT). MATERIALS AND METHODS: We examined six cases of CMT. Cranial and cervical 3D CT was performed in all cases. Facial midline deviation angle (FDA), upper hemifacial width, lower hemifacial width (LHFW), length of hemimandible and zygomatic arcus, posterior hemicranial width (PHCW), anterior hemicranial width and cranial base midline deviation angle (CBDA) were measured on cranial 3D-CT images. Value of orbital index was calculated. Data achieved both ipsilate . . .rally and contralaterally were compared with paired t-test. Atlanto-axial rotation angle (AARA) and atlantodental interval (ADI) values were measured on cervical 3D-CT images. RESULTS: Ages ranged between 2-26 years with a M/F ratio of 1/5. Facial asymmetry was diagnosed in all cases and LHFW was significantly undersized when compared to contralateral side (p < 0.05). FDA was measured 5.4+/-2.0 degrees on the average. Zygomatic arcus and hemimandible were significantly undersized on the side of torticollis (p < 0.05). Occipital plagiocephaly existed in all cases and PHCW was significantly extensive on torticollis side (p < 0.05). CBDA was measured 4.5+/-1.7 degrees on the average. Rotational movement of atlas over axis was observed in all cases where the AARA was 15.0+/-7.4 degrees. ADI was lesser than 3 mm in all cases. CONCLUSION: Even occipital plagiocephaly, maxillary and orbital deformity were commonly found in cases of CMT, most dominant asymmetry was observed in lower hemifacial region, zygomatic arcus and mandible by 3D-CT imaging. Rotational movement of first cervical vertebra over the second one was determined in all cases Daha fazlası Daha az

Koca, Rafet | Çınar, Saniye | Numanoğlu, Gamze | Altınyazar, H. Cedet | Solak-Tekin, Nilgün | Muhtar, Şennur

Article | 2006 | Turkiye Klinikleri Journal of Medical Sciences26 ( 4 ) , pp.453 - 456

Sarcoidosis is a multisystem disorder of unknown etiology, which is histopathologically characterized by noncaseating granulomas. Cutaneous sarcoidosis localizing on the auricle may be observed in various clinical types. Angiolupoid sarcoidosis is a rare form of cutaneous sarcoidosis. We describe a 26-year-old white man with angiolupoid cutaneous sarcoidosis localized on the auricle without systemic involvement. Copyright © 2006 by Türkiye Klinikleri.

Kaya, Ceren | Erkaymaz, Okan | Ayar, Orhan | Özer, Mahmut

Proceedings | 2017 | 2017 Medical Technologies National Conference, TIPTEKNO 20172017-January , pp.1 - 4

'Diabetes Mellitus (Diabetes)' is a disease based on insulin hormone disorders secreted from the pancreas gland. Clinical findings find out that diabetes causes some diseases in vital organs. 'Diabetic Retinopathy' is one of the most common eye diseases based on diabetes, and it is the leading cause of visual loss resulting from structural changes in the retinal vessels. Recent researches show that signals from vital organs can be used to diagnose diseases in the literature. In this study, the features of horizontal and vertical Video-Oculography (VOG) signals from right and left eye are used to classify non-proliferative and prolif . . .erative diabetic retinopathy disease. 25 statistical features are obtained using discrete wavelet transform with VOG signals from 24 subjects. Feature selection is performed using C4.5 decision tree algorithm from 25 features obtained. The statistical features obtained from C4.5 decision tree and discrete wavelet transform are applied as input to artificial neural networks and the classification performance of the 'Diabetic Retinopathy' disease are compared according to these two methods. Our results show that feature selection by C4.5 decision tree algorithm (96.87%) provides better classification performance than feature extraction with discrete wavelet transform (93.75%). © 2017 IEEE Daha fazlası Daha az

Kandemir, Onak Nilüfer | Barut, Figen | Keser, Sevinç | Karadayı, Nimet | Bektaş, Sibel | Gün, Doğan Banu | Bahadır, Burak

Other | 2009 | Türk Onkoloji Dergisi24 ( 4 ) , pp.172 - 176

AMAÇ Bu çalışmada, tiroid papiller karsinomlarında (TPK), kronik lenfositik tiroidit (KLT) görülme sıklığı araştırıldı ve tümörü infiltre eden lenfosit (TİL) varlığının KLT ile ilişkisi değerlendirildi. GEREÇ VE YÖNTEM Çalışma kapsamına 61 TPK olgusu dahil edildi. Tümör içi ve tümör çevresi parankimdeki lenfoid infiltrasyon varlığı, her biri için ayrı şekilde, semi-kantitatif olarak 0-3 arasında derecelendi. Olgular grup I (KLT içeren TPK) ve grup II (KLT içermeyen TPK) olmak üzere iki gruba ayrıldı. BULGULAR TPK'ların %26.3'ünde (grup I) KLT saptandı. Grup I'deki olguların %77'sinde TİL görülürken, grup II'deki olgularda TİL ile uy . . .umlu olarak değerlendirilebilecek lenfoid infiltrasyon saptanmadı. Grup I ve grup II'deki olgular arasında TİL yoğunluğu açısından anlamlı farklılık belirlendi. SONUÇ Bulgularımız, TPK'da KLT'nin sık görülen bir bulgu olduğunu ve TİL varlığının KLT ile ilişkili bir parametre olduğunu göstermektedir. OBJECTIVES This study examined the frequency of chronic lymphocytic thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and the relationship between the presence of tumor-infiltrating lymphocytes (TIL) and CLT. METHODS The study included 61 TPC cases. In each case, the presence of the lymphocyte infiltration in the tumor tissue and nonneoplastic parenchyma was graded semi-quantitatively using a scale of 0 to 3. The cases were classified in two groups, TPC including CLT (Group I) and TPC not including CLT (Group II). RESULTS CLT was detected in 26.3% (Group I) of the TPCs and TIL was observed in 77% of the Group I cases; no lymphoid infiltration compatible with TIL was detected in Group II. A significant difference was observed in the TIL density between Groups I and II. CONCLUSION CLT is a frequent finding in TPC, and the presence of TIL is related to CLT Daha fazlası Daha az