Karakaya, K. | Barut, Figen | Hanci, V | Can, M. | Comert, M. | Ucan, H. B. | Cakmak, G. K.

Article | 2015 | BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY116 ( 1 ) , pp.51 - 56

Introduction: Alcohol consumption is frequently associated with gastric mucosa! lesions. The purpose of this study was to determine the effect of Coenzyme-Q(10) (CoQ(10)) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ(10), at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg . . .ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrificed and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. Results and discussion: Rats pretreated either with famotidine or CoQ(10) had significantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were significantly lower in famotidine 20 mg/kg and CoQ(10), pretreatment for 7 days group (p < 0.00625). Conclusion: CoQ(10) affords gastroprotection against ethanol-induced gastric mucosal lesions in rats especially after repetitive administrations (Tab. 3, Fig. 2, Ref. 35). Text in PDF www.elis.sk Daha fazlası Daha az

Çakmak, Güldeniz Karadeniz | Emre, Ali U. | Taşçılar, Öğe | Bahadır, Burak | Özkan, Selçuk

Proceedings | 2015 | CANCER RESEARCH75 , pp.51 - 56

37th Annual CTRC-AACR San Antonio Breast Cancer Symposium -- DEC 09-13, 2014 -- San Antonio, TX WOS: 000356730201059

Yılmaz, Rıza | Yılmaz, Eyüp | Özdemir, Veli | Can, Muhammet | Pakiş, Işıl | Pişkin, İbrahim E. | Dokgöz, Halis | Özer, Erdal | Numanoğlu, Kemal Varın

Article | 2015 | Journal of Forensic Sciences60 ( 3 ) , pp.648 - 652

Yellow phosphorus (YP) is a powerful protoplasmic poison used in the manufacturing of matches, pest poisons, firecrackers, firework cracker, lights for watches, military ammunition, and agriculture fertilizer. YP is extremely flammable and toxic and easily absorbed from the gastrointestinal tract. In this study, we examined childhood deaths from 1997 to 2012 resulting from the ingestion of firecrackers. The patients ranged from 2 to 15 years of age and were admitted to the hospital with a variety of symptoms. Those that presented with nausea, vomiting, and hypotension rapidly deteriorated and entered a coma. An autopsy was performed . . . in all but one of the 16 cases reviewed. Macroscopically, the livers had a yellowish discoloration with petechial bleeding. Histopathologic examination revealed acute toxic hepatitis. In conclusion, these firecrackers are found in corner shops throughout Turkey, may cause death in children with little warning, and should be banned to prevent further deaths. © 2015 American Academy of Forensic Sciences Daha fazlası Daha az

Karakaya K. | Barut F. | Hanci V. | Can M. | Comert M. | Ucan H.B. | Cakmak G.K.

Article | 2015 | Bratislava Medical Journal116 ( 1 ) , pp.51 - 56

Introduction: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q10 (CoQ10) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol . . . 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrifi ced and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. Results and discussion: Rats pretreated either with famotidine or CoQ10 had signifi cantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were signifi cantly lower in famotidine 20 mg/kg and CoQ10 pretreatment for 7 days group (p < 0.00625). Conclusion: CoQ 10 affords gastroprotection against ethanol-induced gastric mucosal lesions in rats especially after repetitive administrations Daha fazlası Daha az

Buyukates M. | Barut F. | Aktunc E.

Article | 2015 | Journal of Cardiovascular Surgery56 ( 6 ) , pp.913 - 918

Aim. We have conducted this study to seek and observe visual clues through immunohistochemical staining for differences in Et-1/2/3 expression and the free-low capacity measuring the blood flow through grafts, in the left internal mammary artery grafts prepared either with clipped or nonclipped techniques. Methods. A total of 40 consecutive patients with a diagnosis of coronary artery disease who would benefit from elective coronary artery bypass graft surgery were randomised into two groups consisting 20 patients each. Left internal mammary artery was harvested by a traditional clipped (control group) and a modified nonclipped (stu . . .dy group) technique in each of the groups. All harvested arterial segments were evaluated for luminal endothelial integrity through hematoxylin&eosin and immunohistochemical staining. Results. The free-low capacity of left internal mammary artery grafts were significantly higher in nonclipped arteries when compared with that of clipped ones (P=0.001). The arterial lumen of the nonclipped segments were visibly more dilated than the clipped ones. Nonclipped segments presented a lighter immunostaining for Et-1/2/3 when compared with the clipped ones ( Daha fazlası Daha az