Sayin M. | Bakkal, Bekir Hakan

Article | 2011 | Tumori97 ( 1 ) , pp.123 - 125

Herpes zoster is an infectious disease caused by varicella-zoster virus that may occur sporadically at any age. We report on two patients with herpes zoster who received chemotherapy for breast cancer. Both patients were immunocompromised and received filgrastimtherapy for themanagement of neutropenia. Zoster occurred during filgrastim therapy but the symptoms were alleviated rapidly in the course of therapy. We conclude that granulocyte colony-stimulating factor therapy helped symptom alleviation and accelerated the recovery fromherpes zoster in our chemotherapy-treated patients. Free full text available at www.tumorionline.it.

Demir E.O. | Cakmak G.K. | Bakkal, Bekir Hakan | Turkcu U.O. | Kandemir N. | Demir A.S. | Tascilar O.

Article | 2011 | Journal of Investigative Surgery24 ( 4 ) , pp.151 - 158

Aim: This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on anastomotic healing of irradiated rats. Methods: Thirty-two male Wistar albino rats were randomized into four groups containing 8 rats each: I; standard resection plus anastomosis, II; radiation plus standard resection plus anastomosis, III; radiation plus standard resection plus anastomosis plus oral NAC, IV; radiation plus standard resection plus anastomosis plus intraperitoneal NAC. Four types of assessment were performed: bursting pressure, hydroxiproline (OHP) content, histopathology, and biochemical evalu . . .ation, including serum malondialdehyde (MDA), advanced oxidation protein products (AOPP), reduced glutathione (GSH) and superoxide dismutase (SOD) activities. Results: Group comparisons demonstrated that bursting pressure was significantly higher in NAC treated rats. The mean tissue OHP concentration in the anastomotic tissue was significantly lower in irradiated rats (group II) than in the other groups. NAC treatment caused increased activity of SOD and GSH. In contrast, MDA levels were found to be decreased in groups III and IV. Histopathological analysis revealed that NAC administration, either orally or intraperitoneally, leads to a better anastomotic healing in terms of reepithelialization, perianastomotic fibrosis, ischemic necrosis, and muscle layer destruction. Conclusion: The present study supports the hypothesis that NAC administration alleviates the negative effects of radiotherapy on anastomotic healing. Nevertheless, the underlying mechanisms responsible for this protective effect is unknown today. © 2011 Informa Healthcare USA, Inc Daha fazlası Daha az

Barut, Figen | Bektaş, Sibel | Gün, Banu Doğan | Bahadır, Burak | Özdamar, Şükrü Oğuz

Article | 2011 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI31 ( 2 ) , pp.321 - 327

WOS: 000291330700006

Gül, Şanser | Bahadır, Burak | Kalaycı, Murat | Ankaralı, Handan | Erdem, Oktay | Karakaya, Kemal | Açıkgöz, Bektaş

Article | 2011 | TURKIYE KLINIKLERI TIP BILIMLERI DERGISI31 ( 2 ) , pp.390 - 396

Objective: The influence of Ankaferd Blood Stopper (R) (ABS) was experimentally investigated on calvarial defects in rats. Material and Methods: Fourteen Wistar-albino rats equally divided into two groups, control group (G1) and drug group (G2), were included in the study. In G1, only right frontal craniectomy was performed. In G2, 0.5ml ABS was topically applied with a syringe after craniectomy. Surface areas of the defects were measured after four weeks, and comparative reconstruction images with were obtained, computed tomography (CT) as well. Blood samples were also collected to evaluate prothrombin time (PT), international norm . . .alized ratio (INR) and activated partial thromboplastin time (aPTT), and tissue samples were harvested for histologic examination. Results: Mean defect area in G1 (7.20 +/- 2.62 mm(2)) was significantly larger than that in G2 (1.83 +/- 1.65 mm(2)) (p0.05). Three dimensional (3D) CT analysis and histological examination revealed prominent osteogenesis in G2. Conclusion: We observed that surface area of the calvarial defects decreased significantly after ABS administration, and this observation was confirmed by 3D CT analysis and histology. Thus, ABS seems to have a potential of bone promoting effect; however, precise mechanisms underlying this osteogenetic activity still remain unexplained Daha fazlası Daha az

Onak Kandemir N. | Dogan Gün B. | Irkörücü O. | Tokgöz H. | Barut F. | Cömert M. | Özdamar Ş.O.

Letter | 2011 | Turkish Journal of Gastroenterology22 ( 2 ) , pp.235 - 236

[No abstract available]

Sarici G. | Koca R. | Işik S. | Sezer T. | Çinar S. | Kandemir N.O.

Article | 2011 | Turk Dermatoloji Dergisi5 ( 1 ) , pp.13 - 17

Papuloerythroderma of Ofuji is characterized by a pruritic eruption of widespread, red, flat papules that leads to spare skin folds. The disease occurs primarily in elderly men and is often associated with lymphadenopathy, peripheral blood eosinophilia, lymphopenia and elevated immunoglobulin E levels. Association with T and B cell lymphomas, visceral carcinomas, AIDS, atopic dermatitis, psoriasis and hypersensitivity to drugs have been reported. Topical and systemic corticosteroids, psoralen-UVA, etretinate-PUVA, acitretin-PUVA, UVB, cyclosporin, interferon ? and azathioprine have been used in the treatment of this rare disease. In . . . this manuscript, we described two patients with papuloerythroderma of Ofuji Daha fazlası Daha az

Kandemir, Nilüfer Onak | Bahadır, Burak | Bektaş, Sibel | Barut, Figen | Yurdakan, Gamze | Gün, Banu Doğan | Engin, Hüseyin

Article | 2011 | Turkish Journal of Gastroenterology22 ( 1 ) , pp.77 - 82

Konjenital melanositik nevüs, odontogenez sırasında ortaya çıkan ve nöral-krest’den gelişen hamartomatöz lezyonlardır. Bu çalışmada konjenital melanositik nevüsden gelişen ve gastrointestinal sistem metastazları ile bulgu veren iki malign melanoma olgusu sunulmaktadır. İlk olgu, plevral ve peritoneal efüzyon ile başvuran 71 yaşında kadın hasta olup, endoskopik incelenmede doudenumda nodüler lezyonlar saptanmış ve biyopsi yapılmıştır. Karın ağrısı yakınması ile başvuran ikinci olgu 36 yaşında erkek hasta olup, ileumda invajinasyonlara neden olan kitlesel lezyonlar nedeniyle segmenter ileal rezeksiyon uygulanmıştır. Lezyonların histop . . .atolojik incelemesinde tüm mukoza katlarını infiltre eden diffüz neoplastik infiltrasyon görülmüştür. Belirgin atipi ve pleomorfizm içeren neoplastik hücrelerde S-100, HMB-45 ve Melan A immünreaksiyon saptanmıştır. Her iki olguya, malign melanoma tanısı verilmiştir. İlk olguda karın derisinde, ikinci olguda ise femoral bölgede konjenital melanositik nevüs saptanmış ve histopatolojik incelemelerde bu lezyonların malign melanoma yönünde transformasyon gösterdiği belirlenmiştir. Gastrointestinal sistemde malign melanoma gelişimi primer veya metastatik kökenli olabilir. Kesin tanı daima ayrıntılı klinik, histopatolojik ve immünhistokimyasal incelemeleri gerektirir. Congenital melanocytic nevi are hamartomatous lesions that develop from the neural crest and arise during odontogenesis. In this report, we present two malignant melanoma cases developed from congenital melanocytic nevi and revealed by gastrointestinal system metastases. The first case was a 71-year-old female who presented with pleural and peritoneal effusion and underwent biopsy due to detection of nodular lesions in the duodenum by endoscopic examination. The second case was a 36-year-old male patient who presented with abdominal pain in whom segmental ileal resection was performed due to mass lesions causing invaginations in the ileum. Histopathological examination of the lesions showed a diffuse neoplastic infiltration comprising the entire mucosal layers. In neoplastic cells having a marked atypia and pleomorphism, immunoreactions with S-100, HMB-45, and Melan A were detected. Both cases were diagnosed as malignant melanoma. Abdominal skin in the first case and the femoral region in the second case exhibited congenital melanocytic nevi, and those lesions were determined to show a transformation towards malignant melanoma in the histopathological studies. Malignant melanoma development in gastrointestinal system may have a primary or metastatic character. Definitive diagnosis always requires detailed clinical, histopathological and immunohistochemical analyses Daha fazlası Daha az

Onak Kandemir N. | Bahadir B. | Bektaş S. | Barut F. | Yurdakan G. | Dogan Gün B. | Engin H.

Article | 2011 | Turkish Journal of Gastroenterology22 ( 1 ) , pp.77 - 82

Congenital melanocytic nevi are hamartomatous lesions that develop from the neural crest and arise during odontogenesis. In this report, we present two malignant melanoma cases developed from congenital melanocytic nevi and revealed by gastrointestinal system metastases. The first case was a 71-year-old female who presented with pleural and peritoneal effusion and underwent biopsy due to detection of nodular lesions in the duodenum by endoscopic examination. The second case was a 36-year-old male patient who presented with abdominal pain in whom segmental ileal resection was performed due to mass lesions causing invaginations in the . . . ileum. Histopathological examination of the lesions showed a diffuse neoplastic infiltration comprising the entire mucosal layers. In neoplastic cells having a marked atypia and pleomorphism, immunoreactions with S-100, HMB-45, and Melan A were detected. Both cases were diagnosed as malignant melanoma. Abdominal skin in the first case and the femoral region in the second case exhibited congenital melanocytic nevi, and those lesions were determined to show a transformation towards malignant melanoma in the histopathological studies. Malignant melanoma development in gastrointestinal system may have a primary or metastatic character. Definitive diagnosis always requires detailed clinical, histopathological and immunohistochemical analyses Daha fazlası Daha az

Barut A. | Arikan I. | Barut F. | Harma M. | Harma M.I. | Payasli B.

Article | 2011 | Journal of the Pakistan Medical Association61 ( 9 ) , pp.914 - 916

The frequency of cancer during pregnancy is approximately 1 per 1000 live births. This rate may increase as more women postpone childbirth until later in life, when cancer becomes more frequent. Pregnancy affectsmanagement of the cancer, and the cancer affects the management of pregnancy. The most common malignancies, in order of frequency, are breast cancer, leukaemia and lymphomas as a group, melanoma, gynaecologic cancers, and bone tumours. Ovarian tumours are found in about 1 in 1000 pregnancies and 3-6% of these are malignant. Thus, ovarian cancer occurs in approximately 1 in 12,500-25,000 pregnancies. Here, we report a case of . . . ovarian mucinous carcinoma that was diagnosed at 22 weeks of gestation. After conservative surgery, she was given three cycles of carboplatin chemotherapy. She delivered at 33 weeks of gestation and after undergoing surgery she was given six cycles of paclitaxel and carboplatin chemotherapy. The patient is now being followed by the oncology department with no evidence of disease Daha fazlası Daha az

Barut, Figen | Kandemir, Onak Nilüfer | Karakaya, Kemal | Kökten, Neslihan | Özdamar, Şükrü Oğuz

Article | 2011 | Turkish Journal of Gastroenterology22 ( 3 ) , pp.324 - 328

Multifokal ve atlamalı tutulum, primer gastrointestinal lenfomalar için oldukça nadir görülen bir gelişim paternidir. Klinik ve makroskopik özellikleriyle Crohn hastalığını taklit eden kaldırım taşı görünümü ile dikkat çeken bir ince barsağın multifokal diffüz büyük B hücreli lenfoma olgusu, klinik ve patolojik özellikleri ile beraber sunulmuştur. 25 yaşındaki erkek olgunun jejunoileal rezeksiyon materyalinde, arada sağlam görünümde mukoza alanları izlenen, en büyüğü 2,5 cm çapında olan, ülsere, serozayı da infiltre eden polipoid görünümde multipl lezyonlar izlendi. Mikroskopik incelemede, belirgin nükleollü, veziküler nükleuslu, ge . . .niş eozinofilik sitoplazmalı, pleomorfik, atipik karakterde lenfoid hücrelerden oluşmuş tümöral infiltrasyon gözlendi. Bu atipik hücrelerde vimentin, LCA, CD20, CD79a ile B hücre fenotipinde immün reaksiyon izlendi. Olguya, diffüz büyük B hücreli lenfoma tanısı verildi. Crohn hastalığı belirti ve bulguları ile başvuran hastalarda nadir de olsa bu antitenin olabileceği vurgulanmıştır. Multifocal and skip involvement is quite a rare developmental pattern for primary gastrointestinal lymphomas. A 25-year-old male patient with diffuse large B-cell lymphoma of the small intestine, with macroscopic features and clinical aspects imitating Crohn’s disease and attracting attention with cobblestone-like appearance, is presented herein together with the clinical and pathological features. Multiple ulcerated lesions were also observed infiltrating the serosa with polypoid appearance, 2.5 cm in largest diameter, within the resected jejunoileal specimen, which displayed patchy, healthy-appearing mucosal areas. In microscopic examination, a tumoral infiltration was observed comprised of pleomorphic, atypical lymphoid cells with abundant eosinophilic cytoplasm, marked nucleoli and vesicular nuclei. A B-cell phenotype immunoreaction was observed by vimentin, LCA, CD20, and CD79a in those atypical cells. The diagnosis of the case was diffuse large B-cell lymphoma.The possibility of the presence of this disorder, although rare, is emphasized here for patients applying to the hospital with the signs and symptoms of Crohn’s disease Daha fazlası Daha az

Barut F. | Onak Kandemir N. | Karakaya K. | Kökten N. | Özdamar Ş.O.

Article | 2011 | Turkish Journal of Gastroenterology22 ( 3 ) , pp.324 - 328

Multifocal and skip involvement is quite a rare developmental pattern for primary gastrointestinal lymphomas. A 25-year-old male patient with diffuse large B-cell lymphoma of the small intestine, with macroscopic features and clinical aspects imitating Crohn's disease and attracting attention with cobblestone-like appearance, is presented herein together with the clinical and pathological features. Multiple ulcerated lesions were also observed infiltrating the serosa with polypoid appearance, 2.5 cm in largest diameter, within the resected jejunoileal specimen, which displayed patchy, healthy-appearing mucosal areas. In microscopic . . .examination, a tumoral infiltration was observed comprised of pleomorphic, atypical lymphoid cells with abundant eosinophilic cytoplasm, marked nucleoli and vesicular nuclei. A B-cell phenotype immunoreaction was observed by vimentin, LCA, CD20, and CD79a in those atypical cells. The diagnosis of the case was diffuse large B-cell lymphoma.The possibility of the presence of this disorder, although rare, is emphasized here for patients applying to the hospital with the signs and symptoms of Crohn's disease Daha fazlası Daha az

Barut A. | Arikan I. | Harma M. | Harma M.I. | Barut F. | Coskan A.

Article | 2011 | Journal of the Pakistan Medical Association61 ( 10 ) , pp.1016 - 1017

Hydatidiform moles are abnormal conceptions characterised by atypical hyperplastic trophoblasts and hydropic villi. Their incidence is approximately 1 in 1000 pregnancies. The recurrence risk of hydatidiform mole is approximately 1 in 60 in a subsequent pregnancy and 1 in 6.5 in the third pregnancy. In cases with recurrence, the majority of moles are of the same type as that in the preceding pregnancy. Here, we describe the case of a recurrent partial hydatidiform mole after an initial healthy pregnancy. Both pregnancies were evacuated by suction curettage, and the patient was followed by serial monitoring of ß-human chorionic gonad . . .otropin levels. Recurrent molar pregnancy is not an indication for chemotherapy, and subsequent pregnancies do not have an increased risk for other obstetric complications Daha fazlası Daha az