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Intranodal palisaded myofibroblastoma (intranodal hemorrhagic spindle cell tumor with amianthoid fibers): A case report and literature review

Kandemir N.O. | Barut F. | Ekinci T. | Karagülle Ç. | Özdamar Ş.O.

Article | 2010 | Diagnostic Pathology5 ( 1 )

https://dx.doi.org/10.1186/1746-1596-5-12 https://hdl.handle.net/20.500.12628/6290

C-Kit (CD117) expression in classic Kaposi's sarcoma: Experimental dermatology

Kandemir N.O. | Gun B.D. | Bahadir B. | Yurdakan G. | Ozdemir N. | Karadayi N. | Ozdamar S.O.

Article | 2010 | Clinical and Experimental Dermatology35 ( 5 ) , pp.525 - 530

Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin . . .-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity. © 2009 British Association of Dermatologists Daha fazlası Daha az

The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas

Gul A.E. | Keser S.H. | Barisik N.O. | Kandemir N.O. | Cakir C. | Sensu S. | Karadayi N.

Article | 2010 | Diagnostic Pathology5 ( 1 ) , pp.525 - 530

Background: Endometrial carcinoma (EC) is the most common malignancy of the female genital tract. Gene alterations and overexpression of various oncogenes are important in tumor development. The human HER 2 neu (c-erbB-2) gene product is a transmembrane receptor with an intracellular tyrosine kinase that plays an important role in coordinating the endometrial growth factor receptor signaling network. The aim of this study was to investigate the expression of c-erbB-2 in endometrial cancer, to study its correlation to established prognostic parameters and estrogen receptor (ER) and progesterone receptor (PR) status.Methods: Immunohis . . .tochemical (IHC) analyses of ER, PR and c-erbB-2 were performed in 72 EC cases.Results: We detected a positive staining with c erbB 2 in 18.1% of the cases and determined a statistically significant relation between c-erbB-2 and PR. We could not find a statistically significant relation between c-erbB-2 staining and ER. There was not a statistically significant difference between c-erbB-2 and histological grade. The highest level of c-erbB-2 was found in grade 2 cases. There was not any statistically significant relation between c-erbB-2 and menstrual status, myometrial invasion, lymph node status, stage and survival.Conclusions: Although our study provides additional evidence of the potential prognostic role of c-erbB-2, further prospective and controlled studies are required to validate their clinical usefulness. © 2010 Gul et al; licensee BioMed Central Ltd Daha fazlası Daha az

Universal markers of thyroid malignancies: Galectin-3, HBME-1, and Cytokeratin-19

Barut F. | Kandemir N.O. | Bektas S. | Bahadir B. | Keser S. | Ozdamar S.O.

Article | 2010 | Endocrine Pathology21 ( 2 ) , pp.80 - 89

Difficulties in diagnosis of thyroid lesions, even with histologic analysis, are well known. This study has been carried on to evaluate the role of immunohistochemical markers including galectin-3, Hector Battifora mesothelial cell-1 (HBME-1), and cytokeratin-19 in the diagnosis and differential diagnosis of benign and malignant thyroid lesions. The expressions of galectin-3, HBME-1, and cytokeratin-19 were tested in formalin-fixed, paraffin-embedded tissues from 458 surgically resected thyroid lesions including non-neoplastic and neoplastic lesions. Immunostaining with standard avidin-biotin complex technique was performed by using . . . monoclonal antibodies. In malignant neoplastic thyroid lesions, galectin-3, HBME-1, and cytokeratin-19 were diffusely expressed in general. Diffuse expression rates of these three markers were 72.3% (47/65), 70.7% (46/65), and 76.9% (50/65), respectively. The use of galectin-3, HBME-1, and cytokeratin-19 may provide significant contributions in the differential diagnosis of malignant thyroid tumors. Although focal galectin-3, HBME-1, and cytokeratin-19 expression may be encountered in benign lesions, diffuse positive reactions for these three markers are characteristic of malignant lesions. It has concluded that cytokeratin-19 alone and its combinations with other markers were more sensitive in accurate diagnosis of papillary carcinoma than the other combinations; meanwhile, there were similar results for follicular carcinomas with HBME-1 alone and its combinations. © 2009 Springer Science+Business Media, LLC Daha fazlası Daha az

Histological subgroups in classic kaposi sarcoma: A preliminary study

Kandemir, Nilüfer Onak | Gün, Banu Doğan | Barut, Figen | Yurdakan, Gamze | Bahadır, Burak | Bektaş, Sibel | Gün, Mustafa | Keser, Sevinç Hallaç | Özdemir, Nagehan | Özdamar, Şükrü Oğuz

Article | 2010 | TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY44 ( 2 ) , pp.73 - 78

Background and Design: Kaposi sarcomas (KS) are vascular tumors with a low malignant potential which include overlapping infectious, immunologic, and neoplastic processes. Recently, many histological subtypes have been defined. Material and Method: In the present study, 151 cutaneous classic KS lesions in 56 patients were retrospectively evaluated with regard to histological subtypes. Determination of the subtypes was based on the predominant histopathological component in the lesion. We examined changes in epidermis and dermis along with intratumoral inflammatory response characteristics in the lesions. By defining histopathologica . . .l variants of the cases, differences regarding subtypes were investigated. Results: Cases that bear the ordinary characteristics of KS and those that can not be classified otherwise, comprised 82..8% of the study group. Twenty-six cases showed consistency with the subtypes outlined in the literature in terms of their histopathological properties. The most common histological subtype was the lymphangiectatic variant in 7.3% of the cases. Bullous (2.6%), lymphangioma like (2.6%), intravascular (2%), and pyogenic granuloma like (2%) variants were less common. The most uncommon histological subtype was micronodular (0.6%) type. Lymphangiectatic, bullous, intravascular, and pyogenic granuloma like variants were frequently observed in the nodular stage of KSs. Lympangioma like changes were seen to be present in the early KS lesions. Lymphangiectatic type was oftenly associated with bullous component, whereas pyogenic granuloma like type demonstrated superficial ulceration and intense inflammatory response. Lymphangioma like and intravascular types exhibited a characteristic appearance, while other variants were accompanied by components belonging to different subtypes. Conclusion: In KS, histopathological subtypes can develop as a result of different pathological processes. The next stage of the current study, which is one of the largest case series in the literature, will be investigation of the clinical and prognostic characteristics of the variants. (Turkderm 2010; 44: 73-8 Daha fazlası Daha az

Demonstration of the histopathological and immunohistochemical effects of a novel hemostatic agent, ankaferd blood stopper, on vascular tissue in a rat aortic bleeding model

Kandemir O. | Buyukates M. | Kandemir N.O. | Aktunc E. | Gul A.E. | Gul S. | Turan S.A.

Article | 2010 | Journal of Cardiothoracic Surgery5 ( 1 ) , pp.73 - 78

Background: Ankaferd Blood Stopper®(ABS) is a folkloric medicinal plant extract used as a hemostatic agent in traditional Turkish medicine. This experimental study investigated the histopathological and immunohistochemical effects of ABS on vascular tissue in a rat model of aortic bleeding.Methods: Four groups of 11 Wistar albino rats were used. The abdominal aortas of the rats were wounded; an ABS-soaked tampon was applied to rats in Groups 1 and 3, and a plain gauze tampon was applied to rats in Groups 2 and 4 until the bleeding stopped. The bleeding time was recorded. Immediately following sacrificing, the arteriotomy sites from . . .Groups 1 and 2 were removed. The abdominal incisions in Groups 3 and 4 were closed following hemostasis. On Day 7 of the study, Group 3 and 4 rats were sacrificed and the abdominal aorta arteriotomy sites were removed for histopathological and immunohistochemical evaluation.Results: The mean bleeding time in 15 animals in Groups 2 and 4 was 4.9 ± 0.6 s, and in 22 animals in Groups 1 and 3 was 3.1 ± 0.6 s. Distal aortic occlusion was not observed on either Day 1 or 7 in any group. Significantly more widespread and dense endothelial nitric oxide synthase (eNOS) staining was observed in Group 1 animals than Group 2. On Days 1 and 7 after application of ABS, histopathological changes, consisting of necrosis, inflammation, and endothelial cell loss, in the rat abdominal aortas did not differ between Groups 1 and 2. The basophilic discoloration in the ABS group on the operation day was a result of a foreign body reaction and hemosiderin-loaded histiocyte accumulation, which occurred on Day 7.Conclusions: In this study, hemostasis was successfully achieved with ABS in rat abdominal aortas. No histopathological change was found in the rat abdominal aortas between the ABS and control groups on Days 1 and 7. Further studies on the long-term effects of foreign body reactions and hemosiderin-loaded histiocyte accumulation are required. © 2010 Kandemir et al; licensee BioMed Central Ltd Daha fazlası Daha az

Cutaneous horn-related Kaposi's sarcoma: A case report

Kandemir N.O. | Gun B.D. | Barut F. | Tekin N.S. | Ozdamar S.O.

Article | 2010 | Case Reports in Medicine2010 , pp.73 - 78

https://dx.doi.org/10.1155/2010/825949 https://hdl.handle.net/20.500.12628/4966

Intrauterine growth restriction and placental angiogenesis

Barut F. | Barut A. | Gun B.D. | Kandemir N.O. | Harma M.I. | Harma M. | Aktunc E.

Article | 2010 | Diagnostic Pathology5 ( 1 ) , pp.73 - 78

Background: Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (b-FGF), and endothelial nitric oxide synthase (eNOS) are factors that take part in placental angiogenesis. They are highly expressed during embryonic and fetal development, especially in the first trimester. In this study, we aimed to investigate the role of placental angiogenesis in the development of intrauterine growth restriction (IUGR) by comparing the levels of expression of VEGF-A, b-FGF, and eNOS in normal-term pregnancy and IUGR placentas.Methods: The expression of VEGF-A, b-FGF, and eNOS was studied using the avidin-biotin-peroxidase met . . .hod in placental tissues diagnosed as normal (n = 55) and IUGR (n = 55). Results were evaluated in a semi-quantitative manner.Results: The expression of all the markers was significantly higher (p < 0.001) in cytotrophoblasts, syncytiotrophoblasts, extravillous trophoblasts, vascular smooth muscle cells, chorionic villous stromal cells, and villous vascular endothelial cells of the IUGR placentas when compared with those collected from normal-term pregnancies.Conclusion: Increased expression of VEGF-A, b-FGF, and eNOS may be the result of inadequate uteroplacental perfusion, supporting the proposal that abnormal angiogenesis plays a role in the pathophysiology of IUGR. © 2010 Barut et al; licensee BioMed Central Ltd Daha fazlası Daha az

Endothelial nitric oxide synthase expression in gestational trophoblastic diseases

Barut A. | Harma M. | Arikan I. | Harma M.I. | Barut F.

Article | 2010 | International Journal of Gynecological Cancer20 ( 3 ) , pp.337 - 340

Objective: Nitric oxide is thought to play a role in the regulation of trophoblast activity. The aim of this study was to compare endothelial nitric oxide synthase expression in tissue samples taken from gestational trophoblastic diseases and placentas of normal pregnancies. Methods: The expression of endothelial nitric oxide synthase was tested in formalin-fixed, paraffin-embedded tissues from specimens including 8 first trimester placentas, 3 partial hydatidiform moles, 20 complete hydatidiform moles, 2 invasive moles, and 5 choriocarcinomas. The expression of antibody was scored by a semiquantitative scale to define staining inte . . .nsity. Results: The first trimester placentas showed moderate expression in the villous. Gestational trophoblastic diseases displayed strong to very strong endothelial nitric oxide synthase expression in the syncytiotrophoblast, villous, and proliferating mononuclear trophoblasts. Conclusions: Endothelial nitric oxide synthase expression seems to have a strong correlation with proliferation of trophoblastic cells, in gestational trophoblastic diseases and in normal pregnancy. Copyright © 2010 by IGCS and ESGO Daha fazlası Daha az

Does intraabdominal use of Ankaferd Blood Stopper cause increased intraperitoneal adhesions?

Cömert, Mustafa | Karakaya, Kemal | Barut, Figen | Çakmak, Karadeniz Güldeniz | Uçan, Hamdi Bülent | Gültekin, Fatma Ayça | Emre, Ali Uğur

Article | 2010 | Ulusal Travma ve Acil Cerrahi Dergisi16 ( 5 ) , pp.383 - 389

AMAÇ Bu çalışmanın amacı, karın içi kullanılan Ankaferd Blood Stopper’in (ABS) periton içi yapışıklık oluşumunu arttırıp arttırmadığını ve in vivo kullanıma bağlı majör toksik etkilerini irdelemektir. GEREÇ VE YÖNTEM Bu deneysel çalışma, çekal abrazyon uygulanan sıçan modelinde Ankaferd solüsyonunun periton içi yapışıklık oluşumu üzerine etkisini değerlendirmek üzere dizayn edildi. Periton içi yapışıklıklar cerrahi uygulama sonrası 10. gün makroskopik ve histopatolojik inceleme ile belirlendi. Yan etki varlığını irdelemek için kan, akciğer ve karaciğer dokuları alındı. BULGULAR Ankaferd Blood Stopper’in kullanımı ile karın içi yapış . . .ıklık oluşumunun azaldığı görüldü. ABS uygulanmasının kan biyokimyasal incelemelerinde herhangi bir bozulmaya neden olmadığı saptandı. Ancak akciğerlerde ve bağırsakların serozal yüzeylerinde akut ve kronik enflamatuvar değişiklikler ve karaciğerde minör yapısal değişiklikler izlendi. Bu değişikliklerin hiçbiri toksik değişiklik olarak değerlendirilmedi. ABS’nin diğer etkilerinin belirlenmesi için farklı dozlarda ve farklı klinik senaryolarda ileri çalışmalara ihtiyaç vardır. SONUÇ Periton içi yapışıklık oluşumu ABS uygulanan grupta kontrol grubu ve SF grubuna kıyasla daha az görüldü. İntraperitoneal ABS kullanıma bağlı olarak herhangi bir toksik etki saptanmamakla birlikte bazı minör değişiklikler gözlenmiştir. BACKGROUND The aim of this study was to investigate whether intraabdominal Ankaferd Blood Stopper (ABS) causes increased intraabdominal adhesion formation and to determine any side effects of ABS in vivo. METHODS The present experimental study was designed to examine the effects of Ankaferd solution on peritoneal adhesion formation in a rat model of cecal abrasion. Intraperitoneal adhesions were assessed macroscopically and histopathologically on the 10th postoperative day. The possible adverse affects of ABS on liver and lung tissues were analyzed histopathologically, and blood chemistry was also evaluated. RESULTS Our study revealed that ABS reduced intraperitoneal adhesion formation in an experimental rat model. The blood chemistry was not disturbed due to ABS administration. Intraperitoneal administration of ABS led to some minor changes in the lungs and serosal surfaces of the intestines, with minor architectural changes in the liver that were not considered as toxic. Further studies with various application doses and routes with more detailed cellular analysis are thus warranted to clarify the possible pleiotropic and adverse effects of this new agent away from hemostasis. CONCLUSION There was less intraperitoneal adhesion formation in the ABS group than in the control group and saline group. Intraperitoneal administration of ABS has no toxic effects on blood chemistry or the lungs, kidneys and the liver, but it has some minor adverse effects Daha fazlası Daha az

Does intraabdominal use of Ankaferd Blood Stopper cause increased intraperitoneal adhesions? [Ankaferd Blood Stopper'in karin içi kullanim periton içi yapişklk oluşumunu arttrr m?]

Cömert M. | Karakaya K. | Barut F. | Karadeniz Çakmak G. | Uçan H.B. | Gültekin F.A. | Emre A.U.

Article | 2010 | Ulusal Travma ve Acil Cerrahi Dergisi16 ( 5 ) , pp.383 - 389

Background The aim of this study was to investigate whether intraabdominal Ankaferd Blood Stopper (ABS) causes increased intraabdominal adhesion formation and to determine any side effects of ABS in vivo. Methods The present experimental study was designed to examine the effects of Ankaferd solution on peritoneal adhesion formation in a rat model of cecal abrasion. Intraperitoneal adhesions were assessed macroscopically and histopathologically on the 10th postoperative day. The possible adverse affects of ABS on liver and lung tissues were analyzed histopathologically, and blood chemistry was also evaluated. Results Our study reveal . . .ed that ABS reduced intraperitoneal adhesion formation in an experimental rat model. The blood chemistry was not disturbed due to ABS administration. Intraperitoneal administration of ABS led to some minor changes in the lungs and serosal surfaces of the intestines, with minor architectural changes in the liver that were not considered as toxic. Further studies with various application doses and routes with more detailed cellular analysis are thus warranted to clarify the possible pleiotropic and adverse effects of this new agent away from hemostasis. Conclusion There was less intraperitoneal adhesion formation in the ABS group than in the control group and saline group. Intraperitoneal administration of ABS has no toxic effects on blood chemistry or the lungs, kidneys and the liver, but it has some minor adverse effects Daha fazlası Daha az

Ovarian heterotopic pregnancy clinically mimicking endometrioma

Kandemir, Nilüfer Onak | Barut, Figen | Yurdakan, Gamze | Bayar, Ülkü | Özdamar, Şükrü Oğuz

Other | 2010 | Türk Patoloji Dergisi26 ( 1 ) , pp.85 - 88

Heterotopik gebelik; oldukça nadir görülen ve pre-operatif tanısı zor olan bir durumdur. Bu çalışmada 33 yaşında kadın hastada, in vitro fertilizasyon uygulamasını takiben gelişen ve klinik olarak endometrioma' yı taklit eden ovarian heterotopik gebelik olgusu sunulmuştur. Heterotopik gebelik tanısında klinik, histopatolojik ve immünhistokimyasal incelemenin önemi vurgulanmıştır. Heterotopic pregnancy is a very uncommon entity with a difficult preoperative diagnosis. In the present study, we presented an ovarian heterotopic pregnancy case, clinically mimicking endometrioma developed in a 33-year-old female following an in vitro fert . . .ilization procedure. The importance of clinical, histopathological, and immunohistochemical examinations in the diagnosis of heterotopic pregnancy are emphasized Daha fazlası Daha az

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