Armutçu, Feraf | Coşkun, Ömer Faruk | Gürel, Aykut | Şahin, S. | Kanter, Marek | Cihan, Ali | Numanoğlu, Kemal Varın

Article | 2005 | Cell Biology and Toxicology21 ( 1 ) , pp.53 - 60

Acetone may induce oxidative stress leading to disturbance of the biochemical and physiological functions of red blood cells (RBCs) thereby affecting membrane integrity. Vitamin E (vit E) is believed to function as an antioxidant in vivo protecting membranes from lipid peroxidation. The aim of the present study was the evaluation of possible protective effects of vit E treatment against acetone-induced oxidative stress in rat RBCs. Thirty healthy male Wistar albino rats, weighing 200-230 g and averaging 12 weeks old were randomly allotted into one of three experimental groups: Control (A), acetone-treated (B) and acetone + vit E-tre . . .ated groups (C), each containing ten animals. Group A received only drinking water. Acetone, 5% (v/v), was given with drinking water to B and C groups. In addition, C group received vit E dose of 200 mg/kg/day i.m. The experiment continued for 10 days. At the end of the 10th day, the blood samples were obtained for biochemical and morphological investigation. Acetone treatment resulted in RBC membrane destruction and hemolysis, increased thiobarbituric acid reactive substance (TEARS) levels in plasma and RBC, and decreased RBC vit E levels. Vit E treatment decreased elevated TEARS levels in plasma and RBC and also increased reduced RBC vit E levels, and prevented RBC membrane destruction and hemolysis. In conclusion, vit E treatment appears to be beneficial in preventing acetone-induced oxidative RBC damage, and therefore, it can improve RBC rheology. © 2005 Springer Daha fazlası Daha az

Cömert, Mustafa | Sipahi, Emine Yılmaz | Üstün, Hüseyin | Işıkdemir, Fulden | Numanoğlu, Gamze | Barut, Figen | Altunkaya, Hanife | Özer, Yetkin | Ayoğlu, Ferruh Niyazi | Sipahi, Tunç Hakan | Tekin, İshak Özel | Banoğlu, Z. Nur

Article | 2005 | European Journal of Pharmacology511 ( 02.Mar ) , pp.183 - 189

This study was designed to investigate the possible participation of morphine in pulmonary oedema induced by ?-naphthylthiourea (ANTU), which is a well-known noxious chemical agent in the lung. Injection of ANTU (15 mg/kg i.p.) produced pulmonary oedema as indicated by an increase in lung weight/body weight ratio and pleural effusion reaching a maximum within 4 h in rat. Administration of morphine prior to ANTU significantly inhibited to pulmonary oedema with a dose-dependent manner. The protective effect of morphine is prevented by peripheral opioid receptor antagonist, naloxone methiodide. ANTU-treated rats were shown positive by . . .inducible nitric oxide synthase immunohistochemical staining. There was no staining in the control group. On the other hand, the degree of staining was markedly reduced in tissue sections by morphine. These results suggest that previous administration of subcutaneous morphine has preventive effect on ANTU-induced pulmonary inflammatory reaction and its effect mediated via peripheral opioid receptors. Application of naloxone with ANTU has no effect on the lung parameters indicating that endogenous opioids do not modulate ANTU-induced damage. © 2005 Elsevier B.V. All rights reserved Daha fazlası Daha az

Acun, Ceyda | Kargı, Eksal | Üstündağ, Gonca | Hoşnuter, Mübin | Numanoğlu, Gamze

Letter | 2005 | PLASTIC AND RECONSTRUCTIVE SURGERY115 ( 6 ) , pp.1790 - 1792

WOS: 000228884600059 PubMed: 15861107

Keser, Selçuk | Bayar, Ahmet | Numanoğlu, Gamze

Article | 2005 | Knee Surgery, Sports Traumatology, Arthroscopy13 ( 7 ) , pp.585 - 588

Lipoma is the most frequently encountered benign soft tissue tumor. However, intra-articular lipomas are rarely seen. Anterior knee pain is a frequent complaint of adults and is of diverse etiology. This 42-year-old female patient had severe anterior knee pain, unresponsive to medical treatment. Magnetic resonance imaging revealed an intra-articular tumor of the knee joint. Arthroscopic intervention and subsequent histological examination resulted in the diagnosis of strangulated lipoma originating from infrapatellar fat pad. We present clinical, radiological and operative features of this rare case of intra-articular lipoma. © Spri . . .nger-Verlag 2005 Daha fazlası Daha az

Aydemir, Selim | Üstündağ, Yücel | Sert, Mehmet | Sayarlıoğlu, Hayriye | Yenidünya, Sibel | Numanoğlu, Gamze | Tanrıverdi, Alper

Article | 2005 | Akademik Gastroenteroloji Dergisi4 ( 1 ) , pp.60 - 63

Gaucher hastalığı beta glukoserobrozidaz genindeki mutasyon sonucunda gelişen, otozomal resesif kalıtımla geçen, lipit depo hastalığıdır. Mutasyon sonucunda enzim aktivitesindeki azalma sonucunda retikuloendotelial sistemde makrofajlarda glukoserobrozid birikimi olur. Nörolojik komponenti olup (tip 2 ve 3) olmamasına (tip 1) göre klinik üç subtipi vardır. Hastalar sıklıkla hepatosplenomegali, anemi, trombositopeni ve kemik ağrıları vardır. Biz birinde siroz gelişmiş iki tip 1 Gaucher hastasını sunduk. Gaucher's disease is an autosomal recessive glycolipid storage disorder caused by mutations in the beta glucocerebrosidase gene. This . . . defect leads to reduced enzyme activity with accumulation of glucocerebroside in the macrophages of the reticuloendothelial system. Three clinical subtypes of Gaucher's disease have been described on the basis of the absence (type I) or presence (types II and III) of a neurological component. Type I is the more common subtype. Common presenting features include hepatosplenomegaly, anemia, thrombocytopenia, and often bone pains. We present two cases with Gaucher disease type 1, one of whom also had cirrhosis Daha fazlası Daha az