Öztürk, Ertan | Özer, Mahmut

Proceedings | 2005 | Proceedings of the IEEE 13th Signal Processing and Communications Applications Conference, SIU 20052005 , pp.147 - 150

Voltage-gated ion channels in neuronal membrane show random fluctuations between different conformational states. These fluctuations give rise to channel noise current. This channel noise current is of great importance in the determination single-channel properties of voltage-gated ion channels. In this study, single-channel currents of potassium and sodium channels in Wang-Buzsaki neuronal model are examined, and their single-channel conductances and total sodium and potassium channel numbers in the membrane are computed by using non-stationary noise analysis. © 2005 IEEE.

Ekmekçi N. Hakan | Özer, Mahmut

Proceedings | 2005 | Proceedings of the IEEE 13th Signal Processing and Communications Applications Conference, SIU 20052005 , pp.143 - 146

Voltage-gated ion channels are of great importance in the generation and propagation of electrical signals in the excitable membranes. In this study, we introduce the stochastic version of the Hodgkin-Huxley formalism and investigate the effect of channel noise on neuronal dynamic behaviors based on a model with the Gaussian noise. We show that the channel noise may result in a spiking activity for subthreshold stimulus, and that the firing dynamics follows more regular patterns when the membrane patch becomes smaller. It is also shown that the stochastic model converges to the deterministic model for very large membrane patches and . . . the neurons can encode subthreshold stimuli by considering the channel noise. © 2005 IEEE Daha fazlası Daha az