Uzuntarla, Muhammet | Torres, Joaquin J. | Çalım, Ali | Barreto, Ernest

Article | 2019 | Neural Networks110 , pp.131 - 140

We observe and study a self-organized phenomenon whereby the activity in a network of spiking neurons spontaneously terminates. We consider different types of populations, consisting of bistable model neurons connected electrically by gap junctions, or by either excitatory or inhibitory synapses, in a scale-free connection topology. We find that strongly synchronized population spiking events lead to complete cessation of activity in excitatory networks, but not in gap junction or inhibitory networks. We identify the underlying mechanism responsible for this phenomenon by examining the particular shape of the excitatory postsynaptic . . . currents that arise in the neurons. We also examine the effects of the synaptic time constant, coupling strength, and channel noise on the occurrence of the phenomenon. © 2018 Elsevier Lt Daha fazlası Daha az

Uzuntarla, Muhammet | Barreto, Ernest | Torres, Joaquin J.

Article | 2017 | PLoS Computational Biology13 ( 7 ) , pp.131 - 140

Inverse Stochastic Resonance (ISR) is a phenomenon in which the average spiking rate of a neuron exhibits a minimum with respect to noise. ISR has been studied in individual neurons, but here, we investigate ISR in scale-free networks, where the average spiking rate is calculated over the neuronal population. We use Hodgkin-Huxley model neurons with channel noise (i.e., stochastic gating variable dynamics), and the network connectivity is implemented via electrical or chemical connections (i.e., gap junctions or excitatory/inhibitory synapses). We find that the emergence of ISR depends on the interplay between each neuron’s intrinsi . . .c dynamical structure, channel noise, and network inputs, where the latter in turn depend on network structure parameters. We observe that with weak gap junction or excitatory synaptic coupling, network heterogeneity and sparseness tend to favor the emergence of ISR. With inhibitory coupling, ISR is quite robust. We also identify dynamical mechanisms that underlie various features of this ISR behavior. Our results suggest possible ways of experimentally observing ISR in actual neuronal systems. © 2017 Uzuntarla et al Daha fazlası Daha az

Uzuntarla, Muhammet | Torres, Joaquin J. | So, Paul | Özer, Mahmut | Barreto, Ernest

Article | 2017 | Physical Review E95 ( 1 ) , pp.131 - 140

We investigate the behavior of a model neuron that receives a biophysically realistic noisy postsynaptic current based on uncorrelated spiking activity from a large number of afferents. We show that, with static synapses, such noise can give rise to inverse stochastic resonance (ISR) as a function of the presynaptic firing rate. We compare this to the case with dynamic synapses that feature short-term synaptic plasticity and show that the interval of presynaptic firing rate over which ISR exists can be extended or diminished. We consider both short-term depression and facilitation. Interestingly, we find that a double inverse stocha . . .stic resonance (DISR), with two distinct wells centered at different presynaptic firing rates, can appear. © 2017 American Physical Society Daha fazlası Daha az