Effects of calcium channel noise on weak signal detection in neuron-astrocyte interactions

Erkan, Yasemin | Saraç, Zehra | Yılmaz, Ergin

Proceedings | 2018 | 26th IEEE Signal Processing and Communications Applications Conference, SIU 2018 , pp.1 - 4

In this study, the effects of electrically non-excitable astrocyte cell on the weak signal detection capacity of Hodgkin-Huxley neuron are investigated. To do this, by applying a subthreshold weak signal to neuron, we investigate the weak signal detection capacity of the neuron depending on calcium channel noise stemmed from random open-close fluctuations of calcium channels. Obtained results show that astrocyte decreases the weak signal detection capacity of Hodgkin-Huxley neuron. © 2018 IEEE.

Subthreshold signal detection in heterogeneous neural networks

Çalım, Ali | Özer, Mahmut | Uzuntarla, Muhammet

Proceedings | 2018 | 26th IEEE Signal Processing and Communications Applications Conference, SIU 2018 , pp.1 - 4

In this study, effects of the heterogeneity in neuronal networks and subthreshold signal features on subthreshold signal detection in the nervous system is investigated. As most of studies in the literature investigate the subject by considering neuron populations as homogenous systems, in this study, the populations are considered as heterogeneous in terms of neuronal excitability. The information processing performance of the neuron populations is systematically studied by using mathematical equations for modeling the dynamics of the neurons, which are basic units of the system. As a result of the simulations performed, it is seen . . . that the sub-threshold signal frequency and the heterogeneity in the excitability are important system parameters for optimizing the information encoding performance. It is shown that the population encoding performance is maximized depending on the subthreshold signal frequency at different optimum levels of heterogeneity in the population. © 2018 IEEE Daha fazlası Daha az

Effects of astrocytes on neuronal dynamics

Erkan, Yasemin | Özer, Mahmut | Yılmaz, Ergin

Proceedings | 2017 | 2017 Medical Technologies National Conference, TIPTEKNO 20172017-January , pp.1 - 4

Astrocytes are star-shaped glia cells and the most common cell type in the human brain with neurons. Astrocytes fulfill many functions in human brain. Providing support to the cells of the blood-brain barrier, balancing the extracellular ion concentration, supplying nutrients to the nerve tissue, and controlling the development of nerve cells are some of these tasks. In this study, the effects of calcium (Ca2+) ion concentration oscillations occuring in astrocytes on the neuron firing dynamics are investigated. When the obtained results are examined, it is observed that the production rate of insole 1,4,5-Triphosphate (IP3), which i . . .s an agent that triggers calcium release from the resoruces in astrocytes, and the degradation time of that within the cell are important effects on the spike production dynamics of the neuron in contact with astrocyte. It is determined that neurons without any stimulation continue to produce spikes through calcium oscillations in the astrocytes, at high IP3 production rates and longer IP3 degradation times. © 2017 IEEE Daha fazlası Daha az

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