Bakkal, Bekir Hakan | Ugur M.B. | Bahadir B.

Article | 2014 | Journal of the Pakistan Medical Association64 ( 4 ) , pp.468 - 470

The incidence of numerous head and neck tumours is a known issue though bilateral synchronous tonsillar carcinoma reports are so uncommon that only 20 cases were found in a literature review. Most of these patients were treated with bilateral tonsillectomy followed by adjuvant radiotherapy. We report, to our knowledge, the first case of bilateral synchronous tonsillar squamous cell carcinoma treated only with chemoradiotherapy without tonsillectomy.

Kandemir N.O. | Gun B.D. | Bahadir B. | Yurdakan G. | Ozdemir N. | Karadayi N. | Ozdamar S.O.

Article | 2010 | Clinical and Experimental Dermatology35 ( 5 ) , pp.525 - 530

Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin . . .-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity. © 2009 British Association of Dermatologists Daha fazlası Daha az

Onak Kandemir N. | Bahadir B. | Bektaş S. | Barut F. | Yurdakan G. | Dogan Gün B. | Engin H.

Article | 2011 | Turkish Journal of Gastroenterology22 ( 1 ) , pp.77 - 82

Congenital melanocytic nevi are hamartomatous lesions that develop from the neural crest and arise during odontogenesis. In this report, we present two malignant melanoma cases developed from congenital melanocytic nevi and revealed by gastrointestinal system metastases. The first case was a 71-year-old female who presented with pleural and peritoneal effusion and underwent biopsy due to detection of nodular lesions in the duodenum by endoscopic examination. The second case was a 36-year-old male patient who presented with abdominal pain in whom segmental ileal resection was performed due to mass lesions causing invaginations in the . . . ileum. Histopathological examination of the lesions showed a diffuse neoplastic infiltration comprising the entire mucosal layers. In neoplastic cells having a marked atypia and pleomorphism, immunoreactions with S-100, HMB-45, and Melan A were detected. Both cases were diagnosed as malignant melanoma. Abdominal skin in the first case and the femoral region in the second case exhibited congenital melanocytic nevi, and those lesions were determined to show a transformation towards malignant melanoma in the histopathological studies. Malignant melanoma development in gastrointestinal system may have a primary or metastatic character. Definitive diagnosis always requires detailed clinical, histopathological and immunohistochemical analyses Daha fazlası Daha az

Onak Kandemir N. | Barut F. | Keser S. | Karadayi N. | Bektaş S. | Dogan Gün B. | Bahadir B.

Article | 2009 | Turk Onkoloji Dergisi24 ( 4 ) , pp.172 - 176

OBJECTIVES This study examined the frequency of chronic lymphocytic thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and the relationship between the presence of tumor-infiltrating lymphocytes (TIL) and CLT. METHODS The study included 61 TPC cases. In each case, the presence of the lymphocyte infiltration in the tumor tissue and non-neoplastic parenchyma was graded semi-quantitatively using a scale of 0 to 3. The cases were classified in two groups, TPC including CLT (Group I) and TPC not including CLT (Group II). RESULTS CLT was detected in 26.3% (Group I) of the TPCs and TIL was observed in 77% of the Group I cases; no lymp . . .hoid infiltration compatible with TIL was detected in Group II. A significant difference was observed in the TIL density between Groups I and II. CONCLUSION CLT is a frequent finding in TPC, and the presence of TIL is related to CLT. © 2009 Association of Oncology Daha fazlası Daha az

Barut F. | Kertiş G. | Bahadir B. | Özdamar S.O. | Gün B.D. | Seçkiner I. | Kuzey G.M.

Article | 2009 | Journal of Experimental and Clinical Medicine (Turkey)26 ( 2 ) , pp.96 - 98

Bektaş S. | Barut F. | Bahadir B. | Dogan G.Ü.N.B. | Kandemir N.O. | Karadayi N. | Özdamar Ş.O.

Article | 2009 | Turkish Journal of Medical Sciences39 ( 2 ) , pp.185 - 189

Background: The aim of this study was to evaluate intraobserver and interobserver reproducibility of Fuhrman nuclear grading of renal cell carcinoma. Methods: Pathology slides from 46 cases of renal cell carcinoma were rescored by 2 pathologists according to the Fuhrman system. Both intraobserver and interobserver reproducibility were assessed using kappa statistics. Results: The initial Fuhrman grade was grade 1 in 4 of the cases (8.7%), grade 2 in 30 (65.2%), grade 3 in 11 (23.9%), and grade 4 in 1 (2.2%). After reviewing the slides by the same pathologist, grades were reassigned as follows: grade 1 in 8 cases (17.4%), grade 2 in . . .23 (50%), grade 3 in 14 (30.4%), and grade 4 in 1 (2.2%). Intraobserver reproducibility of the Fuhrman system was substantial (k = 0.66). Fuhrman grading by the second pathologist was grade 1 in 11 cases (23.9%), grade 2 in 27 (58.7%), grade 3 in 7 (15.2%), and grade 4 in 1 (2.2%). Interobserver reproducibility of the Fuhrman system was moderate (k = 0.42). Conclusions: Despite substantial intraobserver reproducibility of Fuhrman grading, moderate interobserver reproducibility and low agreement for grade 3 should be a consideration Daha fazlası Daha az

Onak Kandemir N. | Bektaş S. | Barut F. | Bahadir B. | Yurdakan G. | Dogan Gun B. | Mungan A.

Article | 2010 | Turk Onkoloji Dergisi25 ( 2 ) , pp.49 - 56

OBJECTIVES: The contribution of cytological methods to the diagnosis and follow-up of urinary system malignancies was investigated in this study, along with histological diagnosis and clinical follow-up results of the cases. METHODS: One hundred forty-four cases who underwent cystoscopy in ZKÜTF Urology Department between 2003 and 2007 were included in this study, and urinary cytology and biopsy samples were assessed in the Pathology Department. RESULTS: When cytological and histological diagnoses were compared, results in 17 positive cases and in 109 negative cases were consistent. Three cases were false-positive and 15 cases were . . .false-negative. In our series, sensitivity of urinary cytological diagnostic methods was 53% and specificity was 97%. CONCLUSION: Our study shows that urinary cytology has a high diagnostic value in the evaluation of urinary system diseases. However, decrease in the sensitivity of this method in low-grade urothelial tumors should be taken into account. © 2010 Association of Oncology Daha fazlası Daha az

Barut F. | Onak Kandemir N. | Ozdamar S.O. | Gul S. | Bektas S. | Dogan Gun B. | Bahadir B.

Article | 2009 | Turkish Neurosurgery19 ( 4 ) , pp.417 - 422

Bektas S. | Bahadir B. | Kandemir N.O. | Barut F. | Gul A.E. | Ozdamar S.O.

Article | 2009 | Kaohsiung Journal of Medical Sciences25 ( 11 ) , pp.596 - 600

The Fuhrman nuclear grade is the most widely used grading system for renal cell carcinoma. The aim of this study was to evaluate the intraobserver and interobserver variability of the Fuhrman and modified Fuhrman grading systems for conventional renal cell carcinoma. In this study, five pathologists independently classified 110 cases of conventional renal cell carcinoma according to the Fuhrman and modified (three- and two-tiered) Fuhrman grading systems. The intraobserver and interobserver variability of these systems were assessed using ? statistics. The associations between the Fuhrman and modified Fuhrman grades, pathologic stag . . .e and tumor size were determined by correlation analysis. The intraobserver and interobserver combined mean ? values for four-tiered Fuhrman grading were 0.48 and 0.41, respectively. The highest agreement was detected in two-tiered modification (including grades 1 + 2 and 3 + 4); the intraobserver and inter-observer combined mean ? values were 0.67 and 0.62, respectively. Correlations between pathologic stage and tumor size with two-tiered modification (including grades 1 + 2 and 3 + 4) were greater than those in three- and four-tiered Fuhrman grading. Collapsing the Fuhrman grading into a two-tiered scheme improved the intraobserver and interobserver reproducibility. © 2009 Elsevier Daha fazlası Daha az

Barut F. | Bektaş S. | Bahadir B. | Onak Kandemir N. | Karadayi N. | Özdamar Ş.O.

Article | 2009 | Turkiye Klinikleri Journal of Medical Sciences29 ( 1 ) , pp.42 - 47

Objective: The gold standard for diagnosis of papillary thyroid carcinoma is conventional histology, which depends on the characteristic nuclear features, regardless of whether papillary architecture is present or not. This study was carried on to evaluate the utility of cytokeratin-19 in the diagnosis and differential diagnosis of papillary thyroid carcinoma. Material and Methods: Expression of cytokeratin-19 was tested on formalin-fixed, paraffin-embedded tissues from 380 surgically resected thyroid lesions including hyperplasic nodules (n= 243), granulomatous thyroiditis (n= 3), lymphocytic (n= 53) and Hashimoto's thyroiditis (n= . . . 11), follicular adenomas (n= 17), Hurthle cell adenomas (n= 4), well-differentiated thyroid tumor with follicular architecture of uncertain malignant potenti al (n= 1), papillary carcinomas (n= 45), follicular carcinoma (n= 1), insular carcinoma (n= 1), and medullary carcinoma (n= 1). The immunoreactivity was scored as negative, 1+, 2+, 3+, and 4+, based on the extent of the reaction regardless of previous diagnosis. Results: Positive reaction with cytokeratin-19 was denoted in all of the 45 cases of papillary carcino mas with scores of 4+, 3+ and 2+ and the ratios were 57.8% (26/45), 33.3% (15/45) and 8.9% (4/45), respectively. There seemed to be a strong diffuse cytoplasmic reactivity with cytokeratin-19 in papillary thyroid carcinomas. The sensitivity and specificity for cytokeratin-19 in papillary carcinomas among neoplastic thyroid lesions were 91.8% and 86.2%, respectively. Conclusion: In additi on to careful histological evaluation, cytokeratin-19 seems useful for the diagnosis of papillary thyroid carcinomas. Copyright © 2009 by Türkiye Klinikleri Daha fazlası Daha az

Bektaş S. | Bahadir B. | Barut F. | Bayar Ü. | Özdamar Ş.O.

Article | 2010 | Turkiye Klinikleri Jinekoloji Obstetrik20 ( 6 ) , pp.403 - 406

Ovarian lipoleiomyoma composed of an admixture of smooth muscle and adipose tissue is a rare mesenchymal neoplasm. A 54-year-old female patient presented with pelvic pain. Ultrasonography revealed a giant mass with cystic-solid appearance filling of the Douglas pouch. With suspicion of ovarian carcinoma, operation was performed. Gross examination of the left ovary showed a mass measuring 20 x 19 x 11 cm. Histopathologically, the tumor consisted primarily of interlacing spindle cells with scattered of mature adipose tissue. Immunohistochemically, spindle cells exhibited vimentin, smooth muscle actin and desmin positivity. Adipose cel . . .ls revealed positive reaction for S100 protein. A diagnosis of lipoleiomyoma was made. Ovarian lipoleiomyoma may mimic malignancy, both clinically and radiographically, due the the fact that it may reach a giant size and because of its heterogeneous internal structure. Copyright © 2010 by Türkiye Klinikleri Daha fazlası Daha az

Onak Kandemir N. | Bektaş S. | Barut F. | Yurdakan G. | Bahadir B. | Dogan Gün B. | Özdamar Ş.O.

Article | 2010 | Turk Patoloji Dergisi/Turkish Journal of Pathology26 ( 3 ) , pp.230 - 237

Objective: Fine needle aspiration cytology is the first step in the diagnosing breast lesions. This study evaluated factors causing false-negative and false-positive diagnoses when evaluating breast lesions using this technique. Material and Method: In this study, we retrospectively examined 511 breast diagnoses, based on Fine needle aspiration cytology specimens, made in the Medical School of Zonguldak Karaelmas University, Department of Pathology, between 2002 and 2009. Factors affecting the reliability of fine needle aspiration cytology were evaluated by comparing the cytological and biopsy diagnoses and using the clinical parame . . .ters in the diagnosis of breast lesions. Result: In our series, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of fine needle aspiration cytology were 77%, 99%, 95%, 93%, and 95%, respectively. The false-negative diagnosis rate was 4% and the false-positive diagnosis rate was 1%. Conclusion: Sampling errors and erroneous interpretation of cellular monomorphism are the most important reasons for false-negative diagnosis results in the evaluation of breast lesions with fine needle aspiration cytology. Increased cellularity and reactive cell atypia in benign proliferative breast lesions are the most frequent reasons for false-positive diagnosis Daha fazlası Daha az