Barut F. | Kertiş G. | Bahadir B. | Özdamar S.O. | Gün B.D. | Seçkiner I. | Kuzey G.M.

Article | 2009 | Journal of Experimental and Clinical Medicine (Turkey)26 ( 2 ) , pp.96 - 98

Onak Kandemir N. | Bektaş S. | Barut F. | Bahadir B. | Yurdakan G. | Dogan Gun B. | Mungan A.

Article | 2010 | Turk Onkoloji Dergisi25 ( 2 ) , pp.49 - 56

OBJECTIVES: The contribution of cytological methods to the diagnosis and follow-up of urinary system malignancies was investigated in this study, along with histological diagnosis and clinical follow-up results of the cases. METHODS: One hundred forty-four cases who underwent cystoscopy in ZKÜTF Urology Department between 2003 and 2007 were included in this study, and urinary cytology and biopsy samples were assessed in the Pathology Department. RESULTS: When cytological and histological diagnoses were compared, results in 17 positive cases and in 109 negative cases were consistent. Three cases were false-positive and 15 cases were . . .false-negative. In our series, sensitivity of urinary cytological diagnostic methods was 53% and specificity was 97%. CONCLUSION: Our study shows that urinary cytology has a high diagnostic value in the evaluation of urinary system diseases. However, decrease in the sensitivity of this method in low-grade urothelial tumors should be taken into account. © 2010 Association of Oncology Daha fazlası Daha az

Onak Kandemir N. | Bektaş S. | Barut F. | Yurdakan G. | Bahadir B. | Dogan Gün B. | Özdamar Ş.O.

Article | 2010 | Turk Patoloji Dergisi/Turkish Journal of Pathology26 ( 3 ) , pp.230 - 237

Objective: Fine needle aspiration cytology is the first step in the diagnosing breast lesions. This study evaluated factors causing false-negative and false-positive diagnoses when evaluating breast lesions using this technique. Material and Method: In this study, we retrospectively examined 511 breast diagnoses, based on Fine needle aspiration cytology specimens, made in the Medical School of Zonguldak Karaelmas University, Department of Pathology, between 2002 and 2009. Factors affecting the reliability of fine needle aspiration cytology were evaluated by comparing the cytological and biopsy diagnoses and using the clinical parame . . .ters in the diagnosis of breast lesions. Result: In our series, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of fine needle aspiration cytology were 77%, 99%, 95%, 93%, and 95%, respectively. The false-negative diagnosis rate was 4% and the false-positive diagnosis rate was 1%. Conclusion: Sampling errors and erroneous interpretation of cellular monomorphism are the most important reasons for false-negative diagnosis results in the evaluation of breast lesions with fine needle aspiration cytology. Increased cellularity and reactive cell atypia in benign proliferative breast lesions are the most frequent reasons for false-positive diagnosis Daha fazlası Daha az

Barut F. | Özdamar Ş.O. | Bahadir B. | Dogan Gün B. | Bektaş S. | Çolak S. | Mocan Kuzey G.

Article | 2007 | Turkiye Klinikleri Journal of Medical Sciences27 ( 2 ) , pp.179 - 183

Objective: Bronchoalveolar lavage performed during bronchoscopic examination is a type of cytologic sampling with great diagnostic significance. Its diagnostic value is enhanced when biopsy is unavailable and bronchoalveolar lavage is the unique sample. Determining the diagnostic accuracy of bronchoalveolar lavage by comparing it with the diagnostic yield of synchronous biopsies is an indicator of its effectiveness. Material and Methods: In this study, 435 bronchoalveolar lavage and 273 bronchoscopic biopsy specimens obtained from January 2003 to December 2005 in the Department of Pulmonary Diseases were retrospectively evaluated in . . . the Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University. Results: Overall, 373 cases (85.8%) were diagnosed as benign and 12 cases (2.8%) were reported as malignant, while 18 cases (4.1%) were suspected to be malignant; the remaining 32 cases (7.3%) were reported as inadequate. The numbers and percentages of benign, malignant, suspected malignant and inadequate diagnoses of the 273 bronchoalveolar lavage cases with synchronous transbronchial biopsies were 229 (83.9%), 12 (4.5%), 16 (5.8%), and 16 (5.8%), respectively. After suspected malignant and inadequate samples were excluded, coomparison of cytologic and histologic diagnoses revealed that the diagnostic accuracy of bronchoalveolar lavage cytology was 79.4% and 91.6% for benign and malignant diagnoses, respectively; the rate of false negativity was 20.5% and false positivity was 8.3%. Conclusion: While sampling errors seemed to be the primary reason for false negative and false positive diagnoses, the rate of false cytologic evaluation was lower. Considering the false negative diagnoses for cases without biopsy specimens, comparison of bronchoalveolar lavage diagnoses with synchronous biopsies may serve as a quality control programme, since this condition may significantly influence the clinical course. Copyright © 2007 by Türkiye Klinikleri Daha fazlası Daha az