Numanoğlu-Yurdakan, Gamze | Çolak, Sacide | Hoşnuter, Mubin | Gün, Banu D. | Bostan, Süheyla | Özdamar, Oğuz

Article | 2008 | Gazi Medical Journal19 ( 2 ) , pp.80 - 81

İdiopatik skrotal kalsinozis, skrotum derisinde çok sayıda sert nodüllerin varlığıyla karakterizedir. Nodüler kalsifikasyonlar tipik olarak yaşamın 2. dekatında görülür. Bu lezyonlar asemptomatik, yuvarlak sert papüller durumundadır. Olgu 53 yaşında skrotumda ağrısız, sert nodüller ile başvurdu. Lezyonların 23 yaşında iken görülmeye başladığı ve bazılarının zamanla ilerleyerek polipoid forma dönüştüğü öğrenildi. Hastanın öyküsünde travma veya cerrahi tedavi yoktu. Serum kalsiyum, fosfor, kalsitonin ve paratiroid hormon seviyeleri normal sınırlardaydı. Kistlerin histopatolojik incelemesinde epitelle döşeli olmayan keratin içeriklerin . . .in distrofik kalsifikasyonu görüldü. Bilgilerimize göre bu olgu literatürde bildirilen polipoid görünümlü ikinci skrotal kalsinozis olgusudur. Idiopathic scrotal calcinosis is characterized by the presence of multiple firm nodules of scrotal skin. The nodular calcifications are typically found in the second decade of life. The lesions are seen as asymptomatic, round, firm papules. A 53-year-old man was admitted with painless, firm nodules within the scrotum. The lesions had begun to appear at the age of 23 years and some of them had become polypoid progressively over time. There was no trauma or previous surgical treatment. The serum levels of calcium, phosphorus, calcitonin, and parathyroid hormone were within normal limits. The polypoid masses were surgically excised. Histological examination of the cysts revealed dystrophic calcification of their keratin contents but no epithelial lining. To the best of our knowledge, this is the second case of scrotal calcinosis with polypoid appearance in the literature Daha fazlası Daha az

Bahadır, Burak | Kandemir, Nilüfer Onak | Karadayı, Nimet | Özdamar, Şükrü Oğuz

Proceedings | 2008 | VIRCHOWS ARCHIV452 , pp.80 - 81

WOS: 000256192600370

Bektaş, Sibel | Barut, Figen | Bahadır, Burak | Mungan, Aydın | Karadayı, Nimet | Özdamar, Şükrü Oğuz

Proceedings | 2008 | VIRCHOWS ARCHIV452 , pp.80 - 81

WOS: 000256192600630

Çolak, Sacide | Bahadır, Burak | Bektaş, Sibel | Barut, Figen | Kandemir, Nilüfer Onak | Karadayı, Nimet | Özdamar, Şükrü Oğuz

Proceedings | 2008 | VIRCHOWS ARCHIV452 , pp.80 - 81

WOS: 000256192600344

İrkörücü, Oktay | Taşçılar, Öğe | Çakmak, Güldeniz Karadeniz | Karakaya, Kemal | Emre, Ali Uğur | Uçan, Bülent Hamdi | Bahadır, Burak | Açıkgöz, Seferden | Ankaralı, Handan | Uğurbaş, Ebru | Cömert, Mustafa

Article | 2008 | DIGESTIVE DISEASES AND SCIENCES53 ( 6 ) , pp.1618 - 1623

Introduction Sildenafil both enhances vasodilatation by relaxing the smooth muscle in the vessels and inhibits platelet aggregation. We have therefore examined the potential benefits of sildenafil on an animal model for ischemic colitis (IC). Methods Twenty-eight female Wistar albino rats weighing 250-300 g were randomized into three experimental groups as follows: in Group 1, animals were sham operated (n = 8) and received tap water; in Groups 2 and 3, the rats underwent a standardized surgical procedure to induce IC (n = 10 in each group). Group 2 animals served as the controls, receiving only tap water, while Group 3 animals rece . . .ived 10 mg/kg sildenafil per day as a single dose for a 3-day period. All animals were sacrificed 72 h after devascularization. To determine the severity of the ischemia, we scored the macroscopically visible damage, measured the ischemic area and scored the histopathology. Tissue malondialdehyde levels were also evaluated. Results The mean area of ischemic changes were 116.80 +/- 189.93 and 0.55 +/- 1.01 mm(2) in Group 2 and 3 animals, respectively (p = 0.0001), while the macroscopically mean visible damage score decreased to 0.66 +/- 0.70 (p = 0.0001) for Group 3 animals. The Chiu scores were 0.00, 3.80 +/- 0.91 and 2.66 +/- 1.00 in Group 1, 2 and 3 animals, respectively. There was a statistically significant difference between Group 2 and 3 animals (p = 0.017). Conclusions Our findings support the view that sildenafil leads to a improvement in IC due to its well-known effects on the vascular smooth muscle and on the microcirculatory hemodynamics Daha fazlası Daha az

Numanoğlu, Kemal Varın | Tatlı, Duygu

Article | 2008 | Journal of Pediatric Surgery43 ( 7 ) , pp.1618 - 1623

We report the first case of urinary bladder hemangioma that caused hemorrhagic shock consequent to massive hematuria. A 2-year-old girl was presented with hemorrhagic shock and macroscopic hematuria. After rapid resuscitation was performed, radiologic investigations demonstrated a solid enhancing mass originating from the dome of bladder. Partial cystectomy was made. Histopathologic examination of resected specimen revealed cavernous hemangioma. Although bladder hemangiomas are rare benign tumors, it should be kept in mind that they can lead to life-threatening complications when the diagnosis is delayed. © 2008 Elsevier Inc. All ri . . .ghts reserved Daha fazlası Daha az

Numanoğlu-Yurdakan, Gamze | Kertiş, Gürkan | Bahadır, Burak | Numanoğlu, Kemal Varın | Özdamar, Şükü Oğuz

Article | 2008 | Ondokuz Mayis Universitesi Tip Dergisi25 ( 1 ) , pp.25 - 29

Renal dysplasia is a disorganized development of the kidney because anomalous differentiation of the metanephrosis. Abnormalities of the collecting system are common. They include obstruction of the ureteropelvic junction, ureteral atresia and urethral obstruction. The case was a six months old female child with ultrasonografically detected right hydronephrosis and oligohydroamniosis at the 20 th week of gestation. She underwent an operation for bilateral hydroureteronephrosis at 1 month of age. There was no serious and related illness in family history and self-history. She underwent right nephrectomy at 6 months of age. The specim . . .en included an atrophic nephrectomy material with lobulations and a dilated ureter. When sectioned, it was observed that the pericaliceal areas were dilated and the cortex-medulla border was obscured. On microscopic examination, the cortex was thin, contained rare small glomerules, primitive ducts and mononuclear cell infiltration were seen. A focus of cartilage was observed at the cortex-medulla junction. The case was diagnosed as renal hypoplastic dysplasia. During 4 months of follow-up, no complication was reported. This case is presented considering the uncommon occurence of renal dysplasia and its differential diagnosis from other congenital cystic renal malformations Daha fazlası Daha az

Kandemir, N. Onak | Barut, Figen | Yurdakan, G. | Bayar, U.

Conference Object | 2008 | HISTOPATHOLOGY53 , pp.198 - 198

27th International Congress of the International-Academy-of-Pathology -- OCT 12-17, 2008 -- Athens, GREECE WOS: 000259524800452

Yildirim N. | Dogan S.M. | Aydin M. | Hekimoglu K. | Gungorduk A.

Article | 2008 | International Journal of Cardiology127 ( 2 ) , pp.198 - 198

Interrupted aortic arch (IAA) is a rare and usually lethal congenital malformation. Patients with complete IAA very rarely do reach adult age without previous surgical intervention. The present report describes a 26-year-old asymptomatic isolated IAA case with hypertension that was incidentally diagnosed. IAA just distal to the left subclavian artery and a markedly developed collateral circulation was demonstrated by cardiac catheterization and thoracic 3D magnetic resonance angiography. This case report was also interesting that only mild arterial hypertension of the upper extremities was incidentally found in the patient. © 2007 E . . .lsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Dogan S.M. | Yildirim N. | Gursurer M. | Aydin M. | Kalaycioglu E. | Cam F.

Article | 2008 | Journal of Electrocardiology41 ( 1 ) , pp.55 - 59

Aim: P-wave dispersion (PD), and duration has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. The aim of this study was to investigate the PD in patients with coronary slow flow (CSF) phenomenon. Methods: Study population included 48 patients with angiographically proven normal coronary arteries and slow coronary flow in all 3 coronary vessels (group I, 36 men; mean age, 54 ± 9 years) and 32 subjects with angiographically proven normal coronary arteries without associated slow coronary flow (group II, 24 men, mean age, 53 ± 10 years). Coronary flow rates of all patients and control . . .subjects were documented by Thrombolysis In Myocardial Infarction (TIMI) frame count. All patients in group I had TIMI frame counts greater than 2 SD above those of control subjects (group II). The mean TIMI frame count for each patient and control subject was calculated by adding the TIMI frame counts for each major epicardial coronary artery and then dividing the obtained value into 3. The maximum and minimum P-wave duration (Pmax and Pmin) and PD were measured from the 12-lead surface electrocardiogram. Echocardiographic examination was also performed. Results: There was no statistically significant difference between the 2 groups with respect to age, sex, hypertension, diabetes mellitus, hyperlipidemia, and cigarette smoking (P > .05). P-wave dispersion and Pmax of patients with CSF were found to be significantly higher than those of control subjects (39.4 ± 17 vs 21.2 ± 10 milliseconds and 121.6 ± 17.1 vs 104.3 ± 10.4 milliseconds, respectively; P < .0001). Moreover, we found a significant positive correlation between both Pmax and PD with mean TIMI frame count (r = 0.836 and r = 0.806, respectively; P < .0001). Conclusions: P-wave dispersion and P-wave duration both were found to be greater in patients with CSF than in controls. © 2008 Elsevier Inc. All rights reserved Daha fazlası Daha az

Dogan S.M. | Yildirim N. | Aydin M. | Gursurer M. | Cam F. | Celik O.

Article | 2008 | International Journal of Cardiology125 ( 3 ) , pp.404 - 406

Introduction: Coronary artery ectasia (CAE) is defined as localized or diffuse dilatation of the epicardial coronary arteries. We sought to determine whether isolated CAE may alter P-wave duration and dispersion (PD). Methods: The study population consisted of 26 patients (mean age: 61.6 ± 11.0 years) with isolated CAE (group 1) and sex- and age-matched 26 control subjects (group 2). Both groups underwent a standard 12-lead surface electrocardiogram recorded at 50 mm/s. Maximal (Pmax) and minimal P-wave durations (Pmin) are measured. PD was defined as the difference between Pmax and Pmin. Results: In group 1, Pmax (114.2 ± 10.4 ms v . . .s 104.8 ± 10.6 ms, p < 0.002) and PD (34.0 ± 12.7 ms vs 24 ± 10.6, p < 0.004) were significantly higher than those of group 2. Moreover a significant correlation was found between Pmax and PD with ectatic segment number (r = 0.625, r = 0.626, respectively; p = <0.001); and Pmax and PD with ectatic vessel number (r = 0.698, r = 0.704 respectively; p = <0.0001). Conclusion: Isolated CAE and the degree of the ectasia were found to be associated with prolonged Pmax and PD. © 2007 Elsevier Ireland Ltd. All rights reserved Daha fazlası Daha az

Barut, Figen | Kandemir, N. Onak | Bektas, S. | Bahadir, B. | Keser, S. | Hancer, H. | Ozdamar, S.

Conference Object | 2008 | HISTOPATHOLOGY53 , pp.95 - 96

27th International Congress of the International-Academy-of-Pathology -- OCT 12-17, 2008 -- Athens, GREECE WOS: 000259524800216