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Melatonin and oxidation

Özaçmak, Veysel Haktan

Kitap Bölümü | 2011 | Melatonin in the Promotion of Health: Second Edition , pp.541 - 551

[No abstract available]

Effects of S-nitrosoglutathione on intestinal ischemia reperfusion injury-induced oxidative stress and lung injury in rats

Turan, İnci | Özaçmak-Sayan, Hale | Özaçmak, Veysel Haktan | Barut, Figen

Bildiri | 2017 | ACTA PHYSIOLOGICA221 , pp.89 - 90

WOS: 000419806200159

The effect of melatonin on depressive like behaviour, age and S100b levels in diabetic rats

Ergenç, Meryem | Özaçmak-Sayan, Hale | Turan, İnci | Özaçmak, Veysel Haktan

Bildiri | 2018 | NEUROENDOCRINOLOGY107 , pp.33 - 34

3rd International Congress of the Turkish-Neuroendocrinology-Society -- JUN 29-JUL 01, 2018 -- Malatya, TURKEY WOS: 000445952400080

Melatonin reverses depressive and anxiety like-behaviours induced by diabetes: involvement of oxidative stress, age, rage and S100B levels in the hippocampus and prefrontal cortex of rats

Ergenç, Meryem | Özaçmak-Sayan, Hale | Turan, İnci | Özaçmak, Veysel Haktan

Makale | 2019 | Archives of Physiology and Biochemistry , pp.33 - 34

Diabetes is associated with depression and anxiety symptoms. The current investigation was designed to explore the effect of melatonin on depressive and anxiety like-behaviours, oxidative stress, levels of AGE, RAGE and S100B in streptozotocin-induced diabetic rats. The animals were divided into four groups: Normoglycemic; Normoglycemic + melatonin; diabetic; diabetic + melatonin (10 mg/kg, for 4 weeks). The malondialdehyde (MDA), reduced glutathione (GSH), AGE, RAGE and S100B were measured and the depressive and anxiety like-behaviours were assessed by forced swimming and elevated plus maze tests, respectively. Melatonin ameliorate . . .s depressive and anxiety like-behaviours. Concomitantly, melatonin reversed diabetes induced increase of MDA, AGE and decrease of GSH and S100B levels in the hippocampus and prefrontal cortex. In conclusion, our results showed that melatonin administration may exert antidepressant-like and anxiolytic effects in diabetic rats through normalising of AGE/RAGE, S100B and oxidative stress in the prefrontal cortex and hippocampus. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group Daha fazlası Daha az

The effects of 17 beta estradiol, 17 alpha estradiol and progesterone on oxidative stress biomarkers in ovariectomized female rat brain subjected to global cerebral ischemia

Özaçmak, Veysel Haktan | Sayan, Hale

Makale | 2009 | Physiological Research58 ( 6 ) , pp.909 - 912

Neuroprotective effects of estrogens and progesterone have been widely studied in various experimental models. The present study was designed to compare possible neuroprotective effects of 17alpha-estradiol, 17beta-estradiol, and progesterone on oxidative stress in rats subjected to global cerebral ischemia. Global cerebral ischemia was induced in ovariectomized female rats by four vessel occlusion for 10 min. Following 72 h of reperfusion, levels of malondialdehyde (MDA, oxidative stress marker), and reduced glutathione (GSH, major endogenous antioxidant) were assessed in hippocampus, striatum and cortex of rats treated with either . . . 17alpha-estradiol, 17beta-estradiol, progesterone or estradiol + progesterone beforehand. Steroid administration ameliorated ischemia-induced decrease in GSH and increase in MDA levels. Our data offers additional evidence that estrogens and progesterone or combination of two exert a remarkable neuroprotective effect reducing oxidative stress. © 2009 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic Daha fazlası Daha az

Protective effects of L-arginine on rat terminal ileum subjected to ischemia/reperfusion

Sayan, Hale | Özaçmak, Veysel Haktan | Altaner, Şemsi | Aktaş, R. Gülhan | Arslan, S. Oktay

Makale | 2008 | Journal of Pediatric Gastroenterology and Nutrition46 ( 1 ) , pp.29 - 35

OBJECTIVES: Studies have shown that nitric oxide (NO) may play a major role in sustaining mucosal integrity; however, NO has been also implicated in the pathogenesis of ischemia/reperfusion (I/R)-related tissue injury. We investigated the effects of L-arginine and N-nitro L-arginine methyl ester (L-NAME) on the acetylcholine-induced contractile response of ileum and the levels of malondialdehyde (MDA) and reduced glutathione (GSH). Histopathological changes were also evaluated in ileal preparations. MATERIALS AND METHODS: Male Wistar Albino rats were subjected to mesenteric ischemia (30 min) followed by reperfusion (3 hours). Four g . . .roups were designed: sham-operated control; I/R; I/R and L-arginine pretreatment; and I/R and L-NAME pretreatment. After reperfusion, ileum specimens were collected to determine the parameters mentioned above. RESULTS: Following reperfusion, a significant decrease in acetylcholine-induced contractile response, an increase in lipid peroxidation, a decrease in GSH content, and mucosal damage of the ileal preparations were observed. We showed that decreased contractility, increased lipid peroxidation, and reduced GSH content have been reversed by L-arginine but not by L-NAME. Mucosal injury was significantly lowered in the L-arginine group. CONCLUSIONS: Treatment with L-arginine exerted a protective effect in intestinal I/R injury, which was mediated in part by regulating MDA and GSH levels, consequently ameliorating impaired contractile response and mucosal injury. © 2008 Lippincott Williams & Wilkins, Inc Daha fazlası Daha az

Use of autopsy to determine live or stillbirth: new approaches in decision-support systems

Yılmaz, Rıza | Erkaymaz, Okan | Kara, Erdoğan | Ergen, Kıvanç

Makale | 2017 | Journal of Forensic Sciences62 ( 2 ) , pp.468 - 472

Fetal deaths are important cases for forensic medicine, as well as for criminal and civil law. From a legal perspective, the determination of whether a deceased infant was stillborn is a difficult process. Such a determination is generally made during autopsy; however, no standardized procedures for this determination exist. Therefore, new facilitative approaches are needed. In this study, three new support systems based on 10 autopsy parameters were tested for their ability to correctly determine whether deceased infants were alive or stillborn. Performances were analyzed and compared with one another. The artificial neural network . . .s and radial basis function network models had 90% accuracy (the highest among the models tested), 100% sensitivity, and 83.3% specificity. Thus, the models presented here provide additional insights for future studies concerning infant autopsies. © 2016 American Academy of Forensic Science Daha fazlası Daha az

Protective effect of melatonin on contractile activity and oxidative injury induced by ischemia and reperfusion of rat ileum

Özaçmak, Veysel Haktan | Sayan, Hale | Arslan, S. Oktay | Altaner, Şemsi | Aktaş, R.Gülhan

Makale | 2005 | Life Sciences76 ( 14 ) , pp.1575 - 1588

Free radicals derived from molecular oxygen have been reported to be responsible for changes in motility and mucosal damage observed in intestinal ischemia-reperfusion injury. Melatonin has been considered as an antioxidant that prevents injuries resulted from I/R in various tissues. The present study was designed to determine the effect of melatonin on the contractile responses of acetylcholine (Ach) and KCl, on malondialdehyde (MDA), a product of lipid peroxidation, and reduced glutathione (GSH) levels and to assess histopathological changes in the smooth muscle of terminal ileum subjected to ischemia-reperfusion. The intestinal i . . .schemia-reperfusion was induced by occlusion of superior mesenteric artery of rat for 30 min, followed by a period of reperfusion for 3 h. Melatonin at doses of 10 or 50 mg/kg was administered via the tail vein in 5 min prior to reperfusion. Following reperfusion, segments of terminal ileum were rapidly taken and transferred into isolated organ bath and responses to Ach and KCl were recorded. Samples of terminal ileum were also taken for measuring the MDA and GSH levels. EC50 values of these contracting substances were seriously reduced in the ischemia-reperfusion group compared to that of the sham-operated control group. The decreased contraction response to Ach and KCl was significantly ameliorated by a dosage of 50 mg/kg of melatonin, while not by a dosage of 10 mg/kg. Similar pattern of the effect was observed in the tissue levels of MDA and GSH as well as in histological improvement. Melatonin appeared to be restoring the amounts of tissue MDA and GSH back to about control levels. These results suggest that the high dose of melatonin not only physiologically but also biochemically and morphologically could be useful to normalize contractility injured by oxidative stress in intestinal ischemia-reperfusion. © 2004 Elsevier Inc. All rights reserved Daha fazlası Daha az

Cell counting and recognition of immunohistochemically dyed seminiferous tubules with feed-forward neural network

Aydemir, Zübeyr | Erkaymaz, Okan | Ferah, Meryem Akpolat

Bildiri | 2017 | 2017 25th Signal Processing and Communications Applications Conference, SIU 2017 , pp.1575 - 1588

In this study, the features of the seminiferous tubule sections were extracted and the presence of the cells and cell stain types detected with the help of the feed forward artificial neural network. By looking at the section view with a small window, 78 features were extracted from the pixels seen by the window and used as an input to the artificial neural network. Artificial neural network outputs are decides presence of the cell and the staining of the cell. The results obtained with the artificial neural network were determined by using the connected component labeling method. The results obtained with the help of the user and t . . .he results obtained with the artificial neural network were compared. It has been shown that the proposed ANN model performs cell counting process comparable to the literature (%76 accuracy). © 2017 IEEE Daha fazlası Daha az

The effects of angiotensin ii receptor blocker on brain oxidative stress and neurobehavioural alterations in ovariectomized rats

Turan, Inci | Erdem, Salih | Ergenç, Meryem | Özaçmak-Sayan, Hale

Bildiri | 2018 | NEUROENDOCRINOLOGY107 , pp.19 - 19

3rd International Congress of the Turkish-Neuroendocrinology-Society -- JUN 29-JUL 01, 2018 -- Malatya, TURKEY WOS: 000445952400047

The effects of ethyl pyruvate on cognitive function, oxidative stress, and Na-K ATPase levels in vascular dementia model

Özaçmak-Sayan, Hale | Gencer, Ercan | Özaçmak, Veysel Haktan

Bildiri | 2016 | ACTA PHYSIOLOGICA218 , pp.72 - 72

WOS: 000383578300190

Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion

Özaçmak-Sayan, Hale | Özaçmak, Veysel Haktan | Barut, Figen | Jakubowska-Doğru, Ewa

Makale | 2012 | Neurochemistry International61 ( 3 ) , pp.287 - 290

Oxygen free radicals and lipid peroxidation may play significant roles in the progress of injury induced by chronic cerebral hypoperfusion of the central nervous system. Rosiglitazone, a well known activator of PPAR?, has neuroprotective properties in various animal models of acute central nervous system damage. In the present study, we evaluate the possible impact of rosiglitazone on chronic cerebral hypoperfused-rats in regard to the levels of oxidative stress, reduced glutathione, and hippocampal neuronal damage. Chronic cerebral hypoperfusion was generated by permanent ligation of both common carotid arteries of Wistar rats for . . .one month. Animals in treatment group were given rosiglitazone orally at doses of 1.5, 3, or 6 mg/kg per day of the 1 month duration. The treatment significantly lowered the levels of both malondialdehyde and neuronal damage, while elevated the reduced glutathione level markedly. These findings suggest that the beneficial effect of rosiglitazone on hypoperfusion-induced hippocampal neuronal damage might be the result of inhibition of oxidative insult. © 2012 Elsevier Ltd. All rights reserved Daha fazlası Daha az

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