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Conference Object | 1994 | MINE PLANNING AND EQUIPMENT SELECTION 1994 , pp.757 - 764

3rd International Symposium on Mine Planning and Equipment Selection -- OCT 18-20, 1994 -- ISTANBUL, TURKEY WOS: A1994BB59Q00124


Gumus, Mehmet | Soykan, Yuksel

Article | 2017 | JOURNAL OF APPLIED MATHEMATICS & INFORMATICS35 ( 03.Apr ) , pp.267 - 276

The purpose of this paper is to investigate the local asymptotic stability of equilibria, the periodic nature of solutions, the existence of unbounded solutions and the global behavior of solutions of the fractional difference equation x(n+1) = alpha xn-(k+1)/beta+gamma x(n)(p) (k)x(n)(g)-(k+2), n =0,1... where the parameters alpha, beta, gamma; p, q are non-negative numbers and the initial values x - (k + 2), x -(k + 1),..., x-1; x(0) is an element of R+.

Our open heart surgery experience in factor XII deficiency: a case report

Coskun, Elif | Buyukates, Mustafa


Factor XII deficiency is an important hematological problem which is characterized by isolated prolongation of the activated partial thromboplastin time and presents with thrombosis and thromboembolism tendency rather than expected bleeding diathesis in clinical practice. A 55-year-old male patient who was scheduled for aortic coronary bypass graft surgery had elevated activated partial thromboplastin time (109.4 sec) as a laboratory finding. The patient was diagnosed with factor XII deficiency and operated in our clinic. No thromboembolic event was seen during follow-up. The patient was discharged in the seventh postoperative day u . . .neventfully. Herein, we highlight the importance of this disease due to its rare occurrence and present our treatment strategy applied Daha fazlası Daha az

Clodronic acid in the treatment of postmenopausal osteoporosis

Tanakol R. | Yarman S. | Bayraktaroglu T. | Boztepe H. | Alagöl F.

Article | 2007 | Clinical Drug Investigation27 ( 6 ) , pp.419 - 433

Background: Clodronic acid, a first-generation bisphosphonate, has been successfully used in the treatment of high bone turnover states, Paget's disease and osteolytic bone metastases. However, controversies remain over its optimal dosage and method of administration in the treatment of postmenopausal osteoporosis. In this study we aimed to evaluate the effect of clodronic acid treatment for 3 years on bone mineral density (BMD) in women with postmenopausal osteoporosis. Methods: This was a prospective, open-label, randomised, controlled study that was conducted in an outpatient clinic at the Bone Metabolism Unit of a tertiary refer . . .ral centre university hospital. Thirty postmenopausal women (age range 48-73 years) with osteoporosis and a control group of 49 osteoporotic women (age range 47-74 years) received randomised therapy. The clodronic acid group of participants received oral doses of clodronic acid 800mg plus elemental calcium 500mg and 400IU of vitamin D daily, while the control group was treated with calcium and vitamin D only. BMD was measured by dual energy x-ray absorptiometry at yearly intervals. Biochemical markers of bone turnover were also measured. Results: In this clinical study of postmenopausal women with osteoporosis, 36 months of clodronic acid treatment significantly increased average femoral neck BMD by 3.2 ± 2.9%, trochanter BMD by 2.2 ± 2.9% and lumbar spine BMD by 3.1 ± 3%. In the control group, femoral neck, trochanter and lumbar spine BMD decreased by -6 ± 2.7%, -7.3 ± 2.5% and -5.4 ± 2%, respectively (p < 0.01, p < 0.05 and p < 0.05 for clodronic acid vs control, respectively). There was a significant decrease in urinary hydroxyproline (-38.3%) over 3 years in the clodronic acid group compared with baseline (p < 0.05), while no significant change occurred in the control group. Clodronic acid was well tolerated and compliance was good. There were no clinically meaningful differences in the incidence of individual adverse events between the groups. Conclusion: These results indicate that daily oral administration of clodronic acid 800mg provides benefits to skeletal bone density in osteoporotic postmenopausal women. Calcium and vitamin D supplementation alone did not prevent further bone loss. © 2007 Adis Data Information BV. All rights reserved Daha fazlası Daha az

Ultrastructural observations in somatic embryogenesis of natural tetraploid Trifolium pratense L.

Colgecen, Hatice | Buyukkartal, Hatice Nurhan | Koca-Caliskan, Ufuk

Article | 2016 | TURKISH JOURNAL OF BOTANY40 ( 5 ) , pp.496 - 505

Previous reports of plant regeneration of natural tetraploid T. pratense L. 'Elci' could be realized only through the apical meristem calli. In order to proceed to the production stage, other regeneration methods need to be tried. Aseptic seedlings were used for the production of somatic embryos through various 2,4-D and kinetin trials. Nonuniform external callus cells with translucent cytoplasm were observed in various developmental stages of somatic embryos. Beneath these cells, there were uniformly aligned, dark-stained embryo cells with dense cytoplasm. Despite the similar developmental stages and cell characteristics of zygotic . . . and somatic embryos, the walls of somatic embryo cells revealed a highly wavy pattern. The nucleus generally contained only one nucleolus, which was spherical, dark stained, and electron-dense. Electron-dense droplets were seen in vacuoles. The cytoplasm consisted of starch-containing amyloplasts, mitochondria, plastids, ribosomes, endoplasmic reticulum, dictyosomes, lipid, and protein bodies. In some of the somatic embryos at the globular and heart stages, vacuole or electron-translucent zones were observed in the nucleolus. Additionally, a few embryo degenerations were recorded during developmental stages of the zygotic embryo. For the first time, the somatic embryos of natural tetraploid T. pratense were produced from hypocotyl (85%), cotyledon (75%), and apical meristem (60%) explants in 0.3 mg/L 2,4-D and 2 mg/L kinetin-containing MS medium. Our study developed an effective and efficient in vitro production method for using natural tetraploid T. pratense in biotechnological studies Daha fazlası Daha az

A molecular dynamics study: Structures and thermal stability of PdmPt(13-m)Ag42 ternary nanoalloys

Garip, Ali Kemal

Article | 2018 | INTERNATIONAL JOURNAL OF MODERN PHYSICS C29 ( 9 ) , pp.496 - 505

Structural optimization of ternary PdmPt(13-m)Ag42 nanoalloys was performed using the basin-hopping algorithm, and the Gupta many-body potential was adopted to model interatomic interaction. The optimization results show that all compositions have a structure based on icosahedron with a coreshell segregation. While the Ag atoms prefer to segregate to the surface, Pd and Pt atoms were located at the core of the cluster due to the higher surface and cohesive energy. The single platinum atom with the highest cohesive energy in Pd12Pt1Ag42 nanoalloy was located at the center of the cluster. Also in all other compositions except Pd13Ag42 . . ., Pd atoms occupy the second shell position of the icosahedron structure. We used classical molecular dynamics (MD) simulations in canonical ensemble conditions (NVT) to investigate the melting temperatures of ternary PdmPt(13-m)Ag42 nanoalloys with the interatomic interactions modeled by the same potential with optimizations. The icosahedral structures were taken as the initial configurations for MD simulations. We obtained caloric curves and Lindemann indexes to investigate the melting transitions. The simulation results showed that varying the composition gives rise to a fluctuation in melting temperatures. The highest melting temperature belongs to the Pd9Pt4Ag42 nanoalloy cluster within the other compositions. However, the relative stability investigation indicates the Pd8Pt5Ag42 nanoalloy cluster as the most stable composition. The Lindemann indexes obtained for the second and third shell of icosahedral structures show that the melting takes place as a whole without any surface premelting Daha fazlası Daha az

Comparison of test use and multiple-evaluation to test effectiveness of PBL in different grouping strategies

Yaman, Suleyman


Problem-based learning (PBL) involves the process of working toward the understanding or solution of a problem. In educational contexts, PBL provides meaningful problems to improve learning. This study aims to investigate the comparative effectiveness of the achievement test and of multiple evaluation methods, including test use, self, peer, and tutor-evaluation, in PBL environments. Different grouping strategies, specifically tutor- and student-based selection, are used to test effectiveness of the evaluation approaches. The study was conducted with 46 prospective teachers using an experimental design. For the purpose of the study, . . . t-test for independent groups and correlation analysis were used. The prospective teachers in the tutor-selected group were found to be more successful when the complete results of the evaluations were considered. The use of multiple evaluation methods revealed a significant difference between groups, whereas the approach using only the achievement test did not show any statistically significant difference Daha fazlası Daha az

Air Pollution And The Risk Of Venous Thromboembolism

Tor, M. | Cevik, C. | Kurcer, M. | Akbulut, S. | Altuntas, M. | Atalay, F.


WOS: 000208771000726

Classic Kaposi sarcoma with sarcoid-like granulomas: a case report and review of the literature

Kandemir, N. Onak | Yurdakan, G. Gamze | Bektas, S.

Conference Object | 2008 | HISTOPATHOLOGY53 , pp.396 - 397

27th International Congress of the International-Academy-of-Pathology -- OCT 12-17, 2008 -- Athens, GREECE WOS: 000259524800907

Electroconvulsive therapy combined with antipsychotic therapy in the treatment of acute schizophrenia inpatients: symptom profile of the clinical response

Ipekcioglu, Derya | Yazar, Menekse Sila | Canbek, Ozge | Yuksel, Ozge | Meterelliyoz, Kumru Senyasar | Ilnem, Mehmet Cem

Article | 2018 | PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY28 ( 4 ) , pp.363 - 370

OBJECTIVE: The aim of the study was to examine the efficacy of electroconvulsive therapy (ECT) combined with antipsychotic (AP) medication on symptom profile in patients with a diagnosis of schizophrenia who had received acute psychiatric inpatient treatment. METHODS: In this prospective study, patients were evaluated for inclusion in the study who were diagnosed with schizophrenia according to DSM-IV diagnostic criteria and were to receive ECT. The patients were evaluated using the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), and C . . .linical Global Impression - Improvement (CGI-I) sub-scale before the first session ECT, once following every two subsequent sessions and after the final session. RESULTS: The patients showed significant improvements in BPRS scores at each evaluation compared with their scores at baseline, and a significant clinical improvement was found on the CGI-I sub-scale at the end of treatment. Across all SAPS sub-scores, significant decreases were found, and the symptoms related to hallucinations and positive formal thought disorder showed the most rapid response to treatment. Across all SANS sub-scores, significant decreases were found, and affective flattening or blunting symptoms responded most rapidly to treatment. CONCLUSION: One of the most important findings in the present study of hospitalized patients with acute schizophrenia was the good response to treatment, which provided significant improvements in both positive and negative symptoms. The most rapid response to treatment was found for hallucinations, positive formal thought disorder, and affective flattening or blunting symptoms. The most important limitation of our study may be the small number of cases. In future, well-standardized studies using a double-blinded, comparative, prospective design and including a sufficient number of patients are needed Daha fazlası Daha az

A preliminary geoengineering assessment of Bazda antique underground quarries in, Sanliurfa, Turkey

Agan, C. | Yesilnacar, M. I. | Genis, M. | Kulaksiz, S. | Ulusay, R. | Aydan, Oe | Yucel, M. D.


Geoengineering evaluation of man-made antique underground structures improves and provides important information on such structures. Harran City in, Sanliurfa Province of Turkey was constructed probably during Sumerian period BC 3000 (5000 years BP). The building stones consisting of limestones of Harran City were extracted from open-pit and underground quarries known as Bazda quarries. Bazda antique underground quarry pillars suffer some structural stability problems in terms of splitting of high pillars, roof falls, plane or wedge sliding and large sinkholes. The authors have initiated a collaborative integrated research program t . . .o map the antique underground quarries having working levels up to four floor, in-situ rock characterization, identification of stability problems, some geomechanical properties of surrounding rock. This paper describes the first preliminary studies on Bazda antique underground quarries and discusses its implications in modern geomechanics and geoengineering Daha fazlası Daha az

Elemen black pine, a new monumental tree in Dirgine forests Zonguldak

Yaman, Barbaros | Saribas, Metin

Article | 2007 | EKOLOJI16 ( 63 ) , pp.62 - 68

Turkey has monumental Black Pine trees among a great variety of monumental trees recorded in the literature. The old Black Pine (Pinus nigra subsp. pallasiana) in Elemen Plateau of Dirgine in Zonguldak, the monumental properties of which haven't been studied until now, is the subject of the present investigation. The.Elemen Black Pine has no folkloric, historical and mystic properties. However, since its Present Monumental Point (PMP) is higher than Minimal Monumental Point (MMPspecies) of Black Pines, it is a dimensional monument tree. Elemen Black Pine should be considered important as a new addition to the monumental tree invento . . .ry of Black Sea Region of Turkey, and it should be registered officially as a dimensional monumental tree by Ministry of Environment and Forestry of Repuclic of Turkey Daha fazlası Daha az

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