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Bulunan: 33 Adet 0.001 sn
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Laboratory assays of the effects of oxfendazole on biological parameters of Galleria mellonella (Lepidoptera: Pyralidae)

Sugeçti, Serkan | Büyükgüzel, Ender | Büyükgüzel, Kemal

Article | 2016 | Journal of Entomological Science51 ( 2 ) , pp.129 - 137

Galleria mellonella L. larvae were reared on a standard diet amended with varying concentrations (0, 0.0015, 0.015, 0.15, and 1.5%) of the benzimidazole-derivative antihelmintic drug oxfendazole. Survivorship, developmental times, longevity, fecundity, and fertility were monitored over the treatments. Relative to the untreated control, exposure to diet containing 1.5% oxfendazole significantly decreased survivorship in larval, pupal, and adult stages, prolonged the time to reach the adult stage, and reduced adult longevity. Oxfendazole at all concentrations significantly lowered egg production per female and decreased egg hatch. The . . .se results demonstrate that this antihelmintic may be explored as a candidate for insect pest control Daha fazlası Daha az

Solanum tuberosum and lycopersicon esculentum leaf extracts and single metabolites affect development and reproduction of drosophila melanogaster

Ventrella, Emanuela | Adamski, Zbigniew | Chudzinska, Ewa | Miadowicz-Kobielska, Mariola | Marciniak, Pavel | Büyükgüzel, Ender | Büyükgüzel, Kemal | Erdem, Meltem | Falabella, Patrizia | Scrano, Laura | Bufo, Sabino Aurelio

Article | 2016 | PLoS ONE11 ( 5 ) , pp.129 - 137

Glycoalkaloids are secondary metabolites commonly found in Solanaceae plants. They have anti-bacterial, anti-fungal and insecticidal activities. In the present study we examine the effects of potato and tomato leaf extracts and their main components, the glycoalkaloids ?-solanine, ?-chaconine and ?-tomatine, on development and reproduction of Drosophila melanogaster wild-type flies at different stages. Parental generation was exposed to five different concentrations of tested substances. The effects were examined also on the next, non-exposed generation. In the first (exposed) generation, addition of each extract reduced the number . . .of organisms reaching the pupal and imaginal stages. Parent insects exposed to extracts and metabolites individually applied showed faster development. However, the effect was weaker in case of single metabolites than in case of exposure to extracts. An increase of developmental rate was also observed in the next, non-exposed generation. The imagoes of both generations exposed to extracts and pure metabolites showed some anomalies in body size and malformations, such as deformed wings and abdomens, smaller black abdominal zone. Our results further support the current idea that Solanaceae can be an impressive source of molecules, which could efficaciously be used in crop protection, as natural extract or in formulation of single pure metabolites in sustainable agriculture. © 2016 Ventrella et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Daha fazlası Daha az

Electrochemical, continuous-flow determination of p-benzoquinone on a gold nanoparticles poly(propylene-co-imidazole) modified gold electrode

Korkut, Şeyda | Uzunçar, Sinan | Kılıç, Muhammet Samet | Hazer, Baki

Article | 2016 | Instrumentation Science and Technology44 ( 6 ) , pp.614 - 628

A novel continuous flow biosensor based on gold nanoparticles and poly(propylene-co-imidazole) was developed for the online determination of p-benzoquinone. The amperometric response was measured as a function of p-benzoquinone concentration at an applied potential of -50 mV. The hydrogen peroxide concentration was optimized and fixed at 1 mM in samples. The mass transfer resistance of the copolymer film was minimized, and the flow cell was regenerated quickly at 1 mL/min. The resulting device provided good analytical performance based on a linear dynamic range from 5–100 µM, a short response time of 3 s, a detection limit of 3.3 µM . . ., excellent repeatability with a relative standard deviation of 0.82%, long-term stability of 95% after four weeks, and an accuracy of 105%. The gold nanoparticles enhanced the electron transfer rate on the electrode. The apparent Michaelis-Menten constant was 4 mM, showing that the enzyme retained catalytic specificity and provided high activity for p-benzoquinone. © 2016, Taylor & Francis Daha fazlası Daha az

A review of bioinsecticidal activity of solanaceae alkaloids

Chowanski, Szymon | Adamski, Zbigniew | Marciniak, Pawel | Rosiński, Grzegorz | Büyükgüzel, Ender | Büyükgüzel, Kemal | Falabella, Patrizia | Scrano, Laura | Ventrella, Emanuela | Lelario, Filomena | Bufo, Sabino A.

Article | 2016 | Toxins8 ( 3 ) , pp.614 - 628

Only a small percentage of insect species are pests. However, pest species cause significant losses in agricultural and forest crops, and many are vectors of diseases. Currently, many scientists are focused on developing new tools to control insect populations, including secondary plant metabolites, e.g., alkaloids, glycoalkaloids, terpenoids, organic acids and alcohols, which show promise for use in plant protection. These compounds can affect insects at all levels of biological organization, but their action generally disturbs cellular and physiological processes, e.g., by altering redox balance, hormonal regulation, neuronal sign . . .alization or reproduction in exposed individuals. Secondary plant metabolites cause toxic effects that can be observed at both lethal and sublethal levels, but the most important effect is repellence. Plants from the Solanaceae family, which contains numerous economically and ecologically important species, produce various substances that affect insects belonging to most orders, particularly herbivorous insects and other pests. Many compounds possess insecticidal properties, but they are also classified as molluscides, acaricides, nematocides, fungicides and bactericides. In this paper, we present data on the sublethal and lethal toxicity caused by pure metabolites and crude extracts obtained from Solanaceae plants. Pure substances as well as water and/or alcohol extracts cause lethal and sublethal effects in insects, which is important from the economical point of view. We discuss the results of our study and their relevance to plant protection and management Daha fazlası Daha az

Gemifloksasinin Galleria mellonella L. (Lepidoptera: Pyralidae) erginlerinin bazı biyolojik özelliklerine etkisi

Hız, Pınar | Erdem, Meltem | Büyükgüzel, Ender | Büyükgüzel, Kemal

Article | 2016 | Kafkas Üniversitesi Veteriner Fakültesi Dergisi22 ( 5 ) , pp.777 - 784

Büyük bal mumu güvesi Galleria mellonella L. mikrobiyal enfeksiyonların ve klinik ilaçların çalışılmasında memeli modellerine alternatif bir model olarak bilindiği gibi insektisit etkinliği çalışmalarında da model böcek olarak yaygın kullanıma sahiptir. Bu böceğin larvaları yapay besin ortamında beslenerek fluorokinolon sınıfından bir antibiyotik olan gemifloksasinin böceğin eşey oranı, dişi ve erkek ömür uzunluğu, yumurta verimi, açılma oranı gibi ergin biyolojik özellikleri üzerine etkisi laboratuvar şartlarında incelendi. Böceğin birinci evre larvaları %0.001, 0.01, 0.1 ve 1.0 oranında gemifloksasin içeren yapay besinler ile ergi . . .n evreye kadar beslendi. Gemifloksasinin denenen konsantrasyonlarını içeren besinler erkek ve dişi eşey oranı ile erginlerin ömür uzunluğu üzerinde etkili olmadığı halde yumurta verimini önemli derecede düşürdüğü belirlendi. Artan besinsel gemifloksasin konsantrasyonları ile ters orantılı olarak yumurta verimi ve açılma oranı azaldı. Kontrol besini ile yetiştirilen dişiler günde 134.46 adet yumurta üretirken gemifloksasinin yüksek miktarlarında dişiler 26.75 ve 53.5 yumurta bıraktılar. Yumurtaların açılma oranı da gemifloksasinin %0.01'lik konsantrasyonundan itibaren önemli derecede azalmış olup, en yüksek konsantrasyon bu oranı %53.71'e düşürdü. Bu çalışma erginlerin biyolojik özelliklerinin gemifloksasin tarafından önemli derecede etkilendiğini ve bu etkilerin antibiyotiğin konsantrasyonlarına bağımlı değişimler olduğunu gösterdi. Greater wax moth, Galleria mellonella L. is most commonly used as model insects for studying insecticidal efficiency of chemicals as well as it has been known as an alternative model to mamalian model for studying microbial infections and clinical drugs. The effects of a fluoroquinolone antibacterial agent, gemifloxacin, on sex ratio, male and female adult longevity, fecundity and hatchability of this insect were investigated by rearing the first instar larvae on artificial diets in the laboratory condition. The insect was reared from first-instar larvae to adult stage on an artificial diets containing gemifloxacin at 0.001, 0.01, 0.1 or 1.0%. Gemifloxacin did not affect male and female sex ratio and adult longevity while it significantly decreased egg number. Fecundity and hatchability were significantly and inversely decreased by increasing gemifloxacin concentrations. The females reared from control diet produced 134.46 per day, whereas high concentrations of gemifloxacin decreased the egg number to 26.75 and 53.5. Hatchability was also significantly decreased by 0.01% and above concentrations of gemifloxacin whereas, the highest concentration of antibiotic lowered the hatchability to 53.71%. This study indicated sublethal effects of gemifloxacin are likely to have a significant impact on adult biological traits and these effects show concentration-dependent variation in biological traits of the insect Daha fazlası Daha az

Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types

Kılıçay, Ebru | Erdal, Ebru | Hazer, Baki | Türk, Mustafa | Denkbaş, Emir Baki

Article | 2016 | Artificial Cells, Nanomedicine and Biotechnology44 ( 8 ) , pp.1938 - 1948

Amphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. For this purpose, PHB-b-PEG-NH2 block copolymers were synthesized via transesterification reactions. The copolymers obtained were characterized by Proton Nuclear Magnetic Resonance (1H-NMR), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) techniques. The cytotoxic, apoptotic and necrotic effects of these nanoparticles in the MDA 231 human . . .breast cancer cell, the A549 human lung cancer cell and the L929 fibroblast cell lines were also investigated. © 2015 Taylor & Francis Daha fazlası Daha az

Türkçede yeni bir neoloji örneği: Fiilleşen markalar

Karadavut, Arda

Article | 2016 | Selçuk Üniversitesi Türkiyat Araştırmaları Dergisi0 ( 39 ) , pp.245 - 252

Canlı bir varlık olan dilin söz varlığı sürekli gelişim hâlindedir. Dilde önceden mevcut olmayan bir sözcük türetmeye neolojizm denir. Neolojizmler teknolojik, ekonomik, psikolojik veya kültürel sebeplerden ortaya çıkmaktadır. Neolojizm kavramı birçok dil bilimci tarafından dil yozlaşmasının sebeplerinden sayılmaktadır. Bu çalışmada markaların hem üretici hem de tüketici yoluyla nasıl eylem hâline getirildiği, bu eylem hâline getirmenin sebepleri, neolojizm bağlamında üretici ve tüketici açısından ayrı ayrı değerlendirilecektir. Çalışma sonunda neolojizmlerin dilin biçim ve anlam yapısına uyduğunda o dilin söz varlığına katkıda bulu . . .nan sözlük birimler olduğu ispatlanacaktır. The presence of utterance of language, which is an animate asset, is in progress. Naming after a newly produced term in a language is described with the term "neologism" the terminology of linguistics. Neologisms might emerge from technological, economic, psychological or cultural causes. Many linguists consider the concept of neologism one of the causes of language deterioration. In this study, that brand names are rendered to the concept of verbalized through both producer and consumer, and the causes of the rendering to the concept of verbalized in terms of producer and consumer on the basis of neologism will be examined separately. At the end of the research, it will be displayed that neologisms contribute to the vocabulary of a language when these are compatible with the structure of mode and meaning of that language Daha fazlası Daha az

Silver nanoparticle incorporation effect on mechanical and thermal properties of denture base acrylic resins

Köroğlu, Ayşegül | Şahin, Onur | Kürkçüoğlu, Işın | Dede, Doğu Ömür | Özdemir, Tonguç | Hazer, Baki

Article | 2016 | Journal of Applied Oral Science24 ( 6 ) , pp.590 - 596

Objective: The aim of the present study was to evaluate the mechanical and thermal characteristics of two denture base acrylic resins containing silver nanoparticles (AgNPs). Material and Methods: Two different acrylic denture base resins (heat-polymerized and microwave polymerized) containing 0.3, 0.8 and 1.6 wt% AgNPs were evaluated for flexural strength, elastic modulus and impact strength. The glass transition temperature (Tg) and relative heat capacity (Cp) of the samples were determined from the Differential Scanning Calorimetry (DSC) results. For statistical analysis, two-way ANOVA and Tukey-HSD tests were performed. Results: . . . Addition of 0.8% and 1.6% AgNPs in microwave-polymerized resin significantly decreased the transverse strength and elastic modulus. In terms of impact strength, the addition of AgNPs has no effect on both resin groups. Glass transition temperature (Tg) was decreased with the addition of AgNPs for both denture base resins. Conclusions: The incorporation of AgNPs, generally used for antimicrobial efficiency, affected the transverse strength of the denture base acrylic resins depending on the concentration of nanoparticles. Tg was decreased with the addition of AgNPs for both denture base resins. © 2016, Faculdade de Odontologia de Bauru. All rights reserved Daha fazlası Daha az

A new neology sample in turkish: The verbalized brands

Karadavut, Arda

Article | 2016 | TURKIYAT ARASTIRMALARI DERGISI-JOURNAL OF STUDIES IN TURKOLOGY ( 39 ) , pp.245 - 252

https://hdl.handle.net/20.500.12628/1965

Design of a mediated enzymatic fuel cell to generate power from renewable fuel sources

Korkut, Şeyda | Kılıç, Muhammet Samet

Article | 2016 | Environmental Technology (United Kingdom)37 ( 2 ) , pp.163 - 171

The present work reported a compartment-less enzymatic fuel cell (EFC) based on newly synthesized Poly(pyrrole-2-carboxylic acid-co-3-thiophene acetic acid) film containing glucose oxidase and laccase effectively wired by p-benzoquinone incorporated into the copolymer structure. The resulting system generated a power density of 18.8 µW/cm2 with 30 mM of glucose addition at +0.94 V at room temperature. Improvements to maximize the power output were ensured with step-by-step optimization of electrode fabrication design and operational parameters for operating the system with renewable fuel sources. We demonstrated that the improved fu . . .el cell could easily harvest glucose produced during photosynthesis to produce electrical energy in a simple, renewable and sustainable way by generating a power density of 10 nW/cm2 in the plant leaf within 2 min. An EFC for the first time was successfully operated in municipal wastewater which contained glycolytic substances to generate electrical energy with a power output of 3.3 µW/cm2. © 2015 Taylor & Francis Daha fazlası Daha az

The synthesis and characterization of novel quinone-amine polymers from the reactions of 2,3-dichloro-1,4-naphthoquinone and polyoxypropylenediamines

Ayla-Şahinler, Ayla | Bahar, Hakan | Yavuz, Şenol | Hazer, Baki | İbiş, Cemil

Article | 2016 | Phosphorus, Sulfur and Silicon and the Related Elements191 ( 3 ) , pp.438 - 443

A series of novel N-and N,N'-bis(quinonyl)amines were synthesized from the reactions of 2,3-dichloro-1,4-naphthoquinone (1) and polyoxypropylenediamines. The novel quinone-amine polymers were treated with some thiols in next step and N,S-substituted compounds were obtained. The structures of the novel products were characterized by micro-analysis, 1H NMR, UV-VIS, 13C NMR, and MS. The electrochemical properties of some of the novel amine-quinone polymers derivatives were also investigated by cyclic voltammetry. The number of molecular weight (Mn) of polymer compounds was also determined by Gel Permeation Chromatography (GPC). © 2016 . . .Taylor & Francis Group, LLC Daha fazlası Daha az

6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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