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Papuloerythroderma of Ofuji: A report of two cases [Ofuji'nin papuloeritroderması: Iki olgu sunumu]

Sarici G. | Koca R. | Işik S. | Sezer T. | Çinar S. | Kandemir N.O.

Article | 2011 | Turk Dermatoloji Dergisi5 ( 1 ) , pp.13 - 17

Papuloerythroderma of Ofuji is characterized by a pruritic eruption of widespread, red, flat papules that leads to spare skin folds. The disease occurs primarily in elderly men and is often associated with lymphadenopathy, peripheral blood eosinophilia, lymphopenia and elevated immunoglobulin E levels. Association with T and B cell lymphomas, visceral carcinomas, AIDS, atopic dermatitis, psoriasis and hypersensitivity to drugs have been reported. Topical and systemic corticosteroids, psoralen-UVA, etretinate-PUVA, acitretin-PUVA, UVB, cyclosporin, interferon ? and azathioprine have been used in the treatment of this rare disease. In . . . this manuscript, we described two patients with papuloerythroderma of Ofuji Daha fazlası Daha az

Oxidized low-density lipoproteins accumulate in rat lung after experimental lung edema induced by alpha- naphthylthiourea (ANTU)

Sipahi E.Y. | Ozel Tekin I. | Comert M. | Barut F. | Ustun H. | Sipahi T.H.

Article | 2004 | Pharmacological Research50 ( 6 ) , pp.585 - 591

Oxidation of the low-density lipoprotein (LDL) results in the production of modified LDLs. Oxidation of LDL cholesterol plays a role on the pathogenesis of endothelial dysfunction. This study was designed to investigate the possible participation of the oxidative modification of low density lipoprotein in the lung edema induced by alpha-naphthylthiourea (ANTU), which is a well-known noxious chemical agent on the lung endothelium. When ANTU injected intraperitoneally into rats (15 mg kg-1), it produced lung edema as indicated by an increase in lung weight/body weight (LW/BW) ratio and pleural effusion (PE) reaching a maximum within 4 . . . h. A significant lung edema was observed 4 h after intraperitoneally injection of alpha-naphthylthiourea when compared with olive oil-injected control rats. On microscopic examination of alpha-naphthylthiourea-treated rats were shown to have severe lung injury, while no change was observed in olive oil-treated control rats. While there were no staining in control lungs, positive oxidized low-density lipoproteins immune-fluorescent staining were observed in lung edema group. Our study showed that oxidized low-density lipoprotein (oxLDL) accumulated in ANTU-induced lung damage. This is the first study in which accumulation of oxLDL molecules in the intact lung tissue were shown by fluorescent immune-staining method in experimental lung edema. The potential role of oxLDL in this pathology are still under investigation. © 2004 Elsevier Ltd. All rights reserved Daha fazlası Daha az

Ovarian cancer during pregnancy

Barut A. | Arikan I. | Barut F. | Harma M. | Harma M.I. | Payasli B.

Article | 2011 | Journal of the Pakistan Medical Association61 ( 9 ) , pp.914 - 916

The frequency of cancer during pregnancy is approximately 1 per 1000 live births. This rate may increase as more women postpone childbirth until later in life, when cancer becomes more frequent. Pregnancy affectsmanagement of the cancer, and the cancer affects the management of pregnancy. The most common malignancies, in order of frequency, are breast cancer, leukaemia and lymphomas as a group, melanoma, gynaecologic cancers, and bone tumours. Ovarian tumours are found in about 1 in 1000 pregnancies and 3-6% of these are malignant. Thus, ovarian cancer occurs in approximately 1 in 12,500-25,000 pregnancies. Here, we report a case of . . . ovarian mucinous carcinoma that was diagnosed at 22 weeks of gestation. After conservative surgery, she was given three cycles of carboplatin chemotherapy. She delivered at 33 weeks of gestation and after undergoing surgery she was given six cycles of paclitaxel and carboplatin chemotherapy. The patient is now being followed by the oncology department with no evidence of disease Daha fazlası Daha az


Karabag, T. | Aydin, M. | Dogan, S. M. | Cabuk, B. | Sayin, M. R. | Cetiner, M. A. | Celik, O.

Conference Object | 2011 | INTERNATIONAL JOURNAL OF CARDIOLOGY147 , pp.914 - 916

WOS: 000289284500028

Erratum: Letter to the Editor: Isolated interrupted aortic arch, a rare cause of hypertension in adults (International Journal of Cardiology (2008) 127 (e52-e53))

Yildirim N. | Dogan S.M. | Aydin M. | Hekimoglu K. | Gungorduk A.

Erratum | 2010 | International Journal of Cardiology138 ( 3 ) , pp.914 - 916

[No abstract available]

Laser treatment of an oral squamous papilloma in a pediatric patient: A case report

Misir A. | Demiriz L. | Barut F.

Article | 2013 | Journal of Indian Society of Pedodontics and Preventive Dentistry31 ( 4 ) , pp.279 - 281

Oral squamous papilloma is a benign proliferation of the stratified squamous epithelium, which results in a papillary or verrucous exophytic mass induced by human papilloma virus (HPV). These oral mucosa lesions are most often asymptomatic and have small progression. Laser assisted surgery is common nowadays with several advantages including successful hemostasis, devoid of sutures, wound sterilization and minimal post-operative pain and edema. The aim of this report is to present the oral squamous papilloma in a pediatric patient and its treatment with soft tissue laser. The lesion was excised with diode laser and the healing was u . . .neventful in follow-up visit after one year. Oral squamous papillomas can be found in child's oral cavity and laser dentistry can be used by dental clinicians to treat these kinds of oral lesions and should be considered as an alternative to conventional surgery Daha fazlası Daha az

A case report: Liver metastasis of carcinoid tumor with gallbladder adenocarcinoma [Safra kesesi adenokarsinomu ile birlikte karacigerde karsinoid tümör metastazi: Olgu sunumu]

Barut F. | Özdamar Ş.O. | Kertiş G. | Bahadir B. | Cömert M. | Banu Dogan G.Ü.N.

Article | 2008 | Ondokuz Mayis Universitesi Tip Dergisi25 ( 1 ) , pp.30 - 34

Majority of hepatic carcinoid tumors are metastatic, and frequently the origin of the tumor is gastrointestinal system. It is occasionally regarded as primary, after long term of clinical follow up or without any incidental finding during otopsy for focus of tumor. For carcinoid tumor cases, high frequency of secondary non-carcinoid neoplasm sourced from gastrointestinal system especially colon adenocarcinoma is well known. Though, carcinoid tumor accompany with gallbladder carcinoma is extremely rare. 73 years old woman applied to the emergency service with abdominal pain. Abdominal ultrasonography and tomography revealed multiple . . .metastasis concordant with abdominal mass and after that, with the preliminary diagnosis 'acute cholecystitidis' and 'hepatic metastatic mass lesion' the patient underwent cholecystectomy and hepatic local mass exicision. A brown lesion in 1 cm diameter at the fundus is observed during macroscopic examination. Microscopic examination of this lesion showed adenocarcinoma infiltration up to serosa and focal reaction with musicarmine within the tumor cells. Immunohistochemically, there is positive reaction with pancytokeratin (AE1/AE3) with no chromogranin-A expression. Gross examination of hepatic mass lesion is solid with smooth surface and microscopic examination revealed tumor, composed of cells exhibiting organoid pattern, which has centrally located vesicular nucleus and large granular eosinophilic cytoplasm, and adjacent to normal liver tissue. Immunohistochemically, it is determined that there is weak reaction with pancytokeratin (AE1/AE3) within tumor cells and strong and diffuse expression of chromogranin-A and synaptophysin. With these findings, it is concluded that the hepatic mass is 'carcinoid tumor'. To rule out the possibility of a metastatic lesion because of its multiple quantity, further investigations are done to determine a primary focus but cannot be found. For the cases of carcinoid tumor, encountered with gallbladder adenocarcinoma, clinical course of the disease depends upon biologic behaviour of adenocarcinoma. Because of rarerity, we report the case Daha fazlası Daha az

Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma

Kandemir N.O. | Barut F. | Gün B.D. | Tekin N.S. | Keser S.H. | Özdamar T.O.

Article | 2012 | Diagnostic Pathology7 ( 1 ) , pp.30 - 34

Background: In this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.Methods: A total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.Results: Vesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesi . . .cular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.Conclusions: Our findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.Virtual slides: The virtual slide(s) for this article can be found here: © 2012 Kandemir et al.; licensee BioMed Central Ltd Daha fazlası Daha az

Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats

Özaçmak, Veysel Haktan | Sayan, Hale | Akyıldız-İğdem, Ayşenur | Çetin, Alpay | Özaçmak, İhsan Diler

Article | 2007 | European Journal of Pharmacology562 ( 01.Feb ) , pp.138 - 147

Growing number of studies implicate that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have beneficial effects on ischemia/reperfusion injury that are unrelated to their cholesterol-lowering action. In the present study, we aimed to evaluate possible effects of atorvastatin on oxidative stress, neutrophil accumulation, and contractile response of terminal ileum segments in rats subjected to intestinal ischemia/reperfusion. Intestinal ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 30 min followed by reperfusion for 3 h. Oral administration of atorvastatin at a dose of . . . 10 mg/kg/day lasted 3 days just before induction of intestinal ischemia. At the end of reperfusion period, terminal ileum samples were removed to determine the concentrations of malondialdehyde, reduced glutathione, and myeloperoxidase. Samples were collected also to assess histopathological alterations and contractile response to agonists. Ischemia/reperfusion significantly decreased contractile responses, and this decrease was attenuated by atorvastatin. Pretreatment with atorvastatin caused remarkable decrease in both oxidative stress and neutrophil accumulation. Atorvastatin appeared to be restoring amount of reduced glutathione back to about control level. Furthermore, the pretreatment lowered mucosal damage at histopathological level. Our results suggested that pretreatment with atorvastatin attenuated intestinal muscle dysfunction associated with ischemia/reperfusion. This remarkable effect of atorvastatin is accomplished at least by decreasing oxidative stress and neutrophil accumulation as well as preventing the depletion of reduced glutathione. © 2007 Elsevier B.V. All rights reserved Daha fazlası Daha az

The effect of statin treatment on inflammation in patients with metabolic syndrome [Metabolik sendromlu hastalarda statin tedavisinin inflamasyon iizerine etkisi]

Aydin M. | Onuk T. | Dogan S.M. | Yildirim N. | Demirci E. | Kalayciog¨lu E. | Madak H.

Article | 2009 | Turk Kardiyoloji Dernegi Arsivi37 ( 1 ) , pp.26 - 34

Objectives: Inflammation plays an important role in the pathogenesis of metabolic syndrome (MS). We investigated the effect of fluvastatin treatment on inflammatory markers in patients with MS. Study design: The study included 47 patients (36 females; 11 males; mean age 55±8 years) with MS. The diagnosis of MS was based on the presence of at least three criteria of the NCEP ATP III guidelines. All the patients received 80 mg fluvastatin treatment for six weeks. Laboratory parameters were measured before and after treatment, and flow cytomet-ric analysis of peripheral blood leukocytes was performed. The results were compared with tho . . .se of 47 age- and sex-matched healthy controls (33 females, 14 males; mean age 52±8 years). Results: Fluvastatin treatment resulted in significant decreases in levels of total cholesterol, LDL cholesterol, triglycer-ide ( Daha fazlası Daha az

Coronary to pulmonary artery fistula associated with significant coronary atherosclerosis.

Yildirim N. | Dogan S.M. | Gürsürer M. | Aydin M.

Article | 2007 | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology7 ( 4 ) , pp.26 - 34

[No abstract available]

Surgeon performed continuous intraoperative ultrasound guidance decreases re-excisions and mastectomy rates in breast cancer

Karadeniz Çakmak, Güldeniz | Emre, Ali U. | Taşçılar, Öğe | Bahadır, Burak | Özkan, Selçuk

Article | 2017 | Breast33 , pp.23 - 28

Background Intraoperative ultrasound guided (IUG) breast conserving surgery (BCS) is being increasingly embraced by breast surgeons worldwide. We aimed to compare the efficacy of IUG-BCS for palpable and nonpalpable breast cancer with respect to margin status, re-excision rate, tissue sacrifice and cost-time analysis. Methods Intraoperative localization protocol includes intraoperative ultrasound prior to excision to localize the lesion and guide the initial resection. The excised specimen was then examined visually and by palpation and the specimen and cavity was examined with ultrasound. Frozen sections were obtained routinely fro . . .m a portion of all six faces of the resected specimen, and shaved cavity margins were sent for permanent histology. Results Of the 208 patients, 57.2% had nonpalpable tumors. The sensitivity of ultrasound localization was 100%. Negative margins were achieved in 92.43% of nonpalpable and 91.01% of palpable lesions at initial procedure. The involved margins were correctly identified by the surgeon via specimen sonography in 95.4% of cases. Final positive margin rate was 2.4%. Calculated resection ratio and time analysis revealed nothing significant. Conclusion IUG-BCS is an invaluable and effective modality for obtaining clear surgical margins with optimum resection volumes and reducing re-operations. Furthermore, by means of this algorithm, in case of shaving cavity margins of the tumor bed for permanent analysis, frozen section evaluation might be omitted. © 201 Daha fazlası Daha az

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