Bulunan: 18 Adet 0.001 sn
Koleksiyon [7]
Tam Metin [2]
Yayın Türü [2]
Yazar [20]
Yayın Yılı [10]
Konu Başlıkları [20]
Yayıncı [2]
Yayın Dili [1]
Dergi Adı [17]
Low-Density Lipoproteins Oxidized After Intestinal Ischemia/Reperfusion in Rats

Tekin I.O. | Sipahi E.Y. | Comert M. | Acikgoz S. | Yurdakan G.

Article | 2009 | Journal of Surgical Research157 ( 1 )

Background: Intestinal ischemia/reperfusion (I/R) is a complex phenomenon causing destruction of both local and remote tissues, as well as multiple-organ failure. We investigated the role of lipid peroxidation in damage to intestinal, liver, and lung tissues in this pathology. Materials and Methods: The superior mesenteric artery was blocked for 30 min followed by 24 h of reperfusion. Tissues were removed and the presence of oxidized LDL, the activities of the superoxide dismutase enzyme, malondialdehyde levels, and inducible nitric oxide synthase expression were each evaluated in the intestinal, liver, and lung tissues. Results: Wh . . .ile there was no staining in the control group tissues, ischemia/reperfusion resulted in positive oxidized LDL staining in all of the I/R test group tissue samples. Inducible nitric oxide synthase expression was significantly increased in the ischemia/reperfusion group tissues. Compared with those of the control group rats, the ischemia/reperfusion group tissues showed significantly higher malondialdehyde levels and lower superoxide dismutase activities. Conclusions: This study demonstrated for the first time that oxidized LDL accumulated in the terminal ileum, liver, and lung tissues after intestinal ischemia/reperfusion. This occurrence (or the presence of oxidized LDL) may be an indicator of ongoing oxidative stress and enhanced lipid peroxidation. Augmentation of inducible nitric oxide synthase expression may play a role in progression of inflammation and LDL oxidation. These data support the hypothesis that cellular oxidative stress is a critical step in reperfusion-mediated injury in both the intestine and end organs, and that antioxidant strategies may provide organ protection in patients with reperfusion injury, at least through affecting interaction with free radicals, nitric oxide, and oxidized LDL. © 2009 Elsevier Inc. All rights reserved Daha fazlası Daha az

Chronic pelvic abscedation after completion proctectomy in a rectal stump insufficiency; treatment with gracilis muscle flap following vacuum assisted closure therapy

Gultekin F.A. | Bakkal, Bekir Hakan | Tayfun S. | Babuccu O. | Comert M.

Article | 2013 | Annals of Coloproctology29 ( 4 ) , pp.172 - 176

Presacral abscess formation due to rectal stump insufficiency following Hartmann procedure is very rare complication. If the abscess cavity is large, it might delay the reversal of the stoma and will probably result in a devastating future functioning of the neorectum. Moreover, very invasive treatments will be required in order to prevent severe septic complications. We present the case of a 58-year-old man with a past history of Hartmann procedure for a low rectal carcinoma who presented with rectal stump insufficiency and a large presacral abscess. Following extensive debridement and rectal stump resection, a vacuum-assisted clos . . .ure (VAC) system was applied to the large abscess cavity to facilitate gracilis muscle flap reconstruction and to optimize wound healing. The satisfactory results showed in the present report led us to favor a combination of VAC therapy and a gracilis muscle flap in intrapelvic and perineal reconstruction in the case of large defects associated with high risks of septic complications. © 2013 The Korean Society of Coloproctology Daha fazlası Daha az

Near-Total Thyroidectomy Could Be the Best Treatment for Thyroid Disease in Endemic Regions

Acun Z. | Comert M. | Cihan A. | Ulukent S.C. | Ucan B. | Çakmak G.K. | Kebebew E.

Article | 2004 | Archives of Surgery139 ( 4 ) , pp.444 - 447

Hypothesis: Near-total thyroidectomy, on the basis of its low morbidity rate, is an appropriate treatment option in the surgical management of various thyroid diseases in an endemic region in Turkey. Design: Single-institution study of patients with various thyroid diseases treated by means of near-total thyroidectomy within 2 years in an endemic region, with comparison of the results vs the complication rates of bilateral subtotal and total thyroidectomy reported in the literature. Setting: Tertiary academic referral center. Patients: One hundred fifty-two patients who underwent near-total thyroidectomy for various thyroid diseases . . .. Main Outcome Measures: Surgical treatments of various benign thyroid diseases were compared according to the complication rates and the achievable benefits of the procedures. Results: In our clinic, near-total thyroidectomy was the principal surgical procedure performed for benign thyroid disease. The temporary recurrent laryngeal nerve palsy rate with respect to the nerves at risk was 3.3% (10 of 304 nerves), whereas temporary hypoparathyroidism was 7.2% (11 of 152 patients). Neither permanent recurrent laryngeal nerve palsy nor permanent hypoparathyroidism occurred. In 1 patient, wound hematoma developed and required re-exploration. Seroma in another patient needed no medical or surgical intervention. Neither wound infection nor mortality were noted. Conclusions: Near-total thyroidectomy achieves a lower complication rate of hypoparathyroidism and a similar complication rate of recurrent laryngeal nerve palsy and recurrence when compared with the rates reported in the literature for total thyroidectomy. It is an effective and safe surgical treatment option for various benign thyroid diseases Daha fazlası Daha az

Oxidized low-density lipoproteins accumulate in rat lung after experimental lung edema induced by alpha- naphthylthiourea (ANTU)

Sipahi E.Y. | Ozel Tekin I. | Comert M. | Barut F. | Ustun H. | Sipahi T.H.

Article | 2004 | Pharmacological Research50 ( 6 ) , pp.585 - 591

Oxidation of the low-density lipoprotein (LDL) results in the production of modified LDLs. Oxidation of LDL cholesterol plays a role on the pathogenesis of endothelial dysfunction. This study was designed to investigate the possible participation of the oxidative modification of low density lipoprotein in the lung edema induced by alpha-naphthylthiourea (ANTU), which is a well-known noxious chemical agent on the lung endothelium. When ANTU injected intraperitoneally into rats (15 mg kg-1), it produced lung edema as indicated by an increase in lung weight/body weight (LW/BW) ratio and pleural effusion (PE) reaching a maximum within 4 . . . h. A significant lung edema was observed 4 h after intraperitoneally injection of alpha-naphthylthiourea when compared with olive oil-injected control rats. On microscopic examination of alpha-naphthylthiourea-treated rats were shown to have severe lung injury, while no change was observed in olive oil-treated control rats. While there were no staining in control lungs, positive oxidized low-density lipoproteins immune-fluorescent staining were observed in lung edema group. Our study showed that oxidized low-density lipoprotein (oxLDL) accumulated in ANTU-induced lung damage. This is the first study in which accumulation of oxLDL molecules in the intact lung tissue were shown by fluorescent immune-staining method in experimental lung edema. The potential role of oxLDL in this pathology are still under investigation. © 2004 Elsevier Ltd. All rights reserved Daha fazlası Daha az

The presence of oxidized low-density lipoprotein and inducible nitric oxide synthase expression in renal damage after intestinal ischemia reperfusion

Yurdakan G. | Tekin I.O. | Comert M. | Acikgoz S. | Sipahi E.Y.

Article | 2012 | Kaohsiung Journal of Medical Sciences28 ( 1 ) , pp.16 - 22

Intestinal ischemia/reperfusion (I/R) is a complex phenomenon that causes destruction of both local and remote tissues. The objective of this study was to investigate the possible participation of oxidized low-density lipoproteins (oxLDLs) and inducible nitric oxide synthase (iNOS) expression in renal tissue damage after intestinal I/R. The superior mesenteric artery was blocked for 30 minutes, followed by 24 hours of reperfusion. At the end of the reperfusion period, renal tissues were removed; the presence of oxLDL, superoxide dismutase enzyme activity, malondialdehyde levels, and iNOS expression were evaluated. I/R resulted in po . . .sitive oxLDL staining in renal tissue. Compared with control rats, tissue from the I/R group showed significantly higher malondialdehyde levels and lower superoxide dismutase enzyme activity. Strong and diffuse iNOS expression was present in the I/R group. Our findings support the hypothesis that I/R of intestinal tissue results in oxidative and nitrosative stress and enhances lipid peroxidation in the end organ. These data show that oxLDL accumulates in rat renal tissue after intestinal I/R. Antioxidant strategies may provide organ protection in patients with reperfusion injury, at least by affecting interactions with free radicals, nitric oxide, and oxLDL. This study demonstrates for the first time that oxLDL may play a role in renal tissue damage after intestinal I/R. Antioxidant strategies may be beneficial for protection from reperfusion injury. © 2011, Elsevier Taiwan LLC. All rights reserved Daha fazlası Daha az

A novel tunneling method for long-term peritoneal dialysis [3] (multiple letters)

Losanoff J.E. | Millis J.M. | Comert M. | Ucan B.H. | Borazan A. | Kulah E.

Letter | 2005 | Surgical Endoscopy and Other Interventional Techniques19 ( 9 ) , pp.1291 - 1292

[No abstract available]

Multiple intra-hepatic portal vein aneurysms: Findings of magnetic resonance angiography

Erdem C.Z. | Erdem L.O. | Comert M. | Ustundag Y. | Gundogu S.

Article | 2003 | Clinical Radiology58 ( 11 ) , pp.899 - 901

In summary, we conclude that MRA was a useful diagnostic technique for the investigation of vascular aneurysms of the portal venous system. The routine use of non-invasive radiological methods, such as ultrasonography, can indicate PVAs, however, MRA is useful to confirm or resolve any doubt about the diagnosis, without the need for invasive techniques such as angiography.

A randomized prospective study of complications between general surgery residents and attending surgeons in near-total thyroidectomies

Acun Z. | Cihan A. | Ulukent S.C. | Comert M. | Ucan B. | Cakmak G.K. | Cesur A.

Article | 2004 | Surgery Today34 ( 12 ) , pp.997 - 1001

Purpose. Recurrent laryngeal nerve palsy and hypoparathyroidism are the most common and serious complications after thyroid operations. Surgeon experience has been defined as a significant factor in the number of complications occurring in thyroid surgery. There has so far been no prospective randomized study that compares the complication rates between residents and the attending surgeon in statistically similar patient groups in which all of the patients undergo the same type of thyroid surgery by the same surgical team. In this prospective study the performances of residents and attending surgeons were evaluated and compared acco . . .rding to the complication rates in near-total thyroidectomies. Methods. One hundred and fifty-two patients underwent near-total thyroidectomies between April 2001 and May 2003. The number of randomly selected patients operated on by residents at the level of postgraduate year two, under the direct supervision of an attending surgeon, and the number of patients operated on by attending surgeons were 78 and 74, respectively. All patients had preoperative and postoperative videolaryngostroboscopic examinations of the vocal cords and serum calcium level evaluation. Results. The rates of temporary vocal cord paralysis with respect to the nerves at risk for residents and attending surgeons were 3.7% and 2.7%, respectively. The temporary hypoparathyroidism rate was 8.1% for attending surgeons, whereas it was found to be 6.4% for residents. Neither any cases of permanent vocal cord paralysis nor permanent hypoparathyroidism were detected. Conclusion. Our results indicate that the complication rates in near-total thyroidectomies performed by residents and attending surgeons are similar. Thyroid surgery can therefore be safely and effectively performed by residents under close supervision Daha fazlası Daha az

Effects of ozone oxidative preconditioning on radiation-induced organ damage in rats

Gultekin F.A. | Bakkal, Bekir Hakan | Guven B. | Tasdoven I. | Bektas S. | Can M. | Comert M.

Article | 2013 | Journal of Radiation Research54 ( 1 ) , pp.36 - 44

Because radiation-induced cellular damage is attributed primarily to harmful effects of free radicals, molecules with direct free radical scavenging properties are particularly promising as radioprotectors. It has been demonstrated that controlled ozone administration may promote an adaptation to oxidative stress, preventing the damage induced by reactive oxygen species. Thus, we hypothesized that ozone would ameliorate oxidative damage caused by total body irradiation (TBI) with a single dose of 6 Gy in rat liver and ileum tissues. Rats were randomly divided into groups as follows: control group; saline-treated and irradiated (IR) . . .groups; and ozone oxidative preconditioning (OOP) and IR groups. Animals were exposed to TBI after a 5-day intraperitoneal pretreatment with either saline or ozone (1 mg/kg/day). They were decapitated at either 6 h or 72 h after TBI. Plasma, liver and ileum samples were obtained. Serum AST, ALT and TNF-? levels were elevated in the IR groups compared with the control group and were decreased after treatment with OOP. TBI resulted in a significant increase in the levels of MDA in the liver and ileal tissues and a decrease of SOD activities. The results demonstrated that the levels of MDA liver and ileal tissues in irradiated rats that were pretreated with ozone were significantly decreased, while SOD activities were significantly increased. OOP reversed all histopathological alterations induced by irradiation. In conclusion, data obtained from this study indicated that ozone could increase the endogenous antioxidant defense mechanism in rats and there by protect the animals from radiation-induced organ toxicity. © The Author 2012. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology Daha fazlası Daha az

Intrapancreatic lipoma and morgagni hernia: A previously unrecognized association

Erdem L.O. | Erdem C.Z. | Comert M.

Article | 2004 | Digestive Diseases and Sciences49 ( 11.Dec ) , pp.1962 - 1964

[No abstract available]

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