Evaluation of cardiac functions by tissue Doppler echocardiography in the long term follow-up of patients with childhood Hodgkin Lymphoma

Bozkurt, Ceyhun | Orun, Utku Arman | Ertem, Ayse Ulya | Ocal, Burhan | Sahin, Gurses | Yuksek, Nazmiye | Ozdemir, Sonay Incesoy


Aim: Treatment-associated cardiomyopathy which is one of the side effects of treatment, can be asymptomatic in Hodgkin lymphoma patients. The aim of this study was to find out whether tissue Doppler echocardiography was superior to conventional echocardiography in determining potential cardiac problems in the patients diagnosed with Hodgkin lymphoma. Material and Method: A total of 17 Hodgkin lymphoma patients (12 males, 5 females), and whose treatment had been stopped for at least 4 years were being followed-up with disease-free status and without cardiac symptoms and a control group of 14 healthy persons (8 males, 6 females) were . . .included in the study. The cardiac functions of the patients were evaluated by M-mode, 2 dimentional, colour Doppler, CW Doppler and pulse Doppler techniques. Data analyzes were evaluated by program of Statistical Package for Social Science for Windows 11.5, and Shapiro Wilk, Student's t testi, Mann Whitney U, Fisher's exact chi square tests, respectively. Hospital ethic committee consent was received for the study (07.05.2007/no:5639). Results: There were no statistical differences between the two groups (p=0.302 and p=0.860 respectively) when both groups were evaluated in terms of ejection fraction and fraction shortening by conventional echocardiography technique. Evaluation of both groups for the left ventricle isovolumic contraction time revealed a statistically significant longer time in the patient group compared with the control group (p: 0.038). The results were found longer in the patient group compared with the control group when both groups were evaluated in terms of myocardial performance index parameters and the left ventricle isovolumic contraction time parameters (p=0.029 and p=0.049, respectively). Conclusions: We concluded that the left ventricle isovolumic contraction time, the left ventricle isovolumic acceleration time and myocardial performance index tests are important parameters for the early detection of cardiac pathologies that may develop in relation to chemotherapy. (Turk Arch Ped 2011; 46:228-33 Daha fazlası Daha az

Evaluation of therelationship between epicardial adipose tissue and myocardial performance (Tei) index

Kaplan, Sahin | Ozturk, Mustafa | Kiris, Gulhanim | Kaplan, Safiye Tuba


Aim: Epicardial adipose tissue (EAT) is a tissue around the heart with visceral adipose properties. It can affect the structure and functions of the myocardium and coronary arteries through inflammatory markers and regulators. The myocardial performance (Tei) index is a parameter capable of globally assessing systolic and diastolic heart functions. This study investigated the relation between EAT thickness and the Tei index. Methods: The study population was selected from patients without structural heart disease. EAT thickness was measured with two-dimensional imaging in parasternal long axis view and from the anterior face of the . . .right ventricle. Tei index measurement was calculated with tissue Doppler echocardiography from the mitral lateral annulus. The relation between the Tei index and EAT was assessed using multivariate linear regression analysis. Results: Forty-three patients (36 female, 7 male; mean age 50.2 +/- 10.6 years) were included in the study. Mean Tei index was 0.39 +/- 0.09, and mean EAT thickness 4.7 +/- 2.4 mm. A significant correlation was determined between tissue Doppler Tei index and EAT thickness at correlation analysis (r = 0.522, P < 0.001). EAT thickness was independently correlated with Tei index at multivariate linear regression analysis (Beta = 0.443, t = 3.522, P = 0.001). Conclusion: EAT thickness is independently correlation with Tei index. Increased EAT thickness may therefore be a predictor of left ventricular dysfunction Daha fazlası Daha az

The effect of radiotherapy on cardiac function

Dogan S.M. | Bilici H.M. | Bakkal, Bekir Hakan | Aydin M. | Karabag T. | Sayin M.R. | Aktop Z.

Article | 2012 | Coronary Artery Disease23 ( 3 ) , pp.146 - 154

BACKGROUND: Radiation-induced heart disease is a complication that may be encountered after radiotherapy (RT) of tumors in the vicinity of the heart. In this study, we aimed to evaluate the effect of RT on the heart, by comparing conventional and tissue Doppler echocardiography parameters obtained before and after RT. METHODS: Forty patients who had undergone RT for either lung or left breast cancer were included in the study. ECG, conventional, and tissue Doppler echocardiography were performed before and 4-6 weeks after RT. RESULTS: The mean value of the radiation dose applied to all regions of the heart was calculated as 13.1±2.2 . . . Gy (maximum 41.7 Gy). The value for the left ventricle was 10.2±2.0 Gy (maximum 43.6 Gy). A decrease in early transmitral diastolic velocity (E), E/A ratio, EF, Em, and Em/Am, and an increase in E-wave deceleration time, isovolumic relaxation time, isovolumic contraction time, ejection time, and QTc were found after RT. CONCLUSION: We found detrimental effects of RT on systolic and diastolic cardiac functions and the electrical conduction system of the heart. Maximal prevention should be provided for the patients during RT. © 2012 Lippincott Williams & Wilkins, Inc Daha fazlası Daha az

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