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Protective Effects of Lycopene on Cerulein-Induced Experimental Acute Pancreatitis in Rats

Ozkan, Erkan | Akyuz, Cebrail | Dulundu, Ender | Topaloglu, Umit | Sehirli, Ahmet Ozer | Ercan, Feriha | Sener, Goksel

Article | 2012 | JOURNAL OF SURGICAL RESEARCH176 ( 1 ) , pp.232 - 238

Background. The purpose of our study was to evaluate the protective effect of the strong antioxidant and anti-inflammatory agent, lycopene, on oxidative stress in a rat model of cerulein-induced acute edematous pancreatitis. Methods. Sprague-Dawley rats were pretreated with lycopene (50 mg/kg, i.p.) or saline 15 min before cerulein was given 20 mu g/kg (i.p.) at 1-h intervals within 4 h. Twelve hours after cerulein or saline injections, the animals were killed by decapitation. Blood samples were collected to analyze amylase, lipase, and proinflammatory cytokines (TNF-alpha and IL-1 beta). Pancreatic tissues were taken for the determ . . .ination of tissue glutathione (GSH) and malondialdehyde (MDA) levels, Na+/K+-ATPase, and myeloperoxidase (MPO) activities. Tissue samples were also examined histologically. Results. Acute pancreatitis caused significant decrease in tissue GSH levels and Na+/K+-ATPase activity, while pancreatic MDA levels and MPO activity were increased. Furthermore, TNF-alpha, IL-1 beta, and amylase lipase levels were also significantly increased. On the other hand, lycopene pretreatment reserved all these biochemical indices as well as histopathologic alterations that were induced by cerulein. Conclusions. According to the results, lycopene protects the pancreatic tissues from oxidative damage induced by cerulein, and this effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation. These results suggest that high dietary intake of tomatoes may have protective effects against acute pancreatitis. (C) 2012 Elsevier Inc. All rights reserved Daha fazlası Daha az

The protective effect of nebivolol on ischemia/reperfusion injury in rabbit spinal cord

Ilhan, A | Yilmaz, HR | Armutcu, F | Gurel, A | Akyol, O

Review | 2004 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY28 ( 7 ) , pp.1153 - 1160

The aim of this experimental study was to investigate whether nebivolol has protective effects against neuronal damage induced by spinal cord ischemia/reperfusion (I/R). Twenty-one rabbits were divided into three groups: group I (control, no I/R), group II (only I/R) and group III (I/R+nebivolol). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the aortic bifurcation. Seventy-two hours postoperatively, the motor function of the lower limbs was evaluated in each animal. The animals were sacrificed at 72 h, and histopathological and biochemical analyses were carried out in the lumbar s . . .pinal cords. The motor deficit scores in nebivolol group were different from I/R group at 72 h (3.25 0.70 vs. 1.75 +/- 1.28, p=0.01). I/R produced a significant increase in the superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) and myeloperoxidase (MPO) activities in spinal cord tissue when compared with control group. Nebivolol treatment prevented the increase of all those enzymes activities produced by I/R. A significant decrease in spinal cord glutathione peroxidase (GSH-Px) level was seen in I/R group and nebivolol treatment prevented the decrement in the spinal cord tissue GSH-Px contents. On the other hand, I/R produced a significant increase in the spinal cord tissue malondialdehyde (MDA) and nitric oxide (NO) contents, this was prevented by nebivolol treatment. In conclusion, this study demonstrates a considerable neuroprotective effect of nebivolol on neurological, biochemical and histopathological status during periods of spinal cord I/R in rabbits. (C) 2004 Elsevier Inc. All rights reserved Daha fazlası Daha az

Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice

Ilhan A. | Iraz M. | Gurel A. | Armutcu F. | Akyol O.

Article | 2004 | Neurochemical Research29 ( 12 ) , pp.2287 - 2292

Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.

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