Balli, Umut | Dogan, Seyma Bozkurt | Dede, Figen Ongoz | Sertoglu, Erdim | Keles, Gonca Cayir

Article | 2016 | JOURNAL OF ORAL SCIENCE58 ( 4 ) , pp.465 - 473

The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 . . . weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-a. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-alpha (P < 0.008), which declined following treatment (P< 0.025), and lower omentin levels (P Daha fazlası Daha az

Yerlikaya, F. H. | Toker, A. | Cicekler, H. | Aribas, A.

Article | 2015 | BIOTECHNIC & HISTOCHEMISTRY90 ( 1 ) , pp.31 - 37

Serum sialic acid levels are abnormally high in pathological states that exhibit tissue destruction, tissue proliferation or inflammation. We measured total serum sialic acid levels in 139 women and 125 men. Subjects were divided into quartiles according to their body mass index (BMI): Q1 (18-24.9 kg/m(2)), Q2 (25 -29.9 kg/m(2)), Q3 (30 -39.9 kg/m(2)) and Q4 (> 40 kg/m(2)). The patients in Q1 constituted the control group. Serum sialic acid levels of subjects in Q2, Q3 and Q4 were signifi cantly higher than those in Q1. Higher BMI quartiles also were associated with higher levels of serum glucose, insulin, total cholesterol, LDL-cho . . .lesterol, triglycerides, high-sensitivity C-reactive protein, malondialdehyde levels, waist circumference, blood pressure and homeostasis model assessment of insulin resistance in both women and men. Lower BMI quartiles were associated with higher levels of serum HDL-cholesterol levels in both women and men. We found positive associations among serum sialic acid levels, BMI and oxidative stress. Serum sialic acid also is related to some conventional cardiovascular risk factors including elevated lipid profile, increased blood pressure, increased serum glucose and insulin levels, and insulin resistance in obese people Daha fazlası Daha az

Aydin, Bengu Gulhan | Kucukosman, Gamze | Piskin, Ozcan | Okyay, Rahsan Dilek | Ayoglu, Hilal

Article | 2019 | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI57 ( 1 ) , pp.15 - 19

Aim: The aim of our study was to evaluate specific factors in predicting difficult mask ventilation (DMV) in obese patients undergoing elective surgery. Methods: This prospective and observational study was performed in 90 obese patients. We assessed age, height, weight, sex, body mass index (BMI), dental structure, presence of facial hair, modified Mallampati test result, mouth opening, thyromental distance (TMD), sternomental distance, mandibular protrusion, mandibular length, neck circumference (NC), neck length, upper lip bite test result, height to TMD ratio, NC to TMD ratio (NC/TMD), and history of snoring and Obstructive Slee . . .p Apnea syndrome for estimation of DMV. Results: The mean age of the patients was 40.9 +/- 9.4 years and the mean BMI was 44.7 +/- 6.2 kg/m(2). Of all patients 38.9% were determined to have DMV. Clinical variables associated with DMV were male gender, mandibular length, snoring, NC, and NC/TMD. Multiple logistic regression analysis showed that male gender (p=0.047) and snoring (p=0.02) were independent factors. Conclusion: We believe that NC/TMD and ML are predictive tests for DMV in obese patients. Tests and measurements at the bedside are not sufficient alone and we believe that they will be more reliable when considered togethe Daha fazlası Daha az

Balli U. | Ongoz Dede F. | Bozkurt Dogan S. | Gulsoy Z. | Sertoglu E.

Article | 2016 | Oral Diseases22 ( 7 ) , pp.673 - 680

Objective: To investigate changes in the levels of gingival crevicular fluid (GCF) chemerin and interleukin-6 (IL-6) in both obese/non-obese individuals with periodontitis following non-surgical periodontal therapy. Methods: Individuals (n = 80) were split into four groupings according to periodontal/anthropometric parameters: (i) periodontal healthy without obesity; (ii) chronic periodontitis (CP) without obesity; (iii) periodontal healthy with obesity; and (iv) CP with obesity. Individuals with periodontitis were treated with non-surgical periodontal therapy. Both GCF sampling procedures and clinical periodontal measures were perf . . .ormed prior to treatment and 6 weeks thereafter. Enzyme-linked immunosorbent assay was utilized to measure both chemerin and IL-6 levels. Results: Greater values for chemerin and IL-6 were observed in obese individuals compared to their non-obese controls and in individuals with CP compared to their periodontal healthy controls (P Daha fazlası Daha az

Öngöz Dede F. | Bozkurt Doğan Ş. | Balli U. | Avci B. | Durmuşlar M.C. | Baratzade T.

Article | 2016 | Journal of Periodontal Research51 ( 6 ) , pp.726 - 734

Background and objective: The purpose of this study was to investigate the effects of obesity on reduced and oxidized glutathione (GSH and GSSG) levels in the gingival crevicular fluid, plasma and saliva of patients with chronic periodontitis and to evaluate the changes after nonsurgical periodontal therapy. Material and methods: The study included 60 patients: 30 patients with chronic periodontitis (15 obese patients and 15 normal weight patients) and 30 healthy control subjects (15 obese patients and 15 normal weight patients). Gingival crevicular fluid, plasma and saliva samples were collected, and clinical periodontal measuremen . . .ts were recorded at baseline and at the first month after periodontal therapy from patients with chronic periodontitis. GSH and GSSG levels were analyzed with spectrophotometry. Results: The GSH levels in the plasma, saliva and gingival crevicular fluid in obese individuals with chronic periodontitis were lower than in normal weight individuals at baseline (p < 0.01). There was a significant difference in the GSH/GSSG ratio in plasma and gingival crevicular fluid between the obese and normal weight groups at baseline (p < 0.01). The GSH levels in plasma, gingival crevicular fluid and saliva were significantly increased in both chronic periodontitis groups after nonsurgical periodontal therapy (p < 0.01). A significant positive correlation was found between GSH levels in saliva, plasma and gingival crevicular fluid in all groups (p < 0.001). Conclusions: The study revealed that obesity in patients with chronic periodontitis is associated with decreased GSH levels and the GSH/GSSG ratio. Moreover, nonsurgical periodontal therapy may be helpful for improvement in glutathione values in obese and normal weight individuals with chronic periodontitis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Lt Daha fazlası Daha az

Demiryurek, Bekir Enes | Emre, Ufuk | Korucu, Osman | Barut, Banu Ozen | Tascilar, Fatma Nida | Atasoy, Huseyin Tugrul | Demiryurek, Esra

Article | 2016 | IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE69 ( 09.Oct ) , pp.319 - 325

Background - Metabolic Syndrome (MetS) and headaches are common public health problems in whole world. The relationship between headaches and the MetS isn't understood clearly. Purpose - The aim of this study is to determine the prevalence and types of headaches, and evaluate the relationship between headache characteristics and clinical and laboratory parameters analyzed in patients diagnosed with MetS. Materials and methods Of the patients diagnosed with MetS in Endocrinology outpatient clinics between July 2011 and July 2012, 202 patients were included in the study. Hemoglobin, fasting blood glucose (FBG), total cholesterol, trig . . .lyceride, HDL and LDL cholesterol, thyroid function tests and HbA(1C) values of all patients were recorded. Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to all patients. The headache severity was assessed by Visual Analog Scale (VAS). Results - The prevalence of headache in patients with MetS was found to be 61.4%. The incidence of headache was higher in female patients (F: 86.4%, M: 13.6%). The distribution of the subtypes of headaches was as follows: Episodic Tension-TypeHeadaches (ETTH) 24.8%, Episodic Migraine 14.4%, Chronic Tension Type Headaches (CTTH) 11.3%, Episodic Tension-TypeHeadaches (ETTH) and Episodic Migraine 7.9%, and other types of headaches (Cervicogenic Headache and Cluster Headache) 3%. No statistically significant relationship was found between headache and non-headache groups in terms of body mass index, waist circumference, and the laboratory-parameters (p>0.05). The mean BDI and BAI scores were higher in the headache group ( Daha fazlası Daha az