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Factors Related to Microalbuminuria in Patients with Chronic Obstructive Pulmonary Disease

Kaysoydu, Erdal | Arslan, Sulhattin | Yildiz, Guersel | Candan, Ferhan

Article | 2014 | ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE23 ( 5 ) , pp.749 - 755

https://dx.doi.org/10.17219/acem/37236 https://hdl.handle.net/20.500.12628/2639

Neutrophil-to-lymphocyte ratio as a possible indicator of epicardial adipose tissue in patients undergoing hemodialysis

Ozcicek, Adalet | Ozcicek, Fatih | Yildiz, Gursel | Timuroglu, Aysu | Demirtas, Levent | Buyuklu, Mutlu | Kuyrukluyildiz, Ufuk

Article | 2017 | ARCHIVES OF MEDICAL SCIENCE13 ( 1 ) , pp.118 - 123

Introduction: Chronic inflammation is a major risk factor in the pathogenesis of cardiovascular disease in end-stage renal disease (ESRD) patients. Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in healthy subjects and ESRD patients. In the present study we aimed to investigate the relationship between EAT and inflammation parameters including neutrophil-to-lymphocyte ratio (NLR) in hemodialysis (HD) patients. Material and methods: Forty-three HD patients (25 females, 18 males; mean age: 64.1 11.9 years) receiving HD and 30 healthy subje . . .cts (15 females, 15 males; mean age: 59.1 +/- 10.8 years) were enrolled in the study. Epicardial adipose tissue measurements were performed by echocardiography. Results: Neutrophil-to-lymphocyte ratio levels were significantly higher in HD patients than in the healthy control group. Hemodialysis patients were separated into two groups according to their median value of NLR (group 1, NLR < 3.07 (n = 21) and group 2, NLR 3.07 (n = 22)). Group 2 patients had significantly higher EAT, C-reactive protein and ferritin levels, while albumin levels were significantly lower in this group. In the bivariate correlation analysis, EAT was positively correlated with NLR (r = 0.600, p < 0.001) and ferritin (r = 0.485, p = 0.001) levels. Conclusions: Neutrophil-to-lymphocyte ratio was found to be an independent predictor of EAT in HD patients (odds ratio = 3.178; p = 0.008). We concluded that this relationship might be attributed to increased inflammation in uremic patients Daha fazlası Daha az

Relationship of fetuin-A with restenosis in patients who underwent revascularization

Karabag, Turgut | Kucuk, Emrah | Tekin, Ishak Ozel | Sayin, Muhammet Rasit | Gursoy, Yusuf Cemil | Aydin, Mustafa

Article | 2016 | LABORATORIUMSMEDIZIN-JOURNAL OF LABORATORY MEDICINE40 ( 1 ) , pp.43 - 48

Background: We investigated whether fetuin-A (a hepatic secretory protein that prevents arterial calcification) was related to revascularization in patients who had previously undergone coronary revascularization (percutaneous coronary intervention and/or coronary artery bypass grafting operation). Methods: This study included 71 patients who had previously undergone any revascularization procedure. All patients presented to the cardiology outpatient clinic with angina or angina equivalent and underwent coronary angiography upon findings of preliminary tests. The patients were grouped on the basis of the presence of restenosis on an . . .giography: Group 1 consisted of 44 subjects with restenosis on angiography (30 male, 14 female; mean age 64.2 +/- 4.2 years) and group 2; 30 subjects without restenosis on angiography (20 male, 10 female; 61.2 +/- 13.1 years). In addition to routine biochemical tests and lipid panel, all patients underwent C-reactive protein, and fetuin-A measurements. Results: The groups were not significantly different with respect to age, sex, systolic and diastolic blood pressure. As compared to Group 2, Group 1 had a significantly lower fetuin-A level (383.8 +/- 76.2 vs. 416.3 +/- 49.3 ng/mL; p = 0.029). There was a significantly negative correlation between fetuin-A and age; and a significantly positive correlation between fetuin-A and calcium. Conclusions: Fetuin-A levels were significantly lower in patients detected to have restenosis. Lower fetuin-A levels may contribute to restenosis by directly increasing calcium-phosphate precipitation Daha fazlası Daha az

EFFECT OF L-CARNITINE IN PREVENTING SECONDARY DAMAGE IN TRAUMATIC BRAIN INJURY: AN EXPERIMENTAL STUDY

Calikoglu, Cagatay | Akgul, Osman | Akgul, Mehmet Huseyin | Gezen, Ahmet Ferruh | Aytekin, Hikmet | Dosoglu, Murat Servan | Erdem, Havva

Article | 2015 | ACTA MEDICA MEDITERRANEA31 ( 4 ) , pp.777 - 784

Introduction: Prevention of secondary damage occurring after traumatic brain injury (TBI) reduces morbidity and mortality. The present study aimed to evaluate efficacy of L-carnitine, the benefit of which has been proven in many fields such as liver, kidney and neurological diseases, in the treatment of TBI. Matherials and method: Forty adult male Sprague-Dawley rats were included and divided into 4 groups, each containing 10 rats. The control group comprised subjects without induced head trauma and treatment. The trauma group comprised subjects with induced head trauma and no treatment. The carnitine group comprised subjects withou . . .t induced head trauma and with L-carnitine treatment (100 mg/kg via intraperitoneal route for 6 times). The trauma+carnitine group comprised subjects with induced head trauma and L-carnitine treatment. Edema, inflammation, and neuronal damage were histopathologically examined. Results: In the trauma group, all subjects had edema, inflammation, and neuronal damage. In the control, carnitine, and trauma+carnitine groups, edema was detected in 5, 6, and 4 subjects, respectively; inflammation was detected in 2, 4, and 3 subjects, respectively; and neuronal damage was detected in 1, 3, and 7 subjects, respectively. Edema and neuronal damage scores were significantly higher in the trauma group than in the other groups. Inflammation rate was significantly higher in the trauma group than in the control and trauma+carnitine groups. Conclusion: Antiedema, anti-inflammatory, and neuroprotective effects of L-carnitine were histopathologically demonstrated in the rats with experimentally induced head trauma. L-carnitine could be a beneficial treatment option for edema and inflammation secondary to acute TBI in humans Daha fazlası Daha az

Assessment of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Dry Eye Disease

Celik T.

Article | 2018 | Ocular Immunology and Inflammation26 ( 8 ) , pp.1219 - 1222

Purpose: To evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels in patients with dry eye disease (DED). Methods: The white blood cell, neutrophil, platelet, and lymphocyte counts were performed in 78 dry eye patients and 60 controls. The NLR was calculated by dividing neutrophil count by lymphocyte count and the PLR was calculated by dividing platelet count by lymphocyte count. Results: The mean age was 53.4 ± 3.8 years in the DED group and 52.7 ± 3.4 years in the control group. The mean NLR was 2.6 ± 1.2 and the mean PLR was 138.4 ± 62.6 in the DED group and the mean NLR was 1.84 ± 0.5 an . . .d the mean PLR was 118.5 ± 64.7 in the control group. A significant difference was found in the NLR and PLR between the DED and the controls (p = 0.032 and p = 0.026, respectively). Conclusion: The NLR and PLR values were found higher in patients with dry eye than in healthy subjects. ©, © Taylor & Francis Group, LLC Daha fazlası Daha az

Levels of serum IL-1 beta, IL-2, IL-8 and tumor necrosis factor-alpha in patients with unstable angina pectoris

Ozeren, A | Aydin, M | Tokac, M | Demircan, N | Unalacak, M | Gurel, A | Yazici, M

Article | 2003 | MEDIATORS OF INFLAMMATION12 ( 6 ) , pp.361 - 365

Objectives: Inflammation is the most important mechanism of plaque disruption playing an essential role in acute coronary syndromes. It is controversial whether the inflammatory mediators are the cause or the result in the development of plaque rupture. Stimulation of interleukins increases adhesion molecules, fibrinogen and plasminogen activator inhibitors, which cause the activation of inflammation and thrombosis. However, the importance of interleukins in acute coronary syndromes has not been clearly defined. We did not find any article concerning relations between the levels of serum interleukin (IL)-1beta, IL-2, IL-8 and tumor . . .necrosis factor (TNF)-alpha in patients with unstable angina pectoris (UAP). So the aim of this study was to determine the levels of serum IL-1beta, IL-2, IL-8 and TNF-alpha during the early stage of UAP. Methods and results: Thirty-seven patients with UAP (12 females and 25 males; mean age, 57.5 +/- 9.7 years) within 6 h of admission and 20 healthy volunteers (eight females and 12 males; mean age, 51.3 +/- 6.3 years) were included in the study. IL-1beta, IL-2, IL-8 and TNF-alpha levels were measured using the enzyme-linked immunosorbent assay method. Patients with acute or chronic inflammation, renal failure or chronic heart failure were excluded from the study. The age, gender and risk factors of the study and control groups were similar. The levels of IL-1beta, IL-8 and TNF-alpha were significantly increased (p < 0.0001, p < 0.001 and p < 0.016, respectively) in patients with UAP. There was no difference of IL-2 levels between the UAP group and controls. Conclusion: We detected high levels of IL-1 beta, IL-8 and TNF-alpha in patients with UAP during early phase. We suggest that proinflammatory cytokines (e. g. IL-1 beta, IL-8, TNF-alpha) may play an important role in the development of atherosclerosis and its complications Daha fazlası Daha az

Expression of monocyte and lymphocyte adhesion molecules is increased in isolated coronary artery ectasia

Yildirim, Nesligul | Tekin, Ishak O. | Dogan, Sait M. | Aydin, Mustafa | Gursurer, Metin | Cam, Fatih | Gungorduk, Alper

Article | 2007 | CORONARY ARTERY DISEASE18 ( 1 ) , pp.49 - 53

Background Coronary artery ectasia is defined as localized or diffuse dilation of the coronary arteries exceeding the 1.5-fold of normal adjacent segment. Scarce data are available about the role of inflammation in coronary artery ectasia. In the present study, we aimed to evaluate the expression of CD11b and CD45 adhesion molecules in peripheral blood granulocytes, monocytes and lymphocytes from the patients with coronary artery ectasia as possible indicators of inflammation. Method The study consisted of 14 patients who had angiographically normal coronary arteries with coronary artery ectasia and 13 age and sex-matched controls w . . .ithout coronary artery ectasia. Cell surface adhesion molecules were detected by direct immunofluorescence evaluated by flow cytometry using monoclonal antibodies tagged with fluorescent markers. Venous blood samples were taken after coronary angiography. Results Mean fluorescence intensity of CD45 (33.8 +/- 3.1 vs. 13.0 +/- 0.7, P < 0.001) and CD11b (39.1 +/- 13.5 vs. 19.5 +/- 1.32, P < 0.001) on the monocyte surface of patients with coronary artery ectasia were higher than those of controls. Similarly in patients with coronary artery ectasia, the expression of CD11b (7.5 +/- 0.61 vs. 5.6 +/- 0.2, P=0.009) and CD45 (475 +/- 3.6 vs. 36.2 +/- 2.5, P=0.02) on lymphocytes was also significantly higher than those of controls. Conclusion Increased levels of cellular adhesion molecules in patients with coronary artery ectasia may be an indicator of endothelial activation and inflammation and are likely to be in the causal pathway leading to coronary artery ectasia Daha fazlası Daha az

Myocardial functional and textural findings of the right and left ventricles and their association with cellular adhesion molecules in Behcet's disease

Yildirim, Nesligul | Tekin, Nilgun Solak | Tekin, Ishak Ozel | Dogan, Sait | Aydin, Mustafa | Gursurer, Metin | Dursun, Aydin

Article | 2007 | ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES24 ( 7 ) , pp.702 - 711

Aim: This study was designed to assess whether ultrasonic reflectivity, evaluated by integrated backscatter analysis was associated with the severity of inflammation and diastolic dysfunction of the left (LV) and right ventricles (RV) in Behcet's disease (BD). Methods: The study consisted of 20 patients with BD and 18 healthy controls. The expression of CD11b and CD63 on the surface of granulocytes and monocytes were measured by flow cytometry. RV and LV diastolic functions were assessed by tricuspid and mitral annular tissue Doppler recordings, respectively. Backscatter cyclic variation (CV) and maximal intensity (IB) were measured . . . in RV lateral wall, interventricular septum, and posterior LV wall from parasternal long-axis view, apex from apical four-chamber view, anterior, inferior, and lateral LV walls from parasternal short axis view. Results: The mean fluorescence intensity (MFI) of CD11b on granulocytes and CD63 on monocytes in BD patients was higher than those of controls. Patients with BD had smaller mitral and tricuspid annular early diastolic wave velocities and early/late diastolic wave velocity ratios (EIA) than controls. MFI of CD11b and CD63 was inversely correlated with tricuspid and mitral annular E/A in BD patients. CV of RV and global CV of LV were found to be diminished in BD patients than controls. CV of RV and global CV of LV showed a direct correlation with tricuspid and mitral annular EIA ratio, respectively. Conclusion: There is an association between the levels of cellular adhesion molecules, deterioration of diastolic function, and altered myocardial ultrasonic reflectivity in BD Daha fazlası Daha az

The impact of childhood obesity on iron deficiency and its relationship with hepcidin, leptin, interleukin-6

Seyrek, Burak | Ornek, Zuhal | Battal, Fatih

Article | 2016 | Izmir Dr Behcet Uz Cocuk Hastanesi Dergisi6 ( 3 ) , pp.179 - 184

Objective: The relationship between iron deficiency, and obesity has been shown in recent years. The reason is thought to be the anemia of chronic disease caused by chronic inflammation originating from adipose tissue. Our aim is to determine the relationship between obesity and iron deficiency, the place of hepcidin in iron homeostasis, and inflammation occurring in obesity, and also demonstrate its effect of the parametres of iron metabolism in obese children. Methods: This study was performed with 54 obese (body mass index (BMI)>95p) and 51 normal weighted (BMI: 5-95p) children aged between 5-16 years. In two groups serum iron, t . . .otal iron binding capacity (TIBC), ferritin, hemoglobin, transferrin saturation index (TSI), interleukin-6 (IL-6), C-reactive protein (CRP), leptin and hepcidin were studied. Results: When compared with the control group; decreased serum iron (p=0.004), hemoglobin (Hb) (p=0.010), TSI (p=0.001), increased hepcidin (p=0.001), TDBK (p=0.041), leptin (p=0.001), CRP (p=0.001) levels were found in obese children. In 18 cases (%33.3) decreased levels of Hb were detected, while in 8 of these cases (% 14.8) the parameters were found compatible with iron deficiency anemia (IDA). Five cases (% 9.2) were accepted as anemia of chronic disease. In the obese group the number of patients with IDA was found statistically significantly higher (p=0.032). Besides higher BMI (p=0.001), however decreased hepcidin (p=0.008), and ferritin (p=0.006) levels were detected in anemia patients. Conclusion: In our study obesity was found to be associated with iron deficiency. The effect of hepcidin was shown to be the cause of iron deficiency. Every study to be performed in order to understand the relationship between inflammation, obesity and erythropoiesis will contribute to the development of nutritional, and/or pharmacological therapies with the aim to prevent the onset of iron deficiency in obese patients Daha fazlası Daha az

Relationship of fetuin - A with restenosis in patients who underwent revascularization

Karabag T. | Kucuk E. | Tekin I.O. | Sayin M.R. | Gursoy Y.C. | Aydin M.

Article | 2016 | LaboratoriumsMedizin40 ( 1 ) , pp.43 - 48

We investigated whether fetuin-A (a hepatic secretory protein that prevents arterial calcification) was related to revascularization in patients who had previously undergone coronary revascularization (percutaneous coronary intervention and/or coronary artery bypass grafting operation). Methods: This study included 71 patients who had previously undergone any revascularization procedure. All patients presented to the cardiology outpatient clinic with angina or angina equivalent and underwent coronary angiography upon findings of preliminary tests. The patients were grouped on the basis of the presence of restenosis on angiography: G . . .roup 1 consisted of 44 subjects with restenosis on angiography (30 male, 14 female; mean age 64.2±4.2 years) and group 2; 30 subjects without restenosis on angiography (20 male, 10 female; 61.2±13.1 years). In addition to routine biochemical tests and lipid panel, all patients underwent C-reactive protein, and fetuin-A measurements. Results: The groups were not significantly different with respect to age, sex, systolic and diastolic blood pressure. As compared to Group 2, Group 1 had a significantly lower fetuin-A level (383.8±76.2 vs. 416.3±49.3 ng/mL; p=0.029). There was a significantly negative correlation between fetuin-A and age; and a significantly positive correlation between fetuin-A and calcium. Conclusions: Fetuin-A levels were significantly lower in patients detected to have restenosis. Lower fetuin-A levels may contribute to restenosis by directly increasing calcium-phosphate precipitation. © 2016 by De Gruyter Daha fazlası Daha az

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