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Koleksiyon [4]
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Yayın Türü [2]
Yazar [20]
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Yayıncı [7]
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Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats

Kanter, M | Coskun, O | Korkmaz, A | Oter, S

Article | 2004 | ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY279A ( 1 ) , pp.685 - 691

The aim of the present study was to evaluate the possible protective effects of Nigella sativa L. (NS) against beta-cell damage from streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally at a single dose of 50 mg/kg to induce diabetes. NS (0.2 ml/kg/day, i.p.) was injected for 3 days prior to STZ administration, and these injections were continued throughout the 4-week study. Oxidative stress is believed to play a role in the pathogenesis of diabetes mellitus (DM). To assess changes in the cellular antioxidant defense system, we measured the activities of antioxidant enzymes (such as glutathione peroxidas . . .e (GSHPx), superoxide dismutase (SOD), and catalase (CAT)) in pancreatic homogenates. We also measured serum nitric oxide (NO) and erythrocyte and pancreatic tissue malondialdehyde (MDA) levels, a marker of lipid peroxidation, to determine whether there is an imbalance between oxidant and antioxidant status. Pancreatic beta-cells were examined by immunohistochemical methods. STZ induced a significant increase in lipid peroxidation and serum NO concentrations, and decreased antioxidant enzyme activity. NS treatment has been shown to provide a protective effect by decreasing lipid peroxidation and serum NO, and increasing antioxidant enzyme activity. Islet cell degeneration and weak insulin immunohistochemical staining was observed in rats with STZ-induced diabetes. Increased intensity of staining for insulin, and preservation of beta-cell numbers were apparent in the NS-treated diabetic rats. These findings suggest that NS treatment exerts a therapeutic protective effect in diabetes by decreasing oxidative stress and preserving pancreatic beta-cell integrity. Consequently, NS may be clinically useful for protecting beta-cells against oxidative stress. (C) 2004 Wiley-Liss, Inc Daha fazlası Daha az

Comparison of Drug-Eluting Balloon and Standard Balloon Angioplasty for Infrapopliteal Arterial Diseases in Diabetic Patients

Oz I.I. | Serifoglu I. | Bilici M. | Altinbas N.K. | Oz E.B. | Akduman E.I.

Article | 2016 | Vascular and Endovascular Surgery50 ( 8 ) , pp.534 - 540

Objective: To consider the clinical outcomes and restenosis rates of drug-eluting balloons (DEBs) and percutaneous transluminal angioplasty (PTA) in diabetic patients with infrapopliteal (IP) arterial disease. Materials and Methods: This retrospective, single-center study included 51 patients (37 males; mean age: 63.43 ± 9.81 years) with diabetes mellitus having IP arterial disease, from October 2012 to September 2014. Twenty-two patients were treated with PTA, and 29 patients were treated with DEBs. After intervention, the patients were evaluated in the first week and every 3 months, clinically and radiologically. Univariate and mu . . .ltivariate analyses were used to evaluate the clinical outcomes of diabetic patients with IP arterial disease who were treated with either DEBs or PTA. Results: There were no statistically significant differences between the groups in terms of age and gender, risk factors, characteristics of lesions, or the diameters or length of the balloons (P >.05). Primary patency was higher in the DEB group than in the PTA group (97.8% vs 81.1%, P =.020) in the first 3 months. However, there was no statistically significant difference at 1-year follow-up (68.2% vs 48.5%, P =.131). At the 12-month follow-up, there was no difference in clinical improvement between the groups (P =.193). Conclusion: The findings of this study reveal that DEB is a safe alternative treatment method for IP arterial disease in diabetic patients. © The Author(s) 2016 Daha fazlası Daha az

Nuclear morphometric and morphological analysis of exfoliated buccal and tongue dorsum cells in type-1 diabetic patients

Oz Z.S. | Bektas S. | Battal F. | Atmaca H. | Ermis B.

Article | 2014 | Journal of Cytology31 ( 3 ) , pp.139 - 143

Background: Diabetes mellitus type 1 that results from immunologically mediated damage to the ß-cells in the pancreas. Diabetes mellitus is characterized by recurrent or persistent hyperglycemia. Hyperglycemia can be associated with salivary gland dysfunction and alterations in the oral epithelial cells. Aim: The aim of this study was to evaluate the qualitative and quantitative changes in buccal and tongue dorsum epithelial cells using an exfoliative cytology method in type 1 diabetic patients. Materials and Methods: We performed light microscopic analysis of the buccal and tongue dorsum smears in thirty type 1 diabetic patients an . . .d thirty healthy individuals. The oral smears were stained using Papanicolaou method for cytological examination and nuclear morphometric analysis. In each case, the mean nuclear area, perimeter, length, breadth, and roundness factor were evaluated in each smear using the image analysis software (Q Win, Leica™ ). Results: The nuclear area, length, breadth, and perimeters were significantly higher in the diabetic group from tongue dorsum smear than that of the control group (P < 0.05). In the cytological examination, karyorrhexis-karyolysis-karyopyknosis, binucleation, nuclear membrane irregularity, cytoplasmic polymorphism, perinuclear halo were observed in oral smears with type 1 diabetic patients. Binucleation (P = 0.002) and nuclear membrane irregularity (P = 0.024) were significantly more common in buccal smears of diabetic group. Furthermore, the sensitivity of buccal mucosa was significantly higher in the diabetic group (P = 0.006). Conclusion: The light microscopic and nuclear morphometric study indicates that type 1 diabetes can produce morphological and nuclear morphometric changes in the oral mucosa that are noticeable with exfoliative cytology Daha fazlası Daha az

Does Type 2 Diabetes Mellitus Affect the Healing of Bell's Palsy in Adults?

Şevik Eliçora S. | Erdem D.

Article | 2018 | Canadian Journal of Diabetes42 ( 4 ) , pp.433 - 436

Objectives: Bell's palsy (BP) is defined as an acute facial weakness of unknown cause. Many factors affecting the healing of BP have been identified; 1 factor commonly considered relevant is the presence of type 2 diabetes mellitus. Our aim was to investigate the effects of diabetes on the healing of BP. Methods: Sixty patients with BP were followed up for 1 to 3 years and were divided into 2 groups, those with and those without type 2 diabetes. All were prescribed prednisone (initially 1 mg/kg per day, with a tapered dose reduction) and acyclovir (200 mg orally every 4 h, 5 times daily, for 5 days). Their recovery times were compar . . .ed. Results: The healing times of the patients with and without diabetes did not differ. Conclusions: Diabetes does not affect the severity, recovery rate from or healing of BP. © 2017 Diabetes CanadaObjectifs: La paralysie de Bell (PB) se caractérise par une faiblesse faciale soudaine dont la cause est inconnue. Parmi les nombreux facteurs qui nuisent à la guérison de la PB, le facteur généralement jugé pertinent est la présence du diabète sucré de type 2. Notre objectif était d'examiner les répercussions du diabète sur la guérison de la PB. Méthodes: Nous avons suivi 60 patients atteints de PB durant 1 à 3 ans et les avons répartis en 2 groupes : les patients atteints du diabète de type 2 et les patients non atteints. Tous se sont fait prescrire de la prednisone (ordonnance initiale de 1 mg/kg par jour, suivie d'une réduction progressive de la dose) et de l'acyclovir (200 mg par voie orale toutes les 4 heures, 5 fois par jour, durant 5 jours). Nous avons comparé leur vitesse de guérison. Résultats: La vitesse de guérison des patients diabétiques ou non diabétiques ne différait pas. Conclusions: Le diabète n'a pas de répercussions sur la gravité le taux de rétablissement ou la guérison de la PB Daha fazlası Daha az

The Isolated Abducens Nerve Palsy Occured After Postviral Infection in A Diabetic Patient

Gunes, Aygul | Yildiz, Demet | Pekel, Nilufer Buyukkoyuncu | Seferoglu, Meral | Parmak, Neslihan | Yazgan, Serpil | Altintas, Ozge

Article | 2018 | BEZMIALEM SCIENCE6 ( 4 ) , pp.317 - 319

Malignancy, immunosuppressive drug use, and diabetes mellitus (DM) are defined as risk factors for herpes zoster. A 58-year-old male patient with the diagnosis of DM was admitted to the emergency room with the complaints of double vision. His neurological examination revealed under activity of the right lateral rectus muscle and hypoactive deep tendon reflexes. In this report, we discuss a rare case of isolated abducens nerve palsy that occurred after postviral infection in the patient.

Determining the amount of ellagic acid extracted from Eregli (Ottoman) strawberry and histopathological evaluation of possible protective effect of ellagic acid in streptozotocin-induced diabetic rat

Oz, Z. S. | Atabay, M. M. | Gulle, K. | Akpolat, M.

Conference Object | 2015 | FEBS JOURNAL282 , pp.309 - 309

40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life -- JUL 04-09, 2015 -- Berlin, GERMANY WOS: 000362570605161

Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting

Furat, Cevdet | Dogan, Riza | Ilhan, Gokhan | Bayar, Ekrem | Ozpak, Berkan | Kara, Hakan | Bozok, Sahin

Article | 2017 | CARDIOVASCULAR JOURNAL OF AFRICA28 ( 3 ) , pp.191 - 195

Objective: This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus. Methods: Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic charact . . .eristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared. Results: Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively. Conclusion: Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery Daha fazlası Daha az

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